CN204395040U - Wrap fibrous micro crowning massage paster - Google Patents
Wrap fibrous micro crowning massage paster Download PDFInfo
- Publication number
- CN204395040U CN204395040U CN201290001066.7U CN201290001066U CN204395040U CN 204395040 U CN204395040 U CN 204395040U CN 201290001066 U CN201290001066 U CN 201290001066U CN 204395040 U CN204395040 U CN 204395040U
- Authority
- CN
- China
- Prior art keywords
- fiber
- micro crowning
- massage paster
- fibre
- massage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/08—Devices for applying needles to such points, i.e. for acupuncture ; Acupuncture needles or accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/04—Devices for pressing such points, e.g. Shiatsu or Acupressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
Abstract
This utility model relates to bag fibrous micro crowning massage paster, and it contains fiber and solable matter, has the fibre applicator of laminated structure on solable matter.In order to solve the problem of micro crowning massage paster in the past, fiber of the present utility model has following feature, namely, prevent the distortion occurred when water is dried in preparation process or the phenomenon fractureed, and, even if after water is dried, also make pliability maintain, thus when bending or bending also can not be fractureed.
Description
Technical field
This utility model relate to can by medical or beauty treatment for the purpose of usefully use micro crowning massage paster.
Background technology
Micro crowning massage paster (micro-needle massage patch) technology be by medical and improve looks for the purpose of, bore a hole with the horny layer (stratum corneum) of painless mode at epidermis, make effective ingredient be absorbed in technology in skin surface.If press micro crowning massage paster at skin surface in the mode be close to, then and corium overall at epidermis forms fine path, and by this path, the active substance being applied in skin is thrust in skin surface.This micro crowning massage plaster chip technology is as almost not having operation pain, and the easy to use and technology of safety is the new technique that nearest the world of medicine actively promotes research.
Preferably, the feature of micro crowning massage paster is, comprises very thin and has the micro crowning of suitable mechanical strength, stickiness and hardness, can permeate in skin surface.Further, the micro crowning be made up of the solable matter easily dissolving in vivo or permeate can use and be selected from chitosan (chitosan), collagen protein (collagen), gelatin (gelatin) and hyaluronic acid (hyaluronic acid; HA) the organism source solable matter in group, polylactic acid (polylactic acid), polyglycolic acid (polyglycolic acid) and their copolymer, the biocompatible macromolecule of polyethylene glycol oxide, polyacrylate, polyacrylamide etc. and water soluble polymer.And, also micro crowning paster can be used, the feature of above-mentioned micro crowning paster is, forming by having conductive material, the conductivity macromolecules such as polyaniline, polypyrrole and polythiophene and the conductive powder such as white carbon black, metal dust can be used by materials such as the macromolecules of Composite to prepare micro crowning.
As mentioned above, comprise the massage paster of the micro crowning be made up of solubility or conductivity material owing to presenting the phenomenon of distortion in the process of preparation, or when using as product, there is the shortcoming because external stress causes bending etc. not soft, therefore, preparation process is very harsh, and recently, though to the research that the device of the micro crowning (micro-needle) with solubility enlivens, in fact and fail to solve the above problems (with reference to No. 2003-238347, Japanese Laid-Open Patent Publication).
The preparation method of well-known micro crowning massage paster comprises: will be selected from the step being coated on the mould corresponding with the shape of micro crowning as the organism source material in the chitosan of solable matter, collagen protein and gelatin and hyaluronic group and the aqueous solution as required containing at least one in medical agent or cosmetic agent; Dry step is carried out under room temperature (20 to 30 DEG C) or heating (50 to 100 DEG C) condition; And the step of formation is peeled off after drying from mould.In the water as solvent used in this preparation process of drying, the process of other organic solvents, because of distortion or bending phenomenon and to have the fraction defective when preparation process high and make flexibility reduce after the preparation because article shaped is hard, thus there is the characteristic also easily fractureed when bending a little, being therefore badly in need of the technology of exploitation for addressing this is that.
Utility model content
Technical problem
This utility model is in order to solve the problem of prior art as above, there is provided change all the time freely and there is the micro crowning massage paster of outstanding aeration, above-mentioned micro crowning massage paster is prepared in the mode comprising fiber (fiber) at micro crowning massage paster, thus in drying steps in preparation process, there will not be the phenomenon of distortion, maintain pliability, even and if also do not occur bending after the preparation or bend also can not being fractureed.
Further, this utility model providing package is containing the preparation method of the micro crowning massage paster of above-mentioned fiber.
The method of dealing with problems
In order to solve the problem, this utility model providing package fibrous micro crowning massage paster and preparation method thereof.
Because micro crowning of the present utility model needs to supply effective ingredient by thrusting the mode such as to dissolve in skin surface or fracture in skin surface, therefore preferably, use can at the diffluent solable matter of skin surface content, but be not limited to solable matter, comprise the situation of conductive material.
A kind of micro crowning massage paster, containing fiber and solable matter, has the fibre applicator of laminated structure on solable matter.
The solable matter forming micro crowning comprises hyaluronic acid, all water soluble polymers such as chitosan, starch (starch), cellulose (cellulose), polyvinyl alcohol (polyvinyl alcohol), polyethylene glycol oxide (polyethylene oxide) and polyacrylate (polyacrylate), further, all cosmetic compositions such as vitamin C, peptide, protein, caffeine, salicylic acid and stem cell can be added at this to prepare as additive.
Further, except water-soluble high-molecular substance, common polymer substance can also be used, and in this case, suitable solvent can be selected, prepare in the same way.
Thrust by originate micro crowning that solable matter forms of one or more organisms of being selected from above-mentioned solable matter in cell due to needs, therefore, need to be formed in hard mode in order to its function, thus have and easily fracture in preparation process, or the phenomenon of distortion is there is along with the drying of moisture, or after water is dried, when the shortcoming using the phenomenon etc. for producing bending during product because of external stress not soft.
Therefore, this utility model is in order to overcome above-mentioned problem, be provided in the preparation process of micro crowning massage paster and prepare to wrap fibrous mode, to prevent the phenomenon of distortion in the drying steps of preparation process, and after aqueous solution is dried, though also can prevent by the massage paster fiber that comprise bending or bending also can not by the maintenance fractureed flexible massage paster.
The fiber that micro crowning provided by the utility model massage paster comprises means to have elongated and the natural silk that can flexibly bend or artificial silk shape form, the form that the sheet (sheet) of the form and non-woven fabrics, cloth and mesh (mesh) etc. namely with linear structure forms.
Of the present utility modelly be characterised in that, the diameter of fiber is 0.1 μm to less than 100 μm, is preferably 1 μm to less than 30 μm.And comprising aspect ratio (aspect ratio) is macromolecular fibre, metallic fiber, carbon fiber and conductivity macromolecular fibre etc. between 4 to 5000, but is not limited thereto.
As macromolecular fibre, there are acrylic fiber, chitin fiber, cellulose fibre, polyethylene fibre, polypropylene fibre, dacron fibre, polyimide fiber, Fypro etc., but be not limited thereto.As metallic fiber, comprise all metal materials such as rustless steel, aluminum, copper, nickel and titanium.
A kind of micro crowning massage paster, has fiber and the solable matter of the linear structure mixed mutually.
If the content of fiber is less than 1 percentage by weight, then reduce the function preventing twisted phenomena when water is dried, when fiber more than interpolation 80 percentage by weight, be difficult to disperse, thus have difficulties in the production of product, therefore preferably, the content of fiber more than 1 percentage by weight, should be less than 80 percentage by weights.
As long as the structure of micro crowning or form are when substrate is observed to point, fine protrusions with the structure of also massaging from the wide morphogenetic stimulus skin narrowed gradually of the width of substrate, just can not be subject to particular restriction, preferably, length be 20 μm to below 2mm, but to be not limited thereto.
And, the preparation method of above-mentioned massage paster the method by mixing and disperse solable matter and fiber to prepare is provided and by solable matter to after the mould that micro crowning massages paster is poured into, non-woven fabrics etc. is had the preparation method of fibre applicator on solable matter of sheet form.
First, prepare the method for massaging paster comprise by mixing solable matter and fiber: the solable matter of hyaluronic acid, collagen protein, starch, cellulose and chitosan etc. is dissolved, and make fiber mixing and be scattered in the step of the aqueous solution comprising solable matter; The solubility solution being dispersed with fiber is coated on the step of micro crowning mould; Dry step is carried out under room temperature (25 DEG C) or high temperature (50 to 100 DEG C) condition; And the step of above-mentioned dry micro crowning massage paster is separated from mould.When mixing solable matter and fiber in the methods described above, the ratio of the fiber used is preferably below more than 1 percentage by weight, 80 percentage by weights, the diameter of fiber is 0.1 μm to less than 100 μm, and be preferably 1 μm to less than 30 μm, aspect ratio is preferably between 4 to 5000.
Another pattern of the preparation method of above-mentioned massage paster, as the method for the fiber of the cloth form utilizing non-woven fabrics form or prepared by weaving process, mesh form, being comprised: make the step that the solable matter of hyaluronic acid, collagen protein and chitosan etc. dissolves; The above-mentioned aqueous solution comprising solable matter is coated on the step of micro crowning mould; The fiber of chip architecture the step of impregnation of fibers with non-woven fabrics form, cloth form and mesh form is applied at the aqueous solution comprising solable matter; Under room temperature or high temperature (50 to 100 DEG C) condition, drying is carried out to the moisture of the aqueous solution being coated on above-mentioned mould, prepare the step of the massage paster of one end binding fiber thus; And the step of above-mentioned massage paster is separated from mould.The material of the non-woven fabrics used in above-mentioned preparation method, cloth and mesh comprises macromolecular fibre, metal and carbon fiber etc., but is not limited thereto.The thickness of above-mentioned non-woven fabrics etc. be 10 μm to 3mm, be preferably 30 μm to 1mm.
The fiber of above-mentioned non-woven fabrics, cloth and mesh etc. has the architectural feature that can ventilate, and therefore aeration is outstanding, and when being attached to skin, can prevent the side effect of to fester etc. of skin.Further, the additional function such as antibacterial functions, perfume can be added at the fiber of non-woven fabrics, cloth etc.
Accompanying drawing explanation
Fig. 1 is the ideograph that the micro crowning applied with composite fibre 300 and the mode of solable matter 200 massages paster.
Fig. 2 is the ideograph of the massage paster applying the fiber 400 be made up of sheet on solable matter 200.
The explanation of Reference numeral
100: the supporting substrate of massage plaster die
110: the micro crowning of massage plaster die
200: solable matter
300: the fiber of linear structure
400: the fiber be made up of sheet
Detailed description of the invention
Below, by can the preferred embodiment of the present utility model of specific implementation be described above-mentioned object, scope of the present utility model is not by limitation or the restriction of above-described embodiment, and the enforcement carried out numerous variations or comprise technological thought of the present utility model should be considered as all belonging to category of the present utility model.
embodiment 1. mixes the preparation of the fiber of linear structure and the massage paster of solable matter
1) will there is linear structure and the polyester staple fiber 200 that aspect ratio is 5 mixes with the hyaluronic acid as solable matter 300.At this moment, the mixing ratio of fiber and solable matter is 3:7.
2) solable matter being mixed with fiber is coated on mould 100,110 with the amount of 250-300 μm.
3) at the temperature of 50 DEG C, coated mixture is dry 2 hours.
4) be separated dry massage paster from mould, prepare massage paster thus.
embodiment 2. is mixed with the preparation of the fiber of laminated structure and the massage paster of solable matter
1) with by solable matter hyaluronic acid with 30% the concentration mode that is dissolved in water prepared aqueous solution, and prepared solable matter is coated on massage plaster die.
2) there is in the coating of the top of solable matter the polyester fiber of the non-woven fabrics form of laminated structure, make it impregnated in solable matter.The fiber of above-mentioned laminated structure employs the sheet-like fiber that thickness is 150 μm.
3) at the temperature of 70 DEG C, by dry 1 hour for the solable matter aqueous solution being impregnated with fiber.
4) be separated dry massage paster from mould, prepare massage paster thus.
embodiment 3. massages the distortion of paster and the comparison of breakage phenomenon
In order to the minimizing degree comparing distortion and fracture in the preparation process of above-described embodiment 1 with embodiment 2, prepare following massage paster.
As comparative example, massage paster has been prepared in the preparation of not wrapping fibrous massage paster as follows: 1) using as solable matter hyaluronic acid with 30% concentration be dissolved in water, prepared aqueous solution thus; 2) prepared solable matter is coated on massage plaster die; 3) dry 1 hour at the temperature of 70 DEG C; 4) dry massage paster is separated from mould.
Compare the distortion of embodiment 1, embodiment 2 and comparative example, fracture and mouldability.Though the phenomenon that embodiment of the present utility model 1 and embodiment 2 do not present mouldability, distortion and to fracture etc. in preparation process, when comparative example, present about 50% distortion and the phenomenon fractureed.
| Project | Distortion | Fracture | Mouldability |
| Embodiment 1 | 0％ | 0％ | 100％ |
| Embodiment 2 | 0％ | 0％ | 100％ |
| Comparative example | 50％ | 50％ | 60～90％ |
Claims (9)
1. a micro crowning massage paster, is characterized in that, containing fiber and solable matter, having the fibre applicator of laminated structure on solable matter.
2. micro crowning massage paster according to claim 1, it is characterized in that, with the weight basis of micro crowning massage paster, the content of above-mentioned fiber is 1 percentage by weight to 80 percentage by weight.
3. micro crowning massage paster according to claim 1, it is characterized in that, the fiber with laminated structure is non-woven fabrics, cloth, mesh form.
4. micro crowning massage paster according to claim 1, it is characterized in that, above-mentioned solable matter is be selected from the one in the group of hyaluronic acid, chitosan, starch, cellulose, polyvinyl alcohol, polyoxyethylene and polyacrylate.
5. micro crowning massage paster according to claim 1, it is characterized in that, above-mentioned solable matter comprises the one in the group being selected from and being made up of vitamin C, peptide, protein, caffeine, salicylic acid, stem cell, medicine or cosmetic composition.
6. micro crowning massage paster according to claim 1, it is characterized in that, the diameter of above-mentioned fiber is 0.1 μm to 100 μm.
7. micro crowning massage paster according to claim 1, it is characterized in that, above-mentioned fiber is selected from the one in the group be made up of macromolecular fibre, metallic fiber, carbon fiber or conductivity macromolecular fibre.
8. micro crowning massage paster according to claim 7, it is characterized in that, above-mentioned macromolecular fibre is selected from the one in the group be made up of acrylic fiber, chitin fiber, cellulose fibre, polyethylene fibre, polypropylene fibre, dacron fibre, polyurethane fibre or acid fiber by polylactic.
9. micro crowning massage paster according to claim 7, it is characterized in that, above-mentioned metallic fiber is selected from the one in the group be made up of rustless steel, aluminum, copper, nickel and titanium.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2011-0133649 | 2011-12-13 | ||
| KR1020110133649A KR101392947B1 (en) | 2011-12-13 | 2011-12-13 | Micro-needle massage patch containing fiber and method of preparing the same |
| PCT/KR2012/010858 WO2013089461A1 (en) | 2011-12-13 | 2012-12-13 | Massage patch having fine protrusions and comprising fibers, and method for manufacturing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204395040U true CN204395040U (en) | 2015-06-17 |
Family
ID=47837388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201290001066.7U Expired - Lifetime CN204395040U (en) | 2011-12-13 | 2012-12-13 | Wrap fibrous micro crowning massage paster |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR101392947B1 (en) |
| CN (1) | CN204395040U (en) |
| WO (1) | WO2013089461A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236978A (en) * | 2019-05-21 | 2019-09-17 | 江苏悦智生物医药有限公司 | Microneedle patch and method for producing same |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101724654B1 (en) | 2014-06-02 | 2017-04-12 | 주식회사 아모라이프사이언스 | Micro-needle patch and menufacturing method thereof |
| KR101724655B1 (en) | 2014-06-02 | 2017-04-13 | 주식회사 아모라이프사이언스 | Micro-needle patch and menufacturing method thereof |
| KR101976431B1 (en) * | 2017-06-09 | 2019-05-10 | 주식회사 스몰랩 | Micro needle elastic structure |
| KR102369530B1 (en) * | 2017-11-24 | 2022-03-03 | 주식회사 스몰랩 | Micro needle and method of fabricating the same |
| KR101964264B1 (en) | 2018-09-04 | 2019-04-01 | 한국생산기술연구원 | Adhesive material and use thereof |
| KR102163164B1 (en) * | 2019-04-01 | 2020-10-08 | 재단법인대구경북과학기술원 | Nanofiber mesh bioelectrode, and method for producing the same |
| KR102621807B1 (en) * | 2020-06-30 | 2024-01-08 | 주식회사 엘지생활건강 | Microneedle comprising microfibril network structure |
| US20230302266A1 (en) * | 2020-06-30 | 2023-09-28 | Lg Household & Health Care Ltd. | Microneedle comprising microfiber network structure |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03003815A (en) | 2000-10-26 | 2004-08-12 | Johnson & Johnson | Transdermal drug delivery devices having coated microprotrusions. |
| JP4090018B2 (en) | 2002-02-18 | 2008-05-28 | Ｆｏｒ Ｈｅａｄ株式会社 | Functional micropile and manufacturing method thereof |
| WO2004000389A2 (en) * | 2002-06-25 | 2003-12-31 | Sung-Yun Kwon | Rapidly dissolving micro-perforator for drug delivery and other applications |
| KR100792640B1 (en) | 2006-07-14 | 2008-01-09 | 호남석유화학 주식회사 | Skin pricking micro projection apparatus |
| KR100960905B1 (en) * | 2008-02-29 | 2010-06-04 | (주)아모레퍼시픽 | Device for skin massage including micro/nano scale fibrillar structure effectively inspired from the biological attachment system |
| WO2010099548A2 (en) * | 2009-02-27 | 2010-09-02 | Virginia Tech Intellectual Properties, Inc. | Fiber array for optical imaging and therapeutics |
-
2011
- 2011-12-13 KR KR1020110133649A patent/KR101392947B1/en active IP Right Grant
-
2012
- 2012-12-13 CN CN201290001066.7U patent/CN204395040U/en not_active Expired - Lifetime
- 2012-12-13 WO PCT/KR2012/010858 patent/WO2013089461A1/en active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110236978A (en) * | 2019-05-21 | 2019-09-17 | 江苏悦智生物医药有限公司 | Microneedle patch and method for producing same |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130006259A (en) | 2013-01-16 |
| WO2013089461A1 (en) | 2013-06-20 |
| KR101392947B1 (en) | 2014-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20150617 |