CN203764280U - Constant temperature water heating device for microdialysis in-vitro recovery correction experiment - Google Patents
Constant temperature water heating device for microdialysis in-vitro recovery correction experiment Download PDFInfo
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- CN203764280U CN203764280U CN201420110925.7U CN201420110925U CN203764280U CN 203764280 U CN203764280 U CN 203764280U CN 201420110925 U CN201420110925 U CN 201420110925U CN 203764280 U CN203764280 U CN 203764280U
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Abstract
The utility model discloses a constant temperature water heating device for a microdialysis in-vitro recovery correction experiment. The constant temperature water heating device comprises a water tank and a heating tank which are mutually connected, wherein the water tank is sealed by a water tank cover; a heater is fixed inside the heating tank; through holes are formed in the water tank cover; a U-shaped hating pipe and two symmetrically arranged submerged pumps are fixed inside the water tank; an end opening of the U-shaped heating pipe is connected with the heater; each submerged pump is connected to a water outlet pipe; the water outlet pipes are penetrated out of the through holes and are connected with water inlets to form a circulating water route. The constant temperature water heating device has the beneficial effects that the device is simple in structure and can supply circulating water with constant temperature to a microdialysis in-vitro recovery correction container, the device is an intelligent constant temperature heating device with the temperature being accurate to +/- 0.1 DEG C, and 24-hour supply of circulating water with constant temperature is realized continuously, so that the accuracy of microdialysis in-vitro recovery correction experiment results is ensured, the device is small in size, attractive in appearance, convenient to carry and move, good in sealing performance, good in heat preservation effect and high in practicability, the evaporation of hot water can be reduced, ant the use efficiency is greatly improved.
Description
Technical field
The utility model relates to medical science and biological experiment technical field, proofreaies and correct the thermostatic water heating device of experiment in particular to the external rate of recovery of a kind of microdialysis.
Background technology
Microdialysis Technique is a kind of new bio sampling technique, there is " live body, Wicresoft, in real time, the feature such as efficiently ", be widely used in clinical every subjects, in experimental study, clinical diagnosis, monitoring, the aspect such as prognosis and treatment is significant, in recent years, the progress of external related fields is very fast, microdialysis is studied for the multiple organ of people and many animals, as liver, blood, brain, lung, skin etc., due to the impact of inside and outside factor, the diffusion of medicine between tissue fluid and perfusate can not reach balance completely, so no matter which kind of sample of tissue is this technology be used to, the external rate of recovery of probe proofread and correct experiment be all must through proof procedure.
Proofread and correct in experiment in the external rate of recovery of probe, temperature requirement to correcting fluid in the external correction container of microdialysis is higher, the variations in temperature of correcting fluid has had a strong impact on experimental data, therefore the external correction container of microdialysis must carry out in the time that experiment is carried out in water bath with thermostatic control, the variations in temperature of thermostatted water has determined correcting fluid temperature, thereby has determined accuracy and the degree of accuracy of experimental result.The external rate of recovery of current existing probe is proofreaied and correct in experiment does not have concrete thermostatic water heating device, only that external microdialysis correction container is placed in common heating kettle, this heating kettle volume is large, and in pot, current remain static, may cause the water in water-bath to be heated inhomogeneous, the temperature that temperature sensor records is in addition local water temperature, pot temp precision is low, this water-bath seal is poor, and then cannot ensure the temperature required accuracy of the external correction test of microdialysis, the external correction test of microdialysis need to connect multiple devices simultaneously in addition, the use of heating kettle is for whole experiment, inconvenient operation, need multiple people to operate simultaneously, the incoherence of subsequent experimental operation will be caused like this, poor practicability.
Utility model content
Large for overcoming in prior art common thermostatic water heating device volume, low for pot temp precision, water-bath closure is poor, the water of heating can not ensure constant temperature for a long time, and then cannot ensure the defects such as accuracy that the external correction test of microdialysis is temperature required, the purpose of this utility model is that the external rate of recovery of the microdialysis that a kind of high temperature-controlled precision is provided and has the circulatory system proofreaies and correct the thermostatic water heating device of experiment.
For achieving the above object, in the utility model embodiment, provide the external rate of recovery of a kind of microdialysis to proofread and correct the thermostatic water heating device of experiment, comprise interconnective water tank and heating cabinet, water tank seals by tank lid, and fixed heater in heating cabinet, has through hole in tank lid, fixing U-shaped heating tube and two symmetrical immersible pumps of placing in water tank, the port of U-shaped heating tube is connected with heater, and immersible pump connects outlet pipe, and outlet pipe is by passing in through hole and being connected to form circulation waterway with water inlet.
In the technical program, heating cabinet is the water heating in described water tank by U-shaped heating tube, U-shaped heating tube is wider, lay whole water tank bottom, firing rate is fast, and homogeneous heating, the design of immersible pump in addition, in the through hole of the outlet pipe of immersible pump by tank lid, pass, and be connected to form circulation waterway with water inlet, in the time of experimental implementation, this constant temperature heating device is connected with reaction bulb, circulation waterway provides lasting thermostatted water for reaction bulb, and whole device is airtight, dispels the heat little, temperature-controlled precision is high, impact for experiment is little, reduces experimental error, simple to operate.
Further, fixed temperature sensor in water tank, the fixing temperature controller in heating cabinet outside, temperature controller is connected with temperature sensor.Temperature sensor, for responding to the water temperature in water tank, is converted into electrical signal transfer to temperature controller by water temperature simultaneously, and temperature controller is used for showing the temperature in water tank, simple to operate, can observe intuitively the temperature in water tank, without by testing manually, have more intellectuality.Temperature controller is also connected with heater in addition, can set by temperature controller the temperature of required heating, and the precision of temperature control can reach to ± 0.1 DEG C, has intellectuality, easy to use.
Further, fixer bit switch in water tank, liquid-level switch is connected with the solid-state relay in heater.When constant water bath box middle water level is during lower than designated water level, thermostat can stop heating automatically, prevent that heating tube dry combustion method from causing the damage of constant temperature water bath apparatus, also prevent water level too low cause test inaccurate, prevent that electric leakage from causing personal safety, extends the service life of constant temperature water bath apparatus, the accuracy of guarantee test simultaneously, safety coefficient is high, practical.
Further, the fixing protective tube of water tank one side.When the electric current that causes when problems such as constant temperature water bath apparatus internal circuit short circuits is too high, blowout in protective tube, whole device quits work, and anti-locking apparatus damages, increases the service life, and ensures operating personnel's personal safety.
Further, in the through hole of the power line of immersible pump by tank lid, pass.The power line of immersible pump is by passing in through hole and connecting power supply, and the airtight connection of whole device, dispels the heat little, good looking appearance, connects the outlet pipe of immersible pump in addition by passing in through hole, is connected with water inlet, form peripheral passage, thereby water tank and tank lid are combined closely, good airproof performance.
Preferably, in tank lid, connect handle.The design of handle, can mention case lid easily or cover, convenient when making water tank water filling and being connected the operations such as peripheral passage, is convenient to mention water tank move or transport, practical.
Preferably, sandwich establishment in water tank sidewall, fill insulant material in interlayer.Insulation material is polythene material or mineral wool, high insulating effect, and heat radiation is slow, practical.
The beneficial effects of the utility model are: the utility model is simple in structure, the recirculated water of temperature constant can be provided for the external correction container of microdialysis, temperature can precision to the intelligent constant-temperature heater of ± 0.1 DEG C, can within 24 hours, continue to provide circulation constant temperature water, ensure the accuracy of the external correction test result of microdialysis, volume is little, aesthetic in appearance, carry and conveniently moving, and be that the follow-up associative operation that carries out the external correction test of microdialysis provides a great convenience, this water-bath good seal performance in addition, can reduce hot water evaporation, high insulating effect, service efficiency improves greatly, practical.
Brief description of the drawings
Fig. 1 is the front view that the external rate of recovery of a kind of microdialysis described in the utility model embodiment is proofreaied and correct the thermostatic water heating device of experiment;
Fig. 2 is the right view that the external rate of recovery of a kind of microdialysis described in the utility model embodiment is proofreaied and correct the thermostatic water heating device of experiment;
Fig. 3 is the left view that the external rate of recovery of a kind of microdialysis described in the utility model embodiment is proofreaied and correct the thermostatic water heating device of experiment.
Fig. 4 is the top view that the external rate of recovery of a kind of microdialysis described in the utility model embodiment is proofreaied and correct the thermostatic water heating device of experiment;
Fig. 5 is that the external rate of recovery of a kind of microdialysis described in the utility model embodiment is proofreaied and correct the top view of the tank lid of the thermostatic water heating device of experiment;
Fig. 6 is the cutaway view that the external rate of recovery of a kind of microdialysis described in the utility model embodiment is proofreaied and correct the water tank of the thermostatic water heating device of experiment;
Fig. 7 is the use state reference map that the external rate of recovery of a kind of microdialysis described in the utility model embodiment is proofreaied and correct the thermostatic water heating device of experiment.
In figure,
1, water tank; 2, heating cabinet; 3, tank lid; 4, U-shaped heating tube; 5, immersible pump; 6, outlet pipe; 7, water inlet; 8, temperature sensor; 9, temperature controller; 10, liquid-level switch; 11, protective tube; 12, through hole; 13, handle; 14, interlayer; 15, reaction bulb.
Detailed description of the invention
Also by reference to the accompanying drawings the utility model is described in further detail below by specific embodiment.
Embodiment 1, as shown in Fig. 1-6, the external rate of recovery of a kind of microdialysis described in the utility model embodiment is proofreaied and correct the thermostatic water heating device of experiment, comprise interconnective water tank 1 and heating cabinet 2, water tank seals by tank lid 3, fixed heater in heating cabinet, in tank lid, have through hole 12, fixing U-shaped heating tube 4 and two symmetrical immersible pumps 5 of placing in water tank, the port of U-shaped heating tube is connected with heater, immersible pump connects outlet pipe 6, and outlet pipe is by passing in through hole and being connected to form circulation waterway with water inlet 7.
Thermostatic water heating device provided by the utility model has both sides and is with two 1.7cm stainless steel pipelines the water inlet of describing in technique scheme, in water tank, place two immersible pumps, when experiment, can the reaction bulb of external to water pump and microdialysis correction test device be connected by conduit, draw the thermostatted water circulating to water tank outside, for experimental implementation provides water bath with thermostatic control, water temperature is for simulating the environment temperature in human body and animal body.When concrete use, respectively the outlet pipe of two immersible pumps is passed in the through hole by tank lid, simultaneously by the water inlet of outlet pipe coupled reaction bottle, the delivery port of reaction bulb connects the water inlet of this device, thereby formation circulation waterway, immersible pump is mainly used in the water pump in water tank to go out to reaction bulb, simple to operate, easy to use.
Embodiment 2, as shown in Fig. 1-6, the external rate of recovery of a kind of microdialysis described in the utility model embodiment is proofreaied and correct the thermostatic water heating device of experiment, comprise interconnective water tank and heating cabinet, water tank seals by tank lid, fixed heater in heating cabinet, in tank lid, have through hole, fixing U-shaped heating tube and two symmetrical immersible pumps of placing in water tank, the port of U-shaped heating tube is connected with heater, immersible pump connects outlet pipe, and outlet pipe is by passing in through hole and being connected to form circulation waterway with water inlet.
Further, fixed temperature sensor 8 in water tank, the fixing temperature controller 9 in heating cabinet outside, temperature controller is connected with temperature sensor.Further, fixer bit switch 10 in water tank, liquid-level switch is connected with the solid-state relay in heater.Further, the fixing protective tube 11 of water tank one side.Water tank is provided with liquid-level switch, heating tube and temperature sensor, adopts Electric heating, and by temperature sensor and intelligent temperature controller control water temperature, liquid-level switch carries out the protection of switching on of water level protection and protective tube.Further, in the through hole of the power line of immersible pump by tank lid, pass.In tank lid, only have the through hole that two diameters are 2cm, just ensure that the power line of immersible pump and outlet pipe pass, airtight performance is good, reduce heat of vaporization, improve service efficiency, and dwindled to greatest extent the inside and outside volume of water tank, save material, carry or conveniently moving.Preferably, in tank lid, connect handle 13.Preferably, sandwich establishment 14 in water tank sidewall, fill insulant material in interlayer.Insulation material is polythene material or mineral wool, high insulating effect, and heat radiation is slow, practical.
Embodiment 3, as shown in Figure 7, the basic functional principle of this thermostatic water heating device is that the immersible pump in water tank is derived the thermostatted water in water tank, introduce and be placed in reaction bulb 15 by conduit, by connecting into the conduit at the mouth of a river, recirculated water is back in water tank again, form an extraneous water-bath circulatory system, container internal layer is placed with stirrer and correcting fluid, set suitable rotating speed and carry out magnetic agitation, can simulate the interior environment of human body and various animals, microdialysis probe is implanted in correcting fluid, after balance, collect the dislysate of variable concentrations, by just calculating the probe rate of recovery after Mass Spectrometer Method.
Water tank is provided with liquid-level switch, U-shaped heating tube and temperature sensor, adopt Electric heating, by temperature sensor and intelligent temperature controller control water temperature, liquid-level switch carries out the protection of switching on of water level protection and protective tube, two immersible pumps are put into water tank bottom, immersible pump is passed to reaction bulb by conduit by thermostatted water, and the water of being poured out by reaction bulb is directly connected with the mouth of a river that is recycled in water tank outside, form the circulatory system, immersible pump pumps the thermostatted water of specified temp in water tank, flow via a conduit in reaction bulb, for the correcting fluid in reaction bulb provides water bath with thermostatic control, last recirculated water passes back in water tank by conduit again, the reaction bulb of proofreading and correct use is the structure of separating with constant temperature heating device, for the external correction subsequent operation of microdialysis probe provides very big facility, the circulatory system can make the aqueous medium in water tank circulate, make the temperature at each position in water tank keep same, constant, the temperature-controlled precision of intelligent temperature controller is ± 0.1 DEG C, ensure the accuracy of bath temperature, for the experiment in reaction bulb provides isoperibol.When experiment, microdialysis probe is immersed in the correcting fluid in reaction bulb, after balance a period of time, collect the dislysate of variable concentrations gradient, measure content through mass spectrograph, then can be calculated the microdialysis probe rate of recovery, as the basis of follow-up test, tank lid only, with the through hole of two 2cm, just can make outlet pipe and wire stretch out, and reduces heat of vaporization.The utility model can carry out the experiment of two group reaction bottles simultaneously in addition, and water tank can provide the thermostatted water of two groups of experiments, more convenient to operate, save the time, improved service efficiency, dwindled to greatest extent the inside and outside volume of water tank, save material, carry or conveniently moving.
The foregoing is only preferred embodiment of the present utility model, be not limited to the utility model, for a person skilled in the art, the utility model can have various modifications and variations.All within spirit of the present utility model and principle, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection domain of the present utility model.
Claims (7)
1. the external rate of recovery of microdialysis is proofreaied and correct the thermostatic water heating device of experiment, comprise interconnective water tank (1) and heating cabinet (2), water tank is by tank lid (3) sealing, fixed heater in heating cabinet, it is characterized in that: in tank lid, have through hole (12), fixing U-shaped heating tube (4) and two symmetrical immersible pumps (5) of placing in water tank, the port of U-shaped heating tube is connected with heater, immersible pump connects outlet pipe (6), and outlet pipe is by passing in through hole and being connected to form circulation waterway with water inlet (7).
2. the external rate of recovery of microdialysis according to claim 1 is proofreaied and correct the thermostatic water heating device of experiment, it is characterized in that: fixed temperature sensor (8) in water tank, and the fixing temperature controller (9) in heating cabinet outside, temperature controller is connected with temperature sensor.
3. the external rate of recovery of microdialysis according to claim 1 is proofreaied and correct the thermostatic water heating device of experiment, it is characterized in that: fixer bit switch (10) in water tank, liquid-level switch is connected with the solid-state relay in heater.
4. the external rate of recovery of microdialysis according to claim 1 is proofreaied and correct the thermostatic water heating device of experiment, it is characterized in that: water tank one side is fixed protective tube (11).
5. the external rate of recovery of microdialysis according to claim 1 is proofreaied and correct the thermostatic water heating device of experiment, it is characterized in that: in the through hole of the power line of immersible pump by tank lid, pass.
6. the external rate of recovery of microdialysis according to claim 1 is proofreaied and correct the thermostatic water heating device of experiment, it is characterized in that: in tank lid, connect handle (13).
7. the external rate of recovery of microdialysis according to claim 1 is proofreaied and correct the thermostatic water heating device of experiment, it is characterized in that: sandwich establishment (14) in water tank sidewall, fill insulant material in interlayer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420110925.7U CN203764280U (en) | 2014-03-12 | 2014-03-12 | Constant temperature water heating device for microdialysis in-vitro recovery correction experiment |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420110925.7U CN203764280U (en) | 2014-03-12 | 2014-03-12 | Constant temperature water heating device for microdialysis in-vitro recovery correction experiment |
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| CN203764280U true CN203764280U (en) | 2014-08-13 |
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| CN201420110925.7U Expired - Fee Related CN203764280U (en) | 2014-03-12 | 2014-03-12 | Constant temperature water heating device for microdialysis in-vitro recovery correction experiment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109632451A (en) * | 2018-11-27 | 2019-04-16 | 河海大学 | A kind of water-bath system that temperature variable Rate is controllable |
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2014
- 2014-03-12 CN CN201420110925.7U patent/CN203764280U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109632451A (en) * | 2018-11-27 | 2019-04-16 | 河海大学 | A kind of water-bath system that temperature variable Rate is controllable |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140813 Termination date: 20160312 |