CN204351966U - A kind of angioplastic device for 3D biometric print - Google Patents
A kind of angioplastic device for 3D biometric print Download PDFInfo
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- CN204351966U CN204351966U CN201420479918.4U CN201420479918U CN204351966U CN 204351966 U CN204351966 U CN 204351966U CN 201420479918 U CN201420479918 U CN 201420479918U CN 204351966 U CN204351966 U CN 204351966U
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Abstract
This utility model discloses a kind of angioplastic device for 3D biometric print, for biotechnology, is intended to solve the problems such as the angioplastic existed when printing blood vessel by 3D biometric print technology is at present of poor quality, molding length is short.Biological print ink, by 3D biometric print technology, is covered with on the swingle of temperature-sensitive hydrogel to top layer, and can forms required biological blood vessel by further biological culture by this device.This device is by preparing the swingle of different-diameter and length to print the biological blood vessel of different size, and can go out the vascular tissue that thickness is even, have precise Printing size by printing speed, and adoptable 3D printing technique is various, practicality is extensive.
Description
Technical field
The present invention relates to the biological engineering manufacturing technology in field of tissue engineering technology, be specifically related to a kind of angioplastic device for 3D biometric print.
Background technology
Along with the raising of aged tendency of population and living standards of the people, the cardiovascular and cerebrovascular disease incidence rate that China causes because of vascular lesion raises year by year.Report display China cardiovascular diseases in 2012 now suffers from number and reaches 2.9 hundred million, about has 3,500,000 people to die from cardiovascular disease every year, accounts for 41% of total cause of death, occupy first of various disease.Therefore actively develop the Therapy study of blood vessel kind disease, improve the physique of the entire people extremely urgent.The conventional method solving blood vessel kind disease carries out displacement and the transplanting of blood vessel at present, vascular replacement is the effective ways of the important vascular diseases such as treatment aneurysm, arterial thrombus, heart arter bridging, wound class blood vessel injury, the method generally adopts artificial blood vessel, therefore, the successful preparation of artificial blood vessel is the key point of blood vessel kind disease treatment.
On clinical medicine, the normal artificial blood vessel used has dacron-made artificial blood vessel, the macromolecular material artificial blood vessels such as polyurethane material artificial blood vessel, Applications of Pure Silk Vascular Prosthesis.Due to this, series macromolecular material artificial blood vessel all also exists bio-compatibility difference, service life is short, long-term patency rate is poor, easily causes the problems such as palindromia.In recent years, along with the development of organizational project, people begin through 3D biometric print technology exploration and manufacture novel artificial blood vessel, and 3D biometric print technology is the new technique carrying out live body printing using compositions such as polymeric biomaterial, cell, extracellular matrixs as printing prepared Chinese ink.Its advantage is just the 3 D-printing cell of controllable precise and the use of biomaterial, and can according to the customizing print artificial blood vessel of the shape of patient's lesion vessels and size personalization.
The mode that current 3D biometric print technology adopts when printing blood vessel is in culture vessel, pile up biological prepared Chinese ink cell layer by layer, then obtains required artificial blood vessel by follow-up biological culture.The concrete grammar of its angioplastic has two kinds: the first is stacked vertically, as shown in Figure 1, the blood vessel that this method prints owing to being subject to the impact of self gravitation and mechanical performance, to print the blood vessel obtained short, Forming Quality is poor; The second is parallel accumulation molding, and as shown in Figure 2, this method is subject to the mechanical impact of blood vessel bar equally, and artificial blood vessel's cell distribution of acquisition is mixed and disorderly, is not easy accurate control.Meanwhile, these two kinds of blood vessel printing shaping methods all exist that shaping speed is slow, efficiency is low, and the finished product structure printed is undesirable, cannot form the problems such as complete biological blood vessel.
Summary of the invention
In order to overcome the current 3D biometric print technology defect existing when printing blood vessel, the invention provides a kind of blood vessel printing shaping device for 3D biometric print technology, these innovation and creation introduce the bracing frame that swingle prints as blood vessel, using the platform that swingle surface prints as blood vessel, solving the molding undesirable problem of current 3D biometric print technology when printing blood vessel, easily can construct vascular tissue.
The angioplastic device designed in the present invention, mainly comprise the swingle and biometric print shower nozzle that are rotated by driven by motor one end, one end of this swingle to be installed in bearing and to be rotated by driven by motor, the other end of swingle is unsettled, motor is arranged on a bracing frame, bracing frame is arranged on one piece of base by screw, and biometric print shower nozzle moves on the surface at swingle.
The material of the swingle in the present invention is biocompatible materials, and its length and size mainly design according to the shape of blood vessel of required printing and size.In addition motor is can the servomotor of accuracy controlling speed or motor, motor and the connected mode of swingle be connected by an axle sleeve direct, undertaken by axle and drive mechanism be indirectly connected or connected by magnetic drive.
Another object of the present invention sums up new mechanism and the new method of the tubular tissue molding such as blood vessel, and study the shape on forming process surface, molding pore size and porosity, the circle distribution of the alternately shape textile structural of stress equilibrium and axial distribution, organize the impact on cell survival rate such as shaping strength; Study the optimum speed of forming process, molding time, rod-shape and material and best network structure.
Compared with manufacturing forming technique with current blood vessel, the present invention has the following advantages:
1, by the difform bar of design, comparatively complicated biological blood vessel can be printed;
2, can print longer vascular tissue, the vascular tissue of printing is not affected by gravity or affects less, and the vascular tissue of printing is not yielding;
3, adopt the auxiliary printing of swingle, can print speed be accelerated, meet the specific demand that biological vascular tissue prints.
Accompanying drawing explanation
Fig. 1 is stacked vertically blood vessel Method of printing, and wherein accompanying drawing 1 a-h represents cell prepared Chinese ink respectively and supports the arrangement of prepared Chinese ink in print procedure.
Fig. 2 is parallel stacks hematocele pipe Method of printing, and wherein accompanying drawing 2 a-d represents cell prepared Chinese ink respectively and supports the arrangement of prepared Chinese ink in print procedure.
Fig. 3 is 3D rotational forming printing equipment perspective view, and wherein 1 is screw, and 2 is motors, and 3 is swingles, and 4 is the biological prepared Chinese ink printed on swingle surface, and 5 is biometric print shower nozzles, and 6 is bases, and 7 is bracing frames.
Fig. 4 is that in Fig. 3, the relative swingle of the biological shower nozzle of partial printing walks track configuration enlarged drawing.Fig. 5 is that in Fig. 3, the relative swingle of the biological shower nozzle of another partial printing walks track configuration enlarged drawing.
Detailed description of the invention
In order to set forth object of the present invention, technical scheme and advantage further, below in conjunction with accompanying drawing, the present invention is described in more detail.Should be appreciated that concrete enforcement described herein is only in order to explain the present invention, is not limited to the present invention.
The invention provides a kind of blood vessel printing shaping device for 3D biometric print technology, these innovation and creation introduce the bracing frame that swingle prints as blood vessel, using the platform that swingle surface prints as blood vessel, solving the molding undesirable problem of current 3D biometric print technology when printing blood vessel, easily can construct vascular tissue.
The printing shaping apparatus structure that 3D rotational forming Method of printing adopts as shown in Figure 3, wherein one end of swingle 3 to be installed in bearing and to drive rotation by motor 2, the other end of swingle is unsettled, motor is arranged on bracing frame 7 by bolt, bracing frame is arranged on one piece of base by screw, biometric print shower nozzle mainly on swingle and along swingle direction of principal axis move by biological ink jet to swingle surface.
In addition the swingle Material selec-tion in accompanying drawing 3 is biocompatible materials, and its length and size mainly design according to the shape of blood vessel of required printing and size.Motor is can the servomotor of accuracy controlling speed or motor, motor and the connected mode of swingle be connected by an axle sleeve direct, undertaken by axle and drive mechanism be indirectly connected or connected by magnetic drive.
Medium vessels of the present invention prepares shaped device:
1, by computer aided design software design swingle model, its swingle model parameter comes from actual vessel parameter, also can carry out the modeling of blood vessel parameter according to the actual requirements;
2, rapid shaping, machining, electric machining or laser processing technology is utilized to prepare swingle designed in step 1, the Material selec-tion biocompatible materials of swingle, simultaneously at the certain thickness temperature-sensitive hydrogel material of this swingle surface smear one deck, to ensure the compatibility of swingle material and biological cell;
3, the swingle in step 2 to be connected with electric rotating machine indirectly by the intermediate transmission mechanism such as power transmission shaft, decelerator or to be directly connected on motor;
4, control driven by motor swingle to rotate, on the surface by low-temperature precipitation printing technique (LDM) by biological cell print ink to swingle simultaneously, its concrete grammar is that swingle rotates, printing head moves axially along swingle simultaneously, and by biological ink jet to swingle on the surface, first at the biological prepared Chinese ink of the certain thickness endotheliocyte of swingle printout surface one deck, continue after printing to print the biological prepared Chinese ink of the certain thickness smooth muscle cell of one deck on endothelial cell surface, as shown in Figure 4 and Figure 5.
5, after printing, printed vascular tissue and swingle are taken off and puts into bio-incubator, add various cell growth factor and short differentiation factor, acceleration vascular tissue's structure and various physiological function are reached maturity, and finally obtain required biological blood vessel.
The present invention is not limited to appeal embodiment, if do not depart from the spirit and scope of the present invention to various change of the present invention and modification, if these are changed and modification belongs within claim of the present invention and equivalent technologies scope, then the present invention is also intended to comprise these change and modification.
Claims (4)
1. the angioplastic device for 3D biometric print, comprise the swingle and biometric print shower nozzle that are rotated by driven by motor one end, it is characterized in that, motor is arranged on a bracing frame, bracing frame is arranged on one piece of base by screw, one end of swingle to be installed in bearing and to be rotated by driven by motor, and the other end of swingle is unsettled, and biometric print shower nozzle can move on the surface at swingle.
2. angioplastic device according to claim 1, is characterized in that, the material of swingle is biocompatible materials, and its length and size parameter design according to shape of blood vessel and size.
3. angioplastic device according to claim 1, is characterized in that, described motor is the speed motor that can accurately control or servomotor.
4. angioplastic device according to claim 1, is characterized in that, swingle and the connected mode of motor be connected by an axle sleeve direct, undertaken by axle and drive mechanism be indirectly connected or connected by magnetic drive.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420479918.4U CN204351966U (en) | 2014-08-24 | 2014-08-24 | A kind of angioplastic device for 3D biometric print |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420479918.4U CN204351966U (en) | 2014-08-24 | 2014-08-24 | A kind of angioplastic device for 3D biometric print |
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| Publication Number | Publication Date |
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| CN204351966U true CN204351966U (en) | 2015-05-27 |
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| CN201420479918.4U Active CN204351966U (en) | 2014-08-24 | 2014-08-24 | A kind of angioplastic device for 3D biometric print |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104146794A (en) * | 2014-08-24 | 2014-11-19 | 周惠兴 | Blood vessel forming device and method for 3D bioprinting |
| WO2017087904A1 (en) * | 2015-11-20 | 2017-05-26 | Organovo, Inc. | Rotating device and method for continuous fabrication of long biological tubes |
| CN107418873A (en) * | 2016-09-14 | 2017-12-01 | 四川蓝光英诺生物科技股份有限公司 | Biological construct Method of printing and device |
-
2014
- 2014-08-24 CN CN201420479918.4U patent/CN204351966U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104146794A (en) * | 2014-08-24 | 2014-11-19 | 周惠兴 | Blood vessel forming device and method for 3D bioprinting |
| WO2017087904A1 (en) * | 2015-11-20 | 2017-05-26 | Organovo, Inc. | Rotating device and method for continuous fabrication of long biological tubes |
| CN107418873A (en) * | 2016-09-14 | 2017-12-01 | 四川蓝光英诺生物科技股份有限公司 | Biological construct Method of printing and device |
| CN107418873B (en) * | 2016-09-14 | 2021-08-06 | 四川蓝光英诺生物科技股份有限公司 | Biological construct printing method and device |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180206 Address after: 1 No. 611731 Sichuan city of Chengdu province high tech Zone West Park Avenue Dixon Patentee after: SICHUAN REVOTEK BIOTECHNOLOGY CO., LTD. Address before: 100083 Qinghua East Road, Haidian District, Beijing, No. 17, 42-2-1901 Patentee before: Zhou Huixing |
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| TR01 | Transfer of patent right |