CN203310795U - Portable impedance biosensing detector - Google Patents

Abstract

The utility model discloses a portable impedance biosensing detector, which comprises: a control module, an IO expansion module, a display module, an impedance measurement module, a power supply module, a communication module, a voltage sampling module, a data storage module, a clock module, a sound module and system status indication module; the control module is connected with the IO expansion module, display module, impedance measurement module, communication module, voltage sampling module, data storage module and clock module respectively; the IO expansion module is respectively connected with the display module, impedance measurement module, communication The module, the sound module and the system status indication module are connected; the utility model has fast detection speed, accurate detection results, reliable operation, environmental protection and energy saving, convenient operation and portability, and can be widely used in various biological impedance analysis and detection occasions.

Description

A portable impedance biosensing detector

technical field

The utility model relates to the field of impedance detection, in particular to a portable impedance biological sensor detector.

Background technique

In recent years, the problem of food safety has become more and more prominent, and has become a worldwide public health hotspot. Therefore, food safety rapid detection instruments are getting more and more attention. As a new technology, biosensor has the advantages of good selectivity, fast detection speed and high sensitivity, and has been widely used in agriculture, food, medicine and health and other fields. Because its detection accuracy is between large laboratory analysis instruments and conventional rapid methods represented by test strips, and it is easy to carry and can be quickly detected on-site, it is very suitable for rapid screening of food safety to ensure people's physical and mental health and life safety. Maintain social stability and prosperity, and promote economic and trade development. Among them, impedance biosensors have attracted extensive attention due to their advantages of label-free and rapid detection. Impedance biosensors usually consist of bioelectrodes and impedance detectors. At present, impedance detectors are generally completed by large-scale precision impedance detectors, such as British solartron company, American Agilent and German Zahner company have corresponding products, in addition to research and development of small impedance detectors, such as in the United States of Li Yanbin, Ye Zunzhong, etc. The patent (METHODS AND SYSTEMS FOR DETECTION OF CONTAMINANTS, international publication number: WO 2008/028124) provides a device for detecting pollutants based on the impedance method. The handheld device is controlled by a microprocessor, with a built-in impedance detection chip box, English character display, battery power supply and computer serial port communication and other functions. The device has the advantages of being small and portable, but there are still some problems in the device: if the analog signal of the impedance detection is connected to the detection electrode without pre-processing, it is easy to affect the biological material on the detection electrode and cause the measurement result Inaccurate and poor stability of the detection signal; in addition, because the device uses a single excitation frequency, it cannot work normally in multiple frequency bands, especially at lower measurement frequencies; there is no battery charging management function, and ordinary batteries cannot be charged As a result, the use time is short and it is not suitable for long-term work; it cannot communicate with computers without serial ports but has USB ports, Bluetooth or TCP/IP network interfaces, and cannot print the measured data in real time on the testing instrument; it cannot display Chinese and graphics , and the backlight of the liquid crystal display cannot be turned off to save power; there is no time and date circuit function, so parameters such as the measurement date of the test sample cannot be displayed.

Contents of the invention

The purpose of the utility model is to provide a portable impedance biosensing detector aiming at the deficiencies of the prior art.

The technical scheme adopted by the utility model is as follows: a portable impedance biosensing detector, which includes: a control module, an IO expansion module, a display module, an impedance measurement module, a power supply module, a communication module, a voltage sampling module, a data storage module, Clock module, sound module and system status indication module; Wherein, described control module is connected with IO expansion module, display module, impedance measurement module, communication module, voltage sampling module, data storage module and clock module respectively; IO expansion module is connected with The display module, impedance measurement module, communication module, sound module and system status indication module are connected; the power supply module is a control module, an IO expansion module, a display module, an impedance measurement module, a communication module, a voltage sampling module, a data storage module, a clock module, The sound module and the system status indication module supply power.

Further, the impedance measurement module includes: a frequency unit, an impedance reference unit, an impedance calibration unit, an analog signal conditioning unit, and an impedance measurement unit; the analog signal conditioning unit is respectively connected to the impedance reference unit, the impedance calibration unit, and the impedance measurement unit ; The impedance reference unit is connected with the impedance calibration unit; the frequency unit is connected with the impedance measurement unit.

Further, the power module includes a power input unit, a charging unit and a boost unit; wherein the charging unit is connected to the power input unit and the boost unit respectively.

Further, the communication module includes a USB communication unit, a printer unit, a Bluetooth communication unit, a communication signal switching unit, and a TCP/IP communication unit; wherein, the communication signal switching unit is connected to the USB communication unit, the printer unit, and the Bluetooth communication unit respectively. Connect with TCP/IP communication unit.

The beneficial effect that the utility model has is:

1. The utility model adopts frequency division technology, which can measure the impedance of samples in the detection pool at different frequencies, and select the best detection frequency for different samples to improve accuracy.

2. The analog signal to be tested is conditioned by the analog signal conditioning unit and then sent to the impedance measurement module to increase the accuracy of the result.

3. The impedance calibration unit uses different impedances to calibrate the system, which can ensure the reliability of the device operation.

4. The device integrates a variety of communication technologies through the communication module and combines with the device. It can communicate with the computer through the USB interface, perform data communication with the computer through the Bluetooth or TCP/IP network interface, and output the measured data to the printer.

5. The display module can display Chinese and graphic information, and the screen backlight is automatically turned off and sleeps to save power consumption.

6. This device detects and displays the battery voltage and system power supply voltage in real time to ensure the normal and reliable operation of the system.

7. The device has fewer buttons, is easy to operate, and has a fast detection speed. High-performance and large-capacity rechargeable batteries are used, which can be used for a long time and can be charged repeatedly. It can be widely used in various occasions that need to detect biological impedance.

Description of drawings

Fig. 1 is a module block diagram of the present utility model;

Fig. 2 is a structural block diagram of module 4 of the present utility model;

Fig. 3 is a structural block diagram of module 5 of the present utility model;

Fig. 4 is a structural block diagram of module 6 of the present utility model;

Fig. 5 is a program flow chart of the utility model;

Fig. 6 is the circuit diagram of module 1 of the present utility model;

Fig. 7 is the circuit diagram of module 2 of the present utility model;

Fig. 8 is the circuit diagram of module 3 of the present utility model;

Fig. 9 is the circuit diagram of module 4 of the present utility model;

Fig. 10 is the circuit diagram of module 5 of the present utility model;

Fig. 11 is the circuit diagram of module 6 of the present utility model;

Fig. 12 is the circuit diagram of module 7 of the present utility model;

Fig. 13 is the circuit diagram of module 8 of the present utility model;

Fig. 14 is the circuit diagram of module 9 of the present utility model;

Fig. 15 is the circuit diagram of the module 10 of the present utility model;

Fig. 16 is a circuit diagram of the module 11 of the present invention.

In the figure: control module 1, IO expansion module 2, display module 3, impedance measurement module 4, power supply module 5, communication module 6, voltage sampling module 7, data storage module 8, clock module 9, sound module 10, system status indication Module 11, frequency unit 401, impedance reference unit 402, impedance calibration unit 403, analog signal conditioning unit 404, impedance measurement unit 405, power input unit 501, charging unit 502, boost unit 503, USB communication unit 601, printer unit 602 , a Bluetooth communication unit 603 , a communication signal switching unit 604 , and a TCP/IP communication unit 605 .

Detailed ways

Below in conjunction with accompanying drawing and implementation example the utility model is further described.

As shown in Figure 1, the utility model includes: a control module 1, an IO expansion module 2, a display module 3, an impedance measurement module 4, a power supply module 5, a communication module 6, a voltage sampling module 7, a data storage module 8, and a clock module 9 , a sound module 10 and a system status indication module 11; wherein, the control module 1 is connected with the IO expansion module 2, the display module 3, the impedance measurement module 4, the communication module 6, the voltage sampling module 7, the data storage module 8 and the clock module 9 respectively ; The IO expansion module 2 is respectively connected with the display module 3, the impedance measurement module 4, the communication module 6, the sound module 10 and the system status indicator module 11; the power supply module 5 is the control module 1, the IO expansion module 2, the display module 3, and the impedance measurement Module 4, communication module 6, voltage sampling module 7, data storage module 8, clock module 9, sound module 10 and system status indication module 11 supply power. The control module 1 drives the display module 3 to display corresponding parameters according to the user input parameters, and drives the IO expansion module 2 to control the signal timing required for impedance measurement of the impedance measurement module 4, and the control module 1 then controls the impedance measurement module 4 to measure the impedance signal, impedance The signal is stored through the data storage module 8 . The control module 1 transmits the impedance signal to the display module 3 and the communication module 6 .

As shown in Figure 2, impedance measurement module 4 comprises five units: frequency unit 401, impedance reference unit 402, impedance calibration unit 403, analog signal conditioning unit 404 and impedance measurement unit 405; The comparison unit 402 , the impedance calibration unit 403 are connected to the impedance measurement unit 405 ; the impedance reference unit 402 is connected to the impedance calibration unit 403 ; the frequency unit 401 is connected to the impedance measurement unit 405 . The impedance measurement frequency is transmitted from the frequency unit 401 to the impedance measurement unit 405 , and the impedance signal is conditioned by the analog signal conditioning unit 404 and then detected by the impedance measurement unit 405 .

As shown in FIG. 3 , the power module 5 includes a power input unit 501 , a charging unit 502 and a boost unit 503 ; wherein the charging unit 502 is connected to the power input unit 501 and the boost unit 503 respectively. The input power is sent to the power input unit 501 and then to the boost unit 503 via the charging unit 502 .

As shown in Figure 4, communication module 6 comprises USB communication unit 601, printer unit 602, Bluetooth communication unit 603, communication signal switching unit 604 and TCP/IP communication unit 605; Wherein, communication signal switching unit 604 is connected with USB communication unit 601 respectively , a printer unit 602, a Bluetooth communication unit 603 and a TCP/IP communication unit 605 are connected. The communication signal switching unit 604 performs signal transmission with one of the USB communication unit 601 , the printer unit 602 , the Bluetooth communication unit 603 and the TCP/IP communication unit 605 under the action of the control module 1 .

As shown in Figure 5, the working process of the system is described. After the test starts, you can choose different measurement frequencies to measure the impedance of the target to be tested and record the data, and you can choose to print the data when the measurement is over.

As shown in Figure 6, the control module 1 includes: single-chip microcomputer U3, keyboard JP1, crystal oscillator X2, capacitors C4, C5, capacitor C12, and resistor R9; among them, the OK key K1, cancel key K2, print key K3, and measurement key K4 on the keyboard JP1 , up key K5, and down key K6 are respectively connected to pins 1-6 of the single-chip microcomputer U3; the ground pin (7 pins) of the keyboard JP1 is connected to and grounded to the ground pin (20 pins) of the single-chip microcomputer; Pin 1 (pin 19) is connected to crystal oscillator X2 and one end of capacitor C4, crystal oscillator pin 2 (pin 18) of the microcontroller is connected to the other end of crystal oscillator X2 and one end of capacitor C5, and the other end of capacitor C4 and C5 is connected to ground ;The working voltage VCC is connected with the voltage input pin (pin 40) of the microcontroller U3 and the positive pole of capacitor C12, the negative pole of capacitor C12 is connected with the reset pin (pin 9) of the microcontroller and one end of R9, and the other end of R9 is grounded . The single-chip microcomputer U3 realizes the control to the whole device, can adopt the chip of model AT89C51RC produced by ATMEL company, but is not limited to this.

As shown in Figure 7, the IO expansion module 2 includes: IO expansion chips U10, U12; shift data input pins (14 pins) of the IO expansion chip U10, shift clock pins (11 pins) of the IO expansion chips U10, U12 ), the shift latch pin (pin 12) is respectively connected with the reading pin (pin 17) and writing pin (pin 16) of the microcontroller U3 in the control module and the external input timer T0 (pin 14); U10, The shift clock clear pin (pin 10) of U12 is connected to the voltage input pin (pin 16) and then connected to the working voltage VCC, the enable pin (pin 13) is connected to the ground pin (pin 8) and grounded; the U10 The serial data output pin (pin 9) is connected with the shift data input pin (pin 14) of U12. The IO expansion chips U10 and U12 realize the expansion of the IO port of the single-chip microcomputer U3, and the chip of the model 74HC595D produced by NXP Semiconductors can be used, but it is not limited to this.

As shown in Figure 8, the display module 3 includes: a liquid crystal display U6, resistors R6, R11, R8, and a transistor Q3; pins 4-17 of the liquid crystal display U6 are respectively connected to U3 of the control module 1, and the working voltage VCC and the resistor R6 One end of R6 is connected to the power supply voltage input pin (pin 2) of LCD display U6 and the positive end (pin 19) of the backlight, and the other end of R6 is connected to the LCD contrast adjustment pin (pin 3) of U6 and one end of R11 Connection, the other end of R11 is connected to the driving voltage output pin (pin 18) of U6; the power ground pin (pin 1) of U6 is grounded; one end of resistor R8 is connected to the parallel data output pin (pin 4) of the IO expansion chip U12 , BG ON), the other end is connected to the base of the triode Q3, the collector of Q3 is connected to the negative end of the backlight of U6 (20 feet), and the emitter of Q3 is grounded. The liquid crystal display screen U6 realizes the setting of detection parameters, the display of commands and the display of results, and a dot matrix graphic display module of model LCD12864 produced by Yuanjian Company can be used, but it is not limited thereto.

As shown in Figure 9, the impedance measurement module 4 includes: a frequency unit 401, an impedance reference unit 402, an impedance calibration unit 403, an analog signal conditioning unit 404 and an impedance measurement unit 405; the X common terminal of the analog switch U17 in the frequency unit 401 ( 3 pins) are connected with the main clock pulse pin (8 pins) of the measuring chip U2 in the impedance measurement unit 405, and the X common terminal (3 pins) of the analog switch U15 in the impedance reference unit 402 is connected with the resistance in the impedance calibration unit 403 R27, R25, R23, R21, R10, R17, R15, R13, and capacitors C18 and C19 are connected to the common end, and the X common end (pin 3) of the analog switch U15 in the impedance reference unit 402 is connected to the analog signal conditioning unit 404 The negative phase input pin (pin 6) of the operational amplifier U14B is connected to each other, the resistors R26, R24, R22, R18, R7, R16, R14, R12 in the impedance reference unit 402, the common terminals of the capacitors C20 and C21 and the analog signal conditioning The output terminal (pin 7) of the operational amplifier U14B in the unit 404 is connected to one end of R33, and the X common terminal (pin 3) of the analog switch U16 in the impedance calibration unit 403 is connected to the output terminal (pin 7) of the operational amplifier U14A in the analog signal conditioning unit 404 ( 1 pin), one end of R34 in the analog signal conditioning unit 404 is connected to the feedback pin (pin 4) of the measurement chip U2 in the impedance measurement unit 405, and the other end of R34 is connected to the other end of R33 and then connected to the voltage input of U2 Terminal (5 feet) connected; one end of capacitor C9 is connected to the voltage output terminal (6 feet) of U2. The analog switches U15, U16, and U17 realize the selection function of the signal, and the chip of the model CD4051 produced by National Semiconductor can be used, but it is not limited thereto. The operational amplifiers U14A and U14B implement the pre-processing function of the detection signal, and belong to the two channels of the amplifier OPA2344, but are not limited thereto. The measurement chip U2 realizes the measurement of the impedance signal, and a chip of model AD5933 produced by Analog Devices can be used, but is not limited thereto.

As shown in Figure 9, the frequency unit 401 includes: an active crystal oscillator X1, a frequency divider U13 and an analog switch U17; the enable pin (pin 6) and the chip select pin (pin 11, 10, 9) of the analog switch U17 Connect to the parallel data output pins (pins 3, 15, 1, and 2) of the IO expansion chip U12 in the IO expansion module 2 respectively; the voltage input pin (pin 16) of the analog switch U17, the voltage input pin of the active crystal oscillator X1 The pin (pin 4) and the voltage input pin (pin 16) of the frequency divider U13 are connected to the working voltage VCC; the driving voltage output terminal (pin 7) of U17 is connected to the ground pin (pin 8) and grounded; the switch of U17 The pins (13, 14, 15, 12, 1, 5, 2, 4 pins) are respectively connected with the switch pins (9, 7, 6, 5, 3, 2, 4, 13 pins) of U16; The reset pin (pin 11) is connected to the ground pin (pin 8) and grounded; the output pin (pin 3) of the active crystal oscillator X1 is connected to the clock terminal (pin 10) of the frequency divider U13, and the ground pin of X1 (2 pins) to ground. The frequency divider U13 can divide the frequency of the active crystal oscillator X1, and the chip of the model 74HC4040 produced by Philips Semiconductors can be used, but it is not limited thereto.

As shown in Figure 9, the impedance reference unit 402 includes: an analog switch U15, resistors R26, R24, R22, R18, R7, R16, R14, R12, capacitors C20, C21; wherein the chip select pin of the analog switch U15 (9 , 10, 11 pins) are respectively connected to the parallel data output pins (4, 5, 6 pins) of the IO expansion chip U10; the driving voltage output terminal (7 pins) of U15 is connected to the ground pin (8 pins) and grounded , the voltage input pin (pin 16) is connected to the working voltage VCC; the switch pins (pins 4, 2, 5, 1, 12, 15, 14, and 13) of the analog switch U15 are respectively connected to resistors R26, R24, R22, R18, The other ends of R7, R16, R14, and R12 are connected; the capacitor C20 is connected in parallel with the resistor R26, the capacitor C21 is connected in parallel with the resistor R12, and the enabling pin (pin 6) of U15 is grounded.

As shown in Figure 9, the impedance calibration unit 403 includes: an analog switch U16, resistors R27, R25, R23, R21, R10, R17, R15, R13, capacitors C18, C19; wherein the chip select pin (9, 10, 11 pins), enabling pins (6 pins) are respectively connected to the parallel data output pins (15, 1, 2, 3 pins) of the IO expansion chip U10; the driving voltage output terminal (7 pins) of U16 is connected to The ground pin (pin 8) is connected to the ground, and the voltage input pin (pin 16) is connected to the working voltage VCC; the switch pins (pins 4, 2, 5, 1, 12, 15, 14, and 13) of the analog switch U16 are respectively It is connected with the other end of the resistors R27, R25, R23, R21, R10, R17, R15, R13; the capacitor C18 is connected in parallel with the resistor R27, and the capacitor C19 is connected in parallel with the resistor R13.

As shown in Figure 9, the analog signal conditioning unit 404 includes: a measurement signal input interface J2, operational amplifiers U14A, U14B, resistors R29, R30, R31, R32, R33, R34, and a capacitor C9; wherein the measurement signal input interface J2 is connected to an external The detection pool is connected; the output pin (pin 1) of the measurement signal input interface J2 is connected to the negative phase input pin (pin 6) of the operational amplifier U14B; one end of R31 and R32 is connected to the positive phase input pin of U14B pin (5 pins), the other end of R31 is grounded, the other end of R32 is connected to the working voltage VCC; the output end (7 pins) of U14B is connected to R33; one end of capacitor C9 is connected to the output pin (6 pins) of the measuring chip U2 Connected, the other end is connected with resistor R29, one end of R30 and the positive phase input pin (pin 3) of the operational amplifier U14A, the other end of R29 is connected with the voltage input pin (pin 8) of U14A and then connected to the working voltage VCC, R30 The other end of U14A is connected to the ground pin (pin 4) of U14A and then grounded; the negative phase input pin (pin 2) of U14A is connected to the output terminal (pin 1) and then connected to the input pin (pin 4) of the measurement signal input interface J2 ).

As shown in Figure 9, the impedance measuring unit 405 includes: a measuring chip U2; wherein the serial clock line (16 pins) and the serial data line (15 pins) of the measuring chip U2 are respectively connected to the ZSDA (28 pins) of U3 in the control module 1 ), ZSCL (pin 27); the digital voltage input pin (pin 9) of U2 is connected to the analog voltage input pin (pin 10, 11) and then connected to the working voltage VCC, and the digital ground pin (pin 12) is connected to the analog The ground pins (pins 13 and 14) are connected to ground.

As shown in Figure 10, the power module 5 includes: a power input unit 501, a charging unit 502 and a boost unit 503; the charging unit 502 is connected to the power input unit 501 and the boost unit 503 respectively; the power input unit 501 includes a USB power supply VUSB , power adapter J1, diode D7, Schottky diodes D2, D5, capacitors C3, C6, voltage regulator chip U9; charging unit 502 includes light emitting diode D8, Schottky diodes D3, D4, resistors R4, R28, battery E1, Charging chip U5; boost unit 503 includes capacitors C2, C10, capacitors C1, C8, C11, resistors R1, R19, R20, R35, Schottky diode D1, inductor L1, boost chip U1; power input unit 501 The cathode of the special base diode D5 is connected to the cathode of D2 and then connected to the anode of the light-emitting diode D8 in the charging unit 502, and the negative pole of the capacitor C3 in the power input unit 501 is connected to the ground pin (2 pins) of the charging chip U5 in the charging unit 502. ) and then connected to the negative pole of the capacitor C2 in the boost unit 503; the cathodes of the Schottky diodes D3 and D4 in the charging unit 502 are connected to the positive pole of the capacitor C2 through the switch K. The voltage stabilizing chip U9 realizes the voltage stabilizing effect on the external power supply, and the chip of the model LM7805 produced by Fairchild Semiconductor can be used, but is not limited to this. The charging chip U5 realizes the charging function of the battery E1, and a chip of the type LTC4054 produced by Linear Technology can be used, but is not limited thereto. The step-up chip U1 realizes the step-up function, and a chip of model LT1302 produced by Linear Technology can be used, but is not limited thereto.

As shown in Figure 10, the anode of the power adapter J1 in the power input unit 501 is connected to the anode of the diode D7; the cathode of D7 is connected to the anode of the capacitor C6 and the voltage input pin (pin 1) of the voltage stabilizing chip U9; The voltage output terminal (pin 3) of the pressure chip U9 is connected to the positive pole of the capacitor C3 and the anode of the Schottky diode D2; the negative poles of C3 and C6, the ground pin (pin 2) of U9 are connected to the negative pole of J1 and then grounded; The USB power supply VUSB is connected to the anode of the Schottky diode D5; the cathode of D5 is connected to the cathode of D2.

As shown in Figure 10, the negative pole of the battery E1 in the charging unit 502 and the ground pin (pin 2) of the charging chip U5 are connected to one end of R4; the other end of R4 is connected to the program control pin (pin 5) of U5 ;The positive pole of the battery E1 is connected to the battery access pin (pin 3) of the charging chip U5 and the anode of the Schottky diode D4, and the cathode of D4 is connected to the cathode of the Schottky diode D3 and then connected to the switch K; the voltage of U5 The input pin (pin 4) is connected to the anode of D3 and the anode of the light-emitting diode D8; the cathode of D8 is connected to the charging state output pin (pin 1) of U5 after passing through the resistor R28.

As shown in Figure 10, capacitor C2 and capacitor C8 in the boost unit 503 are connected in parallel; the anode of C2 is connected to the voltage input pin (pin 6) of the boost chip U1 and one end of the inductor L1, and the other end of L1 is connected to the Schott The anode of the base diode D1 is connected to the conversion pin (pin 7) of U1; the cathode of D1 is connected to the feedback pin (pin 4) of U1, the capacitor C11, the positive pole of the capacitor C10 and the resistor R19, and the common terminal is The whole circuit provides the output end of the working voltage VCC; the other end of R19 is connected to R20, C10 is connected in parallel with C11; the negative pole of C2, the ground pin (pin 1) of U1, the power ground pin (pin 8), and the negative pole of C10 And the other end of R20 is connected to the ground; the frequency compensation pin (pin 2) of U1 is grounded after the resistor R1 and capacitor C1; the current mode pin (pin 5) of U1 is grounded after the resistor R35.

As shown in Figure 11, communication module 6 comprises: USB communication unit 601, printer unit 602, bluetooth communication unit 603, communication signal switching unit 604 and TCP/IP communication unit 605; The data transmitting end (pin 26) and the serial port data receiving end (pin 25) are respectively connected to the switch pins (pins 12 and 1) of the communication switching chip U11 in the communication signal switching unit 604; the level conversion chip U19 in the printer unit 602 The data sending input pin (pin 10) and the data receiving output pin (pin 9) of the U11 are respectively connected to the switch pins (pins 5 and 14) of U11; the data transmission pin of the bluetooth interface J5 in the bluetooth communication unit 603 ( 2, 3 pins) are respectively connected with the switch pins (15, 2 pins) of U11, and the data transmission pins (2, 3 pins) of the TCP/IP interface J6 in the TCP/IP communication unit 605 are respectively connected with the switch pins of U11 The feet (11, 4 feet) are connected. The level conversion chip U19 realizes the level conversion function, and MAX232 can be used, but not limited to this; the communication switching chip U11 realizes the switching of communication objects, and the chip model CD4052 produced by Fairchild Semiconductor can be used, but not limited to this; The USB-to-serial port chip U18 realizes the virtual communication function of the USB communication interface as a serial port, and the chip of the model CP2101 produced by Silicon Laboratories can be used, but it is not limited to this.

As shown in Figure 11, the USB communication unit 601 includes a USB interface J4, a USB-to-serial port chip U18; the printer unit 602 includes a serial port J3, capacitors C13, C14, C15, C16, and C17, and a level conversion chip U19; the Bluetooth communication unit 603 includes Bluetooth interface J5; the communication signal switching unit 604 includes a communication switching chip U11; the TCP/IP communication unit 605 includes a TCP/IP interface J6; The data receiving end (pin 10) and the serial port data transmitting end (pin 11) are connected, and the chip select pins (pins 10 and 9) of U11 are connected with the parallel data output pins (pins 6 and 7) of U12.

As shown in Figure 11, the voltage input pin (pin 16) of the communication switching chip U11 is connected to the working voltage VCC, the enable pin (pin 6), the negative supply voltage pin (pin 7), and the ground pin (pin 8) Connect to ground; the voltage input pin (pin 1) of Bluetooth interface J5 and TCP/IP interface is connected to the working voltage VCC, and the grounding pin (pin 4) is grounded; the working voltage VCC and the voltage input pin of the level conversion chip U19 Pin (pin 16), capacitor C15, one end of C17 are connected, the other end of C15 is connected to the positive voltage pin (pin 2) generated by the charge pump of U19, the other end of C17 is connected to C16 and grounded; the other end of C16 Connect with the negative voltage pin (pin 6) generated by the charge pump of U19; connect the two ends of capacitor C13 with the positive charge pump pin (pin 1, 3) of U19 respectively; connect the two ends of C14 with the negative charge of U19 respectively The pump pins (pins 4 and 5) are connected; the data sending output pin (pin 7) of U19 is connected with pin 3 of the serial port J3, and the data receiving input pin (pin 8) of U19 is connected with the receiving data pin of the serial port J3. The ground pin (pin 15) of U19 is connected to the ground pin (pin 5) of the serial port J3 and then grounded; the voltage input pin (pin 1) of the USB interface J4 is connected to the USB power supply VUSB, The power input terminal (pin 7) of the USB to serial port chip U18 is connected to the positive terminal (pin 8) of the USB power supply; Pins) are connected; pins 4, 5, and 6 of the USB interface J4 are connected to ground; the ground pin (pin 3) of U18 is also grounded.

As shown in Figure 12, the voltage sampling module 7 includes: a voltage sampling chip U8 and a capacitor C7; wherein the analog voltage input pins (pins 1, 2, and 3) of the voltage sampling chip U8 are respectively connected to the positive pole of the battery E1 in the power module 5, The battery access pin (pin 4) of the charging chip U5 is connected to the junction of R19 and R20; the serial clock line (pin 10) and serial data line (pin 9) of the voltage sampling chip U8 are connected to the control module respectively. The serial clock line (8 pins) and the serial data line (7 pins) of U3 are connected; the working voltage VCC is connected with the reference voltage pin (14 pins) and the voltage input pin (16 pins) of the voltage sampling chip U8 ;The working voltage VCC is grounded after being passed through the capacitor C7; the external pin (12 pins) and the analog ground pin (13 pins) of U8 are connected and then grounded; the device ground pins (5, 6, 7 pins) and the ground pin of U8 (8 feet) connected to ground. The voltage sampling chip U8 monitors the voltage of the battery E1, the charging chip U5, and the working voltage VCC, and the chip of the model PCF8591 produced by NXP Semiconductors can be used, but it is not limited thereto.

As shown in Figure 13, the data storage module 8 includes: a data storage chip U4; the serial clock line (6 pins) and the serial data line (5 pins) of the data storage chip U4 are respectively connected with the serial clock line of U3 in the control module (8 pins) and serial data line (7 pins); the voltage input pin (8 pins) of U4 is connected to the working voltage VCC; the device address line pins (1, 2, 3 pins) of U4, ground pin (pin 4) and the write protection pin (pin 7) are connected to ground. The data storage chip U4 realizes the function of storing the collected data and the set measurement parameters, and can adopt the chip of model 24LC256 produced by Microchip Technology, but is not limited thereto.

As shown in Figure 14, the clock module 9 includes: crystal oscillator X3, timing chip U7, battery E2; wherein the serial clock input pin (7 pins), input and output pins (6 pins), reset pin ( 5 pins) are respectively connected with the external interrupt pin 1 (13 pins) of U3 in the control module, the external input timer 1 (15 pins), and the external interrupt pin 0 (12 pins); the voltage input pin of the timing chip U7 2 (pin 1) is connected to the working voltage VCC, and the ground pin (pin 4) is grounded; the two ends of the crystal oscillator X3 are respectively connected to the crystal pins (pin 2 and 3) of U7; the positive pole of the battery E2 is connected to the voltage input of U7 Pin 1 (pin 8) is connected, and the negative pole is grounded. Timing chip U7 realizes the timing function, and can adopt the model DS1302 chip produced by Dallas Semiconductor, but is not limited to this.

As shown in Figure 15, the sound module 10 includes: a resistor R2, a transistor Q1, and a speaker SP1; wherein one end of R2 is connected to the parallel data output pin (BEEP, 5 pins) of the IO expansion chip U12 in the IO expansion module 2, and R2 The other end of the speaker SP1 is connected to the base of the transistor Q1; one end of the speaker SP1 is connected to the working voltage VCC, and the other end is connected to the collector of the transistor Q1; the emitter of the Q1 is grounded.

As shown in Figure 16, the system status indicator module 11 includes: resistors R3, R5, light-emitting diode D6, transistor Q2; wherein one end of R3 is connected to the parallel data output pin (LED-STA, 7 pin), the other end of R3 is connected to the base of transistor Q2; the working voltage VCC is connected to the anode of light-emitting diode D6 after passing through R5, and the cathode of D6 is connected to the collector of transistor Q2; the emitter of Q2 is grounded.

The power supply module 5 has three forms of USB power supply, power adapter power supply and battery power supply. When any one of the USB power supply and the power adapter power supply is connected, the battery E1 is in a charging state.

R19 and R20 are used for voltage division, so that the value collected by the voltage sampling module does not exceed the range.

The frequency divider U13 can divide the frequency of the active crystal oscillator X1 into a lower frequency, and select a suitable frequency for impedance measurement through the control of the single-chip microcomputer U3.

The analog switches U15 and U16 can select different impedances to realize calibration and measurement of different impedances.

The analog signal conditioning unit 404 is used to condition the obtained analog signal to reduce errors.

The clock module 9 can record measurement time, system time, etc.

The printer unit 602 enables the output of measurement data.

The communication signal switching unit 602 can switch between the printer unit 602 , the USB communication unit 601 , and the Bluetooth communication unit 603 .

The voltage sampling module 7 can collect the voltage of the battery E1 , the output voltage of the boost module, and the input voltage of the power input unit 501 .

The data storage module 8 can store and output the collected sample impedance, sample number, collection time, frequency, etc.

The system status indication module is used to indicate the system status.

Using a Schottky diode can have a smaller voltage drop when the diode is turned on.

The OK key K1 and the cancel key K2 are used to confirm and cancel the content displayed on the LCD screen, the print key K3 is used to print the measured data, the measurement key K4 is used to measure the impedance after the parameters are determined, the up key K5, down Key K6 is used to select the content displayed on the LCD screen.

LED D8 is used to indicate the charging status.

The utility model implements working process as follows,

1) Install the circuit according to the requirements of the schematic diagram, connect the power adapter J1, connect the printer, and connect the detection pool that has assembled the biological detection chip;

2) Turn on the switch K, at this time the portable impedance biosensing detector starts to work, the light-emitting diode D8 lights up, the battery E1 is in the charging state, and the light-emitting diode D6 lights up, indicating that the instrument has entered the working state;

3) Press the OK key K1 to enter the system, then press the up key K5 and down key K6 to select, here select "impedance test", and press the OK key K1 to enter the impedance test interface;

4) Select the required measurement frequency by the up key K5 and down key K6, the detector provides five different frequencies of 100 Hz, 1 KHz, 10 KHz, 20 KHz, 100 KHz, press the OK key K1 to confirm;

5) Selection of sample injection method. The pipeline of the detection pool can be connected with the sampling pump to realize automatic sampling, and the detector can also be connected with the syringe, and the biological sample to be tested can be drawn through the syringe. Inject the sample into the detection cell through a syringe pump or manually, and stabilize for a certain period of time.

6) Press the measurement key K4, and the detector starts to measure the impedance of the detection pool. After the measurement is completed, the LCD screen U6 will display the corresponding data, press the OK key to save the data, and have a corresponding ID number, such as ID: 0007;

7) If you need to repeat the measurement, repeat step 5)

8) If other samples need to be measured, inject other samples after the detection cell is cleaned and repeat step 5)

9) Press the print key K3, select the ID range of the data to be printed through the up key K5 and down key K6, and press the OK key K1, and the printer is working at this time to print the selected data;

10) It can be connected to a computer through Bluetooth communication, USB communication, TCP/IP communication, and can perform functions such as parameter setting, remote measurement, data storage, and readout of stored test data through computer software.

11) After the measurement is completed, turn off the switch K and disconnect the connection with the detection pool.

The above-mentioned specific embodiments are used to explain the utility model, rather than to limit the utility model. Within the spirit of the utility model and the protection scope of the claims, any modifications and changes made to the utility model all fall into the scope of the utility model. A new type of protection.

Claims (4)

1. portable impedance bio-sensing detector, it is characterized in that: it comprises: control module (1), IO expansion module (2), display module (3), impedance measurement module (4), power module (5), communication module (6), voltage sample module (7), data memory module (8), clock module (9), sound module (10) and system state indicating module (11); Wherein, described control module (1) is connected with IO expansion module (2), display module (3), impedance measurement module (4), communication module (6), voltage sample module (7), data memory module (8) and clock module (9) respectively; IO expansion module (2) is connected with display module (3), impedance measurement module (4), communication module (6), sound module (10) and system state indicating module (11) respectively; Power module (5) is control module (1), IO expansion module (2), display module (3), impedance measurement module (4), communication module (6), voltage sample module (7), data memory module (8), clock module (9), sound module (10) and system state indicating module (11) power supply.

2. portable impedance bio-sensing detector according to claim 1, it is characterized in that: described impedance measurement module (4) comprising: frequency cells (401), impedance reference cell (402), impedance calibration unit (403), analog signal conditioner unit (404) and impedance measuring unit (405); Wherein, described analog signal conditioner unit (404) are connected with impedance reference cell (402), impedance calibration unit (403) and impedance measuring unit (405) respectively; Impedance reference cell (402) is connected with impedance calibration unit (403); Frequency cells (401) is connected with impedance measuring unit (405).

3. portable impedance bio-sensing detector according to claim 1, it is characterized in that: described power module (5) comprises power input unit (501), charhing unit (502) and boosting unit (503); Wherein, described charhing unit (502) is connected with boosting unit (503) with power input unit (501) respectively.

4. portable impedance bio-sensing detector according to claim 1, it is characterized in that: described communication module (6) comprises USB communication unit (601), printer unit (602), bluetooth communication unit (603), communication signal switch unit (604) and TCP/IP communication unit (605); Wherein, described communication signal switch unit (604) is connected with USB communication unit (601), printer unit (602), bluetooth communication unit (603) and TCP/IP communication unit (605) respectively.

Images