CN203869974U - Dynamic mechanics experimental device of tissue engineering scaffold - Google Patents
Dynamic mechanics experimental device of tissue engineering scaffold Download PDFInfo
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- CN203869974U CN203869974U CN201420275409.XU CN201420275409U CN203869974U CN 203869974 U CN203869974 U CN 203869974U CN 201420275409 U CN201420275409 U CN 201420275409U CN 203869974 U CN203869974 U CN 203869974U
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- 238000002474 experimental method Methods 0.000 claims abstract description 67
- 239000000463 material Substances 0.000 claims abstract description 29
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- 125000004122 cyclic group Chemical group 0.000 abstract 5
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- Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
Abstract
The utility model discloses a dynamic mechanics experimental device of a tissue engineering scaffold. The device comprises a pressure sensor, a reciprocating motor, a dynamic cyclic stress loading assembly and an assembling support for accommodating the reciprocating motor and the dynamic cyclic stress loading assembly, wherein the pressure sensor comprises a sensing gasket and display equipment, the sensing gasket is arranged between the reciprocating motor and the dynamic cyclic stress loading assembly, and the sensing gasket and the display equipment are connected to the reciprocating motor; the dynamic cyclic stress loading assembly comprises a lower end support for transferring pushing force upwards, a spring for transferring dynamic force, an upper end support for transferring a pressure stress downwards, a thimble for transferring the stress to experimental materials and a locating multi-hole cover for fixing the thimble and an experimental multi-hole plate. The device disclosed by the utility model can meet simulation experiments inside the tissue engineering scaffold loaded under the environment of cyclic stress with different sizes under the frequency of 1-150Hz, and multiple groups of experiments can be carried out simultaneously, so that the experiment efficiency is promoted.
Description
Technical field
The utility model relates to the experimental provision of a kind of mechanics and cell biology, and especially a kind of tissue engineering bracket dynamic experiments device, belongs to medical instruments field.
Background technology
Biosome internal milieu is a circulation dynamic environment, yet, the mechanical property of related organization's engineering scaffold material characterized, simulated vivo degradation, biomimetic mineralization and co-culture of cells and was confined to envelope test more in the past, the research shortcoming to the biomedical applications performance characterization of the dynamic body fluid that circulates, physiological movement state and high velocity impact pathological state undertissue engineering rack.
In the analogue body of the tissue engineering bracket under dynamic mechanical load, the experiment such as fatigue, degraded, co-culture of cells is the emphasis in the performance study field that relates in research organization's engineering rack bionic preparation and bio-medical process thereof.Desirable tissue engineering bracket material should be good biocompatibility, inductivity and organize conduction, mechanical property in a organized way, close with natural tissues, can support vascularization, degradation rate and new organization to form the bioactive materials that speed matches.This just requires the research of tissue engineering bracket material not only will consider from the angle of material science, more will inquire into from the angle of life science.For reaching this purpose, need to be optimized design to the preparation of timbering material, in experiment, more focus on internal milieu that is virtually reality like reality in vitro.The tradition of tissue engineering bracket characterizes and construction method is in vitro function of organization's cell to be seeded on three-dimensional stent material, after certain hour is cultivated, characterizes in its cytology performance or implant into body.Cultural method often adopts standing cultivation.Yet, tissue engineering bracket is that the mechanics factor of receiving surrounding tissue affects in vivo, tissue is also subject to the hydraulic coupling of the fluids such as body fluid, blood, bone tissue engineering scaffold is also subject to the compressive stress impact of surrounding bone tissue, therefore, with circulation dynamic stress, load the more science of traditional static culture method that replaces of cultivating.Equally, tissue engineering bracket material degraded, biomimetic mineralization performance in vivo also inquired under dynamic environment in vitro.
At present, many device and methods that loading is cultivated for dynamic stress are all to adopt the independent cell under stress stimulation to cultivate or adopt Perfusion bioreactor for the mechanical environment of cell more, yet, do not consider that dynamic mechanical stimulates the impact in the processes such as simulation vivo degradation, biomimetic mineralization and co-culture of cells on this stressed main body of tissue engineering bracket.
Utility model content
The purpose of this utility model is in order to solve the defect of above-mentioned prior art, a kind of tissue engineering bracket dynamic experiments device is provided, this apparatus structure is simple, with low cost, easy to operate, diverse in function, and the pulsating stress environment that can meet the difference size under 1～150Hz frequency loads undertissue's engineering rack dynamic experiments.
The purpose of this utility model can be by taking following technical scheme to reach:
Tissue engineering bracket dynamic experiments device, comprises pressure transducer, reciprocating motor, is positioned at the circulation dynamic stress charging assembly of reciprocating motor top and for placing the assembling support of reciprocating motor and circulation dynamic stress charging assembly; Described pressure transducer comprises sensing pad and display device, and described sensing pad is arranged between reciprocating motor and circulation dynamic stress charging assembly, and is connected with display device; Described circulation dynamic stress charging assembly comprises lower end support for upwards transmitting expulsive force, for transmitting the spring of dynamic force, for the upper end support of going down compressive stress, for stress being passed to the thimble of experiment material and for the fixing location perforated lid of porous plate for thimble and experiment; Described spring housing is located on the pillar of upper end frame bottom, and is connected with lower end support; The upper end of described thimble and the bottom connection of upper end support touch, and lower end contacts with experiment material.
As a kind of preferred version, described reciprocating motor comprises motor main body, lifting table, frequency modulator and driving power, and described motor main body is connected with driving power, and drives lifting table to carry out elevating movement; Described frequency modulator is arranged in motor main body, and the sensing pad of described pressure transducer is arranged between lifting table and lower end support, and bottom surface contacts with lifting table, and end face contacts with lower end support.
As a kind of preferred version, described assembling support comprises main support, assistant support and base for supporting, and described assistant support is fixed on main support, for placing porous plate and supporting and location perforated lid for experiment; Described reciprocating motor and circulation dynamic stress charging assembly integral body are placed on base for supporting.
As a kind of preferred version, described main support is the concave structure that both sides stretch out, centre concaves, and the part concaving in the middle of this concave structure has the parallel groove of twice; Described assistant support is comprised of bracing frame and fixed mount, mutually vertical between support frame as described above and fixed mount, and support frame as described above is used for placing experiment use porous plate and supporting and location perforated lid, has two through holes on described fixed mount; Described fixed mount is fixed on the optional position of the parallel groove of twice through after two through holes by two screws, to regulate the height of porous plate for experiment.
As a kind of preferred version, the vibration frequency of described reciprocating motor is in the scope of 1～150Hz, and fidelity load is 5Kg.
As a kind of preferred version, the display device of described pressure transducer is fixed in motor main body, and when showing real-time Mechanical Data, the line item of going forward side by side, can copy and do data analysis and use.
As a kind of preferred version, the upper end of described thimble is provided with sheet rubber, and the bottom connection of this sheet rubber and upper end support touches.
As a kind of preferred version, the rectangular body shape of the needle body of described thimble, lower end are pointed, or the integral body of described thimble is cylindrical shape.
The utility model has following beneficial effect with respect to prior art:
1, tissue engineering bracket dynamic experiments device of the present utility model is used reciprocating motor as circulation dynamic stress output unit, adopt the method for pressurization indirectly to apply circulation dynamic stress, by frequency modulator, can regulate the circulation dynamic frequency of reciprocating motor, the external dynamic stress that the dynamic stress that in analogue body, different tissues position is subject to or clinical course apply, to study the impact on experimental result without mechanics factor.
2, tissue engineering bracket dynamic experiments device of the present utility model has designed assembling support, the parts such as pressure transducer, reciprocating motor, circulation dynamic stress charging assembly can be fixed together and become a complete instrument, the main support of assembling support plays the effect of constraint circulation dynamic stress charging assembly tracks, and parallel channels design makes the adjusting in differing heights tissue engineering bracket material experimentation convenient especially, do not need to design unified height, relaxed design of material factor.
3, tissue engineering bracket dynamic experiments device of the present utility model adopts pressure sensing pad to monitor mechanical signal, there are a plurality of induction points on surface, its Monitoring Data can show and preserve in digital display window, to carry out data processing and analysis in computing machine.
The vibration frequency of the reciprocating motor that 4, the utility model tissue engineering bracket dynamic experiments device is used is at 1～150Hz, and fidelity load reaches 5Kg, substantially meets the requirement of experiment of normal human body dynamic stress frequency.
5, tissue engineering bracket dynamic experiments device of the present utility model is used spring as mechanics Transfer Medium in circulation dynamic stress charging assembly, being used in conjunction with of spring and reciprocating motor, makes thimble realize circulation dynamic stress in material stress application process, keep the contact condition of thimble.
6, tissue engineering bracket dynamic experiments device of the present utility model is provided with sheet rubber in thimble upper end, prevents that scale error small in experimentation from causing thimble cannot contact with upper end support and the experimental error that causes.
7, tissue engineering bracket dynamic experiments device of the present utility model, by placing experiment porous plate on the assistant support at assembling support, can make many group experiments carry out simultaneously, to relating to the carrying out of repeating groups and control experiment, very facilitates.
8, tissue engineering bracket dynamic experiments application of installation scope of the present utility model is wide, and degraded, biomimetic mineralization, vitro cytotoxicity, the cell in vitro that can be used for studying under the simulation body-internal-circulation dynamic stress circumstance of lamellar structure engineering rack and column biological support stick the experiments such as Proliferation, Differentiation.
9, simple, with low cost, easy to operate, the diverse in function of tissue engineering bracket dynamic experiments apparatus structure of the present utility model, the pulsating stress environment that can meet the difference size under various frequencies loads simulated experiment in undertissue's engineering rack body, can carry out many group experiments simultaneously, promote conventional efficient.
Accompanying drawing explanation
Fig. 1 is pressure transducer, display device, reciprocating motor, circulation dynamic stress charging assembly and the assistant support position relationship schematic diagram when experiment in tissue engineering bracket dynamic experiments device of the present utility model.
Fig. 2 assembles supporting structure schematic diagram in tissue engineering bracket dynamic experiments device of the present utility model.
Fig. 3 a is the front view of the first thimble structure in tissue engineering bracket dynamic experiments device of the present utility model; Fig. 3 b is the right view of the first thimble structure; Fig. 3 c is the vertical view of the first thimble structure.
Fig. 4 a is the front view of the second thimble structure in tissue engineering bracket dynamic experiments device of the present utility model; Fig. 4 b is the vertical view of the second thimble structure.
Fig. 5 a is the right view of main bracket structure in tissue engineering bracket dynamic experiments device of the present utility model; Fig. 5 b is the vertical view of main bracket structure.
Fig. 6 a is the front view of assistant support structure in tissue engineering bracket dynamic experiments device of the present utility model; Fig. 6 b is the right view of assistant support structure.
Fig. 7 is that tissue engineering bracket dynamic experiments device of the present utility model is placed the schematic diagram of tissue engineering bracket material on circulation dynamic stress charging assembly.
Fig. 8 is that tissue engineering bracket dynamic experiments device of the present utility model is placed the schematic diagram of sheet biomaterial on circulation dynamic stress charging assembly.
Wherein, 1-motor main body, 2-lifting table, 3-frequency modulator, end support under 4-, 5-spring, the upper end support of 6-, 7-thimble, 8-locates perforated lid, 9-sheet rubber, 10-cell is cultivated porous plate, 11-main support, 12-assistant support, 13-base for supporting, 14-groove, 15-bracing frame, 16-fixed mount, 17-through hole, 18-screw, 19-sensing pad, 20-display device, 21-tissue engineering bracket material, 22-counterweight, 23-sheet biomaterial, 24-pad.
Embodiment
Embodiment 1:
As depicted in figs. 1 and 2, the tissue engineering bracket dynamic experiments device of the present embodiment, comprises pressure transducer, display device, reciprocating motor, circulation dynamic stress charging assembly and assembling support, wherein:
The vibration frequency of described reciprocating motor is in the scope of 1～150Hz, fidelity load is 5Kg, comprise motor main body 1, lifting table 2, frequency modulator 3 and driving power (not shown), described motor main body 1 is connected with driving power, and drives lifting table 2 to carry out elevating movement; Described frequency modulator 3 is arranged in motor main body 1.
Described circulation dynamic stress charging assembly comprises lower end support 4, spring 5, upper end support 6, thimble 7 and location perforated lid 8, consider the load reason in reciprocating motor fidelity situation, lower end support 4, upper end support 6, thimble 7 and location perforated lid 8 are all to adopt acrylic glass material to make, described lower end support 4 is for upwards transmitting expulsive force, and described upper end support 6 is for going down compressive stress; Described thimble 7 is for passing to experiment material by stress, the upper end of thimble 7 is provided with sheet rubber 9, this sheet rubber 9 touches with the bottom connection of upper end support 6, the lower end of thimble 7 contacts with experiment material, experiment material can be tissue engineering bracket material, sheet biomaterial etc., thimble 7 can have two kinds of structures, to meet the requirement of different experiments, wherein a kind of structure is as shown in Fig. 3 a～Fig. 3 c, the rectangular body shape of needle body, lower end are pointed, another kind of structure is as shown in Fig. 4 a～Fig. 4 b, and integral body is cylindrical shape; Described spring 5 is for transmitting dynamic force, and it is set on the pillar of end support 6 bottoms, and is connected with lower end support 4; A plurality of perforates at perforated lid 8 tops, described location are thimble 7 fixedly, and the right and left can be fixed experiment porous plate, and the experiment porous plate that the present embodiment adopts is that cell is cultivated porous plate 10.
Described assembling support adopts stainless steel to make, and comprises main support 11, assistant support 12 and base for supporting 13, and described reciprocating motor and circulation dynamic stress charging assembly integral body are placed on base for supporting 13; Described main support 11 is the concave structure that both sides stretch out, centre concaves, and as shown in Fig. 5 a～Fig. 5 b, the part concaving in the middle of this concave structure has the parallel groove of twice 14; Described assistant support 12 is comprised of bracing frame 15 and fixed mount 16, as shown in Fig. 6 a～6b, mutually vertical between support frame as described above 15 and fixed mount 16, support frame as described above 15, for placing experiment use porous plate and supporting and location perforated lid 8, has two through holes 17 on described fixed mount 16; Described fixed mount 16 is fixed on the optional position of the parallel groove of twice 14 through after two through holes 17 by two screws 18, to regulate the height of porous plate for experiment.
Described pressure transducer comprises sensing pad 19 and display device 20, there are a plurality of induction points on described sensing pad 19 surfaces, can monitor out real-time stress data in experimentation, it is arranged between lifting table 2 and lower end support 4, and bottom surface contacts with lifting table 2, end face contacts with lower end support 4; Described display device 20 is digital display window, and this numeral display window is fixed in motor main body 1, and is connected with sensing pad 19, to observe the real time data that sensing pad 19 gathers.
As shown in Figure 1, Figure 2 and Figure 7, the experimentation of the present embodiment, comprises the following steps:
1) pressure transducer is arranged on reciprocating motor, then reciprocating motor and circulation dynamic stress charging assembly integral body are placed on base for supporting 13;
2) by tissue engineering bracket material 21 in cell is cultivated porous plate 10, then cover location perforated lid 8;
3) thimble 7 is placed in corresponding hole above material, then upper end support 6 is placed on to thimble 7 upper ends, regulates the height of assistant support 12, the lower end of thimble 7 is contacted completely with material in hole, upper end contacts completely with upper end support 6, at the counterweight 22 of the required weight of upper end support 6 upper ends;
4) connect driving power, adopt frequency modulator 3 to regulate the lifting frequency of reciprocating motor, make motor main body 1 drive lifting table 2 to carry out Circularly liftable motion according to the frequency of setting, opening pressure sensor is monitored;
5) lower end support 4 upwards transmits expulsive force when lifting table 2 rises, spring 5 pressurizeds now, and when lifting table 2 declines, upper end support 6 going down compressive stress under the effect of spring 5 and counterweight 22, makes thimble 7 that stress is passed to material in hole;
6) after experiment finishes, close driving power, take off successively counterweight 22, upper end support 6, thimble 7, location perforated lid 8, cell cultivation porous plate 10 and lower end support 4, take out the data that pressure transducer gathers;
7) process experimental data and analyze: the data that gather according to pressure transducer, in conjunction with the lifting frequency of the quality of known device all parts, the amplitude of lifting table 2 and reciprocating motor, in computing machine, by computing formula, be converted to real induction force data.
Step 7) described computing formula is as follows:
F
0+m
2g＝f
F
0+nF＝Mg+m
1g+nm
0
Comprehensive above-mentioned formula: F=(Mg+m
1g+nm
0+ m2g-f)/n
F
0for the power that spring is subject to, the power that f is Sensor monitoring, M is counterbalance mass, m
1for the quality of upper end support, m
2for the quality of lower end support, m
0for the quality of thimble, F is the pressure that material is subject to, and n is material quantity.
Note: this reciprocating motor frequency is low frequency, acceleration is less on the collection impact of pressure data, therefore computing formula is for considering the acceleration action in motor lifting process.
Embodiment 2:
The principal feature of the present embodiment is: as shown in Figure 8, in the experimentation of embodiment 1, step 2) the cell that is placed on to cultivate in porous plate be sheet biomaterial 23, pad with pad 24 bottom of every block of sheet biomaterial 23.All the other are with embodiment 1.
In sum, tissue engineering bracket dynamic experiments apparatus structure of the present utility model is simple, with low cost, easy to operate, diverse in function, the pulsating stress environment that can meet the difference size under 1～150Hz frequency loads simulated experiment in undertissue's engineering rack body, can carry out many group experiments simultaneously, promote conventional efficient.
The above; it is only the utility model patent preferred embodiment; but the protection domain of the utility model patent is not limited to this; anyly be familiar with those skilled in the art in the disclosed scope of the utility model patent; according to the technical scheme of the utility model patent and utility model patent design thereof, be equal to replacement or changed, all being belonged to the protection domain of the utility model patent.
Claims (8)
1. tissue engineering bracket dynamic experiments device, is characterized in that: comprise pressure transducer, reciprocating motor, be positioned at the circulation dynamic stress charging assembly of reciprocating motor top and for placing the assembling support of reciprocating motor and circulation dynamic stress charging assembly; Described pressure transducer comprises sensing pad and display device, and described sensing pad is arranged between reciprocating motor and circulation dynamic stress charging assembly, and is connected with display device; Described circulation dynamic stress charging assembly comprises lower end support for upwards transmitting expulsive force, for transmitting the spring of dynamic force, for the upper end support of going down compressive stress, for stress being passed to the thimble of experiment material and for the fixing location perforated lid of porous plate for thimble and experiment; Described spring housing is located on the pillar of upper end frame bottom, and is connected with lower end support; The upper end of described thimble and the bottom connection of upper end support touch, and lower end contacts with experiment material.
2. tissue engineering bracket dynamic experiments device according to claim 1, it is characterized in that: described reciprocating motor comprises motor main body, lifting table, frequency modulator and driving power, described motor main body is connected with driving power, and drives lifting table to carry out elevating movement; Described frequency modulator is arranged in motor main body, and the sensing pad of described pressure transducer is arranged between lifting table and lower end support, and bottom surface contacts with lifting table, and end face contacts with lower end support.
3. tissue engineering bracket dynamic experiments device according to claim 1, it is characterized in that: described assembling support comprises main support, assistant support and base for supporting, described assistant support is fixed on main support, for placing porous plate and supporting and location perforated lid for experiment; Described reciprocating motor and circulation dynamic stress charging assembly integral body are placed on base for supporting.
4. tissue engineering bracket dynamic experiments device according to claim 3, is characterized in that: described main support is the concave structure that both sides stretch out, centre concaves, and the part concaving in the middle of this concave structure has the parallel groove of twice; Described assistant support is comprised of bracing frame and fixed mount, mutually vertical between support frame as described above and fixed mount, and support frame as described above is used for placing experiment use porous plate and supporting and location perforated lid, has two through holes on described fixed mount; Described fixed mount is fixed on the optional position of the parallel groove of twice through after two through holes by two screws, to regulate the height of porous plate for experiment.
5. tissue engineering bracket dynamic experiments device according to claim 2, is characterized in that: the vibration frequency of described reciprocating motor is in the scope of 1～150Hz, and fidelity load is 5Kg.
6. tissue engineering bracket dynamic experiments device according to claim 2, is characterized in that: the display device of described pressure transducer is fixed in motor main body.
7. tissue engineering bracket dynamic experiments device according to claim 1, is characterized in that: the upper end of described thimble is provided with sheet rubber, and the bottom connection of this sheet rubber and upper end support touches.
8. tissue engineering bracket dynamic experiments device according to claim 1, is characterized in that: the rectangular body shape of needle body of described thimble, lower end are pointed, or the integral body of described thimble is cylindrical shape.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420275409.XU CN203869974U (en) | 2014-05-27 | 2014-05-27 | Dynamic mechanics experimental device of tissue engineering scaffold |
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| CN201420275409.XU CN203869974U (en) | 2014-05-27 | 2014-05-27 | Dynamic mechanics experimental device of tissue engineering scaffold |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104007029A (en) * | 2014-05-27 | 2014-08-27 | 华南理工大学 | Dynamic mechanical experimental device and method for tissue engineering scaffold |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104007029A (en) * | 2014-05-27 | 2014-08-27 | 华南理工大学 | Dynamic mechanical experimental device and method for tissue engineering scaffold |
| CN104007029B (en) * | 2014-05-27 | 2017-01-25 | 华南理工大学 | Dynamic mechanical experimental device and method for tissue engineering scaffold |
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