CN203379465U - Drug-carrying cutting balloon dilating catheter - Google Patents
Drug-carrying cutting balloon dilating catheter Download PDFInfo
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- CN203379465U CN203379465U CN201320196444.8U CN201320196444U CN203379465U CN 203379465 U CN203379465 U CN 203379465U CN 201320196444 U CN201320196444 U CN 201320196444U CN 203379465 U CN203379465 U CN 203379465U
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- Prior art keywords
- cutting balloon
- dilating catheter
- medicine carrying
- blade
- balloon dilating
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- Expired - Lifetime
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- 230000000916 dilatatory effect Effects 0.000 title claims abstract description 31
- 239000003814 drug Substances 0.000 claims abstract description 47
- 229940079593 drug Drugs 0.000 claims abstract description 18
- 208000037803 restenosis Diseases 0.000 claims abstract description 10
- 206010020718 hyperplasia Diseases 0.000 claims abstract description 6
- 239000011248 coating agent Substances 0.000 claims abstract 4
- 238000000576 coating method Methods 0.000 claims abstract 4
- 239000000463 material Substances 0.000 claims description 7
- 229910045601 alloy Inorganic materials 0.000 claims description 6
- 239000000956 alloy Substances 0.000 claims description 6
- 239000007769 metal material Substances 0.000 claims description 5
- 229910000510 noble metal Inorganic materials 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 230000001772 anti-angiogenic effect Effects 0.000 claims description 2
- 210000004204 blood vessel Anatomy 0.000 abstract description 8
- 230000003902 lesion Effects 0.000 abstract description 6
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 238000001125 extrusion Methods 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 6
- 206010060965 Arterial stenosis Diseases 0.000 description 5
- 231100000915 pathological change Toxicity 0.000 description 5
- 230000036285 pathological change Effects 0.000 description 5
- 230000002490 cerebral effect Effects 0.000 description 4
- 206010008118 cerebral infarction Diseases 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 201000006474 Brain Ischemia Diseases 0.000 description 3
- 206010008120 Cerebral ischaemia Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000002966 stenotic effect Effects 0.000 description 3
- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
- 229930012538 Paclitaxel Natural products 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 208000032109 Transient ischaemic attack Diseases 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 210000001627 cerebral artery Anatomy 0.000 description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 2
- 229960003957 dexamethasone Drugs 0.000 description 2
- 238000003618 dip coating Methods 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 229960001592 paclitaxel Drugs 0.000 description 2
- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 2
- 229960003912 probucol Drugs 0.000 description 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
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- 208000024172 Cardiovascular disease Diseases 0.000 description 1
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- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 206010058046 Post procedural complication Diseases 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 208000013527 cardiovascular neoplasm Diseases 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
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- 230000002085 persistent effect Effects 0.000 description 1
- 210000005077 saccule Anatomy 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
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- Materials For Medical Uses (AREA)
Abstract
The utility model relates to a cutting balloon dilating catheter with the surface carrying a drug. The cutting balloon dilating catheter comprises a cutting balloon dilating catheter body and a drug coating, wherein the cutting balloon dilating catheter body comprises a balloon of which the surface is provided with a plurality of blades, and the drug coating is coated on the surfaces of the balloon and the blades. By adopting the cutting balloon dilating catheter, plaque in blood vessels can be cut, full expansion can be realized, thus the extruded plaque can be well fitted with the arterial wall, therefore subsequent inflammation is reduced, and the rate of restenosis is lowered by the enlargement of the lumen. Furthermore, the drug coating can inhibit intimal hyperplasia on the inner surface of the blood vessels damaged by extrusion so as to reduce the rate of restenosis. The cutting balloon dilating catheter shows the superior characteristics especially for the curved complex lesion where a stent can not reach.
Description
Technical field
This novel medical instruments field that relates to, specifically, relate to the Cutting balloon dilating catheter that a kind of balloon surface is loaded with medicine.
Background technology
Cerebrovascular disease is all very high diseases of a kind of sickness rate, mortality rate and disability rate, is one of current mankind " three large killers " (cerebrovascular disease, cardiovascular disease and tumor).Cerebrovascular medium-sized artery stenosis or occlusion is to cause one of topmost reason of apoplexy.According to domestic 7 cities that complete and 21 province's rural area sacred disease Epidemiological study resulting estimates, the annual new apoplexy in the whole nation is 2,000,000 people approximately; Die from approximately 1,500,000 people of patients with cerebrovascular disease every year, survival number (comprising cured person) 600-700 ten thousand.In the patients with cerebrovascular disease of survival, approximately 3/4 disability in various degree, bring tremendous influence and burden to patient, family and society.
Cerebral arteries produces stenosis or occlusion, very easily causes transient ischemic attack (TIA) and death.And the main predisposing factors that produces pathological changes is due to three-hypers (hypertension, hyperlipidemia, hyperglycemia) disease on the one hand, moreover along with the increase at people's age, the blood vessel wall of human body artery inevitably there will be the atherosis arterial lumen that causes to narrow down gradually, even inaccessible when serious, cause cerebral ischemia or cerebral infarction.If the cerebral ischemia persistent period is long, the degree weight, will cause brain cell necrosis.Therefore check when slight cerebral ischemia attack is arranged and have or not cerebral arterial stenosis, the serious or plaque rupture if any stricture of artery, should consider the interventional therapy of cerebrovascular, guarantees health to remove a hidden danger.
Blood saccule expansion plasty and endovascular stent in Interventional Therapy of Cerebrovascular Disease are implanted a kind of very important means that plasty has become the treatment cerebral arterial stenosis, and demonstrate vitality with superioritys such as its wound are little, safe, indication is wide, postoperative complication is few in the treatment of ischemic cerebrovascular.But the support that support is implanted in plasty belongs to foreign body, if restenosis occurs in support, be difficult to treatment, moreover it is also higher to implant the plasty medical expense.In fact more prior is that official jargon is more very thin because cerebrovascular is more roundabout than the traveling of arteria coronaria blood vessel, and caliber changes greatly, and support often can not reach complicated narrow diseased region, and at this moment the balloon expandable plasty just becomes the primary treatment means.
Therefore, need to there is a kind of sacculus dilating catheter can expand fully stenotic lesion, can also prevent neointimal hyperplasia, restenosis rate be dropped to minimum, replace support to implant, obtain good curative effect.
novel content
A kind of Cutting balloon dilating catheter of medicine carrying comprises Cutting balloon catheter body and medication coat, and described Cutting balloon catheter body comprises sacculus, and the surface of described sacculus is provided with a plurality of blades, and at the described medication coat of the surface-coated of sacculus and blade.
To achieve these goals, this novelly provides following technical scheme:
A kind of Cutting balloon dilating catheter of medicine carrying, this foley's tube is the Cutting balloon structure: there is blade on the surface of described sacculus.
Preferably, described sacculus be shaped as cylindrical or conical.
Preferably, the blade shapes on the surface of described sacculus is triangle or wedge shape.
Preferably, the material of described blade is medical macromolecular materials or metal material.
Preferably, described metal material is medical stainless steel, cobalt-base alloys, titanium-base alloy, marmem or noble metal.
Preferably, the quantity of described blade can be three, four or five.
Preferably, described blade is for being evenly distributed on balloon surface
Preferably, being connected between described blade and sacculus can be the contact separation formula, can be also inserted.
Preferably, described medication coat is the medicine that suppresses neointimal hyperplasia, anti-angiogenic restenosis.
Preferably, the medicine of described medication coat is one or more in rapamycin (sirolimus), paclitaxel, blood vessel titanium element probucol, dexamethasone.
Preferably, described medication coat can be coated in the Cutting balloon outer surface by the mode of spraying or dip-coating.
Preferably, the Cutting balloon dilating catheter of described a kind of medicine carrying is for cerebrovascular, cardiovascular or peripheral blood vessel.
From above-mentioned technical scheme, can find out, in this new embodiment, the Cutting balloon dilating catheter of medicine carrying can be cut the speckle in blood vessel, can fully expand simultaneously, the extruding speckle just can carry out good laminating with arterial wall like this, not only reduced inflammatory reaction subsequently, the increase of tube chamber has also reduced restenosis rate; Moreover medication coat can suppress to be extruded the neointimal hyperplasia of impaired vascular inner surface, thereby also reduced restenosis rate.In the crooked complex lesions that especially can not arrive at support, demonstrate its superior characteristic.
The accompanying drawing explanation
In order to be illustrated more clearly in this new embodiment or technical scheme of the prior art, below will do simple introduction to the accompanying drawing of required use in embodiment or description of the Prior Art, obviously, these accompanying drawings are only some specific embodiment of the Cutting balloon dilating catheter of a kind of medicine carrying of putting down in writing of the application.This is novel include but not limited to following these.
Fig. 1 is cerebral arterial stenosis speckle schematic diagram;
Fig. 2 expands the stenotic lesion schematic diagram for the Cutting balloon dilating catheter of a kind of medicine carrying that this new embodiment provides;
The schematic diagram of Cutting balloon structure one broken section of the Cutting balloon dilating catheter of a kind of medicine carrying that Fig. 3 provides for this new embodiment;
The schematic diagram of Cutting balloon structure two broken sections of the Cutting balloon dilating catheter of a kind of medicine carrying that Fig. 4 provides for this new embodiment;
The local structural representation that amplifies in Cutting balloon transverse section that Fig. 5 provides for this new embodiment;
Local two structural representations that amplify in Cutting balloon transverse section that Fig. 6 provides for this new embodiment;
Cutting balloon transverse section one structural representation of a kind of medicine carrying that Fig. 7 provides for this new embodiment;
Cutting balloon transverse section two structural representations of a kind of medicine carrying that Fig. 8 provides for this new embodiment;
Cutting balloon transverse section three structural representations of a kind of medicine carrying that Fig. 9 provides for this new embodiment.
The specific embodiment
Novel in order further to understand this, below in conjunction with embodiment, this novel preferred version is described.These are described and just illustrate this novel feature and advantage, and unrestricted novel protection domain.
Refer to Fig. 2～Fig. 9,
The Cutting balloon dilating catheter 2 of this novel a kind of medicine carrying provided is that a kind of balloon surface scribbles medication coat with blade and with the sacculus outer surface;
In Fig. 3, cutting blade 21 is the contact separation formula with sacculus 22, the material of blade is medical macromolecular materials, the cervical region with the far and near end of sacculus is welded respectively at the two ends that connected mode is blade, between sacculus and blade, fit tightly, sacculus related blade when expansion is cut and is expanded the narrow speckle of pathological changes position like this;
In Fig. 4, cutting blade 21 is inserted with sacculus 22, and the material of blade is metal material, can be medical stainless steel, cobalt-base alloys, titanium-base alloy, marmem or noble metal etc.Blade is embedded on sacculus, and connecting technique can be welding, can be also gluing, and sacculus can be cut and expand the narrow speckle of pathological changes position by related blade when expansion like this;
The shape of cutting blade 21 adopts triangle, consults Fig. 5, also can adopt wedge shape, consults Fig. 6.Purpose is the narrow speckle of fly-cutting, is that sacculus can better be expanded the stenotic lesion place.
The quantity of described blade 21 can be three, four or five, consult Fig. 7, and Fig. 8, Fig. 9, blade is evenly distributed on balloon surface.
Consult Fig. 7, Fig. 8, Fig. 9, the surface of described balloon surface 22 and blade 21 all is loaded with medication coat 3.
Described medication coat 3 is one or more in rapamycin (sirolimus), paclitaxel, blood vessel titanium element probucol, dexamethasone.
Described medication coat can be coated in by the mode of spraying or dip-coating the surface of balloon surface 22 and blade 21.
In sum, the Cutting balloon 2 of this novel disclosed treatment cerebrovascular stenosis pathological changes, sacculus 22 surfaces are with blade 21, blade 21 can be cut the speckle in blood vessel, sacculus 22 can fully be expanded simultaneously, pushes like this speckle and just can carry out good laminating with arterial wall, rebuilds channel of blood flow, not only reduced inflammatory reaction subsequently, the increase of tube chamber has also reduced restenosis rate; Moreover medication coat 3 can suppress to be extruded the neointimal hyperplasia of impaired vascular inner surface, thereby also reduced restenosis rate.
This Novel main will be applicable to, in crooked complex lesions that support can not arrive, be particularly useful for cerebral arteries curved narrow pathological changes.Demonstrate its superior characteristic.
In this description, each embodiment adopts the mode of selection to describe, and what each embodiment stressed is and the difference of other embodiment that between each embodiment, identical similar part cross-references gets final product.
Claims (10)
1. the Cutting balloon dilating catheter of a medicine carrying, comprise Cutting balloon catheter body and medication coat, it is characterized in that: described Cutting balloon catheter body comprises sacculus, and the surface of described sacculus is provided with blade, and at the described medication coat of the surface-coated of sacculus and blade.
2. the Cutting balloon dilating catheter of medicine carrying as claimed in claim 1, it is characterized in that: the sacculus in described Cutting balloon catheter body is shaped as cylindrical or conical.
3. the Cutting balloon dilating catheter of medicine carrying as claimed in claim 1, it is characterized in that: the blade shapes of described balloon surface is triangle or wedge shape.
4. the Cutting balloon dilating catheter of medicine carrying as claimed in claim 1, it is characterized in that: the material of described blade is medical macromolecular materials or metal material.
5. the Cutting balloon dilating catheter of medicine carrying as claimed in claim 4, it is characterized in that: described metal material is medical stainless steel, cobalt-base alloys, titanium-base alloy, marmem or noble metal.
6. as the Cutting balloon dilating catheter of claim 1 or 3 described medicine carrying, it is characterized in that: the quantity of described blade is three, four or five.
7. the Cutting balloon dilating catheter of medicine carrying as claimed in claim 6, it is characterized in that: described blade is evenly distributed on balloon surface.
8. the Cutting balloon dilating catheter of medicine carrying as claimed in claim 1 is characterized in that: being connected between described blade and sacculus is contact separation formula or inserted.
9. the Cutting balloon dilating catheter of medicine carrying as claimed in claim 1, is characterized in that: described Cutting balloon dilating catheter outer surface coated medicament coating.
10. as the Cutting balloon dilating catheter of claim 1 or 9 described medicine carrying, it is characterized in that: described medication coat is the medicine that suppresses neointimal hyperplasia and/or anti-angiogenic restenosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320196444.8U CN203379465U (en) | 2013-04-18 | 2013-04-18 | Drug-carrying cutting balloon dilating catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320196444.8U CN203379465U (en) | 2013-04-18 | 2013-04-18 | Drug-carrying cutting balloon dilating catheter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203379465U true CN203379465U (en) | 2014-01-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320196444.8U Expired - Lifetime CN203379465U (en) | 2013-04-18 | 2013-04-18 | Drug-carrying cutting balloon dilating catheter |
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| CN (1) | CN203379465U (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230640A (en) * | 2013-04-18 | 2013-08-07 | 雅伦生物科技(北京)有限公司 | Medicine-carrying cutting balloon dilating catheter |
| CN107405475A (en) * | 2014-11-03 | 2017-11-28 | 开金血管有限公司 | The air bag of sawtooth |
| US10905863B2 (en) | 2016-11-16 | 2021-02-02 | Cagent Vascular, Llc | Systems and methods of depositing drug into tissue through serrations |
| CN113058135A (en) * | 2021-03-25 | 2021-07-02 | 哈尔滨医科大学 | Ball bag |
| US11123527B2 (en) | 2015-09-17 | 2021-09-21 | Cagent Vascular, Inc. | Wedge dissectors for a medical balloon |
| US11141573B2 (en) | 2008-03-21 | 2021-10-12 | Cagent Vascular, Inc. | Method for plaque serration |
| US11219750B2 (en) | 2008-03-21 | 2022-01-11 | Cagent Vascular, Inc. | System and method for plaque serration |
| US11369779B2 (en) | 2018-07-25 | 2022-06-28 | Cagent Vascular, Inc. | Medical balloon catheters with enhanced pushability |
| US11738181B2 (en) | 2014-06-04 | 2023-08-29 | Cagent Vascular, Inc. | Cage for medical balloon |
-
2013
- 2013-04-18 CN CN201320196444.8U patent/CN203379465U/en not_active Expired - Lifetime
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11141573B2 (en) | 2008-03-21 | 2021-10-12 | Cagent Vascular, Inc. | Method for plaque serration |
| US11529501B2 (en) | 2008-03-21 | 2022-12-20 | Gagent Vascular, Inc. | System and method for plaque serration |
| US11229777B2 (en) | 2008-03-21 | 2022-01-25 | Cagent Vascular, Inc. | System and method for plaque serration |
| US11219750B2 (en) | 2008-03-21 | 2022-01-11 | Cagent Vascular, Inc. | System and method for plaque serration |
| CN103230640A (en) * | 2013-04-18 | 2013-08-07 | 雅伦生物科技(北京)有限公司 | Medicine-carrying cutting balloon dilating catheter |
| US11738181B2 (en) | 2014-06-04 | 2023-08-29 | Cagent Vascular, Inc. | Cage for medical balloon |
| US11040178B2 (en) | 2014-11-03 | 2021-06-22 | Cagent Vascular, Llc | Serration balloon |
| US11298513B2 (en) | 2014-11-03 | 2022-04-12 | Cagent Vascular, Inc. | Serration balloon |
| CN107405475A (en) * | 2014-11-03 | 2017-11-28 | 开金血管有限公司 | The air bag of sawtooth |
| US11701502B2 (en) | 2014-11-03 | 2023-07-18 | Cagent Vascular, Inc. | Serration balloon |
| US11123527B2 (en) | 2015-09-17 | 2021-09-21 | Cagent Vascular, Inc. | Wedge dissectors for a medical balloon |
| US11266818B2 (en) | 2015-09-17 | 2022-03-08 | Cagent Vascular, Inc. | Wedge dissectors for a medical balloon |
| US11266819B2 (en) | 2015-09-17 | 2022-03-08 | Cagent Vascular, Inc. | Wedge dissectors for a medical balloon |
| US11717654B2 (en) | 2015-09-17 | 2023-08-08 | Cagent Vascular, Inc. | Wedge dissectors for a medical balloon |
| US11491314B2 (en) | 2015-09-17 | 2022-11-08 | Cagent Vascular Lac. | Wedge dissectors for a medical balloon |
| US10905863B2 (en) | 2016-11-16 | 2021-02-02 | Cagent Vascular, Llc | Systems and methods of depositing drug into tissue through serrations |
| US11369779B2 (en) | 2018-07-25 | 2022-06-28 | Cagent Vascular, Inc. | Medical balloon catheters with enhanced pushability |
| CN113058135A (en) * | 2021-03-25 | 2021-07-02 | 哈尔滨医科大学 | Ball bag |
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