CN103230640A - Medicine-carrying cutting balloon dilating catheter - Google Patents
Medicine-carrying cutting balloon dilating catheter Download PDFInfo
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- CN103230640A CN103230640A CN2013101351284A CN201310135128A CN103230640A CN 103230640 A CN103230640 A CN 103230640A CN 2013101351284 A CN2013101351284 A CN 2013101351284A CN 201310135128 A CN201310135128 A CN 201310135128A CN 103230640 A CN103230640 A CN 103230640A
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- dilating catheter
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- sacculus
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Abstract
The invention relates a medicine-carrying cutting balloon dilating catheter. The medicine-carrying cutting balloon dilating catheter comprises a cutting balloon dilating catheter body and a medicine coating, wherein the cutting balloon dilating catheter body comprises a balloon, the surface of the balloon is provided with a plurality of blades, and the medicine coating is coated on the surfaces of the balloon and the blades. The medicine-carrying cutting balloon dilating catheter can cut plaques in vessels and fully dilate to be well adhered to arterial walls by pressing the plaques, so that not only subsequent inflammatory responses are reduced, but also the dilation of lumen reduces the restenosis rate. Besides, the medicine coating can restrain the intimal hyperplasia of the vessel inner surface which is damaged by squeezing. Particularly for a bended complex lesion location where a stent cannot reach, the superior advantages of the medicine-carrying cutting balloon dilating catheter are significant.
Description
Technical field
The present invention relates to medical instruments field, specifically, relate to the cutting sacculus dilating catheter that a kind of balloon surface is loaded with medicine.
Background technology
Cerebrovascular disease is all very high diseases of a kind of sickness rate, mortality rate and disability rate, is one of current mankind " three big killers " (cerebrovascular disease, cardiovascular disease and tumor).Cerebrovascular medium-sized artery stenosis or occlusion is to cause one of apoplexy most important reason.According to domestic 7 cities of finishing and 21 provinces rural area sacred disease Epidemiological study resulting estimate, about 2,000,000 people of national annual New Development apoplexy; Die from about 1,500,000 people of patients with cerebrovascular disease every year, survival number (comprising cured person) 600-700 ten thousand.In the patients with cerebrovascular disease of survival, about 3/4 in various degree disability brings tremendous influence and burden for patient, family and society.
Cerebral arteries produces stenosis or occlusion, very easily causes transient ischemic attack (TIA) and death.And the main predisposing factors that produces pathological changes is because three-hypers (hypertension, hyperlipidemia, hyperglycemia) disease on the one hand, moreover along with the increase at people's age, the blood vessel wall of human body artery can occur the atherosis arterial lumen that causes inevitably and narrow down gradually, when serious even obturation, cause cerebral ischemia or cerebral infarction.If cerebral ischemia longer duration, degree weigh, will cause brain cell necrosis.Therefore when being arranged, slight cerebral ischemia attack checks to have or not cerebral arterial stenosis that the serious or speckle ulceration if any stricture of artery should be considered the interventional therapy of cerebrovascular, guarantees health to remove a hidden danger.
Blood vessel sacculus in the cerebrovascular interventional therapy expands into the shape art and endovascular stent is implanted a kind of very important means that plasty has become the treatment cerebral arterial stenosis, and demonstrates vitality with superioritys such as its wound are little, safe, indication is wide, postoperative complication is few in the treatment of ischemic cerebrovascular.But the support that support is implanted in the plasty belongs to foreign body, if restenosis takes place in the support, then be difficult to treatment, moreover it is also higher to implant the plasty medical expense.More prior in fact is because cerebrovascular is more circuitous than the traveling of arteria coronaria blood vessel, and official jargon is more very thin, and caliber changes greatly, and support often can not reach complicated narrow diseased region, and at this moment the balloon expandable plasty just becomes main treatment means.
Therefore, need have a kind of sacculus dilating catheter can expand stenotic lesion fully, can also prevent neointimal hyperplasia, it is minimum that restenosis rate is dropped to, and replaces support to implant, and obtains good curative effect.
Summary of the invention
A kind of cutting sacculus dilating catheter of medicine carrying comprises cutting foley's tube body and medication coat, and described cutting foley's tube body comprises sacculus, and the surface of described sacculus is provided with a plurality of blades, and at the described medication coat of the surface-coated of sacculus and blade.
To achieve these goals, the invention provides following technical scheme:
A kind of cutting sacculus dilating catheter of medicine carrying, this foley's tube is the cutting balloon structure: there is blade on the surface of described sacculus.
Preferably, described sacculus be shaped as cylindrical or conical.
Preferably, the blade shapes on the surface of described sacculus is triangle or wedge shape.
Preferably, the material of described blade is medical macromolecular materials or metal material.
Preferably, described metal material is medical stainless steel, cobalt-base alloys, titanium-base alloy, marmem or noble metal.
Preferably, the quantity of described blade can be three, four or five.
Preferably, described blade is for being evenly distributed on balloon surface
Preferably, being connected between described blade and the sacculus can be the contact separation formula, also can be inserted.
Preferably, described medication coat is the medicine that suppresses neointimal hyperplasia, anti-angiogenic restenosis.
Preferably, the medicine of described medication coat is one or more in rapamycin (sirolimus), paclitaxel, the plain probucol of blood vessel titanium, the dexamethasone.
Preferably, described medication coat can be coated in cutting sacculus outer surface by the mode of spraying or dip-coating.
Preferably, the cutting sacculus dilating catheter of described a kind of medicine carrying is used for cerebrovascular, cardiovascular or peripheral blood vessel.
From above-mentioned technical scheme as can be seen, the cutting sacculus dilating catheter of medicine carrying can cut the speckle in the blood vessel in the embodiment of the invention, can fully expand simultaneously, the extruding speckle just can carry out good applying with arterial wall like this, not only reduced inflammatory reaction subsequently, the increase of tube chamber has also reduced restenosis rate; Moreover medication coat can suppress to be extruded the neointimal hyperplasia of impaired vascular inner surface, thereby also reduced restenosis rate.Especially in the crooked complex lesions that support can not arrive, demonstrate its superior characteristic.
Description of drawings
In order to be illustrated more clearly in the embodiment of the invention or technical scheme of the prior art, to do simple introduction to the accompanying drawing of required use in embodiment or the description of the Prior Art below, obviously, these accompanying drawings only are some specific embodiment of the cutting sacculus dilating catheter of a kind of medicine carrying of putting down in writing of the application.The present invention includes but be not limited to following these.
Fig. 1 is cerebral arterial stenosis speckle sketch map;
Fig. 2 expands the stenotic lesion sketch map for the cutting sacculus dilating catheter of a kind of medicine carrying that the embodiment of the invention provides;
The sketch map of cutting balloon structure one broken section of the cutting sacculus dilating catheter of a kind of medicine carrying that Fig. 3 provides for the embodiment of the invention;
The sketch map of cutting balloon structure two broken sections of the cutting sacculus dilating catheter of a kind of medicine carrying that Fig. 4 provides for the embodiment of the invention;
The local structural representation that amplifies in cutting sacculus transverse section that Fig. 5 provides for the embodiment of the invention;
Local two structural representations that amplify in cutting sacculus transverse section that Fig. 6 provides for the embodiment of the invention;
Cutting sacculus transverse section one structural representation of a kind of medicine carrying that Fig. 7 provides for the embodiment of the invention;
Cutting sacculus transverse section two structural representations of a kind of medicine carrying that Fig. 8 provides for the embodiment of the invention;
Cutting sacculus transverse section three structural representations of a kind of medicine carrying that Fig. 9 provides for the embodiment of the invention.
The specific embodiment
In order further to understand the present invention, below in conjunction with embodiment preferred version of the present invention is described.These descriptions just illustrate the features and advantages of the present invention, and unrestricted protection scope of the present invention.
See also Fig. 2～Fig. 9,
The cutting sacculus dilating catheter 2 of a kind of medicine carrying provided by the invention is that a kind of balloon surface has blade and scribbles medication coat with the sacculus outer surface;
The shape of cutting blade 21 adopts triangle, consults Fig. 5, also can adopt wedge shape, consults Fig. 6.Purpose is the narrow speckle of fly-cutting, is that sacculus can better be expanded the stenotic lesion place.
The quantity of described blade 21 can be three, four or five, consult Fig. 7, and Fig. 8, Fig. 9, blade is evenly distributed on balloon surface.
Consult Fig. 7, Fig. 8, Fig. 9, the surface of described balloon surface 22 and blade 21 all is loaded with medication coat 3.
Described medication coat 3 is one or more in rapamycin (sirolimus), paclitaxel, the plain probucol of blood vessel titanium, the dexamethasone.
Described medication coat can be coated in the surface of balloon surface 22 and blade 21 by the mode of spraying or dip-coating.
In sum, the cutting sacculus 2 for the treatment of cerebrovascular stenosis pathological changes disclosed by the invention, sacculus 22 surfaces are with blade 21, blade 21 can cut the speckle in the blood vessel, sacculus 22 can fully be expanded simultaneously, pushes speckle like this and just can carry out good applying with arterial wall, rebuilds channel of blood flow, not only reduced inflammatory reaction subsequently, the increase of tube chamber has also reduced restenosis rate; Moreover medication coat 3 can suppress to be extruded the neointimal hyperplasia of impaired vascular inner surface, thereby also reduced restenosis rate.
The present invention mainly is applicable in the crooked complex lesions that support can not arrive, is particularly useful for cerebral arteries curved narrow pathological changes.Demonstrate its superior characteristic.
Each embodiment adopts the mode of selection to describe in this description, and what each embodiment stressed is and the difference of other embodiment that identical similar part cross-references gets final product between each embodiment.
Claims (10)
1. the cutting sacculus dilating catheter of a medicine carrying, comprise cutting foley's tube body and medication coat, it is characterized in that: described cutting foley's tube body comprises sacculus, and the surface of described sacculus is provided with a plurality of blades, and at the described medication coat of the surface-coated of sacculus and blade.
2. the cutting sacculus dilating catheter of medicine carrying as claimed in claim 1, it is characterized in that: the sacculus in the described cutting foley's tube is shaped as cylindrical or conical.
3. the cutting sacculus dilating catheter of medicine carrying as claimed in claim 1, it is characterized in that: the blade shapes of described balloon surface is triangle or wedge shape.
4. the cutting sacculus dilating catheter of medicine carrying as claimed in claim 1, it is characterized in that: the material of described blade is medical macromolecular materials or metal material.
5. as the cutting sacculus dilating catheter of claim 1 or 3 described medicine carryings, it is characterized in that: the quantity of described blade is three, four or five.
6. as the cutting sacculus dilating catheter of claim 1 or 3 described medicine carryings, it is characterized in that: described blade is evenly distributed on balloon surface by contact separation formula or inserted connection.
7. as the cutting sacculus dilating catheter of claim 1 or 3 described medicine carryings, it is characterized in that: described medication coat is the medicine that suppresses neointimal hyperplasia and/or anti-angiogenic restenosis.
8. as the cutting sacculus dilating catheter of claim 1 or 3 described medicine carryings, it is characterized in that: the medicine of described medication coat is one or more in rapamycin (sirolimus), paclitaxel, the plain probucol of blood vessel titanium, the dexamethasone.
9. as the cutting sacculus dilating catheter of claim 1 or 3 described medicine carryings, it is characterized in that: described medication coat is coated in cutting sacculus outer surface by the mode of spraying or dip-coating.
10. the cutting sacculus dilating catheter of medicine carrying as claimed in claim 1 is characterized in that: this sacculus dilating catheter is used for cerebrovascular, in cardiovascular or the peripheral blood vessel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013101351284A CN103230640A (en) | 2013-04-18 | 2013-04-18 | Medicine-carrying cutting balloon dilating catheter |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013101351284A CN103230640A (en) | 2013-04-18 | 2013-04-18 | Medicine-carrying cutting balloon dilating catheter |
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| CN103230640A true CN103230640A (en) | 2013-08-07 |
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| CN2013101351284A Pending CN103230640A (en) | 2013-04-18 | 2013-04-18 | Medicine-carrying cutting balloon dilating catheter |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821457A (en) * | 2017-03-06 | 2017-06-13 | 上海长海医院 | One kind carries medicine Cutting balloon |
| CN108295360A (en) * | 2017-01-13 | 2018-07-20 | 翎秀生物科技（上海）有限公司 | A kind of medicine-coated balloon bracket component |
| CN108325050A (en) * | 2018-03-28 | 2018-07-27 | 周胜华 | A kind of novel cyclic sacculus and its application method |
| CN109843204A (en) * | 2016-10-20 | 2019-06-04 | 莱彻韦斯科勒公司 | Method and apparatus for enhancing composition delivering |
| CN109984860A (en) * | 2019-01-30 | 2019-07-09 | 张韬 | Intravascular filter |
| CN110198677A (en) * | 2016-12-30 | 2019-09-03 | 巴德股份有限公司 | With the embedded sacculus for translating embedded silk |
| CN110327538A (en) * | 2019-08-12 | 2019-10-15 | 肖平喜 | A kind of Wolf tooth bar expansion drug delivery balloon |
| CN110507385A (en) * | 2019-09-04 | 2019-11-29 | 肖平喜 | A kind of inserted dilating sacculus |
| CN110732078A (en) * | 2019-11-14 | 2020-01-31 | 昆山金泰医疗科技有限公司 | Balloon |
| CN110801266A (en) * | 2019-08-13 | 2020-02-18 | 赵士春 | Blood vessel dredging device and blood vessel dredging cleaner |
| CN112438776A (en) * | 2020-12-02 | 2021-03-05 | 赛诺医疗科学技术股份有限公司 | Balloon dilatation catheter for thrombus removal |
| CN113768617A (en) * | 2021-09-13 | 2021-12-10 | 武汉大学中南医院 | Integrated incision and expansion knife and using method thereof |
| WO2023087455A1 (en) * | 2021-11-17 | 2023-05-25 | 上海腾复医疗科技有限公司 | Vascular recanalization device |
| CN116549066A (en) * | 2023-07-05 | 2023-08-08 | 北京久事神康医疗科技有限公司 | Drug delivery cutting balloon catheter |
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| US20050222596A1 (en) * | 2004-03-31 | 2005-10-06 | Siemens Aktiengesellschaft | Device for implementing a cutting balloon intervention with IVUS monitoring |
| WO2012146681A1 (en) * | 2011-04-26 | 2012-11-01 | Eurocor Gmbh | Catheter balloon coated with rapamycin and shellac |
| CN102883753A (en) * | 2010-03-25 | 2013-01-16 | 路通医疗股份有限公司 | Drug releasing coatings for medical devices |
| US20130018396A1 (en) * | 2011-07-15 | 2013-01-17 | Boston Scientific Scimed, Inc. | Cutting balloon catheter with flexible cutting blades |
| CN203379465U (en) * | 2013-04-18 | 2014-01-08 | 雅伦生物科技(北京)有限公司 | Drug-carrying cutting balloon dilating catheter |
-
2013
- 2013-04-18 CN CN2013101351284A patent/CN103230640A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20050222596A1 (en) * | 2004-03-31 | 2005-10-06 | Siemens Aktiengesellschaft | Device for implementing a cutting balloon intervention with IVUS monitoring |
| CN102883753A (en) * | 2010-03-25 | 2013-01-16 | 路通医疗股份有限公司 | Drug releasing coatings for medical devices |
| WO2012146681A1 (en) * | 2011-04-26 | 2012-11-01 | Eurocor Gmbh | Catheter balloon coated with rapamycin and shellac |
| US20130018396A1 (en) * | 2011-07-15 | 2013-01-17 | Boston Scientific Scimed, Inc. | Cutting balloon catheter with flexible cutting blades |
| CN203379465U (en) * | 2013-04-18 | 2014-01-08 | 雅伦生物科技(北京)有限公司 | Drug-carrying cutting balloon dilating catheter |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11857748B2 (en) | 2016-10-20 | 2024-01-02 | Asahi Medical Technologies, Inc. | Method and device for enhanced composition delivery |
| CN109843204A (en) * | 2016-10-20 | 2019-06-04 | 莱彻韦斯科勒公司 | Method and apparatus for enhancing composition delivering |
| CN109843204B (en) * | 2016-10-20 | 2024-02-13 | 莱彻韦斯科勒公司 | Methods and devices for enhancing delivery of compositions |
| CN110198677A (en) * | 2016-12-30 | 2019-09-03 | 巴德股份有限公司 | With the embedded sacculus for translating embedded silk |
| CN108295360A (en) * | 2017-01-13 | 2018-07-20 | 翎秀生物科技（上海）有限公司 | A kind of medicine-coated balloon bracket component |
| CN106821457A (en) * | 2017-03-06 | 2017-06-13 | 上海长海医院 | One kind carries medicine Cutting balloon |
| CN108325050A (en) * | 2018-03-28 | 2018-07-27 | 周胜华 | A kind of novel cyclic sacculus and its application method |
| CN109984860A (en) * | 2019-01-30 | 2019-07-09 | 张韬 | Intravascular filter |
| CN110327538A (en) * | 2019-08-12 | 2019-10-15 | 肖平喜 | A kind of Wolf tooth bar expansion drug delivery balloon |
| CN110801266A (en) * | 2019-08-13 | 2020-02-18 | 赵士春 | Blood vessel dredging device and blood vessel dredging cleaner |
| CN110507385A (en) * | 2019-09-04 | 2019-11-29 | 肖平喜 | A kind of inserted dilating sacculus |
| CN110732078A (en) * | 2019-11-14 | 2020-01-31 | 昆山金泰医疗科技有限公司 | Balloon |
| CN112438776A (en) * | 2020-12-02 | 2021-03-05 | 赛诺医疗科学技术股份有限公司 | Balloon dilatation catheter for thrombus removal |
| CN113768617A (en) * | 2021-09-13 | 2021-12-10 | 武汉大学中南医院 | Integrated incision and expansion knife and using method thereof |
| WO2023087455A1 (en) * | 2021-11-17 | 2023-05-25 | 上海腾复医疗科技有限公司 | Vascular recanalization device |
| CN116549066A (en) * | 2023-07-05 | 2023-08-08 | 北京久事神康医疗科技有限公司 | Drug delivery cutting balloon catheter |
| CN116549066B (en) * | 2023-07-05 | 2023-09-26 | 北京久事神康医疗科技有限公司 | Drug delivery cutting balloon catheter |
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Application publication date: 20130807 |