CN204129005U - Electrolyte analyzer and biological chemistry in-vitro diagnosis equipment - Google Patents

Abstract

The utility model discloses an electrolyte analysis device and biochemical in vitro diagnostic equipment. The electrolyte analysis device includes a sampling cup, a standard solution container that is connected to the inlet end of the sampling cup through a standard liquid extraction pump, an electrode box that is connected to the outlet end of the sampling cup, and The electrode box is conductively connected to the sample extraction pump and the waste liquid container, the ion selective electrode measurement assembly is arranged in the electrode box, and the outlet end of the sampling cup is directly connected to the inlet end of the electrode box through a conduit , the sample extraction pump is connected to the outlet end of the electrode box through a conduit, and a liquid detector is arranged on the pipeline between the outlet end of the electrode box and the sample extraction pump. The utility model has the advantages of simple structure, small size, cost saving and low failure rate, and is more suitable for integration into large-scale biochemical in vitro diagnostic equipment; and it is more conducive to simplifying the calibration operation of the extraction pump, improving the accuracy of the calibration of the extraction pump, and improving the stability of the system sex and precision.

Description

Electrolyte analysis device and biochemical in vitro diagnostic equipment

technical field

The utility model relates to the field of biochemical in vitro diagnostic equipment, in particular to an electrolyte analysis device and biochemical in vitro diagnostic equipment.

Background technique

The electrolyte analysis device is an in vitro diagnostic instrument for detecting potassium ions, sodium ions, chloride ions, and ionized calcium (PH) from samples based on ion-selective electrode method and pressure measurement method. The samples to be tested can be whole blood, serum, plasma, urine, dialysate and hydration fluid, etc. The ion-selective electrode is a kind of electrochemical sensor that uses the membrane potential to measure the activity or concentration of ions in the solution. The ionic activity is directly related to the membrane potential. By utilizing the selective voltage response of the ion selective electrode to the ions in the sample to be measured, the concentration of the corresponding ions in the sample can be calculated by measuring the voltage.

With the continuous advancement of automation technology, in vitro diagnostic instruments are developing towards high speed and miniaturization. The electrolyte analysis device based on the ion selective electrode method has been widely used in the field of clinical testing due to its advantages of convenient operation and rapidity. At the same time, high-speed intelligence and miniaturization are also the development directions of electrolyte analysis devices. While ensuring the function and performance of the device, optimizing the design and simplifying the structure not only saves costs but also effectively reduces the failure rate of the instrument, which is an important goal of electrolyte analysis research.

In the electrolyte analysis module of the prior art, in addition to including the main components such as the sampling cup, the extraction pump, the liquid container, the control unit, the data acquisition circuit, and the ion-selective electrode placed in the electrode box, the measurement unit is composed of It is also necessary to include at least two or more liquid detectors located at both ends of the electrode box, through which the liquid detector cooperates with the extraction pump, and the corresponding algorithm is used to calibrate the extraction pump, and electrolyte analysis is performed on this basis.

This kind of electrolyte analysis module that requires more than two liquid detectors has the following disadvantages: relatively large volume and complex structure, it is not easy to integrate into large-scale biochemical in vitro diagnostic equipment; the liquid circuit is relatively complicated, and it is easy to increase equipment after long-term use failure rate.

Utility model content

The technical problem solved by the utility model is to provide an electrolyte analysis device, which is simple in structure, small in size, cost-saving, and low in failure rate, and is more suitable for integration into large-scale biochemical in vitro diagnostic equipment; and it is more conducive to simplifying the extraction pump Calibration operation and improve the accuracy of pump calibration, improve the stability and accuracy of the system.

The technical problem further solved by the utility model is to provide a biochemical in vitro diagnostic device, which has a simplified structure, small size, cost savings, and low failure rate; and is more conducive to simplifying the calibration operation of the pump and improving the calibration of the pump. Accuracy, improve system stability and precision.

In order to solve the above technical problems, the utility model discloses the following solutions:

An electrolyte analysis device, comprising a sampling cup, a standard solution container that is conductively connected to the inlet end of the sampling cup through a standard liquid extraction pump, an electrode box that is conductively connected to the outlet end of the sampling cup, A sample extraction pump and a waste liquid container that are conductively connected to the electrode box, the ion selective electrode measurement assembly is arranged in the electrode box, and the outlet end of the sampling cup is directly connected to the inlet of the electrode box through a catheter The sample extraction pump is connected to the outlet end of the electrode box through a conduit, and a liquid detector is arranged on the pipeline between the outlet end of the electrode box and the sample extraction pump.

Preferably, the liquid detector is arranged on the pipeline at the outlet of the electrode box.

Preferably, the standard liquid extraction pump and the sample extraction pump are arranged side by side on the same horizontal line.

Preferably, the electrode box is arranged above the standard solution pump and the sample pump arranged side by side.

Preferably, the standard liquid container includes a first standard liquid container and a second standard liquid container, and the standard liquid pump correspondingly includes a first standard liquid pump and a second standard liquid pump.

Preferably, the first standard liquid container, the second standard liquid container, and the waste liquid container are arranged side by side on the same horizontal line, and are respectively connected to the first standard liquid extraction pump, the second standard liquid extraction pump, and the sample through curved pipelines. Extraction pump is connected.

Preferably, the bottom of the sampling cup is an inverted cone structure, the outlet end of the sampling cup is arranged at the bottom of the inverted cone, and the horizontal position of the top of the inverted cone is level with the top of the electrode box The position is flush.

Preferably, a data acquisition circuit is also provided in the electrode box.

Preferably, the data acquisition circuit includes a signal amplification circuit, a filter circuit, and an AD conversion circuit electrically connected in sequence.

Correspondingly, the utility model also discloses a biochemical in vitro diagnostic device, which includes an electrolyte analysis module, and the electrolyte analysis module is the electrolyte analysis device as described above.

The beneficial effects of the utility model are:

The embodiment of the utility model only arranges the liquid sensor on the pipeline between the electrode box and the sample extraction pump, thereby reducing the number of liquid sensors, simplifying the structure, reducing the volume, saving cost, and reducing the failure rate. It is more suitable for integration into large-scale biochemical in vitro diagnostic equipment; and achieves the effect of simplifying the calibration operation of the extraction pump, improving the accuracy of the calibration of the extraction pump, and improving the stability and precision of the system.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description These are only some embodiments of the utility model, and those skilled in the art can also obtain other drawings based on these drawings without creative work.

Fig. 1 is a schematic structural view of an embodiment of the electrolyte analysis device of the present invention.

Fig. 2 is a schematic diagram of the liquid circuit structure of an embodiment of the electrolyte analysis device of the present invention.

Detailed ways

An embodiment of the electrolyte analysis device provided by the utility model is described in detail below with reference to Fig. 1 and Fig. 2; A standard solution container 3 connected to the inlet end of 1, an electrode box 4 connected to the outlet end of the sampling cup 1, a sample pump 5 connected to the electrode box 4, and a sample pump 5 connected to the sample The waste liquid container 6 connected to the extraction pump 5 is connected, and the ion selective electrode measurement assembly (not shown) is arranged in the electrode box 4, wherein the outlet end of the sampling cup 1 is directly connected to the The inlet end of the electrode box 4, the sample extraction pump 5 is connected to the outlet end of the electrode box 4 through a conduit, and the pipeline between the outlet end of the electrode box 4 and the sample extraction pump 5 is provided with liquid detector7.

In actual implementation, the liquid detector 7 can be arranged on the pipeline at the outlet of the electrode box 4 .

Further, the standard liquid extraction pump 2 and the sample extraction pump 5 are arranged side by side on the same horizontal line.

Furthermore, the electrode box 2 can be arranged above the standard solution pump 2 and the sample pump 5 arranged side by side.

Furthermore, the standard solution container 3 may specifically include a first standard solution container 31 for accommodating the A standard solution and a second standard solution container 32 for accommodating the B standard solution, and the standard solution extraction pump 2 may correspondingly include a first standard liquid suction pump Pa and a second standard liquid suction pump Pb.

Furthermore, the first standard liquid container 31, the second standard liquid container 32, and the waste liquid container 6 are arranged side by side on the same horizontal line, and are respectively connected to the first standard liquid pump Pa, the second standard liquid pump Pa, and the second standard liquid through curved pipelines. The liquid extraction pump Pb and the sample extraction pump Pc are connected.

The above-mentioned components are arranged in layers according to their structures, and the components of the same structure are arranged in the same layer. Compared with the scattered arrangement structure in the prior art, the effective arrangement space can be greatly increased and the product volume can be reduced.

Furthermore, the bottom of the sampling cup 1 can be configured as an inverted cone structure, the outlet end of the sampling cup 1 is arranged at the bottom of the inverted cone, and the horizontal position of the top of the inverted cone is the same as that of the inverted cone. The top of the electrode box 4 is horizontally aligned; the inlet end and the outlet end of the electrode box 4 are respectively arranged on two sides of the bottom thereof.

In addition, this embodiment may also include a control unit (not shown in the figure) and a data acquisition circuit (not shown in the figure). The control unit is used to control the working process of the whole system; the data acquisition circuit may specifically include a signal amplification circuit, a filter circuit, and an AD conversion circuit electrically connected in sequence. During specific implementation, the data acquisition circuit can be set in the electrode box 4 .

During specific implementation, each extraction pump in this embodiment may adopt any at least one pump structure such as a peristaltic pump, a DC pump, or a vacuum pump.

The calibration principle and calibration method of each extraction pump in this embodiment will be described in detail below.

In this embodiment, the length of the conduit connecting the sampling cup 1 and the electrode box 4 is determined, and the inner diameter of the conduit is determined, so that the internal volume of the conduit can be determined; in addition, the liquid volume in the electrode box 4 is also determined. of. Therefore, the pipeline volume V from the sampling cup 1 to the liquid sensor 7 can be determined.

Based on the above, in this embodiment, the liquid sensor 7 can be used to cooperate with the stepping motor in the extraction pump, and the following steps and algorithms can be used to calibrate the extraction pump:

When the system is initialized, the sample extraction pump 5 works to empty the pipeline between the sampling cup 1 and the liquid sensor 7;

After initialization, the first standard solution extraction pump Pa works, rotates a known number of steps steps1, and injects a certain amount of A standard solution into the sampling cup 1;

The sample extraction pump 5 is working, and the liquid sensor 7 detects whether there is liquid reaching the position of the liquid sensor 7, and when it is detected that the liquid reaches the liquid sensor 7, record the number of steps steps2 that the current sample extraction pump 5 has rotated;

The sample extraction pump 5 continues to rotate, while the liquid sensor 7 detects whether the air reaches the position of the liquid sensor 7, and when it is detected that the air reaches the liquid sensor 7, the number of steps steps3 that the current sample extraction pump 5 has rotated is recorded;

Calculated based on the above data, the pump volume corresponding to the single step of the sample extraction pump 5 is:

$\mathrm{<span\; class="notranslate">\; \&Delta;</span>}{\mathrm{<span\; class="notranslate">\; V</span>}}_{{\mathrm{<span\; class="notranslate">\; P</span>}}_{\mathrm{<span\; class="notranslate">\; C</span>}}}<span\; class="notranslate">\; =</span>\frac{\mathrm{<span\; class="notranslate">\; V</span>}}{{\mathrm{<span\; class="notranslate">\; steps</span>}}_{\mathrm{<span\; class="notranslate">\; 2</span>}}}$

The pump volume corresponding to the single step of the first standard liquid extraction pump Pa is:

$\mathrm{<span\; class="notranslate">\; \&Delta;</span>}{\mathrm{<span\; class="notranslate">\; V</span>}}_{{\mathrm{<span\; class="notranslate">\; P</span>}}_{\mathrm{<span\; class="notranslate">\; a</span>}}}\frac{<span\; class="notranslate">\; (</span>\mathrm{<span\; class="notranslate">\; V</span>}<span\; class="notranslate">\; /</span>{\mathrm{<span\; class="notranslate">\; steps</span>}}_{\mathrm{<span\; class="notranslate">\; 2</span>}}<span\; class="notranslate">\; )</span><span\; class="notranslate">\; \&times;</span><span\; class="notranslate">\; (</span>{\mathrm{<span\; class="notranslate">\; steps</span>}}_{\mathrm{<span\; class="notranslate">\; 3</span>}}<span\; class="notranslate">\; -</span>{\mathrm{<span\; class="notranslate">\; steps</span>}}_{\mathrm{<span\; class="notranslate">\; 2</span>}}<span\; class="notranslate">\; )</span>}{{\mathrm{<span\; class="notranslate">\; steps</span>}}_{\mathrm{<span\; class="notranslate">\; 1</span>}}}$

The second standard liquid pump Pb can be calibrated using the same calibration method as that of the first standard liquid pump Pa mentioned above, which will not be repeated here.

Compared with the prior art, this embodiment has the following advantages:

The structure is simplified, the volume is reduced, and the cost is saved, so that it is more suitable for integration into large-scale biochemical and immunological instruments;

Borrowing the sampling system of large-scale equipment, on the one hand, the structure of the entire equipment is simplified, the overall equipment cost is reduced, and on the other hand, the efficiency and accuracy of sampling are improved;

A convenient and accurate calibration method can be used to calibrate each extraction pump, which is of great help to improve the stability and accuracy of the system.

In addition, in the prior art sampling solutions, most of them use a reversing valve structure to add samples of two standard solutions. This kind of sampling scheme has a complicated liquid path, and long-term use is likely to cause aging and damage to the reversing valve and increase the failure rate of the instrument.

In this embodiment, the two standard liquids are respectively pumped into the sampling cup from the front end by two standard liquid pumps, and then pumped into the measurement chamber by the sample pump from the rear end. This structure does not need to use a reversing valve, and also saves a complicated liquid circuit structure, and also reduces the failure rate.

An embodiment of the biochemical in vitro diagnostic device provided by the present invention will be described in detail below. This embodiment mainly includes an electrolyte analysis module. During specific implementation, the electrolyte analysis module of this embodiment may adopt the electrolyte analysis device described in the foregoing embodiments, and details are not repeated here.

The above content is a further detailed description of the utility model in combination with specific preferred embodiments, and it cannot be assumed that the specific implementation of the utility model is only limited to these descriptions. For a person of ordinary skill in the technical field to which the utility model belongs, without departing from the concept of the utility model, some simple deduction or substitutions can also be made, which should be regarded as belonging to the protection scope of the utility model.

Claims (10)

1. an electrolyte analyzer, include sample introduction cup, by the titer container that titer draw-off pump is connected with the entrance point conducting of described sample introduction cup, the electrode box be connected with the endpiece conducting of described sample introduction cup, the sampling pump be connected with described electrode box conducting and waste fluid container, ion-selective electrode measurement components is provided with in described electrode box, it is characterized in that, the endpiece of described sample introduction cup is directly connected to the entrance point of described electrode box by conduit, described sampling pump is by the endpiece of tubes connection to described electrode box, and detector of liquid is provided with on the pipeline between the endpiece and sampling pump of described electrode box.

2. electrolyte analyzer as claimed in claim 1, it is characterized in that, described detector of liquid is arranged on the pipeline of the exit position of described electrode box.

3. electrolyte analyzer as claimed in claim 1 or 2, it is characterized in that, described titer draw-off pump and sampling pump are located on same level line side by side.

4. electrolyte analyzer as claimed in claim 3, is characterized in that, described electrode box is located at above described titer draw-off pump side by side and sampling pump.

5. electrolyte analyzer as claimed in claim 4, it is characterized in that, described titer container includes the first titer container and the second titer container, described titer draw-off pump include the first titer draw-off pump and the second titer draw-off pump accordingly.

6. electrolyte analyzer as claimed in claim 5, it is characterized in that, described first titer container, the second titer container, waste fluid container are arranged side by side in the same horizontal line, and are connected with described first titer draw-off pump, the second titer draw-off pump, sampling pump respectively by curvilinear conduit.

7. electrolyte analyzer as claimed in claim 6, it is characterized in that, the bottom of described sample introduction cup is inverted cone-shaped structure, and the endpiece of sample introduction cup is located at the bottom of described back taper, and the upper water mean place of described back taper and the upper water mean place of described electrode box concordant.

8. electrolyte analyzer as claimed in claim 7, is characterized in that, be also provided with data acquisition circuit in described electrode box.

9. electrolyte analyzer as claimed in claim 8, it is characterized in that, described data acquisition circuit includes the signal amplification circuit, filtering circuit and the A/D convertor circuit that are electrically connected successively.

10. a biological chemistry in-vitro diagnosis equipment, includes electrolyte analysis module, it is characterized in that, described electrolyte analysis module is electrolyte analyzer as claimed in any one of claims 1-9 wherein.