CN204058310U - Cefixime Micronized active ester production equipment - Google Patents
Cefixime Micronized active ester production equipment Download PDFInfo
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- CN204058310U CN204058310U CN201420519620.1U CN201420519620U CN204058310U CN 204058310 U CN204058310 U CN 204058310U CN 201420519620 U CN201420519620 U CN 201420519620U CN 204058310 U CN204058310 U CN 204058310U
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- centrifugal
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- housing
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Abstract
The utility model belongs to technical field of chemical, particularly relates to a kind of Cefixime Micronized active ester production equipment, comprises the synthesis reactor, centrifugal device, washing device, solvent recovery unit and the drying installation that are communicated with successively; The heat sink that described synthesis reactor comprises kettle, is located at the heating jacket outside described kettle and is located in described kettle; Described centrifugal device is provided with liquor inlet, leakage fluid dram, slag liquid mouth and slag-drip opening; Described washing device is provided with mixed solution import, washings outlet and sludge outlet; Described slag-drip opening is connected by feeding pipe with described mixed solution import, and described feeding pipe is communicated with washings jetting device; Described solvent recovery unit comprises still kettle and solvent recovery tank; The sludge outlet of described washing device is communicated with described drying installation.This Cefixime Micronized active ester production equipment is easy to operate, and heating, cooling is all very fast, can improve synthetic ratio; Be separated, washing effect is good, the purity of product can be improved, and can efficient recovery solvent, save cost.
Description
Technical field
The utility model belongs to technical field of chemical, particularly relates to a kind of Cefixime Micronized active ester production equipment.
Background technology
Cefixime Micronized active ester, chemistry (Z)-2-(thiazolamine-4-base)-2-methoxycarbonyl methoxy imino-mercapto benzothiazole ester by name is the main raw material of third generation oral cephalosporin Cefixime Micronized.
The preparation of Cefixime Micronized active ester mainly with cefixime side chain, DM and triethyl-phosphite for raw material, carry out reacting under organic solvent acetonitrile etc. exists and obtain.Its preparation technology is different, and the production equipment used is also different, and its production efficiency and productive rate are also different, and a large amount of waste liquids can be produced in process of production, due to aftertreatment trouble, cost recovery is higher, waste liquid is shifted elsewhere or directly discharges by many enterprises, causes serious environmental pollution.
Utility model content
Technical problem to be solved in the utility model is: the deficiency existed for prior art, provides a kind of convenient and produces, can efficient recovery solvent, cost-saving, can enhance productivity and the Cefixime Micronized active ester production equipment of productive rate.
For solving the problems of the technologies described above, the technical solution of the utility model is:
Cefixime Micronized active ester production equipment, comprises the synthesis reactor, centrifugal device, washing device, solvent recovery unit and the drying installation that are communicated with successively;
The heat sink that described synthesis reactor comprises kettle, is located at the heating jacket outside described kettle and is located in described kettle, top and the bottom of described kettle are respectively equipped with opening for feed and discharge port;
One end of described centrifugal device is provided with liquor inlet, and the bottom of described centrifugal device is provided with leakage fluid dram, slag liquid mouth and slag-drip opening;
Described washing device one end is provided with mixed solution import, and the bottom of described washing device is provided with washings outlet and sludge outlet;
The slag-drip opening of described centrifugal device is connected by feeding pipe with the mixed solution import of described washing device, and described feeding pipe is communicated with washings jetting device;
Described solvent recovery unit comprises still kettle and solvent recovery tank, and the leakage fluid dram of described centrifugal device exports with the washings of described washing device and is all communicated with described still kettle;
The sludge outlet of described washing device is communicated with described drying installation.
Improve as one, described heat sink comprises coil pipe and lower coil pipe, described upper coil pipe is located on the top of described kettle inner side-wall, described lower coil pipe is located on the bottom of described kettle inner side-wall, described upper coil pipe is provided with cooling water inlet, and described lower coil pipe is provided with cooling water outlet, and described cooling water inlet and cooling water outlet stretch out outside described heating jacket, longitudinally be provided with multiple cooling tubulation between described upper coil pipe and lower coil pipe, described cooling tubulation is communicated with lower coil pipe with described upper coil pipe respectively.
Improve as one, the differential mechanism that described centrifugal device comprises centrifugal housing, is located at the centrifugal assembly in described centrifugal housing and is located at outside described centrifugal housing, described centrifugal assembly comprises rotary drum and is located at the screw feeder outside described rotary drum, described rotary drum and screw feeder are all connected with described differential drive, described liquor inlet is located at one end of described centrifugal housing, and described leakage fluid dram, slag liquid mouth and slag-drip opening are located at the bottom of described centrifugal housing.
Improve as one, the differential mechanism that described washing device comprises washing housing, is located at the wash in described washing housing and is located at outside described washing housing, described wash comprises rotary drum and is located at the screw feeder outside described rotary drum, described rotary drum and screw feeder are all connected with described differential drive, one end of described washing housing is located in described mixed solution import, and described washings outlet and sludge outlet are located at the bottom of described washing housing.
As improving further, described washings jetting device comprise hydro-pump and be connected with described hydro-pump spray into pipe, the described end spraying into pipe is provided with annular nozzle, and described annular nozzle ring contacts with the inwall of described feeding pipe, and described annular nozzle is provided with multiple spray orifice.
As further improving, described multiple spray orifice is towards the central axis of described feeding pipe.
Improve as one, the slag liquid mouth of described centrifugal device is communicated with described liquor inlet by return line, and described return line is provided with reflux pump and reverse flow valve successively.
Owing to have employed technique scheme, the beneficial effects of the utility model are:
The Cefixime Micronized active ester production equipment that the utility model provides, comprise the synthesis reactor, centrifugal device, washing device, solvent recovery unit and the drying installation that are communicated with successively, it is reasonable in design.
Synthesis reactor is used within it reacting each raw material, and heating jacket is used for heating the raw material in kettle and solvent, being incubated, and ensures temperature of reaction; Heat sink is used for lowering the temperature to reaction solution reacted in kettle, upper coil pipe and lower coil pipe are located at the upper and lower in kettle respectively, multiple cooling tubulation is provided with between upper coil pipe and lower coil pipe, water coolant is entered in upper coil pipe by cooling water inlet, flows through each cooling tubulation, and the cooling water outlet finally by lower coil pipe flows out, because cooling tubulation is located in kettle, it directly cools the reaction solution in kettle, lowers the temperature, and its cooling rate is fast, effectively can provide production efficiency.
Centrifugal device is used for the reaction solution after to cooling and carries out solid-liquid separation, utilize the relative movement of augers and rotary drum that the slag-drip opening place that the solid phase being deposited on drum inner wall pushes rotary drum to is discharged, clear liquid after separation is discharged from the leakage fluid dram of centrifugal device, the solid phase particles that particle diameter is very little can be separated from liquid phase, its separation efficiency is high.
Washing device is used for washing to remove impurity to the sediment after centrifugal, improves the purity of product; Solvent recovery unit be used for centrifugal, washing after waste liquid carry out distillating recovering solvent acetonitrile, both cost-saved, turn avoid the waste of resource, also help the protection of environment, drying installation be used for drying is carried out to the finished product.
The Cefixime Micronized active ester production equipment that the utility model provides, it is reasonable in design, easy to operate, and reaction process heating, cooling is all very rapid, can improve reaction efficiency and synthetic ratio; Be separated, washing effect is good, the purity of the finished product can be improved, and can efficient recovery solvent, avoid the wasting of resources, saved cost, protected environment.
Accompanying drawing explanation
Fig. 1 is the equipment flowsheet of the Cefixime Micronized active ester production equipment that the utility model provides;
Fig. 2 is the schematic enlarged-scale view of synthesis reactor in Fig. 1;
Fig. 3 is longitudinal cutaway view Amplified image of centrifugal device in Fig. 1;
Fig. 4 is longitudinal cutaway view Amplified image of washing device in Fig. 1;
Fig. 5 is feeding pipe and spray into longitudinal cutaway view Amplified image of pipe in Fig. 1;
Wherein: 1-synthesis reactor, 2-centrifugal device, 3-washing device, 4-solvent recovery unit, 5-drying installation, 6-rotary drum, 7-screw feeder, 8-differential mechanism, 9-feeding pipe, 10-washings jetting device, 11-kettle, 12-opening for feed, 13-discharge port, 14-heating jacket, the upper coil pipe of 15-, 16-lower coil pipe, 17-cools tubulation, the centrifugal housing of 21-, 22-liquor inlet, 23-leakage fluid dram, 24-slag liquid mouth, 25-slag-drip opening, 26-return line, 31-washs housing, the import of 32-mixed solution, 33-washings exports, 34-sludge outlet, 41-still kettle, 42-solvent recovery tank, 101-hydro-pump, 102-sprays into pipe, 103-annular nozzle, 104-spray orifice, 151-cooling water inlet, 161-cooling water outlet, 261-reflux pump, 262-reverse flow valve.
Embodiment
In order to make the purpose of this utility model, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the utility model is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the utility model, and be not used in restriction the utility model.
As shown in Figure 1, Cefixime Micronized active ester production equipment, comprises the synthesis reactor 1, centrifugal device 2, washing device 3, solvent recovery unit 4 and the drying installation 5 that are communicated with successively, as shown in Figure 2, synthesis reactor 1 comprises kettle 11, the top of kettle 11 and bottom are respectively equipped with opening for feed 12 and discharge port 13, heating jacket 14 is provided with outside kettle 11, heat sink is provided with in kettle 11, heat sink comprises coil pipe 15 and lower coil pipe 16, upper coil pipe 15 is located on the top of kettle 11 inner side-wall, lower coil pipe 16 is located on the bottom of kettle 11 inner side-wall, upper coil pipe 15 is provided with cooling water inlet 151, lower coil pipe 16 is provided with cooling water outlet 161, the outer side wall that cooling water inlet 151 and cooling water outlet 161 pass kettle 11 stretches out outside heating jacket 14, longitudinally multiple cooling tubulation 17 is provided with between upper coil pipe 15 and lower coil pipe 16, cooling tubulation 17 is communicated with lower coil pipe 16 with upper coil pipe 15 respectively.
As shown in figures 1 and 3, centrifugal device 2 comprises centrifugal housing 21, centrifugal assembly is provided with in centrifugal housing 21, centrifugal assembly comprises rotary drum 6 and screw feeder 7, screw feeder 7 is located at the outside of rotary drum 6, differential mechanism 8 is provided with outside centrifugal housing 21, rotary drum 6 and screw feeder 7 are all in transmission connection with differential mechanism 8, one end of centrifugal housing 21 is provided with liquor inlet 22, the bottom of centrifugal housing 21 is provided with leakage fluid dram 23, slag liquid mouth 24 and slag-drip opening 25, leakage fluid dram 23 and slag-drip opening 25 lay respectively at the two ends of centrifugal housing 21, slag liquid mouth 24 is near leakage fluid dram 23, slag liquid mouth 24 is communicated with liquor inlet 22 by return line 26, return line 26 is provided with successively reflux pump 261 and reverse flow valve 262.
As shown in Figure 1 and Figure 4, washing device 3 comprises washing housing 31, wash is provided with in washing housing 31, wash comprises rotary drum 6 and screw feeder 7, screw feeder 7 is located at the outside of rotary drum 6, differential mechanism 8 is provided with outside washing housing 31, rotary drum 6 and screw feeder 7 are all in transmission connection with differential mechanism 8, one end of washing housing 31 is provided with mixed solution import 32, the bottom of washing housing 31 is provided with washings outlet 33 and sludge outlet 34, and washings outlet 33 and sludge outlet 34 are located at the two ends of washing housing 31 respectively.
As shown in Figure 1 and Figure 5, the slag-drip opening 25 of centrifugal device 2 is connected by feeding pipe 9 with the mixed solution import 32 of washing device 3, feeding pipe 9 is communicated with washings jetting device 10, washings jetting device 10 comprise hydro-pump 101 and be connected with hydro-pump 101 spray into pipe 102, the end spraying into pipe 102 is provided with annular nozzle 103, annular nozzle 103 contacts with the inwall of feeding pipe 9, annular nozzle 103 is provided with multiple spray orifice 104, and multiple spray orifice 104 is preferably the central axis towards feeding pipe.
As shown in Figure 1, solvent recovery unit 4 comprises still kettle 41 and solvent recovery tank 42, the leakage fluid dram 23 of centrifugal device 2 exports 33 with the washings of washing device 3 and is all communicated with still kettle 41, and the sludge outlet 34 of washing device 3 is communicated with drying installation 5, and drying installation is preferably vacuum drying apparatus.
The foregoing is only preferred embodiment of the present utility model; not in order to limit the utility model; all do within spirit of the present utility model and principle any amendment, equivalent to replace and improvement etc., all should be included within protection domain of the present utility model.
Claims (7)
1. Cefixime Micronized active ester production equipment, is characterized in that: comprise the synthesis reactor, centrifugal device, washing device, solvent recovery unit and the drying installation that are communicated with successively;
The heat sink that described synthesis reactor comprises kettle, is located at the heating jacket outside described kettle and is located in described kettle, top and the bottom of described kettle are respectively equipped with opening for feed and discharge port;
One end of described centrifugal device is provided with liquor inlet, and the bottom of described centrifugal device is provided with leakage fluid dram, slag liquid mouth and slag-drip opening;
Described washing device one end is provided with mixed solution import, and the bottom of described washing device is provided with washings outlet and sludge outlet;
The slag-drip opening of described centrifugal device is connected by feeding pipe with the mixed solution import of described washing device, and described feeding pipe is communicated with washings jetting device;
Described solvent recovery unit comprises still kettle and solvent recovery tank, and the leakage fluid dram of described centrifugal device exports with the washings of described washing device and is all communicated with described still kettle;
The sludge outlet of described washing device is communicated with described drying installation.
2. Cefixime Micronized active ester production equipment as claimed in claim 1, it is characterized in that: described heat sink comprises coil pipe and lower coil pipe, described upper coil pipe is located on the top of described kettle inner side-wall, described lower coil pipe is located on the bottom of described kettle inner side-wall, described upper coil pipe is provided with cooling water inlet, described lower coil pipe is provided with cooling water outlet, described cooling water inlet and cooling water outlet stretch out outside described heating jacket, longitudinally be provided with multiple cooling tubulation between described upper coil pipe and lower coil pipe, described cooling tubulation is communicated with lower coil pipe with described upper coil pipe respectively.
3. Cefixime Micronized active ester production equipment as claimed in claim 1, it is characterized in that: the differential mechanism that described centrifugal device comprises centrifugal housing, is located at the centrifugal assembly in described centrifugal housing and is located at outside described centrifugal housing, described centrifugal assembly comprises rotary drum and is located at the screw feeder outside described rotary drum, described rotary drum and screw feeder are all connected with described differential drive, described liquor inlet is located at one end of described centrifugal housing, and described leakage fluid dram, slag liquid mouth and slag-drip opening are located at the bottom of described centrifugal housing.
4. Cefixime Micronized active ester production equipment as claimed in claim 1, it is characterized in that: the differential mechanism that described washing device comprises washing housing, is located at the wash in described washing housing and is located at outside described washing housing, described wash comprises rotary drum and is located at the screw feeder outside described rotary drum, described rotary drum and screw feeder are all connected with described differential drive, one end of described washing housing is located in described mixed solution import, and described washings outlet and sludge outlet are located at the bottom of described washing housing.
5. the Cefixime Micronized active ester production equipment as described in any one of claim 1-4, it is characterized in that: described washings jetting device comprise hydro-pump and be connected with described hydro-pump spray into pipe, the described end spraying into pipe is provided with annular nozzle, described annular nozzle ring contacts with the inwall of described feeding pipe, and described annular nozzle is provided with multiple spray orifice.
6. Cefixime Micronized active ester production equipment as claimed in claim 5, is characterized in that: described multiple spray orifice is towards the central axis of described feeding pipe.
7. Cefixime Micronized active ester production equipment as claimed in claim 1, is characterized in that: the slag liquid mouth of described centrifugal device is communicated with described liquor inlet by return line, and described return line is provided with reflux pump and reverse flow valve successively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420519620.1U CN204058310U (en) | 2014-09-10 | 2014-09-10 | Cefixime Micronized active ester production equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420519620.1U CN204058310U (en) | 2014-09-10 | 2014-09-10 | Cefixime Micronized active ester production equipment |
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| Publication Number | Publication Date |
|---|---|
| CN204058310U true CN204058310U (en) | 2014-12-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420519620.1U Expired - Fee Related CN204058310U (en) | 2014-09-10 | 2014-09-10 | Cefixime Micronized active ester production equipment |
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| CN (1) | CN204058310U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114643024A (en) * | 2021-12-07 | 2022-06-21 | 上海安赐环保科技股份有限公司 | Industrialized device and process for liquid-phase thermal synthesis of lithium iron phosphate |
-
2014
- 2014-09-10 CN CN201420519620.1U patent/CN204058310U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114643024A (en) * | 2021-12-07 | 2022-06-21 | 上海安赐环保科技股份有限公司 | Industrialized device and process for liquid-phase thermal synthesis of lithium iron phosphate |
| CN114643024B (en) * | 2021-12-07 | 2024-03-22 | 上海安赐环保科技股份有限公司 | Industrial device and process for lithium iron phosphate liquid-phase thermal synthesis |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141231 Termination date: 20180910 |