CN203705185U - Tissue chip sampler - Google Patents
Tissue chip sampler Download PDFInfo
- Publication number
- CN203705185U CN203705185U CN201320883304.8U CN201320883304U CN203705185U CN 203705185 U CN203705185 U CN 203705185U CN 201320883304 U CN201320883304 U CN 201320883304U CN 203705185 U CN203705185 U CN 203705185U
- Authority
- CN
- China
- Prior art keywords
- hollow tube
- sampling
- tissue chip
- syringe needle
- chip sampler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000005070 sampling Methods 0.000 claims abstract description 40
- 239000007787 solid Substances 0.000 claims abstract description 5
- 230000000694 effects Effects 0.000 claims description 7
- 239000003086 colorant Substances 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 abstract 3
- 230000008520 organization Effects 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 3
- 239000001993 wax Substances 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 238000002493 microarray Methods 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model discloses a tissue chip sampler. The tissue chip sampler comprises a hollow tube body, wherein the upper end of the hollow tube body is connected with a tube cap. The tissue chip sampler is characterized in that the lower part in the hollow tube body is equipped with a front cavity by a blocking ring; the lower end of the hollow tube body is connected with a sampling assembly capable of being changed; the sampling assembly comprises a needle head base, wherein a hollow sampling needle head with a certain diameter is fixed on the center of the needle head base; a solid movable needle core capable of sliding up and down along the inner wall of the sampling needle head is sleeved with the sampling needle head; a circular table is arranged at the upper end of the movable needle core and placed in a front cavity of the hollow tube body; a pushing rod capable of being reset is arranged in the cavity in the upper part of the blocking ring of the hollow tube body; the upper end of the pushing rod is connected with a button outside the tube cap; the lower end of the pushing rod gets through the blocking ring and enters the front cavity, and is aligned to the upper end of the circular table of the movable needle core.
Description
Technical field
The utility model relate to a kind of in clinical medicine and scientific experiment for making the device of organization chip.
Background technology
Organization chip (tissue microarray, TMA), is called again micro-array tissue, belongs to a kind of novel special biochip, is the research tool of a kind of high flux, multisample.It by dozens of even the tissue specimen of thousands of Different Individual be integrated on a solid phase carrier, for Medical Molecular Biology provides a kind of high flux, large sample and the analysis tool of molecular level fast.In this technology, nucleus equipment is organized post sampler exactly, but current domestic the used many dependence on import of organization chip instrument, instrument is expensive, is not applicable to promoting the use of.And the development and production of domestic pertinent instruments are also impracticable, sampling syringe needle can not be changed, and is inconvenient to make the organization chip that different-diameter requires, and has therefore seriously restricted the development of organization chip experimental technique.
Summary of the invention
In order to solve the problem of the complicated and sampling poor effect of existing sampler design in making of organization chip described in background technology, the utility model provides a kind of tissue chip sampler of replaceable sampling syringe needle, its have simple in structure, easy to operate, be easy to carry about with one, with low cost, time saving and energy saving feature.Can accurately control the size of sampling tissue and ensure the integrality of organizing post of getting simultaneously.
For reaching above object, the utility model takes following technical scheme to be achieved:
A kind of tissue chip sampler, comprise hollow tube, upper end is connected with pipe cap, it is characterized in that, the bottom in hollow tube is equipped with an ante-chamber by a screens, hollow tube lower end connects a removable sampling assemble, this sampling assemble comprises a needle holder, and its center fixedly has the hollow sampling syringe needle of certain diameter, and in sampling syringe needle, cover has the solid active needle core that can slide up and down along its inwall, this active needle core upper end is a round platform, and is placed in the ante-chamber of hollow tube; In the cavity on hollow tube screens ring top, be provided with reducible push rod, push rod upper end connects the button outside pipe cap, and lower end enters ante-chamber through screens ring, and the round platform upper end of alignment activity nook closing member.
In such scheme, described removable sampling assemble, its underpart is back taper, the fixing sampling in center syringe needle, needle holder top is cylinder internal thread, matches with hollow tube front end external thread.On the face of cylinder on described needle holder top, can reserve dismounting power-assisted blind hole 11.
Described sampling syringe needle diameter is selected between 0.5mm ?5mm.The sampling syringe needle of different-diameter can adopt different colours to distinguish.
Described sampling syringe needle blade angle β is 85 ° of 5 ?.
Described reducible push rod is divided into two joints, and than upper joint carefully and longer, and cover has back-moving spring, back-moving spring one end to support on push rod, to save lower end lower joint, and the other end supports the screens ring place of bottom in hollow tube.
The lower end periphery of described hollow tube can be provided with supporting retainer handle.
The utility model has the advantages that, all component is all quick detachable, and can directly be placed in the organic solvents such as dimethylbenzene and clean, and convenient for maintaining.And simple structure, facilitates one-handed performance, organize post complete.Sampling syringe needle is detachably changed, and diameter is 0.5mm-5mm, can meet organization chip completely different-diameter is organized the requirement of post.
Brief description of the drawings
Below in conjunction with the drawings and specific embodiments, the utility model is described in further detail.
Fig. 1 is structural representation of the present utility model.
Fig. 2 samples syringe needle assembly assumption diagram in Fig. 1.
Fig. 3 is active needle core structural drawing in Fig. 1.
Fig. 4 is the A portion enlarged drawing in Fig. 2.
In Fig. 1 to Fig. 2: 1. sampling syringe needle (hollow), 2. active needle core (solid), 3. hollow tube, 4. screens ring, 5. push rod, 6. back-moving spring, 7. pipe cap, 8. button, 9. ante-chamber, 10. gear handle, 11. power-assisted blind holes, 12. needle holder.
Embodiment
With reference to figure 1 ?Fig. 3, a kind of tissue chip sampler for destination organization sampling, comprises hollow tube 3, and outside, rear end (upper end) is provided with screw thread and can be spirally connected with pipe cap 7; Front end (lower end) is provided with screw thread and can be spirally connected with sampling assemble, and sampling assemble comprises a needle holder 12, and its underpart is back taper, and center fixedly has the hollow sampling syringe needle 1 of certain diameter; Needle holder top is cylinder internal thread, can conveniently connect hollow tube front end.In sampling syringe needle 1, cover has solid active needle core 2 to slide up and down along sampling syringe needle inwall; Active needle core 2 is a pin shape (Fig. 3), and its upper end is a round platform, and is placed in the ante-chamber 9 of hollow tube 3 interior bottoms.In hollow tube 3, be provided with push rod 5, be divided into two joints, upper joint connects the button 8 outside pipe cap, lower joint than upper joint carefully and longer, and cover has back-moving spring 6, back-moving spring 6 one end support and on push rod, save lower end, the other end supports screens ring 4 places in hollow tube 3 interior bottoms, lower joint lower end enters ante-chamber 9 through screens ring 4, and the upper end of alignment activity nook closing member 2, in the time that syringe needle 1 front end inserts paraffin embedded tissues sampling, active needle core 2 is subject to wax stone resistance and shrinks back, paraffin organization enters into hollow needle 1, formative tissue wax post.Now, press the button 8, external force, by saving pressed home spring 6 on push rod, makes 5 times joint front ends of push rod push up active needle core 2 rear ends, thereby the wax post of organizing of clamp-oning in syringe needle 1 is easily released, release button 8, and push rod 5 will automatically reset under the effect of spring.
Sampling syringe needle 1 can be spirally connected and be convenient for changing by the cylinder internal thread of needle holder 12 and hollow tube front end, can reserve dismounting power-assisted blind hole 11 on the face of cylinder on needle holder top.Syringe needle diameter can be 0.5mm-5mm, and sample length is 1-20mm, can accurately control the get diameter of organizing post.Different sampling syringe needles can be made into multiple color, to distinguish different-diameter, are used for making the organization chip post sample of different sizes.
With reference to figure 4, the cutting edge of sampling syringe needle 1 is through annular polishing, and cutting edge is sharp, and that takes out organizes post neat in edge.Blade angle β can be 5-85 °.
Sampler hollow tube front end periphery can be provided with gear 10, and its effect has the strong point while being sampling.
Sampler hollow tube outer surface can be designed to cylinder groove structure, can improve frictional resistance and outward appearance aesthetic effect while use, and arc groove quantity is 3-8, and the degree of depth is 0.1-1mm.Can adopt the materials such as titanium, titanium alloy, steel, aluminium and aluminium alloy to make.
Claims (8)
1. a tissue chip sampler, comprise hollow tube, upper end is connected with pipe cap, it is characterized in that, the bottom in hollow tube is equipped with an ante-chamber by a screens, hollow tube lower end connects a removable sampling assemble, this sampling assemble comprises a needle holder, and its center fixedly has the hollow sampling syringe needle of certain diameter, and in sampling syringe needle, cover has the solid active needle core that can slide up and down along its inwall, this active needle core upper end is a round platform, and is placed in the ante-chamber of hollow tube; In the cavity on hollow tube screens ring top, be provided with reducible push rod, push rod upper end connects the button outside pipe cap, and lower end enters ante-chamber through screens ring, and the round platform upper end of alignment activity nook closing member.
2. tissue chip sampler as claimed in claim 1, is characterized in that, described removable sampling assemble, and its underpart is back taper, the fixing sampling in center syringe needle, needle holder top is cylinder internal thread, matches with hollow tube front end external thread.
3. tissue chip sampler as claimed in claim 2, is characterized in that, described sampling syringe needle diameter is selected between 0.5mm ?5mm.
4. tissue chip sampler as claimed in claim 3, is characterized in that, the sampling syringe needle of different-diameter adopts different colours to distinguish.
5. tissue chip sampler as claimed in claim 2, is characterized in that, reserved dismounting power-assisted blind hole (11) on the face of cylinder on needle holder top.
6. tissue chip sampler as claimed in claim 1, is characterized in that, described sampling syringe needle blade angle β is 85 ° of 5 ?.
7. tissue chip sampler as claimed in claim 1, is characterized in that, described reducible push rod is divided into two joints, lower joint than upper joint carefully and longer, and cover has back-moving spring, back-moving spring one end to support to save lower end on push rod, the other end supports the screens ring place of bottom in hollow tube.
8. tissue chip sampler as claimed in claim 1, is characterized in that, the lower end periphery of described hollow tube is provided with supporting retainer handle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320883304.8U CN203705185U (en) | 2013-12-27 | 2013-12-27 | Tissue chip sampler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320883304.8U CN203705185U (en) | 2013-12-27 | 2013-12-27 | Tissue chip sampler |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203705185U true CN203705185U (en) | 2014-07-09 |
Family
ID=51055607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320883304.8U Expired - Fee Related CN203705185U (en) | 2013-12-27 | 2013-12-27 | Tissue chip sampler |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203705185U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103743588A (en) * | 2013-12-27 | 2014-04-23 | 中国人民解放军第四军医大学 | Tissue chip sampler |
-
2013
- 2013-12-27 CN CN201320883304.8U patent/CN203705185U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103743588A (en) * | 2013-12-27 | 2014-04-23 | 中国人民解放军第四军医大学 | Tissue chip sampler |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140709 |