CN204269617U - The Pharmaceutical Analysis mobile phase evenly mixing device of LC-MS instrument - Google Patents
The Pharmaceutical Analysis mobile phase evenly mixing device of LC-MS instrument Download PDFInfo
- Publication number
- CN204269617U CN204269617U CN201420835527.1U CN201420835527U CN204269617U CN 204269617 U CN204269617 U CN 204269617U CN 201420835527 U CN201420835527 U CN 201420835527U CN 204269617 U CN204269617 U CN 204269617U
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- China
- Prior art keywords
- pipeline
- mobile phase
- threeway
- pump
- instrument
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Abstract
The utility model discloses a kind of mobile phase evenly mixing device of Pharmaceutical Analysis LC-MS instrument, it accesses two three-way connections between liquid phase pump and six-way valve, mixed and steady flow phase by the shunting of the first three-way connection and the interflow of the second three-way connection, the utility model can when not increasing mixing arrangement dead volume, mix mobile phase fast and effectively, improve the stability of the detecting instrument signal that is connected.
Description
Technical field
The utility model relates to a kind of device increasing mobile phase homogeneity in LC-MS instrument, especially can increase the planarization of Ultraviolet Detector and mass spectrometer baseline and the mobile phase mixing arrangement of stability.
Background technology
At present, the mixing of known LC-MS instrument mobile phase mainly relies on a simple threeway mixing arrangement between two pumps, due to principle of work and the high sensitivity of mass spectrometer itself, the high-throughout feature of two pumps, and the gradient of mobile phase such as to arrange at the correlative factor, from the Blending Efficiency of Blending of existing mobile phase mixer, the mixed effect of threeway vortex mixer affects mass spectrometric accuracy and sensitivity to a certain extent.This problem can be reacted from the fluctuation situation of the baseline of connected detecting device.The stability of mobile phase and homogeneity have impact on the discovery of trace materials in Pharmaceutical Analysis to a great extent and quantitatively detect.
Summary of the invention
The purpose of this utility model is the shortcoming in order to overcome above-mentioned background technology, a kind of multilayer mobile phase evenly mixing device is provided, not only can solve the unevenness of mobile phase in mixed process, the dead volume of mobile phase in pipeline can not be increased in simultaneously, increase the stability of mobile phase, improve Pharmaceutical Analysis and power of test.
The technical solution of the utility model is: a kind of mobile phase evenly mixing device of Pharmaceutical Analysis LC-MS instrument, it comprises: threeway mixer, liquid phase A pump, liquid phase B pump, six-way valve, it also comprises the first distributing T-pipe joint and the second threeway hybrid juction, described liquid phase A pump, liquid phase B pump is respectively equipped with a pipeline and is connected to threeway mixer, described threeway mixer is by tubes connection first distributing T-pipe joint entrance point, the first described distributing T-pipe joint endpiece is provided with two pipelines, pipeline one and pipeline two respectively, these two pipelines are all connected to the entrance point of the second threeway hybrid juction, the endpiece of the second threeway hybrid juction is provided with the conduit for detecting, this tubes connection is to six-way valve.
Described pipeline one and pipeline two respectively by two length not once the consistent PK pipe of internal diameter forms, described pipeline one length range is 2 ~ 5 cm, and described pipeline two length range is 1.5 ~ 4.5 cm.
The beneficial effects of the utility model are: the utility model when not increasing mixing arrangement dead volume, can mix mobile phase fast and effectively, improve the stability of the detecting instrument signal that is connected.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Wherein: 1, threeway mixer, the 2, first distributing T-pipe joint, the 3, second threeway hybrid juction, 4, pipeline one, 5, pipeline two, 6, liquid phase A pump, 7, liquid phase B pump, 8, six-way valve.
Embodiment
The present embodiment is a kind of mobile phase evenly mixing device of Pharmaceutical Analysis LC-MS instrument, it comprises: threeway mixer (1), liquid phase A pump (6), liquid phase B pump (7), six-way valve (8), it also comprises the first distributing T-pipe joint (2) and the second threeway hybrid juction (3).
As shown in Figure 1, described liquid phase A pump (6), liquid phase B pump (7) are respectively equipped with a pipeline and are connected to threeway mixer (1), described threeway mixer (1) is by tubes connection first distributing T-pipe joint (2) entrance point, the first described distributing T-pipe joint (2) endpiece is provided with two pipelines, pipeline one (4) and pipeline two (5) respectively, these two pipelines are all connected to the entrance point of the second threeway hybrid juction (3), the endpiece of the second threeway hybrid juction (3) is provided with the conduit for detecting, and this tubes connection is to six-way valve (8).
Time in specific implementation process, the mobile phase that threeway mixer (1) flows out is divided into two strands uniformly at the first distributing T-pipe joint (2) place, enters pipeline one (4) and pipeline two (5) respectively.Article two, the length of pipeline differs, and when the mobile phase that the same time is shunted arrives the second three-way connection (3), life period is poor.Utilize shunting and interflow, add the object being used for reaching mixing and steady flow phase of mistiming simultaneously.
Claims (2)
1. the Pharmaceutical Analysis mobile phase evenly mixing device of LC-MS instrument, it comprises: threeway mixer, liquid phase A pump, liquid phase B pump, six-way valve, it is characterized in that it also comprises the first distributing T-pipe joint and the second threeway hybrid juction, described liquid phase A pump, liquid phase B pump is respectively equipped with a pipeline and is connected to threeway mixer, described threeway mixer is by tubes connection first distributing T-pipe joint entrance point, the first described distributing T-pipe joint endpiece is provided with two pipelines, pipeline one and pipeline two respectively, these two pipelines are all connected to the entrance point of the second threeway hybrid juction, the endpiece of the second threeway hybrid juction is provided with the conduit for detecting, this tubes connection is to six-way valve.
2. the mobile phase evenly mixing device of Pharmaceutical Analysis LC-MS instrument according to claim 1, it is characterized in that described pipeline one and pipeline two respectively by two length not once the consistent PK pipe of internal diameter forms, described pipeline one length range is 2 ~ 5 cm, and described pipeline two length range is 1.5 ~ 4.5 cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420835527.1U CN204269617U (en) | 2014-12-25 | 2014-12-25 | The Pharmaceutical Analysis mobile phase evenly mixing device of LC-MS instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420835527.1U CN204269617U (en) | 2014-12-25 | 2014-12-25 | The Pharmaceutical Analysis mobile phase evenly mixing device of LC-MS instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204269617U true CN204269617U (en) | 2015-04-15 |
Family
ID=52804478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420835527.1U Expired - Fee Related CN204269617U (en) | 2014-12-25 | 2014-12-25 | The Pharmaceutical Analysis mobile phase evenly mixing device of LC-MS instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204269617U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105044251A (en) * | 2015-07-28 | 2015-11-11 | 李绍平 | On-line micro-reaction device |
-
2014
- 2014-12-25 CN CN201420835527.1U patent/CN204269617U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105044251A (en) * | 2015-07-28 | 2015-11-11 | 李绍平 | On-line micro-reaction device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150415 Termination date: 20201225 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |