CN204078349U - A kind of Novel facial mask packaging three Room bags containing freeze-drying excipient preparation - Google Patents
A kind of Novel facial mask packaging three Room bags containing freeze-drying excipient preparation Download PDFInfo
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- CN204078349U CN204078349U CN201420044151.2U CN201420044151U CN204078349U CN 204078349 U CN204078349 U CN 204078349U CN 201420044151 U CN201420044151 U CN 201420044151U CN 204078349 U CN204078349 U CN 204078349U
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- freeze
- preparation
- drying excipient
- facial mask
- excipient preparation
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Landscapes
- Medicinal Preparation (AREA)
Abstract
The utility model relates to a kind of Novel facial mask packaging three Room bags containing freeze-drying excipient preparation, particularly a kind of Novel facial mask by freeze-drying excipient preparation and matching dissolvent and mask carriers separately preservation in same packaging is packed with three Room bags, this Novel facial mask has additive-free, long shelf-life, functional component is stable not to be destroyed, can automated production preventing pollution, the feature can joined during use.
Description
Technical field
The utility model relates to a kind of Novel facial mask packaging three Room bags and preparation method thereof containing freeze-drying excipient preparation, particularly a kind of Novel facial mask by freeze-drying excipient preparation and matching dissolvent and mask carriers separately preservation in same packaging is packed with three Room bags, this Novel facial mask has additive-free, long shelf-life, functional component is stable not to be destroyed, can automated production preventing pollution, the feature can joined during use.
background technology
Facial mask utilizes the blink covering face, the air that temporary transient isolation is extraneous and pollution, improve skin temperature, the pore expansion of skin, promote sweat gland secretion and metabolism, make the level of oxygen of skin increase, be conducive to the oil substances that skin gets rid of the metabolic product of epidermal cell and accumulation, moisture in facial mask and functional component infiltrate in epidermis, thus reach the effect such as replenishing water and preserving moisture, whitening anti-wrinkling.
The form of current facial mask is still based on hygenic towelette formula, be exactly generally mmic package infiltrate the face paper of Essence and functional component, one side functional component in a liquid easy oxidized degraded loses effectiveness, whole packaging and easily cooperating microorganisms on the other hand, these ways to solve the problem are all lean on various additive to solve, as anti fouling composition, bacteriostat, antioxidant, humectant etc. at present; But these additives can not tackle the problem at its root, when greatly can increase use on the contrary, irritated possibility occurs, this brings great puzzlement to user.
Contriver is devoted to the research of freeze-drying excipient technology always, and freeze-drying excipient preparation is a kind of dosage form utilizing freeze-drying excipient technology to prepare, and forms through cryodesiccated technological process is shaping by be filled into by preparation supplementary material in forming mould again.Because such preparation adopts freeze drying process; thermally sensitive composition, effectively nutritional labeling, readily oxidizable substance can be protected not to be destroyed; can save and not degenerate for a long time; add water or can dissolve rapidly after solvent and recover original proterties; therefore receive and widely use, be widely applied in medicine, food, health food and the cosmetic fields such as oral disnitegration tablet, fast-release tablet, chewable tablets, special cosmetics.
Contriver dedicates itself to innovation, a large amount of deep research and experimental work are carried out, by freeze-drying excipient formulation application in mask product, provide Novel facial mask packaging that a kind of freeze-drying excipient preparation and matching dissolvent thereof, mask carriers separately preserve in same packaging with three Room bags simultaneously, this completes the utility model.This Novel facial mask has additive-free, long shelf-life, and functional component is stable not to be destroyed, can automated production preventing pollution, the feature can joined during use.
summary of the invention
The utility model provides a kind of Novel facial mask packaging three Room bags and preparation method thereof containing freeze-drying excipient preparation.
Three Room bags described in the utility model by bag open end (1), bag tail end (2) and in four road heat seal sealing lips every (3,4) form three cavitys: liquid preparation chamber (5), solid pharmaceutical preparation chamber (6) and mask carriers chamber (7).
The matching dissolvent (8) of encapsulating freeze-drying excipient preparation in described liquid preparation chamber (5), encapsulating freeze-drying excipient preparation (9) in solid pharmaceutical preparation chamber (6), envelope surfaces membrane carrier (10) in described mask carriers chamber (7).
Described open end (1), bag tail end (2) and in four road heat seal process every (3,4) distinguish to some extent on temperature and pressure, but all reach the minimum temperature ensureing its leak tightness, therefore three provided Room bags can be provided, though can be subject in transport storage process in certain external force every (3,4) still can not damaged, three Room can not be caused through, because described three Room bags make properties of materials, every (3 in during heat seal, 4) temperature of heat seal is lower than the temperature 20-50 DEG C of open end (1) and tail end (2) heat seal, therefore every (3 in, 4) sealing strength is a little less than open end (1) and tail end (2), when applying larger pressure in liquid preparation chamber, due to tail end (2) sealing-strength be greater than in every the sealing-strength of (3), freeze-drying excipient preparation during solvent is forced to break through in (3) with solid pharmaceutical preparation chamber is mixed to form mixed solution (11), again to liquid and solid pharmaceutical preparation chamber through after cavity apply larger pressure time, in like manner mixed solution (11) be forced to break through in every (4) entering surface membrane carrier chamber (7), mask carriers (10) is immersed in mixed solution (11) fully to be infiltrated, tear along the both sides otch (13) near open end (1), thus obtain required facial mask (12).
Three described Room bags are formed by specific aluminum-plastic composite membrane hot pressing, and it is higher that this specific aluminum-plastic composite membrane has heat-seal temperature, the characteristic that sealing strength is higher.
Described material basic structure is internal layer and skin is two plastic layers, and middle one deck is aluminium lamination.
Aluminium lamination (forming the interlayer of the said vesse) thickness of described material is 5-500 micron, preferred 5-100 micron, 10-100 micron, 12-200 micron, 30-150 micron, 50-200 micron, 80-300 micron, 100-500 micron, most preferably 10-60 micron; Plastic layer (forming internal layer and the skin of the said vesse) thickness of described material is 5-500 micron, preferred 5-100 micron, 10-100 micron, 15-100 micron, 15-200 micron, 20-200 micron, 30-150 micron, 50-200 micron, 80-300 micron, 100-500 micron, most preferably 15-200 micron.
Described specific aluminum-plastic composite membrane can manufacture acquisition voluntarily.During manufacture, structure is the basic structure of plastic layer-aluminium lamination-plastic layer, and wherein the plastic layer of both sides can be certain plastic sheeting or the multilayer composite plastic Film laminated of selecting individual layer.
The aluminium used in described specific aluminum-plastic composite membrane can be fine aluminium film or metallized film etc.; The plastics used in described specific aluminum-plastic composite membrane can be polyvinylchloride, polyethylene, polyethylene terephthalate, ethene-vinyl acetate copolymer, polypropylene, or based on the coextrusion plastic material etc. of polyethylene, polypropylene, ethene-vinyl acetate copolymer.
The utility model also comprises the preparation method of described three Room bags:
(1) open end (1) heat seal, loads mask carriers (10);
(2) every (4) heat seal (heat-seal temperature is lower than open end 20-50 DEG C) in, freeze-drying excipient preparation (9) is loaded;
(3) every (3) heat seal (heat-seal temperature with in every 4) in, the matching dissolvent (8) of freeze-drying excipient preparation is loaded;
(4) bag tail end (2) heat seal (heat-seal temperature is with open end 1), otch (13);
Described mask carriers (10) can be the mask carriers using various material to make various required form, include but not limited to square, circular, irregular shape or compressed configuration, material includes but not limited to as nonwoven fabrics, cotton textiles, natural cotton, silk, terylene, blending, paper etc.
The matching dissolvent (8) of described freeze-drying excipient preparation can be water or other can with freeze-drying excipient preparation directly with the use of various solvents.
Described freeze-drying excipient preparation. (9) can be the freeze-drying excipient preparations of various formula, form, for being distributed into the preparation in solid pharmaceutical preparation chamber after carry out freeze-drying in forming mould.
Described freeze-drying excipient preparation (9) is primarily of functional component and adhesive agent composition.
The volume ratio of the binder content of described adhesive agent after this freeze-drying excipient preparation freeze-drying and lyophilized excipient is 0.1mg/ml to 600mg/ml (weight/volume); Wherein more preferably 1mg/ml to 200mg/ml.
Described adhesive agent is edible or pharmaceutically useful a kind of water-soluble high-molecular material, can be polysaccharide, polypeptide, protein, also may be synthetic polymeric's Polymer, or through the natural macromolecular material of remodeling or its compound.Conventional adhesive agent includes but not limited to glue class (collagen, gelatin, gelatin hydrolysate, Arabic gum, xanthans, carragheen, pectin, konjac glucomannan, carrageenan, locust bean gum, natural gum, locust bean gum etc.), cellulose ethers (carboxymethyl cellulose, carboxyethyl cellulose, HEMC, hydroxypropyl methylcellulose etc.), modified starch series (pulullan, hydroxypropul starch etc., see R.P.Scherer US4305502A), PVP, PVA, hyalomitome acids, albumin, shitosan, dextran, agar, polyaminoacid, glucan and their combination etc. thereof, polyaminoacid (polyglutamic acid, polyalanine, polylysine etc.), glycan (fucoidin, synanthrin, glucan) etc.
Described functional component can be water-soluble also can be water-fast material, and described functional component can be selected from one or more the combination in traditional Chinese medicine ingredients, natural extract, bioactive ingredients, skin nursing beneficiating ingredient.
There is no particular limitation for functional component involved by the utility model, can be selected from but be not limited to the composite of one or more compositions following.
Natural plant extracts: as aloe extract, yam extract, Bilberry fruit P.E, Bitter Melon P.E, green-tea extract, fucoidin, glabridin, Paeoniflorin etc.;
Bioactive ingredients: EGF, bFGF, aFGF, KGF, IGF, PDGF, VEGF, placenta hydrolyzate, milk extract etc.
Cosmetic beneficiating ingredient: collagen, hyaluronic acid, sodium alginate, aloe extract, general ginsenoside, arasaponin, Chinese rhubarb extract, bamboo lotus water Bulbus Lilii extract, peony extract, EGF, bFGF, aFGF, KGF, IGF, PDGF, VEGF, placenta hydrolyzate, milk extract, various surfactants, algae extract, various vitamin, various beneficial mineral matter, SOD, metallothionein, other raw materials see " international cosmetic raw material standard Chinese catalogue (version in 2010) "
Described freeze-drying excipient preparation, it primarily of functional component, adhesive agent composition, and needs to add or not add skeleton supporting agent and other auxiliary material (as thickening supensoid agent, antioxidant, flavouring and essence, skin penetration enhancer, pH adjusting agent etc.) according to preparation process.
Described skeleton supporting agent comprises the material such as amino acid (as amino acetic acid, alanine, glutamic acid etc.) and inorganic salts (as sodium phosphate, aluminium silicate etc.) being not limited to sugar (as maltose, trehalose etc.), sugar alcohol (as sweet mellow wine, sorbierite), 2-12 carbon atom.
Other described auxiliary material is including but not limited to thickening supensoid agent, antioxidant, flavouring and essence, skin penetration enhancer, pH adjusting agent etc.; Wherein thickening supensoid agent can be selected from the combination etc. of any one or they in the natural origin glue classes such as dextran, Arabic gum, xanthans, carragheen, pectin, konjac glucomannan, agar, carbomer, carrageenan and synthetic macromolecular compound and other polypeptide or polysaccharide; Described antioxidant includes but not limited to the compound of one or several in the polyhydric phenols of vitamin C and derivant thereof, anthocyanidin, resveratrol, plant origin; Described flavouring and essence include but not limited to the compound of mint flavored, chocolate flavoured, the essence such as vanilla flavored, caf, tea flavour, corn taste, lemon, milk flavor or more one or more fragrance; Described skin penetration enhancer include but not limited to lecithin, saponin(e, bay alkyd, the compound of any one or several in azone, tween, sapn; Described pH adjusting agent includes but not limited to any one in citric acid, tartaric acid, carbonate, sodium carbonate, phosphate or several compound.
The preparation method of described freeze-drying excipient preparation:
A () will include but not limited to the solution that functional component, water, adhesive agent and other auxiliaries are formed or suspension injection moulding mould; Or by solid constituent (functional component, adhesive agent and other auxiliary materials can be comprised) injection moulding mould, then add water and be made into suspension;
B solution that (a) obtains by () or suspension carry out degassed in forming mould;
(c) (b) is obtained degassed after suspension or without degassed direct that (a) is freezing at low temperatures;
D preparation that (c) obtains by () carries out lyophilisation in forming mould, obtains freeze-drying excipient preparation;
E freeze-drying excipient preparation that (d) obtains by () is detached into mould, is fitted in packing device.
In above-mentioned preparation method, wherein Liquid Injection can adopt the liquid-transfering devices such as accurate quantification pipet, liquid-transfering gun, electronic liquor-transferring rifle, also plunger pump, gear type pump, peristaltic pump etc. can be adopted, the solution configured, suspension or suspending fluid are injected quantitative forming mould, and solid injection molding can adopt accurate solid measurer, vibrations capillary tub flow of powder controller;
Wherein degas method can adopt centrifugal degassing method, vacuum degasification method and ultrasonic degas method etc.;
The wherein freezing mode that can adopt liquid nitrogen or liquid, dry ice spray refrigeration or sleeve pipe cooling back installation, turbine expander refrigeration mode or cascade refrigeration mode, at-20 DEG C--at 196 DEG C of temperature, become solid by freezing to solution, suspension or suspending fluid rapidly;
Wherein freeze-drying adopts the degree of vacuum of 0.01-20 millibar, temperature freeze-drying between-70 DEG C to 50 DEG C scopes;
Aforesaid operations all uses automatic equipment to complete in dust proof workshop, effectively prevents the pollution that manual operation causes, and time saving and energy savingly cuts the waste.
Accompanying drawing explanation
Fig. 1 is the section of three Room bags described in the utility model and each block diagram
Fig. 2 is for using step schematic diagram
Detailed description of the invention
Further illustrate the utility model by the following examples, but the utility model is not restricted to this.
Embodiment
Adopt pearl powder: hyaluronic acid=1:100, hyaluronic acid 100mg, after wherein 90mg hyaluronic acid mixes with 1mg pearl fine powder, accurately fillingly enter in 0.5ml mould, 10mg hyaluronic acid, after the water-soluble solution of 0.3ml, pours into in the mould containing 90mg hyaluronic acid and 1mg pearl powder, stirs and makes aqueous dispersion in powder, quick-frozen is to-20 degrees Celsius, and freeze-drying becomes skin care solid elite;
Internal layer is adopted to be the PP-PE of 50um, interlayer is the aluminium lamination of 20um, skin be the aluminum-plastic composite membrane of the PET of 40um as three Room bag bags described in the utility model, the feature of this composite plastic film be nontoxic, high resistant wet, high resistant oxygen, elasticity are good, heat sealing strength raises and increasing etc. with temperature;
First by open end (1) heat seal (heat-seal temperature 160 DEG C) in packaging process, the mask carriers of natural cotton material is loaded in mask carriers chamber, every (4) heat seal (heat-seal temperature 120 DEG C) in inciting somebody to action again, skin care solid elite is loaded in solid pharmaceutical preparation chamber, every (3) heat seal (heat-seal temperature 120 DEG C) in inciting somebody to action again, purified water is loaded in liquid preparation chamber, again by bag tail end (2) heat seal (heat-seal temperature 160 DEG C), and cut in open end the Novel facial mask product that tearable mouth (13) both obtained containing skin care solid elite;
Aforesaid operations all uses automatic equipment to complete in dust proof workshop, effectively prevents the pollution that manual operation causes, and time saving and energy savingly cuts the waste.
Heat insulation conjunction intensity detection in above-mentioned three Room bags: place 48 hours under getting the condition of 10 bags in-30 DEG C ± 2 DEG C, three Room bag sample, and then place 48 hours under the condition of 50 DEG C ± 2 DEG C, place under 23 DEG C ± 2 DEG C conditions again after 24 hours, sample is lain between two flat boards, the pressure of 60Kpa can be born, remain intact without cracking every still in 10 minutes, when continuation increase external pressure reaches about 75Kpa, in heat insulation conjunction district cracking, three chambers are through, realize mixing and process that mask carriers is soaked of freeze-drying excipient preparation and water, now three bag two ends, Room still stand intact.
First pressure is applied to liquid preparation chamber during use, every (3) during water in liquid preparation chamber breaks through, be mixed to form with the skin care solid elite in solid pharmaceutical preparation chamber and mix Essence (11), again to liquid and solid pharmaceutical preparation chamber through after new chamber apply pressure, mixing Essence (11) break through in every (4) entering surface membrane carrier chamber (7), the mask carriers (10) of natural cotton material to be immersed in the mixing Essence (11) of fresh configuration thus to be obtained required facial treatment mask (12), open end is torn from the tearable mouth (13) near open end (1), facial treatment mask (12) is taken out from bag and can use.
Packaging structure of the present utility model is not limited to form cited in embodiment, and embodiment is only preferred embodiment of the present utility model, can not limit protection domain with this.All with the simple or equivalent change described in right of the present utility model and modification, all belong to protection domain of the present utility model.
Claims (4)
1. the Novel facial mask packaging three Room bags containing freeze-drying excipient preparation, it is characterized in that, described three Room bags by bag open end (1), bag tail end (2) and in four road heat seal sealing lips every (3,4) form three cavitys: liquid preparation chamber (5), solid pharmaceutical preparation chamber (6) and mask carriers chamber (7); The matching dissolvent (8) of encapsulating freeze-drying excipient preparation in described liquid preparation chamber (5), encapsulating freeze-drying excipient preparation (9) in solid pharmaceutical preparation chamber (6), envelope surfaces membrane carrier (10) in described mask carriers chamber (7).
2. a kind of Novel facial mask packaging containing freeze-drying excipient preparation is with three Room bags as claimed in claim 1, and it is characterized in that, described three Room bags are formed by aluminum-plastic composite membrane hot pressing, and aluminum-plastic composite membrane basic structure is plastic layer-aluminium lamination-plastic layer.
3. a kind of Novel facial mask packaging containing freeze-drying excipient preparation is with three Room bags as claimed in claim 2, and it is characterized in that, described aluminum layer thickness is 5-500 micron, and the aluminium used is selected from the one in fine aluminium film or metallized film; Described plastic layer is 5-500 micron, the plastics used are selected from polyvinylchloride, polyethylene, polyethylene terephthalate, ethene-vinyl acetate copolymer, polypropylene, or based on the one in the coextrusion plastic material of polyethylene, polypropylene, ethene-vinyl acetate copolymer.
4. a kind of Novel facial mask containing freeze-drying excipient preparation is packed with three Room bags as claimed in claim 1, it is characterized in that, described mask carriers (10) can be the mask carriers using various material to make various required form, described shape is selected from the one in square, circular, irregular shape or compressed configuration, and described material is selected from the one in nonwoven fabrics, cotton textiles, natural cotton, silk, terylene, blending, paper.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420044151.2U CN204078349U (en) | 2014-01-24 | 2014-01-24 | A kind of Novel facial mask packaging three Room bags containing freeze-drying excipient preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420044151.2U CN204078349U (en) | 2014-01-24 | 2014-01-24 | A kind of Novel facial mask packaging three Room bags containing freeze-drying excipient preparation |
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| Publication Number | Publication Date |
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| CN204078349U true CN204078349U (en) | 2015-01-07 |
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|---|---|---|---|
| CN201420044151.2U Expired - Lifetime CN204078349U (en) | 2014-01-24 | 2014-01-24 | A kind of Novel facial mask packaging three Room bags containing freeze-drying excipient preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104803082A (en) * | 2014-01-24 | 2015-07-29 | 李和伟 | Novel three-chamber facial mask packing bag including freeze-drying endowed preparation and preparation method thereof |
| CN105984641A (en) * | 2015-02-12 | 2016-10-05 | 李和伟 | Novel double-chamber packaging bag |
| CN106176255A (en) * | 2016-07-22 | 2016-12-07 | 银川凤仪堂生物工程有限公司 | Facial mask making and packaging method |
| CN108750417A (en) * | 2018-07-11 | 2018-11-06 | 吴星 | A kind of portable disposable is cleared up packet and its application method using sterilization |
-
2014
- 2014-01-24 CN CN201420044151.2U patent/CN204078349U/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104803082A (en) * | 2014-01-24 | 2015-07-29 | 李和伟 | Novel three-chamber facial mask packing bag including freeze-drying endowed preparation and preparation method thereof |
| CN105984641A (en) * | 2015-02-12 | 2016-10-05 | 李和伟 | Novel double-chamber packaging bag |
| CN106176255A (en) * | 2016-07-22 | 2016-12-07 | 银川凤仪堂生物工程有限公司 | Facial mask making and packaging method |
| CN108750417A (en) * | 2018-07-11 | 2018-11-06 | 吴星 | A kind of portable disposable is cleared up packet and its application method using sterilization |
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