CN105232179A - Rapid prototyping preparation method of implant material of plastic surgery - Google Patents
Rapid prototyping preparation method of implant material of plastic surgery Download PDFInfo
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Abstract
The invention discloses a rapid prototyping preparation method of an implant material of a plastic surgery. The method comprises the following steps of designing a three-dimensional structural model of a plastic part by using computer-aided design (CAD) software; importing CAD model data in a three-dimensional printer and performing slicing processing; preparing a biological material into a solution or directly adding the biological material in the three-dimensional printer; setting relevant parameters; starting the three-dimensional printer and printing the model layer by layer; and performing aftertreatment on a prototype to obtain the implant material of the plastic surgery or directly taking the prototype as the implant material of the plastic surgery. An implantable biological material is used for preparing a stent, immunological rejection is not caused, and biological compatibility is good; and moreover, the stent is prepared by a rapid prototyping technology, geometric profile, aperture, porosity and hole distribution of the stent are controlled accurately, a personalized plastic treatment scheme is formulated, a preparation technology is convenient and speedy, operation steps are simple, and an application prospect is wide.
Description
Technical field
The invention belongs to the preparing technical field of bio-medical material, be specifically related to a kind of rapid shaping preparation method of plastic surgery's embedded material.
Background technology
Liking to be beautiful is the nature of people, and along with the continuous progress of science and technology and the lifting of people's economic capability, the pursuit mode of people to U.S. is also more diversified, and shaping and beauty is exactly one of them.Plastic surgery is the means adopting medical science and art, to incompleteness, the deformity of tissue, organ, carries out repair and reconstruction, and beautifying and mould normal person's body, reaches the restoration and reconstruction of function, the improvement of form and beautifying.Plastic surgery is the transplanting that the method for performing the operation carries out various tissue, can adopt autologous tissue or allosome tissue, but autologous tissue source is very limited, and produces second operation, more painful brings to patient; Allograft also exists again immunological rejection and carries the risk of virus and antibacterial.Therefore adopting the biomaterial with good biocompatibility, and implant after being built into the shape matched with shaping position in vitro, is a kind of desirable shape means.But how according to the requirement of different patient and the feature of material therefor, accurately controlling the distribution in the geometric shape of implant frame, aperture, porosity and hole, the orthopedic treatment scheme of rapid development personalization, is one of problem anxious to be resolved at present.
Rapid shaping technique (RP) is born in the later stage eighties 20th century, based on principle that is discrete and that pile up, pass through CT, behind NMR (Nuclear Magnetic Resonance)-imaging scanning human lesion defective region, computer is utilized to set up the cad model consistent with human lesion defective region geometrical body, or according to the requirement of product, design threedimensional model on computers, then hierarchy slicing is carried out to it, the profile of each layer section is made approximate processing, and carry out approximate model with a series of little triangle projective planum, be transferred to rapidform machine by STL formatted file to process, accurately pile up in appointed part, manufacture the technology setting up the consistent part of cad model with computer.RP can accurately regulate and control pore size, porosity and support geometry and not by the impact of complexity.Rapid shaping technique is combined with bio-medical material and is applied to plastic surgery, be a kind of brand-new thinking, there is boundless application prospect.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of rapid shaping preparation method of plastic surgery's embedded material is provided.
Rapid shaping technique combines with bio-medical material by the present invention, prepare a kind of plastic surgery's embedded material, this preparation method not only technique is convenient and swift, operating procedure is simple, and can according to the feature of the requirement of different patient and material, formulate personalized orthopedic treatment scheme, accurately regulate and control geometry and the internal structure of support, match with specific shaping position better.
The object of the invention is achieved through the following technical solutions:
A rapid shaping preparation method for plastic surgery's embedded material, comprises the following steps:
(1) utilize computer-aided design (CAD) software design to go out the 3 d structure model at shaping position, and this threedimensional model is saved as STL formatted file, then import in three-dimensional printer, carry out layered shaping by delamination software;
(2) implantable biomaterial deionized water be mixed with solution or directly add in three-dimensional printer, print temperature, platform temperature, syringe needle size, extrusion pressure, extruded velocity, internal structure and aperture parameters are set, then start three-dimensional printer by the 3 d structure model at shaping position successively printing shaping, obtain three dimensional structure support blank;
(3) finally the three dimensional structure support blank obtained is carried out post processing or is not processed directly obtaining a kind of orthopedic embedded material.
Further, described plastic surgery's embedded material can be used for any place or the many places at following shaping position: chest, buttocks, the bridge of the nose, lower jaw, forehead, eye and lip;
Further, in step (1), described 3 d structure model is utilize CASE(Computer Aided Software Engineering) to be set to the 3 d structure model of given shape, specific dimensions, specific standard according to the different shaping position of human body;
Further; in step (2), described implantable biomaterial be following any one or multiple: de-cell collagen, hyaluronic acid, sodium alginate, chitosan, silica gel, agar, lactic acid monohydroxy acetate multipolymer, polylactic acid, polyglycolic acid, polycaprolactone, polyhydroxyalkanoate, hydroxyapatite, tricalcium phosphate and bio-vitric;
Further, in step (2), described file printing temperature is 2 ~ 170 DEG C, and platform temperature is 0 ~ 65 DEG C, and syringe needle size is 0.2 ~ 0.4mm, and extrusion pressure is 1.0 ~ 3.5bar, and extruded velocity is 1.0 ~ 5.0mm/s, and aperture is 0.1 ~ 1.2mm;
Further, in step (2), described internal structure is that nozzle angle 0 ~ 179 ° is staggered, and lift height is 0.16 ~ 0.32mm;
Further, in step (2), in the solution that described biomaterial is mixed with, solution concentration is 0.01 ~ 0.2g/ml;
Further, in step (3), the porosity of described three dimensional structure support blank is 60 ~ 80%, and porosity communication rate is more than 90%;
Further, in step (3), described post-processing approach be following any one or multiple: crosslinked and 800 ~ 1200 DEG C of calcinings of lyophilization, vacuum drying, genipin; The concentration of described genipin is 0.1 ~ 0.5mg/ml.
Compared with prior art, tool of the present invention has the following advantages and technique effect:
(1) in the present invention, the support blank of plastic surgery's embedded material is prepared from by rapid shaping technique, not only preparation technology is convenient and swift, operating procedure is simple, and can according to the feature of the requirement of different patient and material, formulate personalized orthopedic treatment scheme, match with specific shaping position better.
(2) the present invention uses implantable biomaterial to prepare support, without immunological rejection, has good biocompatibility.
(3) plastic surgery's embedded material that prepared by the present invention not only has personalized outward appearance, also there is the internal structure of complicated porous simultaneously, therefore while playing filling effect in vivo, also help the growth of cell, blood vessel and tissue, thus make material have certain biological activity.
Accompanying drawing explanation
Fig. 1 is the process schematic of the specific embodiment of the invention.
Fig. 2 is the three-dimensional microscope photograph of upper surface of the embodiment of the present invention 1 bridge of the nose orthopedic implant materials internal structure.
Fig. 3 is the three-dimensional microscope photograph of cross section of the embodiment of the present invention 1 bridge of the nose orthopedic implant materials internal structure.
Fig. 4 is the time m-OD value figure of proliferative conditions on the bridge of the nose orthopedic implant materials that obtains in the embodiment of the present invention 1 of Marrow Mesenchymal Stem Cells (BMSCs).
Detailed description of the invention
For understanding the present invention further, below in conjunction with embodiment, the invention will be further described, but the scope of protection of present invention is not limited to embodiment.
Embodiment 1
A rapid shaping preparation method for bridge of the nose orthopedic implant materials, comprises the following steps:
(1) utilize computer-aided design (CAD) software design to go out the 3 d structure model at bridge of the nose shaping position, and this threedimensional model is saved as STL formatted file, then import in three-dimensional printer, carry out layered shaping by delamination software;
(2) be that the polylactic acid monohydroxy acetate multipolymer of 50:50 adds in the rustless steel barrel of three-dimensional printer by 2g molecular weight 3.1 ten thousand, PLA:PGA, in VisualMachines software, arrange print temperature is 150 DEG C, platform temperature is 20 DEG C, and standing 30min makes the abundant melting mixing of material even; Then arranging syringe needle size is 0.2mm, and extrusion pressure is 3bar, and extruded velocity is 1.5mm/s, and aperture is 0.6mm, and internal structure is 0 ° and 90 ° and is staggered, and lift height is 0.16mm; Start three-dimensional printer by the 3 d structure model successively printing shaping at bridge of the nose shaping position;
(3) three dimensional structure support blank phosphate buffer (PBS) at the bridge of the nose shaping position obtained is cleaned three times, obtain the orthopedic embedded material of a kind of bridge of the nose.Measure through CT, the porosity of the bridge of the nose plastic surgery embedded material obtained is 78.6%, and porosity communication rate is 98.3%.
As shown in drawings, Fig. 1 is concrete process schematic; Fig. 2 is the three-dimensional microscope photograph of upper surface of bridge of the nose orthopedic implant materials internal structure; Fig. 3 is the three-dimensional microscope photograph of cross section of bridge of the nose orthopedic implant materials internal structure; Fig. 4 is the time m-OD value figure of Marrow Mesenchymal Stem Cells (BMSCs) proliferative conditions on bridge of the nose orthopedic implant materials.
Vitro cytotoxicity experiment (CCK-8 method):
Arrange blank group (BMSCs mouse mesenchymal cell), experimental group (3D prints bridge of the nose plastic surgery embedded material, BMSCs mouse mesenchymal cell).Before repopulating cell, first 3D being printed bridge of the nose plastic surgery embedded material is soak 2h in the alcoholic solution of 75% in volume fraction, is then taken out and washs 5 times with PBS, irradiate 30min respectively by each of material under uviol lamp.Then, by material at 37 DEG C respectively submergence spend the night in the medium, every hole adds L929 cell suspension 500 μ l subsequently, put into 37 DEG C, 5% carbon dioxide, 95% humidity incubator cultivate.
Cell proliferation detecting kit CCK-8 is utilized to evaluate the proliferative conditions of BMSCs cell on bridge of the nose plastic surgery embedded material.In predetermined point of time by CCK-8 stock solution culture medium by 1:10(v/v) dilution obtain working solution; Suck the culture medium in orifice plate, add 200 μ l working solutions to every hole; After in incubator, lucifuge hatches 2h, slight oscillatory mixes, and then sucks in 100 μ l supernatant working solution to 96 orifice plates, detects its absorption value by microplate reader at 450nm wavelength place, record OD value (as Fig. 4).As shown in Figure 4,3D of the present invention prints bridge of the nose plastic surgery embedded material safe without toxic side effect, has good biocompatibility.
Embodiment 2
A rapid shaping preparation method for chest orthopedic implant materials, comprises the following steps:
(1) utilize computer-aided design (CAD) software design to go out the 3 d structure model at chest shaping position, and this threedimensional model is saved as STL formatted file, then import in three-dimensional printer, carry out layered shaping by delamination software;
(2) 15g being taken off cell collagen adds in 100ml deionized water, stirring 2h to dissolving completely, obtaining de-cell collagen aqueous solution, after being filtered, filtrate being added in the barrel of three-dimensional printer, centrifugal, leaves standstill 24 hours; Then in VisualMachines software, arrange print temperature is room temperature, and platform temperature is 10 DEG C, and syringe needle size is 0.3mm, extrusion pressure is 1.2bar, and extruded velocity is 3.0mm/s, and aperture is 0.8mm, internal structure is 0 ° and 90 ° and is staggered, and lift height is 0.24mm; Start three-dimensional printer by the 3 d structure model successively printing shaping at chest shaping position;
(3) with the genipin aqueous solution 100ml of deionized water preparation 0.25mg/ml, the three dimensional structure support blank at the chest shaping position obtained is put into genipin aqueous solution and processes 20min, then taking-up phosphate buffer (PBS) cleans three times, obtains a kind of chest orthopedic implant materials.Measure through CT, the porosity of the chest plastic surgery embedded material obtained is 73.5%, and porosity communication rate is 96.8%.
Embodiment 3
A rapid shaping preparation method for lower jaw shaping composite implant material, comprises the following steps:
(1) utilize computer-aided design (CAD) software design to go out the 3 d structure model at lower jaw shaping position, and this threedimensional model is saved as STL formatted file, then import in three-dimensional printer, carry out layered shaping by delamination software;
(2) 15g being taken off cell collagen adds in 100ml deionized water, stir 2h to dissolving completely, obtain de-cell collagen aqueous solution, after being filtered, filtrate is added in the barrel of three-dimensional printer, centrifugal, leave standstill 24 hours, be that the polylactic acid monohydroxy acetate multipolymer of 50:50 adds in the rustless steel barrel of three-dimensional printer by 2g molecular weight 3.1 ten thousand, PLA:PGA simultaneously; Then in VisualMachines software, arrange the print temperature of bi-material respectively, the print temperature of collagen is room temperature, and the print temperature of polylactic acid monohydroxy acetate multipolymer is 150 DEG C, and platform temperature is set to 10 DEG C, leaves standstill 30min and keeps temperature stabilization; Then the syringe needle size arranging collagen is 0.3mm, and extrusion pressure is 2.8bar, and extruded velocity is 3.0mm/s, and aperture is 0.4mm, and internal structure is 0 ° and 90 ° and is staggered, and lift height is 0.24mm; The syringe needle size arranging polylactic acid monohydroxy acetate multipolymer is 0.3mm, and extrusion pressure is 1.5bar, and extruded velocity is 4.0mm/s; Start three-dimensional printer successively to be printed by the 3 d structure model outer rim polylactic acid monohydroxy acetate multipolymer at lower jaw shaping position, inner mesh structure is by collagen successively printing shaping;
(3) with the genipin aqueous solution 100ml of deionized water preparation 0.3mg/ml, the three dimensional structure compound rest blank at the lower jaw shaping position obtained is put into genipin aqueous solution and processes 15min, then taking-up phosphate buffer (PBS) cleans three times, obtains a kind of lower jaw shaping composite implant material.Measure through CT, the porosity of the lower jaw plastic surgery embedded material obtained is 74.6%, and porosity communication rate is 97.3%.
Embodiment 4
A rapid shaping preparation method for buttocks orthopedic implant materials, comprises the following steps:
(1) utilize computer-aided design (CAD) software design to go out the 3 d structure model at buttocks shaping position, and this threedimensional model is saved as STL formatted file, then import in three-dimensional printer, carry out layered shaping by delamination software;
(2) 10g is taken off cell collagen and 3g sodium alginate adds in 100ml deionized water, stirring 2h to dissolving completely, obtaining the mixed aqueous solution of de-cell collagen and sodium alginate, then filtered, filtrate is added in the barrel of three-dimensional printer, centrifugal, leave standstill 24 hours; Then in VisualMachines software, arrange print temperature is room temperature, and platform temperature is 10 DEG C, and syringe needle size is 0.2mm, extrusion pressure is 2.8bar, and extruded velocity is 1.2mm/s, and aperture is 0.5mm, internal structure is 0 ° and 90 ° and is staggered, and lift height is 0.16mm; Start three-dimensional printer by the 3 d structure model successively printing shaping at buttocks shaping position;
(3) with the genipin aqueous solution 100ml of deionized water preparation 0.2mg/ml, the three dimensional structure support blank at the buttocks shaping position obtained is put into genipin aqueous solution and processes 20min, then taking-up phosphate buffer (PBS) cleans three times, obtains a kind of buttocks orthopedic implant materials.Measure through CT, the porosity of the buttocks plastic surgery embedded material obtained is 75.9%, and porosity communication rate is 94.5%.
Embodiment 5
A rapid shaping preparation method for eye plastic operation embedded material, comprises the following steps:
(1) utilize computer-aided design (CAD) software design to go out the 3 d structure model at eye plastic operation position, and this threedimensional model is saved as STL formatted file, then import in three-dimensional printer, carry out layered shaping by delamination software;
(2) 10g is taken off cell collagen and 3g hyaluronic acid adds in 100ml deionized water, stirring 2h to dissolving completely, obtaining de-cell collagen and hyaluronic mixed aqueous solution, then filtered, filtrate is added in the barrel of three-dimensional printer, centrifugal, leave standstill 24 hours; Then in VisualMachines software, arrange print temperature is room temperature, and platform temperature is 5 DEG C, and syringe needle size is 0.4mm, extrusion pressure is 1.0bar, and extruded velocity is 4.0mm/s, and aperture is 0.8mm, internal structure is 0 ° and 90 ° and is staggered, and lift height is 0.32mm; Start three-dimensional printer by the 3 d structure model at eye plastic operation position successively printing shaping;
(3) with the genipin aqueous solution 100ml of deionized water preparation 0.15mg/ml, the three dimensional structure support blank at the eye plastic operation position obtained is put into genipin aqueous solution and processes 30min, then taking-up phosphate buffer (PBS) cleans three times, obtains a kind of eye plastic operation embedded material.Measure through CT, the porosity of the eye plastic operation Srgery grafting material obtained is 76.3%, and porosity communication rate is 97.2%.
Embodiment 6
A rapid shaping preparation method for lip orthopedic implant materials, comprises the following steps:
(1) utilize computer-aided design (CAD) software design to go out the 3 d structure model at lip shaping position, and this threedimensional model is saved as STL formatted file, then import in three-dimensional printer, carry out layered shaping by delamination software;
(2) 10g is taken off cell collagen and 3g chitosan adds in 100ml deionized water, stirring 2h to dissolving completely, obtaining the mixed aqueous solution of de-cell collagen and chitosan, then filtered, filtrate is added in the barrel of three-dimensional printer, centrifugal, leave standstill 24 hours; Then in VisualMachines software, arrange print temperature is room temperature, and platform temperature is 5 DEG C, and syringe needle size is 0.2mm, extrusion pressure is 3.0bar, and extruded velocity is 3.5mm/s, and aperture is 0.5mm, internal structure is 0 ° and 90 ° and is staggered, and lift height is 0.16mm; Start three-dimensional printer by the 3 d structure model successively printing shaping at lip shaping position;
(3) with the genipin aqueous solution 100ml of deionized water preparation 0.15mg/ml, the three dimensional structure support blank at the lip shaping position obtained is put into genipin aqueous solution and processes 30min, then taking-up phosphate buffer (PBS) cleans three times, obtains a kind of lip orthopedic implant materials.Measure through CT, the porosity of the lip plastic surgery embedded material obtained is 75.8%, and porosity communication rate is 97.6%.
The above embodiment only have expressed several embodiment of the present invention, but can not be interpreted as limitation of the scope of the invention.For the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make other multi-form distortion and improvement, these all belong to protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with claims.
Accompanying drawing explanation is carried out below with the rapid shaping preparation method of embodiment 1 one kinds of bridge of the nose orthopedic implant materials.Accompanying drawing is only used as exemplary illustration, can not be interpreted as limitation of the present invention.
Claims (8)
1. a rapid shaping preparation method for plastic surgery's embedded material, is characterized in that, comprise the following steps:
(1) utilize computer aided design cad software design to go out the 3 d structure model at shaping position, and this threedimensional model is saved as STL formatted file, then import in three-dimensional printer, carry out layered shaping by delamination software;
(2) implantable biomaterial deionized water be mixed with solution or directly add in three-dimensional printer, print temperature, platform temperature, syringe needle size, extrusion pressure, extruded velocity, internal structure and aperture parameters are set, then start three-dimensional printer by the 3 d structure model at shaping position successively printing shaping, obtain three dimensional structure support blank;
(3) finally the three dimensional structure support blank obtained is carried out post processing or is not processed directly obtaining a kind of orthopedic embedded material.
2. the rapid shaping preparation method of a kind of plastic surgery's embedded material according to claim 1, it is characterized in that, described orthopedic embedded material can be used for any place or the many places at following shaping position: chest, buttocks, the bridge of the nose, lower jaw, forehead, eye and lip.
3. the rapid shaping preparation method of a kind of plastic surgery's embedded material according to claim 1, it is characterized in that, in step (2), described implantable biomaterial be following any one or multiple: de-cell collagen, hyaluronic acid, sodium alginate, chitosan, silica gel, agar, lactic acid monohydroxy acetate multipolymer, polylactic acid, polyglycolic acid, polycaprolactone, polyhydroxyalkanoate, hydroxyapatite, tricalcium phosphate and bio-vitric.
4. the rapid shaping preparation method of a kind of plastic surgery's embedded material according to claim 1, it is characterized in that, in step (2), described file printing temperature is 2 ~ 170 DEG C, platform temperature is 0 ~ 65 DEG C, and syringe needle size is 0.2 ~ 0.4mm, and extrusion pressure is 1.0 ~ 3.5bar, extruded velocity is 1.0 ~ 5.0mm/s, and aperture is 0.1 ~ 1.2mm.
5. the rapid shaping preparation method of a kind of plastic surgery's embedded material according to claim 1, is characterized in that, in step (2), described internal structure is that nozzle angle 0 ~ 179 ° is staggered, and lift height is 0.16 ~ 0.32mm.
6. the rapid shaping preparation method of a kind of plastic surgery's embedded material according to claim 1, is characterized in that, in step (2), in the solution that described biomaterial is mixed with, solution concentration is 0.01 ~ 0.2g/ml.
7. the rapid shaping preparation method of a kind of plastic surgery's embedded material according to claim 1, is characterized in that, in step (3), the porosity of described three dimensional structure support blank is 60 ~ 80%, and porosity communication rate is more than 90%.
8. the rapid shaping preparation method of a kind of plastic surgery's embedded material according to claim 1, it is characterized in that, in step (3), described post-processing approach be following any one or multiple: crosslinked and 800 ~ 1200 DEG C of calcinings of lyophilization, vacuum drying, genipin; The concentration of the genipin aqueous solution that described genipin is cross-linked is 0.1 ~ 0.5mg/ml.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1453748A (en) * | 2003-05-13 | 2003-11-05 | 中国医学科学院整形外科医院 | Digitized prepn of artificial implant for personalized facial plastics |
| US20050104241A1 (en) * | 2000-01-18 | 2005-05-19 | Objet Geometried Ltd. | Apparatus and method for three dimensional model printing |
| CN101032430A (en) * | 2007-04-13 | 2007-09-12 | 中国人民解放军第三军医大学第一附属医院 | Method for preparing integrated frame fabrication of cartilage of tissue-engineered bone having function interface |
| CN103057123A (en) * | 2013-01-23 | 2013-04-24 | 南通大学 | Three-dimensional organism printing system and method for preparing nerve regeneration implant based on three-dimensional organism printing system |
| CN103284815A (en) * | 2013-05-17 | 2013-09-11 | 中山大学 | 3D-printing fast forming method of nano composite degradable bone repair material |
| CN104758085A (en) * | 2014-12-26 | 2015-07-08 | 南京师范大学 | Three dimensional biology printing device and method |
-
2015
- 2015-08-27 CN CN201510541602.2A patent/CN105232179A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050104241A1 (en) * | 2000-01-18 | 2005-05-19 | Objet Geometried Ltd. | Apparatus and method for three dimensional model printing |
| CN1453748A (en) * | 2003-05-13 | 2003-11-05 | 中国医学科学院整形外科医院 | Digitized prepn of artificial implant for personalized facial plastics |
| CN101032430A (en) * | 2007-04-13 | 2007-09-12 | 中国人民解放军第三军医大学第一附属医院 | Method for preparing integrated frame fabrication of cartilage of tissue-engineered bone having function interface |
| CN103057123A (en) * | 2013-01-23 | 2013-04-24 | 南通大学 | Three-dimensional organism printing system and method for preparing nerve regeneration implant based on three-dimensional organism printing system |
| CN103284815A (en) * | 2013-05-17 | 2013-09-11 | 中山大学 | 3D-printing fast forming method of nano composite degradable bone repair material |
| CN104758085A (en) * | 2014-12-26 | 2015-07-08 | 南京师范大学 | Three dimensional biology printing device and method |
Cited By (10)
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|---|---|---|---|---|
| CN105688281A (en) * | 2016-03-08 | 2016-06-22 | 北京航空航天大学 | Vascularized artificial tissue organ construction method combining cell three-dimensional printing and dielectrophoresis adsorption |
| CN105688280A (en) * | 2016-03-08 | 2016-06-22 | 北京航空航天大学 | Three-dimensional cell assembly method based on dielectrophoresis adsorption principle |
| CN105999424A (en) * | 2016-05-23 | 2016-10-12 | 江苏阳生生物股份有限公司 | Human body large bone tissue repair stent and manufacturing method thereof |
| CN106073943A (en) * | 2016-07-19 | 2016-11-09 | 青岛三帝生物科技有限公司 | The antiseep breast prosthesis forming method printed based on 3D and breast prosthesis |
| CN107874872A (en) * | 2017-11-07 | 2018-04-06 | 陕西百普生医疗科技发展有限公司 | A kind of degradable nose dummy of 3D printing |
| CN108081515A (en) * | 2017-12-25 | 2018-05-29 | 南通东概念新材料有限公司 | A kind of method of the external bionic-mouse stomach model of 3D printing |
| CN110171979A (en) * | 2019-05-23 | 2019-08-27 | 华南理工大学 | A kind of preparation method of large scale personalized biological active ceramic implant |
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