CN203613127U - Avermectin benzoate production system - Google Patents
Avermectin benzoate production system Download PDFInfo
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- CN203613127U CN203613127U CN201320849974.8U CN201320849974U CN203613127U CN 203613127 U CN203613127 U CN 203613127U CN 201320849974 U CN201320849974 U CN 201320849974U CN 203613127 U CN203613127 U CN 203613127U
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- discharging pipeline
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Abstract
The utility model relates to an avermectin benzoate production system which is characterized in that a discharging pipeline at the tower bottom of a reaction kettle is connected with the tower top of an esterification reaction stop kettle; a discharging pipeline at the tower bottom of the esterification reaction stop kettle is connected with a test mirror, a discharging pipeline at the lower part of the test mirror is divided into two parts, the two parts are connected with an organic phase liquid transfer tank and an aqueous phase liquid transfer tank respectively, and a discharging pipeline at the tower bottom of the organic phase liquid transfer tank is connected with the tower top of a freeze dehydration kettle; the tower bottom of the freeze dehydration kettle is connected with the tower top of a deprotection reaction kettle, and a discharging pipeline at the tower bottom of the deprotection reaction kettle is connected with the tower top of a washing kettle; a discharging pipeline at the tower bottom of the washing kettle is connected with a test mirror, and a discharging pipeline at the lower part of the test mirror is connected with a wastewater tank and a rear organic phase liquid transfer tank respectively; a discharging pipeline at the tower bottom of the rear organic phase liquid transfer tank is connected with a distillation kettle, and a discharging pipeline at the tower top of the distillation kettle is connected with a condenser. According to the avermectin benzoate production system, a simple and perfect reactor is provided for synthesizing novel avermectin benzoate derivatives.
Description
Technical field
The utility model relates to the production system of a kind of avermectin derivatives in biological technical field, particularly a kind of Avrmectin benzoic ether production system.
Background technology
Avrmectin (Avermectin is called for short AVM) belongs to macrolides antibiotics insecticidal/acaricidal agent, is the fermentating metabolism product of soil microorganisms streptomyces griseus element.Can effectively prevent and treat Diptera, Homoptera, Coleoptera and lepidoptera pest and multiple harmful mite, particularly have drug-fast harmful mite and insect to there is excellent effect to common pesticides.
But along with the universal of Avrmectin and derived product thereof in recent years with promote, its resistance is also more and more obvious, add the thermal destruction of Avrmectin own and photodegradation very serious, the lasting period is short, more and more less than its advantage of chemical pesticide.Therefore, in recent years Avrmectin is carried out to modification and become extremely urgent developing direction, we are devoted to the target of Development of Novel environmental protection, green, Sustainable development agricultural chemicals, through great many of experiments, obtained a kind of Novel Abamectin benzoic acid ester compounds with and synthetic method.Therefore for this synthetic method, we have proposed a set of Avrmectin benzoic ether production system that is applicable to production.
Summary of the invention
Technical problem to be solved in the utility model is to overcome the problem existing in background technology, and a kind of Avrmectin benzoic ether production system is provided.This Avrmectin benzoic ether production system is the production equipment of a new rational feasibility, enables to reach the needs that meet scale operation.
The invention for solving the technical problem can reach by following technical solution: this Avrmectin benzoic ether production system, comprise C-5 protection and C-4 reaction kettle of the esterification, described reactor tower top connects feeding line, and the discharging pipeline connecing at the bottom of tower connects esterification and stops still tower top; Esterification stops discharging pipeline at the bottom of still tower and is connected with one and shows on trial, and the discharging pipeline of the bottom of showing on trial is divided into two portions, and two portions discharging pipeline connects respectively organic phase and falls flow container and water and fall flow container, and organic phase is fallen flow container and the water top of falling flow container and is connected to respectively valve; The organic phase tower of falling flow container end discharging pipeline connects lyophilization still tower top; Lyophilization still tower bottom tube line connects deprotection reaction still tower top, and the discharging pipeline at the bottom of deprotection reaction still tower connects washing kettle tower top; At the bottom of washing kettle tower, discharging pipeline has one to show on trial repeatedly, and the discharging pipeline of the bottom of showing on trial is divided into two portions, and two portions discharging pipeline is connected with respectively waste water tank and rear organic phase and falls flow container; Described waste water tank and the rear organic phase top of falling flow container are connected to respectively valve; The discharging pipeline at the rear organic phase tower of the falling flow container end connects still kettle, and the discharging pipeline of still kettle tower top connects condenser; The discharging pipeline of condenser connects recovery solvent tank.
The utility model is compared and can be had following beneficial effect with above-mentioned background technology: this Avrmectin benzoic ether production system is owing to adopting above-mentioned flow process, be Avrmectin benzoic ether new reasonably, have the production equipment of feasibility, enable to reach the needs that meet scale operation.
Accompanying drawing explanation
Accompanying drawing 1 is system flowchart of the present utility model.
In figure: 1-reactor; 2-esterification stops still; 3-organic phase is fallen flow container; 4-water falls flow container; 5-lyophilization still; 6-deprotection reaction still; 7-washing kettle; 8-waste water tank; After 9-, organic phase is fallen flow container; 10-still kettle; 11-condenser; 12-reclaims solvent tank.
embodiment:
Below in conjunction with accompanying drawing, the utility model is described in further detail:
The invention for solving the technical problem can reach by following technical solution: this Avrmectin benzoic ether production system, comprise C-5 protection and C-4 reaction kettle of the esterification 1, and at the bottom of described reactor 1 tower, pick out material pipeline; Described discharging pipeline connects esterification and stops still 2 tower tops; Esterification stops connecting discharging pipeline at the bottom of still 2 towers, discharging pipeline is connected with one and shows on trial, the discharging pipeline of bottom of showing on trial is divided into two portions, and two portions discharging pipeline connects respectively organic phase and falls flow container 3 and water and fall flow container 4, and organic phase is fallen flow container 3 and water and fallen flow container 4 tops and be connected to respectively valve; Organic phase is fallen and is connected discharging pipeline at the bottom of flow container 3 towers, and discharging pipeline connects lyophilization still 5 tower tops; At the bottom of lyophilization still 5 towers, connect deprotection reaction still 6 tower tops, connect discharging pipeline at the bottom of deprotection reaction still 6 towers, discharging pipeline connects washing kettle 7 tower tops; At the bottom of washing kettle 7 towers, discharging pipeline has one to show on trial repeatedly, and the discharging pipeline of the bottom of showing on trial is divided into two portions, and two portions discharging pipeline is connected with respectively waste water tank 8 and rear organic phase and falls flow container 9; Described waste water tank 8 and rear organic phase are fallen flow container 9 tops and are connected to respectively valve; Rear organic phase is fallen and is connected discharging pipeline at the bottom of flow container 9 towers, and discharging pipeline connects still kettle 10, and still kettle 10 tower tops connect discharging pipelines, and discharging pipeline connects condenser 11; Condenser 11 connects discharging pipeline, and discharging pipeline connects recovery solvent tank 12; Described C-5 protection and C-4 reaction kettle of the esterification 1, esterification stop still 2, lyophilization still 5, deprotection reaction still 6, washing kettle 7 and still kettle 10 and are all connected to whipping appts; At the bottom of freezing C-5 protection and C-4 reaction kettle of the esterification 1, dehydrating kettle 5, deprotection reaction still 6 towers, on discharging pipeline, be connected with valve.
Claims (2)
1. an Avrmectin benzoic ether production system, comprises C-5 protection and C-4 reaction kettle of the esterification (1), it is characterized in that: the discharging pipeline at the bottom of described reactor (1) tower connects esterification and stops still (2) tower top; Discharging pipeline at the bottom of esterification termination still (2) tower is connected with one and shows on trial, the discharging pipeline of bottom of showing on trial is divided into two portions, two portions discharging pipeline connects respectively organic phase and falls flow container (3) and water and fall flow container (4), and organic phase is fallen flow container (3) and water and fallen flow container (4) top and be connected to respectively valve; Organic phase is fallen discharging pipeline at the bottom of flow container (3) tower and is connected lyophilization still (5) tower top; Lyophilization still (5) tower bottom tube line connects deprotection reaction still (6) tower top, and the discharging pipeline at the bottom of deprotection reaction still (6) tower connects washing kettle (7) tower top; At the bottom of washing kettle (7) tower, discharging pipeline has one to show on trial repeatedly, and the discharging pipeline of the bottom of showing on trial is divided into two portions, and two portions discharging pipeline is connected with respectively waste water tank (8) and rear organic phase and falls flow container (9); Described waste water tank (8) and rear organic phase are fallen flow container (9) top and are connected to respectively valve; The discharging pipeline that rear organic phase is fallen at the bottom of flow container (9) tower connects still kettle (10), and the discharging pipeline of still kettle (10) tower top connects condenser (11); The discharging pipeline of condenser (11) connects recovery solvent tank (12).
2. according to a kind of Avrmectin benzoic ether production system described in claim 1, it is characterized in that: described C-5 protection and C-4 reaction kettle of the esterification (1), esterification stop still (2), lyophilization still (5), deprotection reaction still (6), washing kettle (7) and still kettle (10) and be all connected to whipping appts; At the bottom of freezing C-5 protection and C-4 reaction kettle of the esterification (1), dehydrating kettle (5), deprotection reaction still (6) tower, on discharging pipeline, be connected with valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320849974.8U CN203613127U (en) | 2013-12-23 | 2013-12-23 | Avermectin benzoate production system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320849974.8U CN203613127U (en) | 2013-12-23 | 2013-12-23 | Avermectin benzoate production system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203613127U true CN203613127U (en) | 2014-05-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320849974.8U Expired - Fee Related CN203613127U (en) | 2013-12-23 | 2013-12-23 | Avermectin benzoate production system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203613127U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105461771A (en) * | 2015-12-30 | 2016-04-06 | 内蒙古嘉宝仕生物科技股份有限公司 | Emamectin benzoate preparation system |
-
2013
- 2013-12-23 CN CN201320849974.8U patent/CN203613127U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105461771A (en) * | 2015-12-30 | 2016-04-06 | 内蒙古嘉宝仕生物科技股份有限公司 | Emamectin benzoate preparation system |
| CN105461771B (en) * | 2015-12-30 | 2019-02-12 | 内蒙古嘉宝仕生物科技股份有限公司 | Emamectin benzoate preparation system |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140528 Termination date: 20141223 |
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| EXPY | Termination of patent right or utility model |