CN203556300U - Device for simulating oral dissolution of oral product - Google Patents
Device for simulating oral dissolution of oral product Download PDFInfo
- Publication number
- CN203556300U CN203556300U CN201320696430.2U CN201320696430U CN203556300U CN 203556300 U CN203556300 U CN 203556300U CN 201320696430 U CN201320696430 U CN 201320696430U CN 203556300 U CN203556300 U CN 203556300U
- Authority
- CN
- China
- Prior art keywords
- storage cup
- solvent
- oral
- solvent storage
- dissolution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004090 dissolution Methods 0.000 title abstract description 12
- 239000013588 oral product Substances 0.000 title abstract 3
- 229940023486 oral product Drugs 0.000 title abstract 3
- 239000002904 solvent Substances 0.000 claims abstract description 50
- 239000000203 mixture Substances 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 210000000214 mouth Anatomy 0.000 abstract description 2
- 238000011160 research Methods 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract 1
- 210000000887 face Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 231100000041 toxicology testing Toxicity 0.000 description 2
- 235000019504 cigarettes Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Images
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model provides a device for simulating oral dissolution of an oral product, and belongs to the technical research field of an experimental apparatus. The device consists of an adjustable solvent storage cup and a vessel used for simulating the oral dissolution and arranged below the adjustable solvent storage cup, wherein the adjustable solvent storage cup consists of a solvent storage cup (2), a cup cover (1) arranged at the upper end of the solvent storage cup (2), a solvent drainage tube (3) below the solvent storage cup (2), a first flow control valve (4) and a second flow control valve (5); the vessel for simulating the oral dissolution consists of a sample groove (6) arranged inside the vessel, drainage inclined faces (7) arranged on the both sides of the sample groove (6) and a solution drainage tube (8). The device provided by the utility model has the beneficial effects that the solvent is in a quantitative and continuous flowing state by simulating a dissolution manner of the oral product in an oral cavity; a sample is not entirely soaked in the solvent; with the effect being similar with an oral state, different dissolving rates and dissolution amounts of samples at different dissolving time can be truly reflected..
Description
Technical field:
The utility model relates to a kind of for sucking the device of the Mouthsimulator stripping of type goods, belongs to laboratory apparatus technical research field.
Background technology:
No matter food, medicine or medical equipment, before listing, it is carried out to the necessary links that toxicological evaluation has become security management and control, when in to food, this class such as candy, lozenge is sucked type goods and is carried out sample preparation, conventionally adopt and directly soak the method for dissolving after dissolving or grinding, while utilizing the method to carry out stripping to being dissolved in the goods of solvent completely as candy etc., the sample stripping liquid concentration obtaining is constant, can not truly reflect the difference of rate of dissolution under the different dissolution times of sample; In addition, while utilizing the method to carry out stripping to can not consoluetly sucking type goods as sucked cigarette etc., goods are directly soaked in solvent, this and actually suck goods soaking state of living under state and have notable difference, cause testing stripping quantity and can not truly reflect actual stripping quantity.Target sample is as the actual dissolved state of simulation substance preferably, and what will affect toxicological evaluation result can referential.
Summary of the invention:
The purpose of this utility model is exactly for the deficiencies in the prior art, provides a kind of for sucking the device of the Mouthsimulator stripping of type goods.
Adjustable solvent storage cup of the present utility model is utilized pressure differential to control solvent by adjustable control valve and is entered Mouthsimulator stripping ware with given pace, goods are positioned in the sample cell of Mouthsimulator stripping ware, between sample cell and horizontal plane, inclination angle is 15 degree, owing to can only storing limited solvent in sample cell, when solvent continues to flow into Mouthsimulator stripping ware sample cell in solvent storage cup, the solvent first flowing into will flow out and be collected along conduit.
Dissolving device of the present utility model is by adjustable solvent storage cup, and Mouthsimulator stripping ware two parts that are placed in below adjustable solvent storage cup form; Wherein: adjustable solvent storage cup consists of solvent storage cup (2), the bowl cover (1) that is placed in solvent storage cup (2) upper end, the solvent drainage tube (3) that is placed in solvent storage cup (2) below and first flow control valve (4) and second control valve (5); Mouthsimulator stripping ware forms by being placed in the sample cell (6) of stripping ware, the drainage inclined plane (7) that is placed in sample cell (6) both sides and solution drainage tube (8).
The utility model adopts glass material to make according to a conventional method.All can carry out reusing after the conventional high temperature in laboratory, autoclave sterilization processing.
The beneficial effects of the utility model are: by simulation, suck the stripping form of type goods in oral cavity, solvent is in quantitatively continuing flow regime, and sample is not soaked in solvent completely, collects the pre-treatment sample obtaining and can reflect more really different rate of dissolution and the stripping quantities of sample under different dissolution times.
Accompanying drawing explanation:
Fig. 1 is structural representation of the present utility model.
The specific embodiment:
As shown in Figure 1, of the present utility model a kind of for the device of Mouthsimulator stripping of sucking type goods by adjustable solvent storage cup, and Mouthsimulator stripping ware two parts that are placed in adjustable solvent storage cup below form; Wherein: adjustable solvent storage cup consists of solvent storage cup 2, the bowl cover 1 that is placed in solvent storage cup 2 upper ends, the solvent drainage tube 3 that is placed in solvent storage cup 2 belows and first flow control valve 4 and second control valve 5; Mouthsimulator stripping ware forms by being placed in the sample cell 6 of stripping ware, the drainage inclined plane 7 that is placed in sample cell 6 both sides and solution drainage tube (8).Eight parts all adopt glass material to make according to a conventional method.
Use procedure of the present utility model is as follows:
1. before using, open bowl cover 1 a little solvent is injected in solvent storage cup 2, open after first flow control valve 4, more slowly open second control valve 5, solvent flow rate is controlled under required flow rate;
2. close first flow control valve 4, second control valve 5 is held open;
3. inject a certain amount of solvent to solvent storage cup 2, cover bowl cover 1, reopen first flow control valve 4;
4. solvent enters Mouthsimulator stripping ware by solvent drainage tube 3, contacts with sample to be dissolved in sample cell 6, along with the interior original solution of continuous inflow sample cell 6 of novel solvent overflows gradually, along drainage inclined plane 7, flows down, and through solution drainage tube 8, flows out.By experiment demand, can collect stage by stage, solvent is in quantitatively continuing flow regime, and sample is not soaked in solvent completely, collects the pre-treatment sample obtaining and can reflect more really different rate of dissolution and the stripping quantities of sample under different dissolution times.
Claims (1)
1. for sucking a device for the Mouthsimulator stripping of type goods, it is characterized in that this device is by adjustable solvent storage cup, and be placed in the Mouthsimulator stripping ware two parts compositions of adjustable solvent storage cup below; Wherein: adjustable solvent storage cup consists of solvent storage cup (2), the bowl cover (1) that is placed in solvent storage cup (2) upper end, the solvent drainage tube (3) that is placed in solvent storage cup (2) below and first flow control valve (4) and second control valve (5); Mouthsimulator stripping ware forms by being placed in the sample cell (6) of stripping ware, the drainage inclined plane (7) that is placed in sample cell (6) both sides and solution drainage tube (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320696430.2U CN203556300U (en) | 2013-11-06 | 2013-11-06 | Device for simulating oral dissolution of oral product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320696430.2U CN203556300U (en) | 2013-11-06 | 2013-11-06 | Device for simulating oral dissolution of oral product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203556300U true CN203556300U (en) | 2014-04-23 |
Family
ID=50506054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320696430.2U Expired - Lifetime CN203556300U (en) | 2013-11-06 | 2013-11-06 | Device for simulating oral dissolution of oral product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203556300U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104698141A (en) * | 2015-03-25 | 2015-06-10 | 川渝中烟工业有限责任公司 | Device for simulating oral dissolution of gum-base tobacco product |
| CN106770246A (en) * | 2016-12-26 | 2017-05-31 | 重庆中烟工业有限责任公司 | Nicotine detecting system in one tobacco articles dissolution fluid |
-
2013
- 2013-11-06 CN CN201320696430.2U patent/CN203556300U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104698141A (en) * | 2015-03-25 | 2015-06-10 | 川渝中烟工业有限责任公司 | Device for simulating oral dissolution of gum-base tobacco product |
| CN106770246A (en) * | 2016-12-26 | 2017-05-31 | 重庆中烟工业有限责任公司 | Nicotine detecting system in one tobacco articles dissolution fluid |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108072751B (en) | Fracturing fluid and reservoir interaction simulation experiment system and experiment method | |
| CN105842028B (en) | Cell block preparation facilities with pressurization, extract function | |
| CN202013341U (en) | External simulation dynamic release device for oral containing type tobacco | |
| CN203742571U (en) | Experimental device used for manufacturing foam for oil displacement under different pressure conditions | |
| CN206823229U (en) | Liquid feeding for textile inspection vibrates integrated apparatus | |
| CN202562790U (en) | Deoxygenization visual device of polymer solution | |
| CN203556300U (en) | Device for simulating oral dissolution of oral product | |
| EP4276440A3 (en) | Methods and apparatus for measuring aspiration pressure at low aspiration volumes | |
| CN104198662B (en) | The device of simulation buccal smokeless tobacco product oral cavity stripping and analogy method thereof | |
| CN102735589B (en) | Device for rapidly and accurately determining hydraulic conductivity of plants | |
| CN106570768B (en) | A kind of characterizing method that greenhouse tomato library is strong | |
| CN202126438U (en) | Automatic analyzer for platelets | |
| CN204988821U (en) | Special centrifuging tube of preparation cell piece | |
| CN105363239A (en) | Traditional Chinese medicine extraction device for detecting extraction rate in real time | |
| WO2014176167A3 (en) | Drug concentration from an oral fluid | |
| CN104181071A (en) | Method for detecting water absorption of cigarette filter | |
| CN201397216Y (en) | Fluid container leakage testing machine | |
| CN103131693A (en) | Separation method of rare cells in blood | |
| CN204479596U (en) | Medical science quality control system | |
| CN202735319U (en) | Device capable of rapidly and precisely determining hydraulic conductivity of plant | |
| CN203908836U (en) | Automatic device for preparing cell wax blocks | |
| CN204495684U (en) | A kind of blood sampling with a scale, blood sedimentation tube | |
| CN104459074B (en) | A kind of experimental technique measuring body eutrophication driving force factors | |
| CN203853099U (en) | Automatic fixed ice-bath device for low-temperature test | |
| CN105277721A (en) | Method for distinguishing honeysuckle from wild honeysuckle flowers |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140423 |
|
| CX01 | Expiry of patent term |