CN203758917U - Dry chemistry test paper for quantitatively measuring content of albumins in human body blood - Google Patents
Dry chemistry test paper for quantitatively measuring content of albumins in human body blood Download PDFInfo
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- CN203758917U CN203758917U CN201320792112.6U CN201320792112U CN203758917U CN 203758917 U CN203758917 U CN 203758917U CN 201320792112 U CN201320792112 U CN 201320792112U CN 203758917 U CN203758917 U CN 203758917U
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- albumins
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- 238000012360 testing method Methods 0.000 title claims abstract description 44
- 102000009027 Albumins Human genes 0.000 title claims abstract description 28
- 108010088751 Albumins Proteins 0.000 title claims abstract description 28
- 210000004369 blood Anatomy 0.000 title claims abstract description 10
- 239000008280 blood Substances 0.000 title claims abstract description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 31
- 238000009792 diffusion process Methods 0.000 claims abstract description 22
- 238000006243 chemical reaction Methods 0.000 claims abstract description 16
- 238000001035 drying Methods 0.000 claims description 11
- 239000004744 fabric Substances 0.000 claims description 8
- 239000004695 Polyether sulfone Substances 0.000 claims description 5
- 229920002492 poly(sulfone) Polymers 0.000 claims description 5
- 229920006393 polyether sulfone Polymers 0.000 claims description 5
- 239000004677 Nylon Substances 0.000 claims description 3
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 claims description 3
- 229920001778 nylon Polymers 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 claims 1
- 238000003759 clinical diagnosis Methods 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000003745 diagnosis Methods 0.000 abstract description 2
- 238000000338 in vitro Methods 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000463 material Substances 0.000 description 16
- 239000000126 substance Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- -1 polyethylene terephthalate Polymers 0.000 description 6
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 6
- 238000013016 damping Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- FRPHFZCDPYBUAU-UHFFFAOYSA-N Bromocresolgreen Chemical compound CC1=C(Br)C(O)=C(Br)C=C1C1(C=2C(=C(Br)C(O)=C(Br)C=2)C)C2=CC=CC=C2S(=O)(=O)O1 FRPHFZCDPYBUAU-UHFFFAOYSA-N 0.000 description 3
- 235000017858 Laurus nobilis Nutrition 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 3
- 244000125380 Terminalia tomentosa Species 0.000 description 3
- 235000010724 Wisteria floribunda Nutrition 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000001384 succinic acid Substances 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 2
- 239000013504 Triton X-100 Substances 0.000 description 2
- 229920004890 Triton X-100 Polymers 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000003370 dye binding method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 229950008882 polysorbate Drugs 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 239000006035 Tryptophane Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- ABIUHPWEYMSGSR-UHFFFAOYSA-N bromocresol purple Chemical compound BrC1=C(O)C(C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C=C(Br)C(O)=C(C)C=2)=C1 ABIUHPWEYMSGSR-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 235000020905 low-protein-diet Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 235000003715 nutritional status Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
The utility model belongs to the technical field of in-vitro clinical diagnosis reagents, and particularly discloses dry chemistry test paper for quantitatively measuring the content of albumins in human body blood. The test paper is shaped like a long strip with one end which serves as a test area and the other end which serves as a handheld end, and is sequentially composed of an upper support layer, a diffusion layer, a reaction layer and a lower support layer from top to bottom, wherein circular holes are respectively formed in areas, corresponding to the diffusion layer and the reaction layer, on the upper support layer and the lower support layer, and are a sample adding hole and a test hole respectively; the reaction layer is coated with a reagent needed for measuring the albumins. A test sample is dripped on the diffusion layer form the sample adding hole, after the sample diffuses to the reaction layer, the albumins in the sample is subjected to colour development reaction with the reagent in the reaction layer, and the colour on the reaction layer is tested from the test hole by using a reflection-type photometer. The test paper strip is used for quantitatively measuring the content of albumins in the human body blood and providing a basis for disease diagnosis, and is suitable for being popularized and used in emergency wards of hospitals.
Description
Technical field
The utility model belongs to technical field of in-vitro clinical diagnostic reagent, is specifically related to a kind of test strips that is applicable to Fast Measurement human albumin content.
Background technology
Albumin molecular weight is 66300, at human body, by liver, is synthesized, and is the plasma proteins of unique a kind of not carbohydrate containing.Albumin is important bond and the transport protein of many kinds of substance in blood plasma, and is the key component that maintains plasma osmolarity.In clinical examination, blood albumin is usually used as one of diagnosis index of the symptoms such as dysfunction of liver, low protein diet, nephrotic syndrome.In blood, also to can be considered be the index of individual health and nutritional status to albumin concentration, particularly to old age and chronic.
Through development for many years, formed the albuminous method of many measure, as salting out method, tryptophane method, dye binding method etc.Wherein the operation of dye binding method mensuration albumin is easier, method specificity is high, is used now by most of clinical labororatory.
The albumin measuring reagent type that clinical labororatory is used can be divided into two classes, and a class is liquid reagent, and another kind of is dry chemistry reagent.Dry chemistry reagent compare with liquid reagent have easy and simple to handle, measure the advantages such as quick, in hospital emergency clinical laboratory, obtained application more widely.
The mensuration blood albumin dry chemistry reagent that domestic hospitals is used is at present imported product, wherein take U.S. Johnson & Johnson and Japanese fuji product as main.The dry chemical product of Johnson & Johnson and Fuji is that the coating technology in film production field has been applied to clinical diagnosis field, and it is coated on various reagent required in assaying reaction on transparent plastic sheet according to the bottom-up layering uniformly respectively of the precedence of reaction.On the one hand, these product processes more complicated, high to production equipment requirement, production cost is higher, needs to be equipped with large-scale testing tool simultaneously, expensive, causes some middle and small hospitals, particularly community hospital to be difficult to accept.On the other hand, due to the reasons such as material that this type of dry chemistry reagent is used, daily need stored refrigerated, need to place in advance equilibrium at room temperature and just can test after half an hour during use, causes using inconvenient.In addition, also have the defects such as test speed is slow, test sample book amount is larger, as Johnson & Johnson's albumin dry chemistry reagent test duration needs 2.5 minutes, Fuji's albumin dry chemistry reagent test sample book amount needs 10 microlitres.
The utility model adopts preferred test paper material, optimizes reaction formula, produces a kind of production technology simple, can room temperature preservation, and test sample book amount is less, and test speed is albumin dry chemical scrip faster.
Summary of the invention
The purpose of this utility model be to provide a kind of easy to use, test sample book amount is few, test albumin measuring dry chemical scrip fast.
The drying chemical reagent paper of the quantitatively determining human blood albumin content that the utility model provides, it is long strips, and one end is test section, and the other end is handheld terminal.The formation of test section is upper supporting layer, diffusion layer, responding layer and lower supporting layer from top to bottom successively; Wherein, the regional location corresponding to diffusion layer and responding layer in upper supporting layer, lower supporting layer has circular hole, and the circular hole on upper supporting layer is well, and the circular hole on lower supporting layer is instrument connection; Described responding layer is coated with measures the required reagent of albumin.
During use, test sample book is added drop-wise on diffusion layer from well, the effect of diffusion layer is that sample is distributed to responding layer rapidly and uniformly, sample diffuses to after responding layer, albumin in sample and the reagent generation chromogenic reaction in responding layer, the depth of color is directly proportional to albuminous concentration in sample, by using baffled photometer from the color on instrument connection test reaction layer, can arrive the object of albumin concentration in quantitative measurement sample.
In the utility model, described upper and lower supporting layer can adopt the materials such as polyethylene terephthalate, polystyrene or Polyvinylchloride, wherein take pet material as best.What upper and lower supporting layer played is mainly supporting role, and it can be bonded together by glue.Supporting layer can be divided into holding area and test section, the main part that test section is test strips.At test zone, diffusion layer and responding layer material are clipped in the middle of upper and lower supporting layer in upper and lower superimposed mode, and upper and lower supporting layer has circular hole in this region, are respectively well and instrument connection.
In the utility model, in order to reduce the consumption of test sample book, the material of diffusion layer is not suitable for using has adsorbing material to test sample book, as filter paper, nonwoven fabrics, synthetic film etc., to guarantee that test sample book almost all diffuses to responding layer and is not diffused layer absorption.Suitable diffusion layer material can be selected nylon, tygon or polypropylene etc., wherein best with screen cloth form.In order to make sample can diffuse to rapidly and uniformly responding layer, diffusion layer material can be used surfactant or hydrophilic substance to carry out water wettability processing, surfactant is nonionic surfactant, as polysorbate or Triton X-100 etc., hydrophilic substance is as hydroxyethyl cellulose, polyvinylpyrrolidone or cellulose acetate etc., wherein preferred nonionic surfactants.Can adopt the mode of immersion to process diffusion layer.
In the utility model, the coated reagent of described responding layer comprises the compositions such as dyestuff, damping fluid, surfactant.When sample diffuses to responding layer, albumin in sample can show and react with the dyestuff being coated in responding layer under the effect of sour environment and surfactant, color becomes blueness from yellow gradually, and the depth of end reaction color depends on albuminous concentration in sample.Research shows, reacts membrane material and responding layer reagent content that needed sample size used with responding layer with reaction velocity relevant.The utility model preferred film material and optimization responding layer reagent content are to reach test fast and the little object of test sample book amount.Wherein the preferred polysulfones of responding layer membrane material, polyethersulfone synthesize film, and pore size is 0.2～15 μ m, and thickness is 50-250 μ m.Dyestuff is bromcresol green or bromcresol purple, and content is 0.05%～1%, and the damping fluid using is succinic acid damping fluid, and pH is 4.2, and concentration is 0.1mol/L～1mol/L, and surfactant is polyoxyethylene laurel ether, and content is 1%～5%.
For albumin content in quantitative measurement blood, can use the baffled photometer supporting with dry chemical scrip of the present invention to test.This instrument can be controlled at temperature of reaction 37 ± 0.5 ℃, and mensuration wavelength is 630nm, reaches and sets after the reaction time, instrument reads reflection density automatically, and by built-in typical curve, light signal is converted into albumin concentration, and automatically report and stores test results, and printable.
Accompanying drawing explanation
Fig. 1 is drying chemical reagent paper structural diagrams of the present utility model.
Fig. 2 is drying chemical reagent paper structure elucidation figure of the present utility model.
Number in the figure: 1 is test section, 2 is holding area, and 3 is upper supporting layer, and 4 is lower supporting layer, and 5 is diffusion layer, and 6 is responding layer, and 7 is well, and 8 is instrument connection.
Embodiment
embodiment 1:
Upper and lower supporting layer material adopts polyethylene terephthalate material, and thickness is 0.18mm, and length is 20cm, and width is 20cm.Wherein go up lower supporting layer one side with viscose glue.At one end get respectively well and instrument connection, bore dia is 4 mm, pitch-row 8mm.
The preparation of diffusion layer: diffusion layer adopts nylon net cloth is soaked screen cloth 5 minutes in 1% Triton X-100 aqueous solution, in 45 degree baking ovens, is dried 30 minutes, and the screen cloth of handling well is pasted to the well position at upper supporting layer.
The preparation of responding layer: responding layer adopts polysulfone membrane, and polysulfone membrane is pasted to the instrument connection position at lower supporting layer.The reactant liquor preparing is added drop-wise in polysulfone membrane to 5 μ l/ holes.The responding layer that was coated with reagent is put into 45 degree drying boxes, after 60 minutes, take out, edge that it is alignd with the diffusion layer preparing is bonded together.With hobboing cutter machine, it cuts into the wide test strips of 8mm, puts into drying.
The formula of reactant liquor reagent is as follows:
Succinic acid damping fluid 0.5mol/l
Bromcresol green 0.2%
Polyoxyethylene laurel ether 3%
The albumin sample of test variable concentrations, drips 5 μ l test sample books in well, with baffled photometer, measures, and the test duration is 1 minute.
。
embodiment 2:
Upper and lower supporting layer material adopts polystyrene material, and thickness is respectively 0.11mm and 0.18mm, and length is 20cm, and width is 20cm.Wherein go up lower supporting layer one side with viscose glue.At one end get respectively well and instrument connection, bore dia is 5mm, pitch-row 8mm.
The preparation of diffusion layer: diffusion layer adopts tygon screen cloth is soaked screen cloth 10 minutes in 0.5% polysorbate aqueous solution, in 45 degree baking ovens, is dried 30 minutes, and the screen cloth of handling well is pasted to the well position at upper supporting layer.
The preparation of responding layer: responding layer adopts the synthetic film of polyethersulfone, pastes the instrument connection position at lower supporting layer by the synthetic film of polyethersulfone.The reactant liquor preparing is added drop-wise on the synthetic film of polyethersulfone to 5 μ l/ holes.The responding layer that was coated with reagent is put into 45 degree drying boxes, after 60 minutes, take out, edge that it is alignd with the diffusion layer preparing is bonded together.With hobboing cutter machine, it cuts into the wide test strips of 8mm, puts into drying.
The formula of reactant liquor reagent is as follows:
Succinic acid damping fluid 0.2mol/l
Bromcresol green 0.15%
Polyoxyethylene laurel ether 2%
The albumin sample of test variable concentrations, is added on well by 5 μ l sample drop, with baffled photometer, measures, and reads the OD value at 1min place.
。
Claims (3)
1. a drying chemical reagent paper for quantitatively determining human blood albumin content, is characterized in that for long strips, and one end is test section, and the other end is handheld terminal; The formation of test section is upper supporting layer, diffusion layer from top to bottom successively, be coated with responding layer and the lower supporting layer of measuring the required reagent of albumin; Wherein, the regional location corresponding to diffusion layer and responding layer in upper supporting layer, lower supporting layer has circular hole, and the circular hole on upper supporting layer is well, and the circular hole on lower supporting layer is instrument connection.
2. drying chemical reagent paper according to claim 1, is characterized in that described reaction tunic selects polysulfones or the synthetic film of polyethersulfone, and the pore size of this film is 0.2～15 μ m, and thickness is 50-250 μ m.
3. drying chemical reagent paper according to claim 1, is characterized in that described diffusion layer adopts nylon, tygon or polyacrylic screen cloth form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320792112.6U CN203758917U (en) | 2013-12-03 | 2013-12-03 | Dry chemistry test paper for quantitatively measuring content of albumins in human body blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320792112.6U CN203758917U (en) | 2013-12-03 | 2013-12-03 | Dry chemistry test paper for quantitatively measuring content of albumins in human body blood |
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| Publication Number | Publication Date |
|---|---|
| CN203758917U true CN203758917U (en) | 2014-08-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320792112.6U Expired - Lifetime CN203758917U (en) | 2013-12-03 | 2013-12-03 | Dry chemistry test paper for quantitatively measuring content of albumins in human body blood |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203758917U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108463726A (en) * | 2016-01-15 | 2018-08-28 | 帝斯曼知识产权资产管理有限公司 | The method for testing and analyzing object |
| CN109632774A (en) * | 2018-11-22 | 2019-04-16 | 广州万孚生物技术股份有限公司 | Dry chemical detection sensor and preparation method thereof |
-
2013
- 2013-12-03 CN CN201320792112.6U patent/CN203758917U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108463726A (en) * | 2016-01-15 | 2018-08-28 | 帝斯曼知识产权资产管理有限公司 | The method for testing and analyzing object |
| CN109632774A (en) * | 2018-11-22 | 2019-04-16 | 广州万孚生物技术股份有限公司 | Dry chemical detection sensor and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140806 |