CN204165989U - A kind of magnetic particle cleaning is separated settling flux device - Google Patents
A kind of magnetic particle cleaning is separated settling flux device Download PDFInfo
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- CN204165989U CN204165989U CN201420660753.0U CN201420660753U CN204165989U CN 204165989 U CN204165989 U CN 204165989U CN 201420660753 U CN201420660753 U CN 201420660753U CN 204165989 U CN204165989 U CN 204165989U
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Abstract
The utility model discloses the cleaning of a kind of magnetic particle and be separated settling flux device, belong to magnetic particle cleaning separation field.This utility model comprises a cleaning Disengagement zone, settling flux district, No. two cleaning Disengagement zone, No. two settling flux districts, fixed strip, aspirating needle and cleaning needle, and a described cleaning Disengagement zone is leading portion magnet array; A described settling flux district is made up of three pieces of suspension magnets; No. two described cleaning Disengagement zone are back segment magnet array; No. two described settling flux districts are made up of three pieces of suspension magnets; A described cleaning Disengagement zone, settling flux district, No. two cleaning Disengagement zone, No. two settling flux districts are fixed on fixed strip in turn.The utility model utilizes the settling flux effect of reversed magnetic field, improves cleaning efficiency and quality, makes luminescence-producing reaction more accurate, sensitive.
Description
Technical field
The utility model relates to a kind of magnetic particle cleaning field, particularly relates to the cleaning of a kind of magnetic particle and is separated settling flux device.
Background technology
Automatic chemiluminescence immunoassay system is a kind of instrument that can carry out immunology quantitative test to the body fluid sample of patient, can check the disease syndromes such as the monitoring of anaemia, angiocardiopathy, congenital disorders, sex hormone, infectious disease, metabolic function, tumor markers, medicine and thyroid gland.Automatic chemiluminescence immunoassay system have highly sensitive, the range of linearity is wide, instrument and equipment is simple, easy to operate, analysis speed fast, checkout procedure realizes the advantages such as robotization completely, greatly improve immunoassay efficiency, eliminate artificial subjective error, stabilize the quality of immunity inspection, be widely used in the diagnosis of modern clinic immunoassay and life science field at present.
Automatic chemiluminescence immunoassay system generally comprises following subsystem: consumables automatic loading device, sample loading system, load reagents system, incubation system, purging system, sample adding system, fluid path, photometric measure system and computer control system etc.Automatic chemiluminescence immunoassay generally all will use two kinds of basic reagent, and one is magnetic particle reagent, and one is luminous substrate reagent, and two kinds of reagent all want coated antibody or antigen; According to the specific binding principle of antigen-antibody, to carry the patient's sample of antigen or antibody for intermediate, magnetic particle and luminous substrate combine, and remaining luminous substrate can't combine with magnetic particle.How to remove unnecessary luminous substrate, and retain magnetic particle to greatest extent as far as possible, be directly connected to the accuracy of final test results.
Carrying out in chemiluminescence immune assay, sample is added in reaction cup, the luminescent substance combined with effective sample and magnetic particle clean through magnetic particle and are separated, siphon away unnecessary luminescent substance, enter light-metering room and carry out luminescence, thus find that magnetic particle cleaning is separated in chemiluminescent process progresses and plays an important role.
Current cleaning separation method is simple by magnetic particle cleaning separation, and do not make unconjugated shiner be separated thoroughly, chemiluminescent sensitivity falls flat.Also the device carrying out settling flux is had in prior art, United States Patent (USP) 6143578 discloses a kind of water and rinses the method for carrying out settling flux, also has the method using concussion settling flux, all there are some problems in above-mentioned settling flux method in practical operation, magnetic particle can not abundant settling flux, cause luminescent substance not to be sufficiently rinsed and can not be fully luminous, affect luminous measured value.
Summary of the invention
In view of above-mentioned the deficiencies in the prior art, the purpose of this utility model is to provide the method that the cleaning of a kind of magnetic particle is separated settling flux, makes magnetic particle fully clean separation, settling flux, thus can be fully luminous.
For achieving the above object, the utility model is by the following technical solutions:
A kind of magnetic particle cleaning is separated settling flux device, comprise cleaning Disengagement zone (21), settling flux district (22), No. two cleanings Disengagement zone (23), No. two settling flux districts (24), fixed strip (2), aspirating needle (18) and cleaning needle (17) composition, is characterized in that described cleaning Disengagement zone (21) is leading portion magnet array (19); A described settling flux district (22) is made up of a suspension magnet (7), No. two suspension magnets (8), No. three suspension magnets (9); No. two described cleanings Disengagement zone (23) are back segment magnet array (20); No. two described settling flux districts (22) are made up of No. four suspension magnets (14), No. five suspension magnets (15), No. six suspension magnets (16); Described cleaning Disengagement zone (21), settling flux district (22), No. two cleanings Disengagement zone (23), No. two settling flux districts (24) are fixed on (2) on fixed strip in turn.
Described leading portion magnet array (19) comprises four groups of magnet, be divided into one group of single glass of magnet, three groups of two cup magnet, single glass of magnet (3) is positioned at low level, one group of two cup magnet (4) tilts upward, two groups two cup magnet (5) (6) are positioned at a high position, and four groups of magnet are fixed on fixed strip (2) in turn.
Three pieces of suspension magnets of a described settling flux district (22) discharge in turn, used aloned, the magnetic field intensity of every block magnet is significantly less than the magnetic field intensity of magnet array, a suspension magnet (7), No. three suspension magnets (9) are contrary with leading portion magnet array magnetic field (19) direction, No. two suspension magnets (8) are contrary with suspension magnet (7) magnetic direction, and No. two suspension magnets (8) are fixed on fixed strip; Described No. two settling flux districts (24) are identical with a settling flux district (22).
Described back segment magnet array (20) comprises four groups of magnet, be divided into one group of single glass of magnet, three groups of two cup magnet, single glass of magnet (10) is positioned at a high position, one group of two cup magnet (11) is tilted to down, two groups two cup magnet (12) (13) are positioned at low level, and four groups of magnet are fixed on fixed strip (2) in turn.
The bottom of described aspirating needle (18) intercalation reaction cup, described cleaning needle (17) is on the top of reaction cup (1).
The cleaning of magnetic particle that the utility model provides is separated settling flux device, by an easy oblique magnet, is adsorbed from top to bottom or from bottom to top by magnetic particle suspending liquid, the particulate fully in absorption suspending liquid; By repeatedly cleaning the settling flux of separation and reverse magnet, improve cleaning efficiency, ensure that abundant luminescence during light-metering.
Accompanying drawing explanation
Fig. 1 is that the cleaning of the utility model magnetic particle is separated settling flux device schematic diagram
Fig. 2 is that the cleaning of the utility model magnetic particle is separated settling flux device vertical view
In figure: 1 is reaction cup, 2 is fixed strip, 3 is low level single glass of magnet, 4 is two glasss of magnet obliquely, 5 is the two cup magnet of a high position, 6 is the two cup magnet of No. two high positions, 7 is a suspension magnet, 8 is No. two suspension magnets, 9 is No. three suspension magnets, 10 is high-order single glass of magnet, 11 is two glasss of magnet obliquely, 12 is the two cup magnet of a low level, 13 is the two cup magnet of No. two low levels, 14 is No. four suspension magnets, 15 is No. five suspension magnets, 16 is No. six suspension magnets, 17 is cleaning needle, 18 is aspirating needle, 19 is leading portion magnet array, 20 is back segment magnet array, 21 is a cleaning Disengagement zone, 22 is a settling flux district, 23 is No. two cleaning Disengagement zone, 24 is No. two settling flux districts.
Embodiment
The utility model provides a kind of magnetic particle to clean and is separated settling flux device, and for making object of the present invention, technical scheme and effect are better clear, clear and definite, are described in detail the specific embodiment of the present invention referring to accompanying drawing.
As shown in Figure 1 and Figure 2, a kind of magnetic particle cleaning is separated settling flux device, comprise cleaning Disengagement zone (21), settling flux district (22), No. two cleanings Disengagement zone (23), No. two settling flux districts (24), fixed strip (2), aspirating needle (18) and cleaning needle (17) composition, is characterized in that described cleaning Disengagement zone (21) is leading portion magnet array (19); A described settling flux district (22) is made up of a suspension magnet (7), No. two suspension magnets (8), No. three suspension magnets (9); No. two described cleanings Disengagement zone (23) are back segment magnet array (20); No. two described settling flux districts (24) are made up of No. four suspension magnets (14), No. five suspension magnets (15), No. six suspension magnets (16); Described cleaning Disengagement zone (21), settling flux district (22), No. two cleanings Disengagement zone (23), No. two settling flux districts (24) are fixed on (2) on fixed strip in turn.
As shown in Figure 1 and Figure 2, described leading portion magnet array (19) comprises four groups of magnet, be divided into one group of single glass of magnet, three groups of two cup magnet, single glass of magnet (3) is positioned at low level, one group of two cup magnet (4) tilts upward, and two groups two cup magnet (5) (6) are positioned at a high position, and four groups of magnet are fixed on fixed strip (2) in turn.
As shown in Figure 1 and Figure 2, three pieces of suspension magnets of a described settling flux district (22) discharge in turn, used aloned, the magnetic field intensity of every block magnet is significantly less than the magnetic field intensity of magnet array, a suspension magnet (7), No. three suspension magnets (9) are contrary with leading portion magnet array magnetic field (19) direction, No. two suspension magnets (8) are contrary with suspension magnet (7) magnetic direction, and No. two suspension magnets are fixed on fixed strip; Described No. two settling flux districts (24) are identical with a settling flux district.
As shown in Figure 1 and Figure 2, described back segment magnet array (20) comprises four groups of magnet, be divided into one group of single glass of magnet, three groups of two cup magnet, single glass of magnet (10) is positioned at a high position, one group of two cup magnet (11) is tilted to down, and two groups two cup magnet (12) (13) are positioned at low level, and four groups of magnet are fixed on fixed strip (2) in turn.
As shown in Figure 1, the bottom of described aspirating needle (18) intercalation reaction cup, described cleaning needle (17) is on the top of reaction cup (1).
Workflow of the present utility model is as follows:
As shown in Figure 1, 2, magnetic particle was suspended in liquid before entering cleaning area, and when reaction cup (1) enters B position, leading portion magnet array (19) starts effect, and magnetic particle is the neighbouring gathering of the center line of magnet up and down constantly; Move to the process of position F in reaction cup (1) from position B, through the magnet combination tilted upward, magnetic particle is along inclined direction upper mobile; When reaction cup (1) moves to position F, magnetic particle is gathered near the center line of magnet, and aspirating needle (18) extracts the liquid in cup, and cleaning needle (17) injects cleaning fluid in reaction cup (1); When reaction cup (1) moves to position H, aspirating needle (18) extracting liquid, cleaning needle (17) injects cleaning fluid in reaction cup (1).
When reaction cup (1) moves to position I, magnetic particle is adsorbed onto the opposite side of wall of cup by a suspension magnet (7), because the magnetic of magnet is more weak, the magnetic particle assembled can not be in the past mobile rapidly together, but dispersion move slowly, the unnecessary material wrapped up in magnetic particle just dissolves in liquid again; When reaction cup (1) moves to position J, magnetic particle is slowly sucked back by No. two suspension magnets (8) again; When reaction cup (1) moves to position K, magnetic particle is adsorbed onto the opposite side of wall of cup again by No. three suspension magnets (9).
After reaction cup (1) in-position L, due to the effect of back segment magnet array (20), magnetic particle is sucked back rapidly, and the magnetic particle suspended in liquid is gathered together again; Move to the process of position P in reaction cup (1) from position L, the magnet combination under being tilted to, the magnetic particle of gathering is along inclined direction lower mobile; When reaction cup (1) moves to position P, aspirating needle (18) extracts the liquid in cup, and cleaning needle (17) injects cleaning fluid in reaction cup (1); When reaction cup (1) moves to position R, the liquid in cup extracted out by aspirating needle (18), and cleaning needle (17) injects cleaning fluid to (1) in reaction cup again.
When reaction cup (1) moves to position S, magnetic particle is adsorbed onto the opposite side of wall of cup by No. four suspension magnets (14), because the magnetic of magnet is more weak, the magnetic particle assembled can not be in the past mobile rapidly together, but dispersion move slowly, the unnecessary material wrapped up in magnetic particle just dissolves in liquid again; When reaction cup (1) moves to position T, magnetic particle is slowly sucked back by No. five suspension magnets (15) again; When reaction cup (1) moves to position U, magnetic particle is adsorbed onto the opposite side of wall of cup again by above-mentioned three settling flux by No. six suspension magnets (16), magnetic particle Eddy diffusion.
When reaction cup (1) moves to position V, reaction cup (1) leaves device described in the utility model, after adding exciting liquid, carries out luminous measured value, obtains required data.
Claims (5)
1. a magnetic particle cleaning is separated settling flux device, comprise cleaning Disengagement zone (21), settling flux district (22), No. two cleanings Disengagement zone (23), No. two settling flux districts (24), fixed strip (2), aspirating needle (18) and cleaning needle (17) composition, is characterized in that described cleaning Disengagement zone (21) is leading portion magnet array (19); A described settling flux district (22) is made up of a suspension magnet (7), No. two suspension magnets (8), No. three suspension magnets (9); No. two described cleanings Disengagement zone (23) are back segment magnet array (20); No. two described settling flux districts (24) are made up of No. four suspension magnets (14), No. five suspension magnets (15), No. six suspension magnets (16); Described cleaning Disengagement zone (21), settling flux district (22), No. two cleanings Disengagement zone (23), No. two settling flux districts (24) are fixed on (2) on fixed strip in turn.
2. a kind of magnetic particle cleaning according to claim 1 is separated settling flux device, it is characterized in that described leading portion magnet array (19) comprises four groups of magnet, be divided into one group of single glass of magnet, three groups of two cup magnet, single glass of magnet (3) is positioned at low level, one group of two cup magnet (4) tilts upward, and two groups two cup magnet (5) (6) are positioned at a high position, and four groups of magnet are fixed on fixed strip (2) in turn.
3. a kind of magnetic particle cleaning according to claim 1 is separated settling flux device, it is characterized in that three pieces of suspension magnets of a described settling flux district (22) discharge in turn, used aloned, the magnetic field intensity of every block magnet is significantly less than the magnetic field intensity of magnet array, a suspension magnet (7), No. three suspension magnets (9) are contrary with leading portion magnet array magnetic field (19) direction, No. two suspension magnets (8) are contrary with suspension magnet (7) magnetic direction, and No. two suspension magnets (8) are fixed on fixed strip (2); Described No. two settling flux districts (24) are identical with a settling flux district (22).
4. a kind of magnetic particle cleaning according to claim 1 is separated settling flux device, it is characterized in that described back segment magnet array (20) comprises four groups of magnet, be divided into one group of single glass of magnet, three groups of two cup magnet, single glass of magnet (10) is positioned at a high position, one group of two cup magnet (11) is tilted to down, and two groups two cup magnet (12) (13) are positioned at low level, and four groups of magnet are fixed on fixed strip (2) in turn.
5. a kind of magnetic particle cleaning according to claim 1 is separated settling flux device, and it is characterized in that the bottom of described aspirating needle (18) intercalation reaction cup, described cleaning needle (17) is on the top of reaction cup (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420660753.0U CN204165989U (en) | 2014-11-06 | 2014-11-06 | A kind of magnetic particle cleaning is separated settling flux device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420660753.0U CN204165989U (en) | 2014-11-06 | 2014-11-06 | A kind of magnetic particle cleaning is separated settling flux device |
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| CN204165989U true CN204165989U (en) | 2015-02-18 |
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| CN201420660753.0U Active CN204165989U (en) | 2014-11-06 | 2014-11-06 | A kind of magnetic particle cleaning is separated settling flux device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109909217A (en) * | 2019-03-27 | 2019-06-21 | 苏州长光华医生物医学工程有限公司 | A kind of immunity analysis instrument magnetic cleaning separator |
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
-
2014
- 2014-11-06 CN CN201420660753.0U patent/CN204165989U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109909217A (en) * | 2019-03-27 | 2019-06-21 | 苏州长光华医生物医学工程有限公司 | A kind of immunity analysis instrument magnetic cleaning separator |
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: GETEIN BIOTECH, INC. Free format text: FORMER NAME: NANJING EGG-BASED BIOTECHNOLOGY CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: Liuhe District of Nanjing City, Jiangsu province 211505 Yangtze River Industrial Development Zone Bo Fu Road No. 9 Patentee after: Ji Dan biotech inc Address before: Liuhe District of Nanjing City, Jiangsu province 211505 Yangtze River Industrial Development Zone Bo Fu Road No. 9 Patentee before: Nanjing Egg-based Biotechnology Co., Ltd. |