CN204147437U - A kind of closed loop light stimulus system for spinal function regulation and control - Google Patents
A kind of closed loop light stimulus system for spinal function regulation and control Download PDFInfo
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- CN204147437U CN204147437U CN201420588300.1U CN201420588300U CN204147437U CN 204147437 U CN204147437 U CN 204147437U CN 201420588300 U CN201420588300 U CN 201420588300U CN 204147437 U CN204147437 U CN 204147437U
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Abstract
This case is the closed loop light stimulus system for spinal function regulation and control, and comprising: flexible light-electrode, it comprises the metal electrode for gathering electroneurographic signal and the LED for photostimulation; Signal gathering unit, it is connected with described flexible light-electrode communication, to receive the spinal cord conduction signal of telecommunication that described metal electrode collects; Main control unit, it is connected with described signal gathering unit communication, and according to the spinal cord conduction signal of telecommunication collected, adjustment LED driving instruction; LED drive unit, it is connected with described main control unit communication, and according to described LED driving instruction, drives described LED to work; Power supply unit, it is powered to described flexible light-electrode, main control unit, signal gathering unit and LED drive unit.Native system self adaptation regulation and control can possess the whole nervous pathway at the neuron place of light sensitive characteristic, more adapts to the diversity of Different Individual, thus reaches better regulating effect.
Description
Technical field
This utility model relates to a kind of closed loop photic stimulator, is specifically related to a kind of closed loop light stimulus system for spinal function regulation and control.
Background technology
Spinal cord is position very easily impaired in central nervous system, and the disability rate of spinal cord injury is high, seriously jeopardizes the health of the mankind.Reparation after spinal cord injury is the difficult point of medical domain always.After spinal cord injury, nerve growth factor (NGF) under certain conditions, can promote that non-injured neuron sprouts, and rebuilds destroyed neural circuit.But when not having extraneous the intervention, middle severe injury endogenous NGF expression is not enough to the effect played protection and repair, and it is shorter to hold time.
At present, cell transplantation and gene therapy are the important means of spinal cord injury treatment, the effect achieved in zoopery, but also far from clinical practice.The holding time and how to apply the series of problems such as neurotrophic factor, immunosuppressive drug of desirable cell concentration needed for cellular transplantation therapy, transplantation effect.The gene therapy of spinal cord injury is also faced with many problems: (1) central nervous system's rejection; (2) transplanted cells can not long-term surviving in host; (3), after genetically modified cell is transplanted, transgene expression extends in time and declines, and loses therapeutical effect; (4) safety issue, as the carcinogenecity of exogenous gene.
In recent years, the development in inhibition of pain, treatment spinal cord injury and plant man wake up etc. of spinal cord stimulation trial technology is very fast.This Therapeutic Method is that electrode is placed directly in spinal cord relevant position, produces electric stimulation pulse and treats relevant disease, achieve gratifying effect clinically by stimulator.
Along with the development of light sensation gene regulation technology in recent years, it is found that photostimulation can stimulate for specific neuron more accurately, light hereditism is applied to spinal cord stimulation, be expected to obtain effect more better than electricity irritation.Opsin gene, based on optics and light gene engineering, is added that specific promoter imports specific neuronal populations by virus transfection, then comes excited by the photostimulation of specific wavelength or suppress such neuronic physiological activity by light hereditism.Such as, blue light stimulates can the neuron of excited band photosensitive protein ChR2, and under the stimulation of gold-tinted, the neuron activity of band photosensitive protein NaHR is by suppressed.Relative to electricity irritation, light hereditism achieves to be stimulated specific neuronic accurate targeting, and avoids the injury of electric current to tissue.
In prior art, the Unidirectional light of spinal cord is stimulated and cannot make adjustment according to spinal cord state, so regulating effect is limited.
Utility model content
For overcoming the deficiencies in the prior art, the purpose of this utility model is to provide a kind of closed loop photic stimulator system for spinal function regulation and control, this system is intended to the spinal cord conduction signal of telecommunication being gathered user by flexible light-electrode, analyze to determine spinal cord state to it, and carry out light regulation and control according to the neuron of respective algorithms driving LED to the band photosensitive protein being implanted into spinal cord specific part, repair the spinal cord after damage targetedly.
For achieving the above object, this utility model is achieved through the following technical solutions:
Closed loop light stimulus system for spinal function regulation and control described in the utility model, comprising:
Flexible light-electrode, it comprises the metal electrode for gathering electroneurographic signal and the LED for photostimulation;
Signal gathering unit, it is connected with described flexible light-electrode communication, to receive the spinal cord conduction signal of telecommunication that described metal electrode collects;
Main control unit, it is connected with described signal gathering unit communication, and according to the spinal cord conduction signal of telecommunication collected, adjustment LED driving instruction;
LED drive unit, it is connected with described main control unit communication, and according to described LED driving instruction, drives described LED to work;
Power supply unit, it is powered to described flexible light-electrode, main control unit, signal gathering unit and LED drive unit.
Preferably, the described closed loop light stimulus system for spinal function regulation and control, wherein, also comprises:
Host computer, it is by communication unit and described main control unit communication, to preserve information wherein.
Preferably, the described closed loop light stimulus system for spinal function regulation and control, wherein, also comprises:
Retainer ring, it is arc spring lamination, is looped around on the body of receptor;
Adapter, it is set in the middle part of described retainer ring, and the both sides of described adapter are provided with winding displacement interface, described winding displacement seam is also respectively arranged with renovates one and renovate two, described renovate one and the one end of renovating two be all articulated on adapter, the other end can be connected on adapter, to clamp winding displacement;
Wherein, described flexible light-electrode is connected to adapter by winding displacement, and signal gathering unit and LED drive unit are also connected to adapter by winding displacement.
Preferably, the described closed loop light stimulus system for spinal function regulation and control, wherein, described flexible light-electrode is arranged on flexible PCB, stretch out LED at the middle part of one end of described flexible PCB, stretch out a metal microelectrode in the both sides of described LED respectively;
Preferably, the described closed loop light stimulus system for spinal function regulation and control, wherein, described signal gathering unit can adopt bipolar electrode to input or the input of three electrodes.
Preferably, the described closed loop light stimulus system for spinal function regulation and control, wherein, the metal electrode in described flexible light-electrode and LED electrical pole accessible site are same parts, or discrete be different parts.
Preferably, the described closed loop light stimulus system for spinal function regulation and control, wherein, flexible light-electrode is by Operation body, and fit on spinal nerves, LED is positioned at damaged part metal electrode and is then positioned at damaged part rear and front end.
Preferably, the described closed loop light stimulus system for spinal function regulation and control, wherein, described flexible light-electrode can be plane electrode or three-dimensional multiconductor metal electrode.
Preferably, the described closed loop light stimulus system for spinal function regulation and control, wherein, described LED has two or more.
Preferably, the described closed loop light stimulus system for spinal function regulation and control, described LED can unify light-emitting mode or independent controlled.
The beneficial effects of the utility model are: the flexible light that this utility model utilizes flexible material to make-electrode gathers the spinal cord conduction signal of telecommunication and LED carries out photostimulation, possess spinal cord conduction electrical signal collection function and photostimulation function simultaneously, both are by the closed loop photostimulation of algorithm realization to spinal cord, the multiple signals that main control unit analysis collects also feed back stimulus modelity, system solves the problem the problem that Unidirectional light stimulates regulation and control limited, self adaptation regulation and control can possess the whole nervous pathway at the neuron place of light sensitive characteristic, more adapt to the diversity of Different Individual, thus reach better regulating effect.
Accompanying drawing explanation
Fig. 1 is the structured flowchart of the closed loop photic stimulator system for spinal function regulation and control described in this utility model one embodiment.
Fig. 2 for described in this utility model one embodiment for spinal function regulation and control closed loop photic stimulator system in adapter plate structure schematic diagram.
Fig. 3 for described in this utility model one embodiment for spinal function regulation and control closed loop photic stimulator system in flexible light-electric electrode structure schematic diagram.
Detailed description of the invention
Below in conjunction with accompanying drawing, this utility model is described in further detail, can implements according to this with reference to description word to make those skilled in the art.
The present embodiment for be the repair of spinal cord injury of mice, the closed loop light stimulus system for spinal function regulation and control described in the utility model, mainly comprises:
Flexible light-electrode 4, consulting Fig. 3, is described flexible light-electric electrode structure schematic diagram, comprises for gathering the metal electrode 41 of electroneurographic signal and the LED42 for photostimulation;
Signal gathering unit 23, it is connected with described flexible light-electrode communication, to receive the spinal cord conduction signal of telecommunication that described metal electrode collects;
Main control unit 22, is controller (STM32L151CBT6), is communicated by SPI interface with signal gathering unit (ADS1292), arrange sample frequency and the mode of operation of ADS1292, and obtain two-way 24 position digital signal; By special algorithm, the spinal cord conduction signal of telecommunication collected is analyzed, thus regulate stimulus parameter in real time, comprise the cycle of stimulus waveform, pulsewidth and amplitude, according to parameter adjustment LED driving instruction;
LED drive unit 24, for the built-in DA of STM32L151CBT6 adds amplifier AD8603, LED drive unit, according to LED driving instruction, works to drive described LED;
Power supply unit 25, comprises lithium battery and voltage chips ADP151, and it is powered to flexible light-electrode, main control unit 22, signal gathering unit and LED drive unit.
Closed loop light stimulus system for spinal function regulation and control described in the utility model, can also comprise following situation.
Further, also comprise host computer 1, the signal of telecommunication, photostimulation parameter and battery electric quantity state, by communication unit 12 and 21 and described main control unit communication, are transferred to host computer display by wireless communication unit or preserve by computer 11 wherein.
This utility model can also comprise: retainer ring, and it is arc spring lamination, is looped around on the body of receptor, and retainer ring is looped around on mice body here;
Adapter 32, as shown in Figure 2, it is set in the middle part of described retainer ring, and the both sides of described adapter are provided with winding displacement interface, described winding displacement seam is also respectively arranged with renovates one 31 and renovate 2 34, described renovate one and the one end of renovating two be all articulated on adapter, the other end can be connected on adapter, to clamp winding displacement 35;
Wherein, described flexible light-electrode is connected to adapter by winding displacement, and signal gathering unit and LED drive unit are also connected to adapter by winding displacement.
Further, described flexible light-electrode is arranged on flexible PCB, stretches out LED at the middle part of one end of described flexible PCB, stretches out a metal microelectrode in the both sides of described LED respectively; Wherein, the put procedure whole process of LED is carried out under the microscope, with point gum machine by conductive silver glue point on positive and negative electrode, note not short circuit, then LED is placed on it and positive and negative terminal is alignd with electrode, place one day, conductive silver glue is solidified, encloses one deck Parylene subsequently as insulating barrier;
This utility model can also comprise following distortion: described signal gathering unit can adopt bipolar electrode to input or the input of three electrodes.When namely adopting three electrode inputs, except being positioned at a metal electrode (work metal electrode of the both sides of LED on spinal nerves, and neighbouring reference metal electrode), also comprise an electrode altogether, the position of placing due to LED two lateral electrode is different, the signal of input is also different, the signal that described signal gathering unit gathers is the current potential of work metal electrode relative to reference metal electrode, be total to ground electrode and be used to make the ground of circuit board and subjects in one plane, to reach better effect; Also two electric level input can be adopted, namely above-mentioned ground electrode is altogether saved, the signal that signal gathering unit gathers also is the current potential of work metal electrode relative to reference metal electrode, the method needs to ensure that input signal is no more than circuit board input range by back-end processing, and the method more easily realizes;
This utility model can also comprise following situation, and the metal electrode in described flexible light-electrode and LED electrical pole accessible site are same parts, or discrete be different parts.
Further, described flexible light-electrode is by Operation body, and fit on spinal nerves, LED is positioned at damaged part metal electrode and is then positioned at damaged part rear and front end.
Further, described flexible light-electrode can be plane electrode or three-dimensional multiconductor metal electrode.
This utility model can also comprise following situation, and described LED can have two or more.
Further, described two or more LED can unify light-emitting mode or independent controlled, and that is, several LED can with identical frequency, brightness flicker, also can separately according to frequencies different separately, brightness flicker.
For the repair of spinal cord injury of mice, the using method of the closed loop light stimulus system for spinal function regulation and control experiment described in the utility model is as follows:
Step 1: the induced multi-potent stem cells transplanting band photosensitive protein, to site spinal cord injury, carries out light regulation and control after cell differentiation.
Step 2: implanted flexible light-electrode front end, fit on spinal nerves, LED is positioned at damaged part metal electrode and is then positioned at damaged part rear and front end.
Step 3: connect flexible light-electrode and keyset, fixed transfer plate, connects keyset and closed loop photostimulation module by winding displacement.
Step 4: be placed in knapsack by closed loop photic stimulator, knapsack is born by mice.
Step 5: open closed loop photic stimulator on and off switch, user sends " beginning " order by upper computer software, and closed loop photic stimulator is started working, and software shows the waveform and current stimulus parameter that collect.
Step 6: user sends " time-out " or " termination " order by upper computer software.
Although embodiment of the present utility model is open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable field of the present utility model completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, this utility model is not limited to specific details and illustrates here and the legend described.
Claims (10)
1., for a closed loop light stimulus system for spinal function regulation and control, it is characterized in that, comprising:
Flexible light-electrode, it comprises the metal electrode for gathering electroneurographic signal and the LED for photostimulation;
Signal gathering unit, it is connected with described flexible light-electrode communication, to receive the spinal cord conduction signal of telecommunication that described metal electrode collects;
Main control unit, it is connected with described signal gathering unit communication, and according to the spinal cord conduction signal of telecommunication collected, adjustment LED driving instruction;
LED drive unit, it is connected with described main control unit communication, and according to described LED driving instruction, drives described LED to work;
Power supply unit, it is powered to described flexible light-electrode, main control unit, signal gathering unit and LED drive unit.
2., as claimed in claim 1 for the closed loop light stimulus system of spinal function regulation and control, it is characterized in that, also comprise:
Host computer, it is by communication unit and described main control unit communication, to preserve information wherein.
3., as claimed in claim 1 or 2 for the closed loop light stimulus system of spinal function regulation and control, it is characterized in that, also comprise:
Retainer ring, it is arc spring lamination, is looped around on the body of receptor;
Adapter, it is set in the middle part of described retainer ring, and the both sides of described adapter are provided with winding displacement interface, described winding displacement seam is also respectively arranged with renovates one and renovate two, described renovate one and the one end of renovating two be all articulated on adapter, the other end can be connected on adapter, to clamp winding displacement;
Wherein, described flexible light-electrode is connected to adapter by winding displacement, and signal gathering unit and LED drive unit are also connected to adapter by winding displacement.
4., as claimed in claim 3 for the closed loop light stimulus system of spinal function regulation and control, it is characterized in that,
Described flexible light-electrode is arranged on flexible PCB, stretches out LED at the middle part of one end of described flexible PCB, stretches out a metal microelectrode in the both sides of described LED respectively;
5., as claimed in claim 4 for the closed loop light stimulus system of spinal function regulation and control, it is characterized in that,
Described signal gathering unit can adopt bipolar electrode to input or the input of three electrodes.
6., as claimed in claim 5 for the closed loop light stimulus system of spinal function regulation and control, it is characterized in that, the metal electrode in described flexible light-electrode and LED electrical pole accessible site are same parts, or discrete be different parts.
7., as claimed in claim 6 for the closed loop light stimulus system of spinal function regulation and control, it is characterized in that,
Flexible light-electrode is by Operation body, and fit on spinal nerves, LED is positioned at damaged part metal electrode and is then positioned at damaged part rear and front end.
8., as claimed in claim 7 for the closed loop light stimulus system of spinal function regulation and control, it is characterized in that, described flexible light-electrode can be plane electrode or three-dimensional multiconductor metal electrode.
9., as claimed in claim 8 for the closed loop light stimulus system of spinal function regulation and control, it is characterized in that, described LED has two or more.
10. as claimed in claim 9 for the closed loop light stimulus system of spinal function regulation and control, it is characterized in that, described LED can unify light-emitting mode or independent controlled.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420588300.1U CN204147437U (en) | 2014-10-11 | 2014-10-11 | A kind of closed loop light stimulus system for spinal function regulation and control |
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| CN201420588300.1U CN204147437U (en) | 2014-10-11 | 2014-10-11 | A kind of closed loop light stimulus system for spinal function regulation and control |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436447A (en) * | 2014-10-11 | 2015-03-25 | 中国科学院苏州生物医学工程技术研究所 | Closed loop photostimulation system used for regulating and controlling functions of spinal cord |
| CN105126258A (en) * | 2015-10-10 | 2015-12-09 | 中国科学院苏州生物医学工程技术研究所 | Wireless program-control light stimulation device |
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- 2014-10-11 CN CN201420588300.1U patent/CN204147437U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436447A (en) * | 2014-10-11 | 2015-03-25 | 中国科学院苏州生物医学工程技术研究所 | Closed loop photostimulation system used for regulating and controlling functions of spinal cord |
| CN104436447B (en) * | 2014-10-11 | 2017-01-11 | 中国科学院苏州生物医学工程技术研究所 | Closed loop photostimulation system used for regulating and controlling functions of spinal cord |
| CN105126258A (en) * | 2015-10-10 | 2015-12-09 | 中国科学院苏州生物医学工程技术研究所 | Wireless program-control light stimulation device |
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Granted publication date: 20150211 Termination date: 20191011 |
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| CF01 | Termination of patent right due to non-payment of annual fee |