CN204261808U - A kind of combined magnetic force frame - Google Patents

A kind of combined magnetic force frame Download PDF

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Publication number
CN204261808U
CN204261808U CN201420703241.8U CN201420703241U CN204261808U CN 204261808 U CN204261808 U CN 204261808U CN 201420703241 U CN201420703241 U CN 201420703241U CN 204261808 U CN204261808 U CN 204261808U
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CN
China
Prior art keywords
test tube
micro
rack
magnet
columnar part
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201420703241.8U
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Chinese (zh)
Inventor
李翠芬
张建东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vast Lucky Health Biotechnology (beijing) Co Ltd
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Vast Lucky Health Biotechnology (beijing) Co Ltd
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Priority to CN201420703241.8U priority Critical patent/CN204261808U/en
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Publication of CN204261808U publication Critical patent/CN204261808U/en
Expired - Fee Related legal-status Critical Current
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Abstract

The utility model discloses a kind of combined magnetic force frame.Combined magnetic force frame provided by the utility model, comprises magnet frame and micro-rack for test tube, and described magnet frame is formed primarily of magnet frame base and the columnar part that is vertically fixed on magnet frame base in it to be provided with magnet; Described micro-rack for test tube is primarily of micro-rack for test tube flat board and the columnar part formation with cavity structure being vertically fixed on the dull and stereotyped lower end of micro-rack for test tube; The described columnar part with cavity structure matches with the vertical columnar part being fixed on magnet frame base in it to be provided with magnet, realizes being separated and combination of magnet frame and micro-rack for test tube; Described micro-rack for test tube flat board has the micro-test tube hole for placing micro-test tube; Described micro-test tube hole includes convex stupefied and boss body.The operations such as combined magnetic force frame provided by the utility model makes user micro-test tube and magnetic frame can be done as a wholely to overturn, tilt, rotate, concussion, increase work efficiency and operation homogeneity between micro-test tube exponentially.

Description

A kind of combined magnetic force frame
Technical field
The utility model relates to a kind of magnetic frame, particularly a kind of combined magnetic force frame.
Background technology
Utilize super paramagnetic beads microparticle to obtain extensive use in the technology of liquid phase separation large biological molecule on biomedical boundary, as isolated protein, antibody, with nucleic acid etc.After the liquid containing magnetic bead microparticle puts into micro-test tube, when not having magnetic force, magnetic bead microparticle can distribute in the liquid phase after agitation; But when this micro-test tube is placed in a magnetic field, super paramagnetic beads microparticle is magnetized and attracted to the strongest position, magnetic field and be gathered into closely one on micro-test tube wall simultaneously.
Though existing magnetic frame product can partly meet user's requirement, there are many deficiencies.Comprise:
1) most of magnet and micro-rack for test tube are designed to integrated inseparable opening structure, and user needs repeatedly to repeat the one by one transfer of micro-test tube between magnetic frame and common micro-rack for test tube.
2) hole of putting micro-test tube is designed to regular circle, and simultaneously for adapting to the diameter difference of micro-test tube of numerous producer, the diameter in hole is forced to the maximum of the diameter being greater than micro-test tube that market finds, make most of micro-test tube reliably not be fixed in hole, the process of overturning mixing cannot be completed.
3) after hole put into by micro-test tube, the flange of its mouth of pipe and the upper plane of shelf fit tightly, and make to take off micro-test tube difficulty.
4) shape of magnet and position are not optimized, and make that the magnetic bead aggregation of formation is loose, at the bottom of pipe, (as used vavuum pump extracted liquid) magnetic bead loses simultaneously in washing process.
5) the micro-test tube at the bottom of multiple pipe can not be adapted to.
Summary of the invention
The utility model is the deficiency making up above field, provides a kind of combined magnetic force frame.
Combined magnetic force frame provided by the utility model, comprise magnet frame (1) and micro-rack for test tube (2), it is characterized in that: described magnet frame (1) is formed primarily of magnet frame base (3) and the columnar part (4) that is vertically fixed on magnet frame base (3) in it to be provided with magnet; Described micro-rack for test tube (2) is primarily of micro-rack for test tube flat board (5) and the formation of the columnar part (6) with cavity structure being vertically fixed on micro-rack for test tube flat board (5) lower end; The described columnar part (6) with cavity structure matches with the vertical columnar part (4) being fixed on magnet frame base (3) in it to be provided with magnet, realizes being separated and combination of magnet frame (1) and micro-rack for test tube (2); Described micro-rack for test tube flat board (5) has the micro-test tube hole (7) for placing micro-test tube; Described micro-test tube hole (7) includes convex stupefied (8) and boss body (9).
The quantity of described convex stupefied (8) is 3-10, and be evenly distributed in the circumference in described micro-test tube hole, the circular diameter formed is 9-11mm.
The width of described convex stupefied (8) is 1 degree of-300 degree.
The quantity of described boss body (9) is 1-20, and the height of described boss body (9) is 1-5mm, and the radian of described boss body (9) is 1 degree of-360 degree.
The arrangement mode of described magnet is that N end or S end are vertical with the contact plane of micro-test tube; Described N end is held in the same way with S, or N end is held alternately with S.
Described micro-rack for test tube flat board (5) has lockhole (10), and the columnar part (4) of described magnet frame has the lock core (11) that lockhole (10) corresponding to micro-rack for test tube matches.
Combined magnetic force frame provided by the utility model has the following advantages:
1) be separated with in the two kinds of situations combined at magnet with micro-rack for test tube, all micro-test tubes and micro-rack for test tube are stablized fixing, micro-test tube and magnetic frame can be done by user as a wholely to overturn, tilt, rotate, the operation such as concussion, increase work efficiency exponentially and operation homogeneity between micro-test tube.
2) the most high-intensity magnetic field of magnet is vertical with test tube, makes the multiple pipe Bottom Shape of adaptation, sharp cone distal, blunted cone shape, circle etc.
3) magnet array mode, the plane contacted with micro-test tube is vertically pointed to respectively in N and S pole, and make magnetic force ceiling effect play magnetic force magnetic bead aggregation tight, on tube wall, Gathering area is little, and the magnetic bead in magnetic bead washing process can be avoided completely to lose.
4) magnet placement location makes to form certain space at the bottom of the magnetic bead aggregation of formation and pipe, avoids the magnetic bead in magnetic bead washing process to lose, makes elute soln do not polluted by magnetic bead simultaneously.
Accompanying drawing explanation
Fig. 1 is the oblique top view in the overall front of magnetic frame of embodiment 1.
Fig. 2 is that the magnet frame of embodiment 1 is separated front view with micro-rack for test tube, and top and the bottom structure is respectively micro-rack for test tube and magnet frame.
Fig. 3 is the side-looking of magnetic frame front and the top view of embodiment 1.
Fig. 4 is the magnetic frame side cutaway view of embodiment 1.
Fig. 5 is the magnet array mode top view of embodiment 1; The figure first half shows all magnet N and S and arranges in the same way, and figure Lower Half shows between all magnet N and S-phase and arranges.
Fig. 6 is the oblique top view in the overall front of magnetic frame of embodiment 2.
Fig. 7 is that the magnet frame of embodiment 2 is separated front view with micro-rack for test tube, and top and the bottom structure is respectively micro-rack for test tube and magnet frame.
1-magnet frame, the micro-rack for test tube of 2-, 3-magnet frame base, columnar part on 4-magnet frame base, the micro-rack for test tube of 5-is dull and stereotyped, the columnar part with cavity structure of dull and stereotyped 5 lower ends of the micro-rack for test tube of 6-, the micro-test tube hole of 7-, 8-is convex stupefied, 9-boss body, 10-lockhole, 11-lock core, 12-permanent magnet, 13-magnetic bead aggregation, h-micro-rack for test tube upper flat plate thickness, h1-magnet height, the distance of h2-magnet lower edge and micro-test tube, h3-micro-test tube hole upper limb boss height, d1-micro-test tube Kongzui major diameter, the circular diameter of 3 convex stupefied formation in d2-micro-test tube circular port, the radian of α-convex stupefied formation, the radian that β-boss body is formed.
Detailed description of the invention
Embodiment 1,
As depicted in figs. 1 and 2, magnetic frame comprise separable with combination magnet frame 1 and micro-rack for test tube 2; Magnet frame 1 is formed primarily of magnet frame base 3 and the columnar part 4 that is vertically fixed on magnet frame base 3 in it to be provided with magnet; Micro-rack for test tube 2 is formed primarily of micro-rack for test tube dull and stereotyped 5 and the columnar part 6 with cavity structure that is vertically fixed on dull and stereotyped 5 lower ends of micro-rack for test tube; The described columnar part 6 with cavity structure matches with the vertical columnar part 4 being fixed on magnet frame base 3 in it to be provided with magnet, realizes being separated and combination of magnet frame 1 and micro-rack for test tube 2; The described columnar part 6 with cavity structure also can be used as the pedestal of micro-rack for test tube 2; The thickness (h) of described micro-rack for test tube flat board 5 is 7mm, it has the micro-test tube hole 7 for placing micro-test tube.
As shown in Figure 3, described micro-test tube hole 7 includes convex stupefied 8, described convex stupefied be 3-4, be evenly distributed in circumference; Described convex stupefied formed circular diameter (d2) is 10.5mm; Described convex stupefied width (α) is 24 degree; Also containing boss body 9 on described micro-test tube hole 7, the boss body quantity corresponding to each hole is 2-4; The height (h3) of boss body is 1.5mm; The radian of boss body is 24 degree; Described boss body 9 can one_to_one corresponding being connected with described convex stupefied 8, also can in number of locations onrelevant.Circular diameter (d2) φ 10 tolerance of 3 convex stupefied formation in described micro-test tube hole is slightly less than market finding micro-test tube diameter minimum of a value, produce a small amount of deformation after micro-like this test tube inserts, the extruding produced and frictional force reliably make micro-test tube be fixed in micro-rack for test tube.The test tube that tolerance is larger can be installed on rack for test tube by less deflection, is unlikely to cause cylinder to join circular hole locking and dismantles the situation appearance of not getting off.Forming 3 boss bodies with circular port top can make the lower end at micro-test tube mouth edge and the surface of micro-test tube circular port form certain distance, makes extracting and being easy of micro-test tube.
Polylith permanent magnet 12 (N is the arctic, and S is the South Pole) is sealed in the magnet frame columnar part 4 by injection molding, and arrangement mode is that N and S end is vertical with the contact plane of micro-test tube; All magnet N and S in the same way, or arrange between N and S-phase.After magnet frame is engaged with micro-rack for test tube, magnet positions is positioned at the height (h2) of 5-15mm bottom test tube, magnetic bead is enable to be gathered in more than 5mm position bottom test tube, form magnetic bead aggregation 13, reduce magnetic bead assemble index raising collection quality and be convenient to drawing liquid and take waste liq to greatest extent away and do not lose magnetic bead (Fig. 4, Fig. 5) simultaneously.
Embodiment 2,
As shown in Figure 6 and Figure 7, magnetic frame comprise separable with combination magnet frame 1 and micro-rack for test tube 2; Magnet frame 1 is formed primarily of magnet frame base 3 and the columnar part 4 that is vertically fixed on magnet frame base 3 in it to be provided with magnet; Micro-rack for test tube 2 is formed primarily of micro-rack for test tube dull and stereotyped 5 and the columnar part 6 with cavity structure that is vertically fixed on dull and stereotyped 5 lower ends of micro-rack for test tube; The described columnar part 6 with cavity structure matches with the vertical columnar part 4 being fixed on magnet frame base 3 in it to be provided with magnet, realizes being separated and combination of magnet frame 1 and micro-rack for test tube 2; And described in there is cavity structure columnar part 6 also can be used as the pedestal of micro-rack for test tube 2; The thickness (h) of described micro-rack for test tube flat board 5 is 1-15mm, it has the micro-test tube hole 7 for placing micro-test tube; Described micro-rack for test tube flat board 5 also has lockhole 10, and respectively there is a ridge on the both sides, columnar part 4 upper end of described magnet frame, are the lock core 11 that lockhole corresponding to micro-rack for test tube matches; Micro-rack for test tube is placed on the top of magnet frame, the lock core of magnet frame is aimed at the lockhole of micro-rack for test tube, slightly namely lock with the micro-rack for test tube of downward pressure and magnet frame; When need separate, both hands thumb pins the lock core of magnet frame, and other finger is upwards carried micro-rack for test tube and the two can be separated.
As shown in Figure 3, described micro-test tube hole 7 includes convex stupefied 8, describedly convexly stupefiedly is evenly distributed in circumference for 3-10; Described convex stupefied formed circular diameter (d2) is 9-11mm; Described convex stupefied width (α) is 1 degree of-300 degree; Also containing boss body 9 on described micro-test tube hole 7, the boss body quantity corresponding to each hole is 1-20; The height (h3) of boss body is 1-5mm; The radian (β) of boss body is 1 degree of-360 degree; Described boss body 9 can one_to_one corresponding being connected with described convex stupefied 8, also can in number of locations onrelevant (Fig. 3).Circular diameter (d2) φ 10 tolerance of 3 convex stupefied formation in described micro-test tube hole is slightly less than market finding micro-test tube diameter minimum of a value, produce a small amount of deformation after micro-like this test tube inserts, the extruding produced and frictional force reliably make micro-test tube be fixed in micro-rack for test tube.The test tube that tolerance is larger can be installed on rack for test tube by less deflection, is unlikely to cause cylinder to join circular hole locking and dismantles the situation appearance of not getting off.Forming 3 boss bodies with circular port top can make the lower end at micro-test tube mouth edge and the surface of micro-test tube circular port form certain distance, makes extracting and being easy of micro-test tube.
Polylith permanent magnet 12 (N is the arctic, and S is the South Pole) is sealed in the magnet frame columnar part 4 by injection molding, and arrangement mode is that N and S end is vertical with the contact plane of micro-test tube; All magnet N and S in the same way, or arrange between N and S-phase.After magnet frame is engaged with micro-rack for test tube, magnet positions is positioned at the height (h2) of 5-15mm bottom test tube, magnetic bead is enable to be gathered in more than 5mm position bottom test tube, form magnetic bead aggregation 13, reduce magnetic bead assemble index raising collection quality and be convenient to drawing liquid and take waste liq to greatest extent away and do not lose magnetic bead (Fig. 4, Fig. 5) simultaneously.

Claims (6)

1. a combined magnetic force frame, comprise magnet frame (1) and micro-rack for test tube (2), it is characterized in that: described magnet frame (1) is formed primarily of magnet frame base (3) and the columnar part (4) that is vertically fixed on magnet frame base (3) in it to be provided with magnet; Described micro-rack for test tube (2) is primarily of micro-rack for test tube flat board (5) and the formation of the columnar part (6) with cavity structure being vertically fixed on micro-rack for test tube flat board (5) lower end; The described columnar part (6) with cavity structure matches with the vertical columnar part (4) being fixed on magnet frame base (3) in it to be provided with magnet, realizes being separated and combination of magnet frame (1) and micro-rack for test tube (2); Described micro-rack for test tube flat board (5) has the micro-test tube hole (7) for placing micro-test tube; Described micro-test tube hole (7) includes convex stupefied (8) and boss body (9).
2. combined magnetic force frame according to claim 1, is characterized in that: the quantity of described convex stupefied (8) is 3-10, and be evenly distributed in the circumference in described micro-test tube hole, the circular diameter formed is 9-11mm.
3. combined magnetic force frame according to claim 2, is characterized in that: the width of described convex stupefied (8) is 1 degree of-300 degree.
4. combined magnetic force frame according to claim 3, it is characterized in that: the quantity of described boss body (9) is 1-20, the height of described boss body (9) is 1-5mm, and the radian of described boss body (9) is 1 degree of-360 degree.
5. combined magnetic force frame according to claim 1, is characterized in that: the arrangement mode of described magnet is that N end or S end are vertical with the contact plane of micro-test tube; Described N end is held in the same way with S, or N end is held alternately with S.
6. combined magnetic force frame according to claim 1, it is characterized in that: described micro-rack for test tube flat board (5) has lockhole (10), the columnar part (4) of described magnet frame has the lock core (11) that lockhole (10) corresponding to micro-rack for test tube matches.
CN201420703241.8U 2014-11-20 2014-11-20 A kind of combined magnetic force frame Expired - Fee Related CN204261808U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201420703241.8U CN204261808U (en) 2014-11-20 2014-11-20 A kind of combined magnetic force frame

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201420703241.8U CN204261808U (en) 2014-11-20 2014-11-20 A kind of combined magnetic force frame

Publications (1)

Publication Number Publication Date
CN204261808U true CN204261808U (en) 2015-04-15

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105087379A (en) * 2015-09-10 2015-11-25 佛山市百特思舞台设备有限公司 Magnetic substance extraction method and special magnetic frame for magnetic substance extraction
CN105396687A (en) * 2015-12-04 2016-03-16 苏州英芮诚生化科技有限公司 Multi-channel magnetic-material quick transfer magnetic device
CN105665132A (en) * 2014-11-20 2016-06-15 瀚吉康生物科技(北京)有限公司 Combined type magnetic frame
WO2020192090A1 (en) * 2019-03-27 2020-10-01 苏州长光华医生物医学工程有限公司 Kit storage rack preventing magnetic particle deposition

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105665132A (en) * 2014-11-20 2016-06-15 瀚吉康生物科技(北京)有限公司 Combined type magnetic frame
CN105087379A (en) * 2015-09-10 2015-11-25 佛山市百特思舞台设备有限公司 Magnetic substance extraction method and special magnetic frame for magnetic substance extraction
CN105396687A (en) * 2015-12-04 2016-03-16 苏州英芮诚生化科技有限公司 Multi-channel magnetic-material quick transfer magnetic device
WO2020192090A1 (en) * 2019-03-27 2020-10-01 苏州长光华医生物医学工程有限公司 Kit storage rack preventing magnetic particle deposition

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C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150415

Termination date: 20171120

CF01 Termination of patent right due to non-payment of annual fee