CN115779269A - Device and wearable equipment of rodent treatment interstitial cystitis of electricity stimulation - Google Patents
Device and wearable equipment of rodent treatment interstitial cystitis of electricity stimulation Download PDFInfo
- Publication number
- CN115779269A CN115779269A CN202211505265.8A CN202211505265A CN115779269A CN 115779269 A CN115779269 A CN 115779269A CN 202211505265 A CN202211505265 A CN 202211505265A CN 115779269 A CN115779269 A CN 115779269A
- Authority
- CN
- China
- Prior art keywords
- animal
- stimulation
- nerve
- controller
- interstitial cystitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000638 stimulation Effects 0.000 title claims abstract description 50
- 208000005615 Interstitial Cystitis Diseases 0.000 title claims abstract description 27
- 241000283984 Rodentia Species 0.000 title claims abstract description 24
- 230000005611 electricity Effects 0.000 title description 3
- 241001465754 Metazoa Species 0.000 claims abstract description 47
- 239000012636 effector Substances 0.000 claims abstract description 40
- 210000000578 peripheral nerve Anatomy 0.000 claims abstract description 38
- 230000007383 nerve stimulation Effects 0.000 claims abstract description 33
- 230000004936 stimulating effect Effects 0.000 claims abstract description 32
- 210000005036 nerve Anatomy 0.000 claims abstract description 17
- 210000002972 tibial nerve Anatomy 0.000 claims abstract description 10
- 239000000017 hydrogel Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 238000001467 acupuncture Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000002411 adverse Effects 0.000 description 3
- 230000002567 autonomic effect Effects 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000001734 parasympathetic effect Effects 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 210000000278 spinal cord Anatomy 0.000 description 3
- 230000002889 sympathetic effect Effects 0.000 description 3
- 210000003403 autonomic nervous system Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 206010029446 nocturia Diseases 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 210000005037 parasympathetic nerve Anatomy 0.000 description 1
- 210000001002 parasympathetic nervous system Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000024470 urgency of urination Diseases 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Rehabilitation Therapy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention discloses a device for electrically stimulating rodents to treat interstitial cystitis and wearable equipment, which comprise a controller, a first peripheral nerve effector for applying a first electric nerve stimulation signal to a hidden nerve of an animal, a second peripheral nerve effector for applying a second electric nerve stimulation signal to a tibial nerve of the animal and a power supply for supplying electric energy, wherein the controller is connected with the power supply, the first peripheral nerve effector and the second peripheral nerve effector, the wearable equipment comprises a wearing part and the device for electrically stimulating the rodents to treat the interstitial cystitis, wherein the wearing part is worn on the body of the animal, the controller and the power supply are installed on the wearing part, and the first peripheral nerve effector and the second peripheral nerve effector are installed at the electric stimulation position of the animal.
Description
Technical Field
The invention belongs to the technical field of biomedicine and electricity, and relates to a device for electrically stimulating rodents to treat interstitial cystitis and wearable equipment.
Background
Interstitial cystitis is a syndrome with unknown reasons and clinical manifestations of frequent micturition, urgency of urination, nocturia, suprapubic area and pelvic pain after bladder filling, and relief after urination. The disease brings great pain to patients and seriously reduces the quality of life. Since the etiology and pathogenesis of interstitial cystitis are not clear at present, interstitial cystitis is mainly diagnosed by clinical manifestations and exclusion methods. At present, clinical treatment aims to control symptoms, although treatment methods are many, exact curative medicines and methods are not available, epidemiological data about interstitial cystitis are extremely limited, but from the existing data analysis, the interstitial cystitis is probably one of the most overlooked and most bewildering difficult diseases of urology surgery. Currently, oral drugs may not be fully effective and carry a high risk of adverse side effects, resulting in intolerance and frequent drug discontinuation, and there is a need for effective therapies that reduce side effects.
In some embodiments, systems and methods may include a wearable device having a conductive skin interface that excites underlying nerves by passing through a body surface stimulator. The dimensions of the device may be set for a range of user sizes, with stimulation electrodes positioned to target appropriate nerves, such as the saphenous and/or tibial nerves. The stimulation may include burst rapid pulse stimulation and involves receiving input regarding the rodent's autonomic nervous system activity and modifying a brain or spinal cord autonomic feedback loop related to bladder function based on the input to balance the rodent's parasympathetic and sympathetic nervous system activities.
However, the following problems exist in the prior art:
in the prior art, the electrical stimulation range is large, and influences can be caused on surrounding non-target tissues; some experiments need to anaesthetize the animals during electric stimulation, which can cause certain influence on the animals and is not beneficial to the subsequent experiments.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a device and a wearable device for electrically stimulating rodents to treat interstitial cystitis, which can avoid influencing surrounding non-target tissues and do not need to anaesthetize the animals during electric stimulation.
In order to achieve the purpose, the invention adopts the following technical scheme:
in one aspect, the present invention provides a device for electrically stimulating a rodent to treat interstitial cystitis, comprising a controller, a first peripheral nerve effector for applying a first electrical nerve stimulation signal to a saphenous nerve of the animal, a second peripheral nerve effector for applying a second electrical nerve stimulation signal to a tibial nerve of the animal, and a power source for providing electrical energy, wherein the controller is coupled to the power source, the first peripheral nerve effector, and the second peripheral nerve effector.
The electrical stimulation rodent device for treating interstitial cystitis is further improved by the following steps:
the system also comprises a biomedical sensor used for collecting feedback information of the animal, wherein the biomedical sensor is connected with the controller.
And the display screen is connected with the controller.
The first electrical nerve stimulation signal and the second electrical nerve stimulation signal are both short-matrix rapid pulse stimulation signals.
The frequency regulation range of the first electrical nerve stimulation signal is 5Hz-30Hz;
the frequency regulation range of the second electrical nerve stimulation signal is 10Hz-20Hz.
The first peripheral nerve effector comprises a first stimulating electrode plate and a first patch, wherein the first stimulating electrode plate is adhered to the position of the electrical stimulation of the animal through the first patch, and the first stimulating electrode plate is connected with the controller.
The second peripherical nerve effector comprises a second stimulating electrode plate and a second patch, wherein the second stimulating electrode plate is adhered to the position of the electrical stimulation of the animal through the second patch, and the second stimulating electrode plate is connected with the controller.
The first stimulating electrode slice and the second stimulating electrode slice are hydrogel patches.
In a second aspect, the invention provides a wearable device, comprising a wearing part and the claimed device for electrically stimulating rodents to treat interstitial cystitis, wherein the wearing part is worn on the body of an animal, the controller and the power supply are installed on the wearing part, and the first peripheral nerve effector and the second peripheral nerve effector are installed at the electric stimulation position of the animal.
The wearable device of the invention is further improved in that:
still include the display screen and be used for gathering the biomedical sensor of the feedback information of animal, wherein, biomedical sensor installs on the animal health, the display screen install in on wearing the part, display screen and biomedical sensor are connected with the controller.
The invention has the following beneficial effects:
when the device for electrically stimulating the rodent to treat the interstitial cystitis and the wearable equipment are specifically operated, the controller controls the first peripheral nerve effector and the second peripheral nerve effector to respectively generate the first electric nerve stimulation signal and the second electric nerve stimulation signal, so that the hidden nerve and the tibial nerve of the rodent are electrically stimulated, and the influence on peripheral non-target tissues is avoided. In addition, the wearable electric stimulation device adopts a wearable mode, when in use, the wearable part is worn on the animal body, and then electric stimulation is applied to the animal, so that the animal does not need to be anesthetized in the whole electric stimulation process, and the adverse effect on the subsequent experiment is avoided.
Further, feedback information of the electrical stimulation of the animal is acquired by the biomedical sensor, and the controller adjusts parameters of the first electrical nerve stimulation signal and the second electrical nerve stimulation signal according to the feedback information to modify a brain or spinal cord autonomic feedback loop related to bladder function and balance sympathetic and parasympathetic activity to reduce symptoms of interstitial cystitis.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are included to illustrate an exemplary embodiment of the invention and not to limit the invention. In the drawings:
FIG. 1 is a non-limiting block diagram relating to bladder function;
FIG. 2 is a schematic structural view of the present invention;
FIG. 3 is a structural view of a third embodiment;
FIG. 4 is a positional diagram of Zusanli and Sanyinjiao in mice;
fig. 5 is a diagram showing the installation positions of the first and second peripheral nerve effectors 1 and 2 according to the third embodiment.
Wherein, 1 is a first peripheral nerve effector, 2 is a second peripheral nerve effector, 3 is a controller, 4 is a biomedical sensor, 5 is a display screen, and 6 is a power supply.
Detailed Description
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that the terms "first," "second," and the like in the description and claims of the present invention and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the invention described herein are capable of operation in sequences other than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
The invention is described in further detail below with reference to the accompanying drawings:
example one
Referring to fig. 2, an apparatus for electrically stimulating a rodent according to the present invention for treating interstitial cystitis comprises;
a power supply 6 for supplying electric power;
a first peripheral nerve effector 1 for applying a first electrical nerve stimulation signal to a saphenous nerve of an animal;
a second peripherical nerve effector 2 for applying a second electrical nerve stimulation signal to the tibial nerve of the animal;
the biomedical sensor 4 is used for collecting feedback information of the animal;
a controller 3 for adjusting and controlling the first and second peripheral neuroeffectors 1, 2 according to feedback information of the animal to adjust parameters of the first and second electrical neuro-stimulation signals to reduce symptoms of interstitial cystitis by modifying brain or spinal cord autonomic feedback loops related to bladder function and balancing sympathetic and parasympathetic activity, wherein the present invention is not configured for implantation in the animal, and the first and second electrical neuro-stimulation signals may each include burst fast pulse stimulation, wherein the burst fast pulse stimulation is alpha burst fast pulse stimulation, delta burst fast pulse stimulation or theta burst fast pulse stimulation.
In the present invention, the first peripheral nerve effector 1 transcutaneously delivers a first electrical nerve stimulation signal to the saphenous nerve, and the second peripheral nerve effector 2 transcutaneously delivers a second electrical nerve stimulation signal to the tibial nerve, wherein the first peripheral nerve effector 1 and the second peripheral nerve effector 2 are controlled by the controller 3 to adjust the frequency of the first electrical nerve stimulation signal and the second electrical nerve stimulation signal, wherein the frequency of the first electrical nerve stimulation signal is adjusted in a range of 5Hz to 30Hz, the frequency of the second electrical nerve stimulation signal is adjusted in a range of 10Hz to 20Hz, the feedback signal includes the autonomic nervous system activity of the rodent, and the stimulation may be burst, offset, or alternation (alternating) between multiple nerves.
Preferably, the first peripheral nerve effector 1 of the present invention includes a first stimulation electrode pad and a first patch, wherein the first stimulation electrode pad is adhered to the electrical stimulation position of the animal through the first patch, the first stimulation electrode pad is connected to the controller 3, the first stimulation electrode pad is adhered to the electrical stimulation position of the animal through the first patch, and the controller 3 controls a parameter of a first electrical nerve stimulation signal sent by the first stimulation electrode pad, so as to stimulate the saphenous nerve. Preferably, the controller 3 is connected to the first and second stimulation electrode pads through wires.
The second peripheral nerve effector 2 comprises a second stimulating electrode plate and a second patch, wherein the second stimulating electrode plate is adhered to the electric stimulation position of the animal through the second patch, the second stimulating electrode plate is connected with the controller 3, the second stimulating electrode plate is adhered to the electric stimulation position of the animal through the second patch, and the controller 3 is used for controlling the parameter of a second electric nerve stimulating signal sent by the second stimulating electrode plate so as to stimulate the tibial nerve. Preferably, the first patch and the second patch may be hydrogel patches.
The first stimulation electrode plate and the second stimulation electrode plate are adopted to stimulate the animal, so that stimulation of the electrical stimulation to surrounding non-target tissues is reduced, the animal is protected from damage, test interference is eliminated, and test operation errors are reduced.
The specific working process of the device for electrically stimulating rodents to treat interstitial cystitis comprises the following steps:
the controller 3 sends a first electric nerve stimulation signal and a second electric nerve stimulation signal to the saphenous nerve and the tibial nerve of the animal through the first peripheral nerve effector 1 and the second peripheral nerve effector 2 respectively, stimulates the animal through the first electric nerve stimulation signal and the second electric nerve stimulation signal, collects a feedback signal of the animal through the biomedical sensor 4, and then adjusts parameters, such as frequency, of the first electric nerve stimulation signal and the second electric nerve stimulation signal according to the feedback signal of the animal so as to balance parasympathetic nerve and sympathetic nerve system activities of the animal and better treat bladder related symptoms in a targeted manner.
Example two
The wearable device comprises a wearing part, wherein the controller 3 and the power supply 6 are installed on the wearing part, the wearing part is worn on the animal body when the wearable device works, and then the biomedical sensor 4, the first peripheral nerve effector 1 and the second peripheral nerve effector 2 are installed on the animal body.
Preferably, still include display screen 5, display screen 5 sets up on wearing the part, display screen 5 is connected with controller 3, shows the frequency of first electric nerve stimulation signal and second electric nerve stimulation signal through display screen 5 to the feedback information that the biomedical sensor 4 gathered is shown.
Preferably, the power supply 6 is a storage battery, and the display screen 5 is a flexible LED screen so as to meet the wearable requirement.
EXAMPLE III
Referring to fig. 1, the present invention is applied to a mouse, a first peripheral nerve effector 1 and a second peripheral nerve effector 2 are placed under the knee and/or above the ankle of the mouse to stimulate the saphenous nerve and/or the tibial nerve of the mouse, and acupuncture points (acupuncture points) are stimulated to be tsusanli and sanyin crosses by electrically stimulating the acupuncture points, as shown in fig. 3, 4 and 5, in an electrical stimulation experiment of the tsusanli and sanyin crosses of the mouse, the present invention can safely separate the acupuncture points and peripheral non-acupuncture point tissues, has little influence on the non-acupuncture point tissues, can electrically stimulate the mouse with movement, and after a period of electrical stimulation treatment (about 20 minutes), the mouse does not have the appearance of falling-off parts and other adverse injuries, and the quality of final experimental data is not lower than that obtained by using the prior art.
Finally, it should be noted that: although the present invention has been described in detail with reference to the above embodiments, it should be understood by those skilled in the art that: modifications and equivalents may be made to the embodiments of the invention without departing from the spirit and scope of the invention, which is to be covered by the claims.
Claims (10)
1. A device for electrically stimulating rodents to treat interstitial cystitis, comprising a controller (3), a first peripheral nerve effector (1) for applying a first electrical nerve stimulation signal to the implicit nerve of the animal, a second peripheral nerve effector (2) for applying a second electrical nerve stimulation signal to the tibial nerve of the animal, and a power source (6) for providing electrical power, wherein the controller (3) is connected to the power source (6), the first peripheral nerve effector (1) and the second peripheral nerve effector (2).
2. The apparatus for electrically stimulating rodents to treat interstitial cystitis as claimed in claim 1, further comprising a biomedical sensor (4) for collecting feedback information from the animal, wherein said biomedical sensor (4) is connected to said controller (3).
3. An electrically stimulated rodent device for treating interstitial cystitis according to claim 1, further comprising a display screen (5) connected to the controller (3).
4. The apparatus for electrically stimulating a rodent to treat interstitial cystitis as recited in claim 1, wherein said first and second electrical nerve stimulating signals are both burst fast pulse stimulating signals.
5. The apparatus for electrically stimulating a rodent for treating interstitial cystitis as recited in claim 1, wherein said first electrical nerve stimulation signal has a frequency modulation range of 5Hz to 30Hz;
the frequency regulation range of the second electrical nerve stimulation signal is 10Hz-20Hz.
6. An electrically stimulated rodent device for treatment of interstitial cystitis as claimed in claim 1, wherein the first peripheral nerve effector (1) comprises a first stimulation electrode pad and a first patch, wherein the first stimulation electrode pad is adhered to the animal at the site of electrical stimulation via the first patch, and wherein the first stimulation electrode pad is connected to the controller (3).
7. The device for electrically stimulating rodents to treat interstitial cystitis as claimed in claim 6, wherein the second perimetral neuroeffector (2) comprises a second stimulation electrode pad and a second patch, wherein the second stimulation electrode pad is adhered to the electrical stimulation site of the animal via the second patch, and wherein the second stimulation electrode pad is connected to the controller (3).
8. The device of claim 1, wherein the first and second stimulation electrode pads are hydrogel patches.
9. A wearable device comprising a wearing member and the device for electrically stimulating a rodent to treat interstitial cystitis of claim 1, wherein the wearing member is worn on the body of the animal, the controller (3) and the power source (6) are mounted on the wearing member, and the first peripheral nerve effector (1) and the second peripheral nerve effector (2) are mounted at the electrical stimulation location of the animal.
10. The wearable device according to claim 9, further comprising a display screen (5) and a biomedical sensor (4) for collecting feedback information of the animal, wherein the biomedical sensor (4) is mounted on the body of the animal, the display screen (5) is mounted on the wearing part, and the display screen (5) and the biomedical sensor (4) are connected with the controller (3).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211505265.8A CN115779269A (en) | 2022-11-28 | 2022-11-28 | Device and wearable equipment of rodent treatment interstitial cystitis of electricity stimulation |
| PCT/CN2023/133781 WO2024114508A1 (en) | 2022-11-28 | 2023-11-23 | Apparatus for electrically stimulating rodent animal for treatment of interstitial cystitis and wearable device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211505265.8A CN115779269A (en) | 2022-11-28 | 2022-11-28 | Device and wearable equipment of rodent treatment interstitial cystitis of electricity stimulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115779269A true CN115779269A (en) | 2023-03-14 |
Family
ID=85442529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211505265.8A Pending CN115779269A (en) | 2022-11-28 | 2022-11-28 | Device and wearable equipment of rodent treatment interstitial cystitis of electricity stimulation |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN115779269A (en) |
| WO (1) | WO2024114508A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024114508A1 (en) * | 2022-11-28 | 2024-06-06 | 中国科学院深圳先进技术研究院 | Apparatus for electrically stimulating rodent animal for treatment of interstitial cystitis and wearable device |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10086197B2 (en) * | 2013-10-09 | 2018-10-02 | GiMer Medical Co., Ltd. | Method for reducing overactive bladder syndrome and computer-readable medium thereof |
| US11077301B2 (en) * | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
| AU2017211048B2 (en) * | 2016-01-21 | 2022-03-10 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
| CN110809486A (en) * | 2017-04-03 | 2020-02-18 | 卡拉健康公司 | Peripheral neuromodulation systems, methods, and devices for treating diseases associated with overactive bladder |
| WO2019143790A1 (en) * | 2018-01-17 | 2019-07-25 | Cala Health, Inc. | Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation |
| US10363414B1 (en) * | 2018-04-12 | 2019-07-30 | Feinstein Patents, Llc | Combined bladder scanner and (functional) interferential electrical stimulation device |
| CA3130147A1 (en) * | 2019-03-08 | 2020-09-17 | Cala Health, Inc. | Wearable peripheral nerve stimulation for the treatment of diseases utilizing rhythmic biological processes |
| CN115779269A (en) * | 2022-11-28 | 2023-03-14 | 中国科学院深圳先进技术研究院 | Device and wearable equipment of rodent treatment interstitial cystitis of electricity stimulation |
-
2022
- 2022-11-28 CN CN202211505265.8A patent/CN115779269A/en active Pending
-
2023
- 2023-11-23 WO PCT/CN2023/133781 patent/WO2024114508A1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024114508A1 (en) * | 2022-11-28 | 2024-06-06 | 中国科学院深圳先进技术研究院 | Apparatus for electrically stimulating rodent animal for treatment of interstitial cystitis and wearable device |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024114508A1 (en) | 2024-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210308457A1 (en) | Treatment of Headaches by Electrical Stimulation | |
| AU2019240656B2 (en) | Systems and methods for transcutaneous direct current block to alter nerve conduction | |
| CN108697890B (en) | System and method for treating various neurological diseases by synchronously activating nerves | |
| EP2699310B1 (en) | Apparatus for assessing neural activation | |
| US8825166B2 (en) | Multiple-symptom medical treatment with roving-based neurostimulation | |
| US10029106B2 (en) | Remote access and post program telemonitoring | |
| CN107106841B (en) | Methods and systems for monitoring and treating conditions via posterior tibial nerve stimulation | |
| KR20170127056A (en) | Extracranial implantable devices, systems and methods for the treatment of neurological disorders | |
| AU2008251685A1 (en) | Neural signal duty cycle | |
| AU2020348841B2 (en) | System, method, and apparatus for applying electrical stimulation | |
| WO2021067751A1 (en) | Peripheral nerve stimulation for restless legs syndrome | |
| WO2024114508A1 (en) | Apparatus for electrically stimulating rodent animal for treatment of interstitial cystitis and wearable device | |
| US20200297992A1 (en) | Primary Dysmenorrhea Pain Reduction | |
| US11420042B2 (en) | Systems and methods for delivering neurostimulation using exogenous electrodes | |
| EP4041376A1 (en) | Peripheral nerve stimulation for restless legs syndrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication |