CN203310795U - Portable impedance biosensing detector - Google Patents

Portable impedance biosensing detector Download PDF

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Publication number
CN203310795U
CN203310795U CN2013203185778U CN201320318577U CN203310795U CN 203310795 U CN203310795 U CN 203310795U CN 2013203185778 U CN2013203185778 U CN 2013203185778U CN 201320318577 U CN201320318577 U CN 201320318577U CN 203310795 U CN203310795 U CN 203310795U
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China
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module
pin
unit
impedance
communication
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CN2013203185778U
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Chinese (zh)
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应义斌
叶尊忠
徐文道
吴坚
李延斌
王剑平
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Zhejiang University ZJU
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Zhejiang University ZJU
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Abstract

The utility model discloses a portable impedance biosensing detector which comprises a control module, an IO extension module, a display module, an impedance measuring module, a power module, a communication module, a voltage sampling module, a data storage module, a clock module, a sound module and a system state indicating module, wherein the control module is connected with the IO extension module, the display module, the impedance measuring module, the communication module, the voltage sampling module, the data storage module and the clock module respectively; and the IO extension module is connected with the display module, the impedance measuring module, the communication module, the sound module and the system state indicating module respectively. The portable impedance biosensing detector disclosed by the utility model has the advantages of fast detection, accurate detection result, reliable operation, environmental protection, energy saving and convenience in operation and carrying, and can be widely applied to various occasions of biological impedance analysis and detection.

Description

A kind of portable impedance bio-sensing detector
Technical field
The utility model relates to the impedance detection field, relates in particular to a kind of portable impedance bio-sensing detector.
Background technology
In recent years, food-safety problem is more and more outstanding, has become world today's property public health focus.Therefore the Rapid food safety inspection instrument device also more and more is subject to people's attention.And biology sensor has the advantages such as selectivity is good, detection speed is fast, sensitivity is high as a kind of new technology, in field widespread uses such as agricultural, food, medical and health.Because its accuracy of detection is between the conventional fast method of representative between large-scale experiment chamber analytical instrument and test strips, but and be convenient for carrying field quick detection, be very suitable for the food security rapid screening, guarantee people's physical and mental health and life security, maintain social stability and prosperity, promote the development of economy and trade.Wherein impedance biosensor because having the mark of exempting from, detect the advantage such as quick and be subject to extensive concern.Impedance biosensor is comprised of bioelectrode and impedance detection instrument usually.The impedance detection instrument is generally completed by large-scale precision impedance detection instrument at present, as Britain solartron company, U.S. Agilent and German Zahner company, corresponding product is arranged, also has in addition the small-sized impedance detection instrument of research and development, if in the United States Patent (USP) (METHODS AND SYSTEMS FOR DETECTION OF CONTAMINANTS, international publishing number: WO 2008/028124) at Li Yanbin, Ye Zunzhong etc., provided a kind of device based on impedance method detection of contamination.This hand-held device adopts microprocessor to control, built-in impedance detection chip cartridges, and English character shows, adopts the functions such as serial ports on-line communication of powered battery and computing machine.That this device has is small-sized, can be portable etc. advantage, but also there are some problems in this device: the simulating signal as this impedance detection just is not connected on detecting electrode through pre-process, easily the biomaterial on detecting electrode is impacted and causes measurement result to be forbidden and the detection signal poor stability; In addition, because this device adopts single excitation frequency, therefore can't under a plurality of frequency ranges, work, particularly under lower survey frequency, work; There is no the battery charging management function, adopt common batteries, can not charge and cause service time short, be not suitable for long working; Can not with there is no serial ports but have the computing machine of USB mouth, bluetooth or TCP/IP network interface to carry out data communication, can not be on detecting instrument the data measured of real time print; Can not Chinese display and figure, and can not close the backlight with save power of liquid crystal display; Have no time and the date circuit function, therefore can not show the parameters such as measurement date of specimen.
Summary of the invention
The purpose of this utility model is for the deficiencies in the prior art, and a kind of portable impedance bio-sensing detector is provided.
The technical solution adopted in the utility model is as follows: a kind of portable impedance bio-sensing detector, and it comprises: control module, IO expansion module, display module, impedance measurement module, power module, communication module, voltage sample module, data memory module, clock module, sound module and system state indicating module; Wherein, described control module is connected with clock module with IO expansion module, display module, impedance measurement module, communication module, voltage sample module, data memory module respectively; The IO expansion module is connected with display module, impedance measurement module, communication module, sound module and system state indicating module respectively; Power module is control module, IO expansion module, display module, impedance measurement module, communication module, voltage sample module, data memory module, clock module, sound module and the power supply of system state indicating module.
Further, described impedance measurement module comprises: frequency cells, impedance reference cell, impedance calibration unit, analog signal conditioner unit and impedance measuring unit; The analog signal conditioner unit is connected with impedance measuring unit with impedance reference cell, impedance calibration unit respectively; The impedance reference cell is connected with the impedance calibration unit; Frequency cells is connected with impedance measuring unit.
Further, described power module comprises power input unit, charhing unit and boosting unit; Wherein, described charhing unit is connected with boosting unit with power input unit respectively.
Further, described communication module comprises USB communication unit, printer unit, bluetooth communication unit, communication signal switch unit and TCP/IP communication unit; Wherein, described communication signal switch unit is connected with USB communication unit, printer unit, bluetooth communication unit and TCP/IP communication unit respectively.
The beneficial effect the utlity model has is:
1, the utility model has adopted frequency splitting technology, can be under different frequency to detection cell in the sample impedance measure, for different samples, select its optimum detection frequency, improve accuracy.
2, deliver to the impedance measurement module after by the analog signal conditioner unit, simulating signal to be measured being nursed one's health, increase the accuracy of result.
3, the impedance calibration unit adopts different impedances to proofread and correct system, but the assurance device reliability of operation.
4, this device by communication module by multiple mechanics of communication integrated and with this device combination, can carry out with computer that data communication is carried out in USB interface communication, computing machine by bluetooth or TCP/IP network interface and the data that will record output to printer.
5, display module energy Chinese display and graphical information, screen backlight are closed with sleep operation automatically to save electrical source consumption.
6, this device detects in real time and shows cell voltage, system power supply voltage etc., guarantees the work of system normal reliable.
7, this device button is few, easy and simple to handle, and detection speed is fast.Adopted the jumbo rechargeable battery of high-performance, service time length and the use of repeatedly charging.Can be widely used in the various occasions that need the detection of biological impedance.
The accompanying drawing explanation
Fig. 1 is that module of the present utility model forms structured flowchart;
Fig. 2 is that module 4 of the present utility model forms structured flowchart;
Fig. 3 is that module 5 of the present utility model forms structured flowchart;
Fig. 4 is that module 6 of the present utility model forms structured flowchart;
Fig. 5 is program flow diagram of the present utility model;
Fig. 6 is the circuit diagram of module 1 of the present utility model;
Fig. 7 is the circuit diagram of module 2 of the present utility model;
Fig. 8 is the circuit diagram of module 3 of the present utility model;
Fig. 9 is the circuit diagram of module 4 of the present utility model;
Figure 10 is the circuit diagram of module 5 of the present utility model;
Figure 11 is the circuit diagram of module 6 of the present utility model;
Figure 12 is the circuit diagram of module 7 of the present utility model;
Figure 13 is the circuit diagram of module 8 of the present utility model;
Figure 14 is the circuit diagram of module 9 of the present utility model;
Figure 15 is the circuit diagram of module 10 of the present utility model;
Figure 16 is the circuit diagram of module 11 of the present utility model.
In figure: control module 1, IO expansion module 2, display module 3, impedance measurement module 4, power module 5, communication module 6, voltage sample module 7, data memory module 8, clock module 9, sound module 10, system state indicating module 11, frequency cells 401, impedance reference cell 402, impedance calibration unit 403, analog signal conditioner unit 404, impedance measuring unit 405, power input unit 501, charhing unit 502, boosting unit 503, USB communication unit 601, printer unit 602, bluetooth communication unit 603, communication signal switch unit 604, TCP/IP communication unit 605.
Embodiment
The utility model is described in further detail below in conjunction with accompanying drawing and embodiment.
As shown in Figure 1, the utility model comprises: control module 1, IO expansion module 2, display module 3, impedance measurement module 4, power module 5, communication module 6, voltage sample module 7, data memory module 8, clock module 9, sound module 10 and system state indicating module 11; Wherein, control module 1 is connected with IO expansion module 2, display module 3, impedance measurement module 4, communication module 6, voltage sample module 7, data memory module 8 and clock module 9 respectively; IO expansion module 2 is connected with display module 3, impedance measurement module 4, communication module 6, sound module 10 and system state indicating module 11 respectively; Power module 5 is control module 1, IO expansion module 2, display module 3, impedance measurement module 4, communication module 6, voltage sample module 7, data memory module 8, clock module 9, sound module 10 and 11 power supplies of system state indicating module.Control module 1 drives display module 3 according to user's input parameter and shows corresponding parameter, and the impedance measurement desired signal sequential of driving IO expansion module 2 control group measurement modules 4, control module 1 then control group measurement module 4 records impedance signal, and impedance signal is stored by data memory module 8.Control module 1 reaches display module 3 and communication module 6 by impedance signal.
As shown in Figure 2, impedance measurement module 4 comprises five unit: frequency cells 401, impedance reference cell 402, impedance calibration unit 403, analog signal conditioner unit 404 and impedance measuring unit 405; Analog signal conditioner unit 404 is connected with impedance reference cell 402, impedance calibration unit 403 and impedance measuring unit 405 respectively; Impedance reference cell 402 is connected with impedance calibration unit 403; Frequency cells 401 is connected with impedance measuring unit 405.The impedance measurement frequency transfers to impedance measuring unit 405 by frequency cells 401, and impedance signal detects by impedance measuring unit 405 after 404 conditionings of analog signal conditioner unit.
As shown in Figure 3, power module 5 comprises power input unit 501, charhing unit 502 and boosting unit 503; Wherein charhing unit 502 is connected with boosting unit 503 with power input unit 501 respectively.Input power is delivered to power input unit 501, through charhing unit 502 to boosting unit 503.
As shown in Figure 4, communication module 6 comprises USB communication unit 601, printer unit 602, bluetooth communication unit 603, communication signal switch unit 604 and TCP/IP communication unit 605; Wherein, communication signal switch unit 604 is connected with USB communication unit 601, printer unit 602, bluetooth communication unit 603 and TCP/IP communication unit 605 respectively.Communication signal switch unit 604 under control module 1 effect with USB communication unit 601, printer unit 602, bluetooth communication unit 603 and TCP/IP communication unit 605 in one carry out the signal transmission.
The course of work of this system has been described as shown in Figure 5.After detecting beginning, can select different survey frequencies to carry out impedance measurement record data to target to be measured, can select print data when measuring while finishing.
As shown in Figure 6, control module 1 comprises: single-chip microcomputer U3, keyboard JP1, crystal oscillator X2, capacitor C 4, C5, capacitor C 12, resistance R 9; Wherein keyboard JP1 is upper determines that key K1, cancel key K2, printing key K3, measurement key K4, upwarding key K5, down Arrow K6 are connected with the 1-6 pin of single-chip microcomputer U3 respectively; The grounding pin of keyboard JP1 (7 pin) is connected with the grounding pin (20 pin) of single-chip microcomputer and ground connection; The crystal oscillator pin 1 of single-chip microcomputer (19 pin) is connected with an end of crystal oscillator X2, capacitor C 4, the other end of the crystal oscillator pin 2 of single-chip microcomputer (18 pin) and crystal oscillator X2, and an end of capacitor C 5 is connected, ground connection after the other end of capacitor C 4, C5 connects; Operating voltage VCC is connected with the voltage input pin (40 pin) of single-chip microcomputer U3, the positive pole of capacitor C 12, and the negative pole of capacitor C 12 is connected with the end of the reset pin of single-chip microcomputer (9 pin) and R9, the other end ground connection of R9.Single-chip microcomputer U3 realizes the control to whole device, and the model that can adopt atmel corp to produce is the chip of AT89C51RC, but is not limited to this.
As shown in Figure 7, IO expansion module 2 comprises: IO extended chip U10, U12; The shift clock pin (11 pin) of the shifted data input pin of IO extended chip U10 (14 pin), IO extended chip U10, U12, displacement latch pin (12 pin) respectively with control module in the reading pin (17 pin), write pin (16 pin) and the outside timer T0(14 pin of inputting of single-chip microcomputer U3) be connected; The shift clock of U10, U12 meets operating voltage VCC after removing pin (10 pin) and voltage input pin (16 pin) being connected, ground connection after enable pin (13 pin) is connected with grounding pin (8 pin); The serial data output pin of U10 (9 pin) is connected with the shifted data input pin (14 pin) of U12.IO extended chip U10, U12 realize the IO mouth expansion to single-chip microcomputer U3, and the model that can adopt NXP Semiconductors company to produce is the chip of 74HC595D, but is not limited to this.
As shown in Figure 8, display module 3 comprises: LCDs U6, resistance R 6, R11, R8, triode Q3; The 4-17 pin of LCDs U6 is connected with the U3 of control module 1 respectively, one end of operating voltage VCC and resistance R 6, the supply voltage input pin of LCDs U6 (2 pin), backlight anode (19 pin) are connected, the other end of R6 is connected with the end that the liquid crystal display contrast of U6 is regulated pin (3 pin), R11, and the other end of R11 is connected with the driving voltage output pin (18 pin) of U6; Power supply ground pin (1 pin) ground connection of U6; The parallel data output pin of resistance R 8 one ends and IO extended chip U12 (4 pin, BG ON) is connected, and the other end connects the base stage of triode Q3, and the collector of Q3 is connected with the backlight negative terminal (20 pin) of U6, the grounded emitter of Q3.LCDs U6 realization is to the setting of detected parameters, the demonstration of order and the demonstration of result, and the model that can adopt foresight company to produce is the Lattice and graphic display module of LCD12864, but is not limited to this.
As shown in Figure 9, impedance measurement module 4 comprises: frequency cells 401, impedance reference cell 402, impedance calibration unit 403, analog signal conditioner unit 404 and impedance measuring unit 405, in frequency cells 401, the X common port of analog switch U17 (3 pin) is connected with the main clock pulse pin (8 pin) of measurement chip U2 in impedance measuring unit 405, the resistance R 27 in impedance reference cell 402 in the X common port of analog switch U15 (3 pin) and impedance calibration unit 403, R25, R23, R21, R10, R17, R15, R13, capacitor C 18, the common port of C19 is connected, and in impedance reference cell 402, the X common port of analog switch U15 (3 pin) is connected with the negative input pin (6 pin) of operational amplifier U14B in analog signal conditioner unit 404, and in impedance reference cell 402, resistance R 26, R24, R22, R18, R7, R16, R14, R12, capacitor C 20, in the common port of C21 and analog signal conditioner unit 404, the output terminal (7 pin) of operational amplifier U14B and the end of R33 are connected, in impedance calibration unit 403, the X common port of analog switch U16 (3 pin) is connected with the output terminal (1 pin) of operational amplifier U14A in analog signal conditioner unit 404, the feedback pin (4 pin) of measuring chip U2 in analog signal conditioner unit 404 in the end of R34 and impedance measuring unit 405 is connected, the R34 other end with the voltage input end (5 pin) of U2, be connected again after the R33 other end is connected, one end of capacitor C 9 is connected with the voltage output end of U2 (6 pin).Analog switch U15, U16, U17 realizes the selection effect to signal, the model that can adopt National Semiconductor company to produce is the chip of CD4051, but is not limited to this.Operational amplifier U14A, U14B realize the pre-process function to detection signal, belong to two passages of amplifier OPA2344, but are not limited to this.Measure chip U2 and realize the measurement to impedance signal, the model that can adopt Analog Devices company to produce is the chip of AD5933, but is not limited to this.
As shown in Figure 9, frequency cells 401 comprises: active crystal oscillator X1, frequency divider U13 and analog switch U17; The enable pin of analog switch U17 (6 pin), sheet select pin (11,10,9 pin) with the parallel data output pin (3,15,1,2 pin) of IO extended chip U12 in IO expansion module 2, to be connected respectively; The voltage input pin (4 pin) of the voltage input pin of analog switch U17 (16 pin), active crystal oscillator X1 and the voltage input pin (16 pin) of frequency divider U13 meet operating voltage VCC; Ground connection after the driving voltage output terminal of U17 (7 pin) is connected with grounding pin (8 pin); The switch pin of U17 (13,14,15,12,1,5,2,4 pin) is connected with the switch pin (9,7,6,5,3,2,4,13 pin) of U16 respectively; Ground connection after the reset pin of U16 (11 pin) is connected with grounding pin (8 pin); The output pin of active crystal oscillator X1 (3 pin) is connected with the clock end (10 pin) of frequency divider U13, the grounding pin of X1 (2 pin) ground connection.Frequency divider U13 can be by the frequency division of the frequency of active crystal oscillator X1, and the model that can adopt Philips Semiconductors company to produce is the chip of 74HC4040, but is not limited to this.
As shown in Figure 9, impedance reference cell 402 comprises: analog switch U15, resistance R 26, R24, R22, R18, R7, R16, R14, R12, capacitor C 20, C21; Wherein the sheet of analog switch U15 selects pin (9,10,11 pin) with the panel data output pin (4,5,6 pin) of IO extended chip U10, to be connected respectively; Ground connection after the driving voltage output terminal of U15 (7 pin) is connected with grounding pin (8 pin), voltage input pin (16 pin) meets operating voltage VCC; The switch pin of analog switch U15 (4,2,5,1,12,15,14,13 pin) is connected with the other end of resistance R 26, R24, R22, R18, R7, R16, R14, R12 respectively; Capacitor C 20 is in parallel with resistance R 26, and capacitor C 21 is in parallel with resistance R 12, the enable pin of U15 (6 pin) ground connection.
As shown in Figure 9, impedance calibration unit 403 comprises: analog switch U16, resistance R 27, R25, R23, R21, R10, R17, R15, R13, capacitor C 18, C19; Wherein the sheet of analog switch U16 selects pin (9,10,11 pin), enable pin (6 pin) with the panel data output pin (15,1,2,3 pin) of IO extended chip U10, to be connected respectively; Ground connection after the driving voltage output terminal of U16 (7 pin) is connected with grounding pin (8 pin), voltage input pin (16 pin) meets operating voltage VCC; The switch pin of analog switch U16 (4,2,5,1,12,15,14,13 pin) is connected with the other end of resistance R 27, R25, R23, R21, R10, R17, R15, R13 respectively; Capacitor C 18 is in parallel with resistance R 27, and capacitor C 19 is in parallel with resistance R 13.
As shown in Figure 9, analog signal conditioner unit 404 comprises: measuring-signal input interface J2, operational amplifier U14A, U14B, resistance R 29, R30, R31, R32, R33, R34, capacitor C 9; Wherein measuring-signal input interface J2 is connected with external detection cell; The output pin of measuring-signal input interface J2 (1 pin) is connected with the negative input pin (6 pin) of operational amplifier U14B; The end of R31, R32 meets the positive input pin (5 pin) of U14B, the other end ground connection of R31, another termination operating voltage VCC of R32 after being connected; The output terminal of U14B (7 pin) is connected with R33; One end of capacitor C 9 is connected with the output pin (6 pin) of measuring chip U2, the other end and resistance R 29, the positive input pin of R30 mono-end and operational amplifier U14A (3 pin) is connected, the other end of R29 with meet operating voltage VCC after the voltage input pin (8 pin) of U14A is connected, ground connection after the other end of R30 is connected with the grounding pin of U14A (4 pin); The negative input pin of U14A (2 pin) and the input pin (4 pin) that meets measuring-signal input interface J2 after output terminal (1 pin) is connected.
As shown in Figure 9, impedance measuring unit 405 comprises: measure chip U2; The serial time clock line (16 pin), serial data line (15 pin) of wherein measuring chip U2 respectively with control module 1 in the ZSDA(28 pin of U3), the ZSCL(27 pin) be connected; The digital voltage input pin of U2 (9 pin) with meet operating voltage VCC after aanalogvoltage input pin (10,11 pin) is connected, ground connection after digital grounding pin (12 pin) is connected with analogue ground pin (13,14 pin).
As shown in figure 10, power module 5 comprises: power input unit 501, charhing unit 502 and boosting unit 503; Charhing unit 502 is connected with boosting unit 503 with power input unit 501 respectively; Power input unit 501 comprises USB power supply VUSB, power supply adaptor J1, diode D7, schottky diode D2, D5, capacitor C 3, C6, voltage stabilizing chip U9; Charhing unit 502 comprises light emitting diode D8, schottky diode D3, D4, resistance R 4, R28, battery E1, charging chip U5; Boosting unit 503 comprises capacitor C 2, C10, capacitor C 1, C8, C11, and resistance R 1, R19, R20, R35, schottky diode D1, inductance L 1, chip U1 boosts; In power input unit 501, the negative electrode of schottky diode D5 is connected with the anode of light emitting diode D8 in charhing unit 502 after with the negative electrode of D2, being connected, and with the negative pole of capacitor C 2 in boosting unit 503, is connected after the grounding pin (2 pin) of the charging chip U5 in power input unit 501 in the negative pole of capacitor C 3 and charhing unit 502 is connected again; In charhing unit 502, the negative electrode of schottky diode D3, D4 is connected with the positive pole of capacitor C 2 through K switch after being connected.Voltage stabilizing chip U9 realizes the pressure stabilization function to external power supply, and the model that can adopt Fairchild Semiconductor company to produce is the chip of LM7805, but is not limited to this.Charging chip U5 realizes the charge function to battery E1, and the model that can adopt Linear Technology company to produce is the chip of LTC4054, but is not limited to this.The chip U1 that boosts realizes boost function, and the model that can adopt Linear Technology company to produce is the chip of LT1302, but is not limited to this.
As shown in figure 10, in power input unit 501, the positive pole of power supply adaptor J1 is connected with the anode of diode D7; The negative electrode of D7 is connected with the positive pole of capacitor C 6 and the voltage input pin (1 pin) of voltage stabilizing chip U9; The voltage output end of voltage stabilizing chip U9 (3 pin) is connected with the positive pole of capacitor C 3 and the anode of schottky diode D2; Ground connection after the negative pole of C3, C6, the grounding pin of U9 (2 pin) are connected with the negative pole of J1; USB power supply VUSB is connected with the anode of schottky diode D5; The negative electrode of D5 is connected with the negative electrode of D2.
As shown in figure 10, in charhing unit 502, the grounding pin of the negative pole of battery E1, charging chip U5 (2 pin) is connected with the end of R4; The other end of R4 is connected with the programmed control pin (5 pin) of U5; Battery access pin (3 pin) and the anode of schottky diode D4 of the positive pole of battery E1 and charging chip U5 are connected, the negative electrode of D4 with connect K switch after schottky diode D3 negative electrode is connected; The voltage input pin of U5 (4 pin) connects the anode of D3 and the anode of light emitting diode D8; The negative electrode of D8 connects the charged state output pin (1 pin) of U5 after resistance R 28.
As shown in figure 10, in boosting unit 503, capacitor C 2 is in parallel with capacitor C 8; The positive pole of C2 is connected with the voltage input pin (6 pin) of the chip U1 that boosts and an end of inductance L 1, and the other end of L1 is connected with the switched pins (7 pin) of anode and the U1 of schottky diode D1; The negative electrode of D1 and the feedback pin of U1 (4 pin), capacitor C 11, the positive pole of capacitor C 10 and resistance R 19 are connected, and this common port is the output terminal that whole circuit provides operating voltage VCC; The other end of R19 is connected with R20, and C10 is in parallel with C11; The negative pole of C2, the grounding pin of U1 (1 pin), power supply ground pin (8 pin), the negative pole of C10 and the other end of the R20 rear ground connection that is connected; The frequency compensation pin of U1 (2 pin) is through resistance R 1, the rear ground connection of capacitor C 1; The current-mode pin of U1 (5 pin) ground connection after resistance R 35.
As shown in figure 11, communication module 6 comprises: USB communication unit 601, printer unit 602, bluetooth communication unit 603, communication signal switch unit 604 and TCP/IP communication unit 605; Serial data transmitting terminal (26 pin), serial data receiving end (25 pin) that in USB communication unit 601, USB turns serial port chip U18 are connected with the switch pin (12,1 pin) of communication switching chip U11 in communication signal switch unit 604 respectively; In printer unit 602, the data of level transferring chip U19 send input pin (10 pin), data receiver output pin (9 pin) is connected with the switch pin (5,14 pin) of U11 respectively; In bluetooth communication unit 603, the data of blue tooth interface J5 transmission pins (2,3 pin) are connected with the switch pin (15,2 pin) of U11 respectively, and in TCP/IP communication unit 605, the data of TCP/IP interface J6 transmission pins (2,3 pin) are connected with the switch pin (11,4 pin) of U11 respectively.Level transferring chip U19 realizes the function of level conversion, can adopt MAX232, but be not limited to this; Communication switching chip U11 realizes the switching to communication object, and the model that can adopt Fairchild Semiconductor company to produce is the chip of CD4052, but is not limited to this; USB turns serial port chip U18 and realizes that the USB communication interface is virtual for the serial communication function, and the model that can adopt Silicon Laboratories company to produce is the chip of CP2101, but is not limited to this.
As shown in figure 11, USB communication unit 601 comprises USB interface J4, and USB turns serial port chip U18; Printer unit 602 comprises serial ports J3, capacitor C 13, C14, C15, C16, C17, level transferring chip U19; Bluetooth communication unit 603 comprises blue tooth interface J5; Communication signal switch unit 604 comprises communication switching chip U11; TCP/IP communication unit 605 comprises TCP/IP interface J6; The X common port of U11 (13 pin), Y common port (3 pin) are connected with serial data receiving end (10 pin), the serial data transmitting terminal (11 pin) of U3 respectively, and the sheet of U11 selects pin (10,9 pin) to be connected with the parallel data output pin (6,7 pin) of U12.
As shown in figure 11, the voltage input pin (16 pin) of communication switching chip U11 meets operating voltage VCC, ground connection after enable pin (6 pin), negative supply voltage pin (7 pin), grounding pin (8 pin) are connected; The voltage input pin of blue tooth interface J5, TCP/IP interface (1 pin) all meets operating voltage VCC, and grounding pin (4 pin) is ground connection all; The end of the voltage input pin (16 pin) of operating voltage VCC and level transferring chip U19, capacitor C 15, C17 is connected, and the other end of C15 generates positive voltage pin (2 pin) with the charge pump of U19 and is connected, and the other end of C17 is connected also ground connection with C16; The other end of C16 generates negative voltage pin (6 pin) with the charge pump of U19 and is connected; The two ends of capacitor C 13 are connected with the positive charge pump pin (1,3 pin) of U19 respectively; The two ends of C14 are connected with the negative charge pump pin (4,5 pin) of U19 respectively; The data of U19 send output pin (7 pin) and are connected with 3 pin of serial ports J3, and the data receiver input pin of U19 (8 pin) is connected with the reception data pin (2 pin) of serial ports J3; The grounding pin of U19 (15 pin) the rear ground connection that is connected with the grounding pin (5 pin) of serial ports J3; The voltage input pin of USB interface J4 (1 pin) is connected with power input (7 pin), USB power positive end (8 pin) that USB power supply VUSB, USB turn serial port chip U18; The signal of USB interface J4 transmits pin (2,3 pin) and is connected with the signal wire pin (4,5 pin) of U18; 4,5,6 pin of the USB interface J4 rear ground connection that is connected; The grounding pin of U18 (3 pin) is ground connection also.
As shown in figure 12, voltage sample module 7 comprises: voltage sample chip U8, capacitor C 7; Wherein the aanalogvoltage input pin of voltage sample chip U8 (1,2,3 pin) respectively with power module 5 in battery access pin (4 pin), the R19 of positive pole, charging chip U5 of battery E1 with the junction of R20, be connected; The serial time clock line of voltage sample chip U8 (10 pin), serial data line (9 pin) are connected with serial time clock line (8 pin), the serial data line (7 pin) of U3 in control module respectively; Operating voltage VCC is connected with reference voltage pin (14 pin), the voltage input pin (16 pin) of voltage sample chip U8; Operating voltage VCC is ground connection after capacitor C 7; The external pin of U8 (12 pin), in analog pin (13 pin) be connected after ground connection; Ground connection after the device ground pin of U8 (5,6,7 pin), grounding pin (8 pin) are connected.Voltage sample chip U8 realizes the voltage of monitoring battery E1, charging chip U5, operating voltage VCC, and the model that can adopt NXP Semiconductors company to produce is the chip of PCF8591, but is not limited to this.
As shown in figure 13, data memory module 8 comprises: pin-saving chip U4; The serial time clock line of pin-saving chip U4 (6 pin), serial data line (5 pin) are connected with serial time clock line (8 pin), the serial data line (7 pin) of U3 in control module respectively; The voltage input pin of U4 (8 pin) meets operating voltage VCC; Ground connection after the address of devices wire pin of U4 (1,2,3 pin), grounding pin (4 pin), write-protect pin (7 pin) are connected.Pin-saving chip U4 realizes the measurement parameter function of storage of collected data and setting, and the model that can adopt Microchip Technology company to produce is the chip of 24LC256, but is not limited to this.
As shown in figure 14, clock module 9 comprises: crystal oscillator X3, timing chip U7, battery E2; Wherein the serial clock input pin of timing chip U7 (7 pin), input and output pin (6 pin), reset pin (5 pin) respectively with control module in the external interrupt pin 1(13 pin of U3), outside input timer 1(15 pin), external interrupt pin 0(12 pin) be connected; The voltage input pin 2(1 pin of timing chip U7) meet operating voltage VCC, grounding pin (4 pin) ground connection; The two ends of crystal oscillator X3 are connected with the crystal oscillator pin (2 pin, 3 pin) of U7 respectively; The voltage input pin 1(8 pin of the positive pole of battery E2 and U7) be connected minus earth.Timing chip U7 realizes clocking capability, and the model that can adopt Dallas Semiconductor to produce is the chip of DS1302, but is not limited to this.
As shown in figure 15, sound module 10 comprises: resistance R 2, triode Q1, loudspeaker SP1; Wherein in the end of R2 and IO expansion module 2, the parallel data output pin of IO extended chip U12 (BEEP, 5 pin) is connected, and the other end of R2 is connected with the base stage of triode Q1; The end of loudspeaker SP1 is connected with operating voltage VCC, the collector of another termination triode Q1; The grounded emitter of Q1.
As shown in figure 16, system state indicating module 11 comprises: resistance R 3, R5, light emitting diode D6, triode Q2; Wherein in R3 mono-end and IO expansion module 2, the panel data output pin of IO extended chip U10 (LED-STA, 7 pin) is connected, and the R3 other end is connected with the base stage of triode Q2; Operating voltage VCC is connected with light emitting diode D6 anode after R5, the negative electrode of D6 is connected with the collector of triode Q2; The grounded emitter of Q2.
Power module 5 has USB Power supply, power supply adaptor power supply, three kinds of forms of powered battery.When any one connection in USB Power supply, power supply adaptor power supply, battery E1 is in charged state.
R19, R20 be for dividing potential drop, make the voltage sample module adopt value be no more than range.
Frequency divider U13 can become lower frequency by the frequency division of the frequency of active crystal oscillator X1, by single-chip microcomputer U3, controls the measurement of selecting suitable frequency to carry out impedance.
Analog switch U15, U16 can select correction and the measurement of different impedances to realize different impedance magnitude.
Analog signal conditioner unit 404 is nursed one's health for the simulating signal to obtaining, and reduces error.
Clock module 9 can record Measuring Time, system time etc.
Printer unit 602 can be realized the output of measurement data.
Communication signal switch unit 602 can be used the switching between printer unit 602, USB communication unit 601, bluetooth communication unit 603.
Voltage sample module 7 can be adopted to obtain the input voltage of battery E1 voltage, boost module output voltage, power input unit 501.
Data memory module 8 can be stored and export the sample impedance that gathers, sample label, acquisition time, frequency etc.
The system state indicating module is used to indicate system state.
Adopt schottky diode that less pressure drop can be arranged in diode current flow.
Determine that key K1, cancel key K2 are for determining, cancel the content of liquid crystal display screen display, printing key K3 is for printing the data of having surveyed, measure key K4 for determining the impedance measurement after parameter, upwarding key K5, down Arrow K6 are used for the selection to displaying contents on LCDs.
Light emitting diode D8 is used to indicate charged state.
The utility model implementation process is as follows,
1) according to schematic diagram, require to install circuit, the adapter J1 that connects with the mains, connect printer, connects the detection cell that has assembled biological detection chip;
2) open K switch, now this portable impedance bio-sensing detector is started working, and light emitting diode D8 is luminous, and battery E1 is in charged state, and light emitting diode D6 is luminous, means that instrument has entered duty;
3) press and determine that key K1 enters system, then by upwarding key K5, down Arrow K6 button, select, select " testing impedance " herein, and press and determine that key K1 enters the testing impedance interface;
4) by upwarding key K5, down Arrow K6, select the survey frequency needed, this detector provides 100 Hz, 1 KHz, and 10 KHz, 20 KHz, the different frequency of 100 five of KHz, press and determine that key K1 determines;
5) selection of sample feeding mode.Can with sampling pump, be connected the detection cell pipeline to realize auto injection, also can with syringe, be connected detecting device, draw biological sample to be measured by syringe.By syringe pump or manually sample is expelled in detection cell, stablize certain hour.
6) press and measure key K4, now detector starts to measure the impedance of detection cell, and after measurement, LCDs U6 can show corresponding data, presses and determines the key save data, and have corresponding No. ID, for example ID:0007;
7) if need duplicate measurements, repeating step 5)
8) if need to measure other samples, after cleaning, injects detection cell so other samples repeating step 5 again)
9) press printing key K3, by upwarding key K5, down Arrow K6, select the ID scope of the data that will print, and press and determine key K1, now printer work, print selected data;
10) can pass through bluetooth communication, USB communication, TCP/IP communication and be connected with computing machine, can carry out parameter setting, remote metering, data storing and read the functions such as test data of having deposited by computer software.
11) measurement is complete, closing switch K, and disconnection is connected with detection cell.
Above-mentioned embodiment is used for the utility model of explaining; rather than the utility model is limited; in the protection domain of spirit of the present utility model and claim, any modification and change to the utility model is made, all fall into protection domain of the present utility model.

Claims (4)

1. portable impedance bio-sensing detector, it is characterized in that: it comprises: control module (1), IO expansion module (2), display module (3), impedance measurement module (4), power module (5), communication module (6), voltage sample module (7), data memory module (8), clock module (9), sound module (10) and system state indicating module (11); Wherein, described control module (1) is connected with IO expansion module (2), display module (3), impedance measurement module (4), communication module (6), voltage sample module (7), data memory module (8) and clock module (9) respectively; IO expansion module (2) is connected with display module (3), impedance measurement module (4), communication module (6), sound module (10) and system state indicating module (11) respectively; Power module (5) is control module (1), IO expansion module (2), display module (3), impedance measurement module (4), communication module (6), voltage sample module (7), data memory module (8), clock module (9), sound module (10) and system state indicating module (11) power supply.
2. portable impedance bio-sensing detector according to claim 1, it is characterized in that: described impedance measurement module (4) comprising: frequency cells (401), impedance reference cell (402), impedance calibration unit (403), analog signal conditioner unit (404) and impedance measuring unit (405); Wherein, described analog signal conditioner unit (404) are connected with impedance reference cell (402), impedance calibration unit (403) and impedance measuring unit (405) respectively; Impedance reference cell (402) is connected with impedance calibration unit (403); Frequency cells (401) is connected with impedance measuring unit (405).
3. portable impedance bio-sensing detector according to claim 1, it is characterized in that: described power module (5) comprises power input unit (501), charhing unit (502) and boosting unit (503); Wherein, described charhing unit (502) is connected with boosting unit (503) with power input unit (501) respectively.
4. portable impedance bio-sensing detector according to claim 1, it is characterized in that: described communication module (6) comprises USB communication unit (601), printer unit (602), bluetooth communication unit (603), communication signal switch unit (604) and TCP/IP communication unit (605); Wherein, described communication signal switch unit (604) is connected with USB communication unit (601), printer unit (602), bluetooth communication unit (603) and TCP/IP communication unit (605) respectively.
CN2013203185778U 2013-06-03 2013-06-03 Portable impedance biosensing detector Expired - Fee Related CN203310795U (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014194555A1 (en) * 2013-06-03 2014-12-11 浙江大学 Portable impedance bio-sensing detector
CN104807858A (en) * 2014-01-29 2015-07-29 先技股份有限公司 Tunable chemical sensing device
CN104849322A (en) * 2015-04-22 2015-08-19 中国农业大学 Impedance biosensor and bio-impedance detection analysis method

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014194555A1 (en) * 2013-06-03 2014-12-11 浙江大学 Portable impedance bio-sensing detector
CN104807858A (en) * 2014-01-29 2015-07-29 先技股份有限公司 Tunable chemical sensing device
CN104849322A (en) * 2015-04-22 2015-08-19 中国农业大学 Impedance biosensor and bio-impedance detection analysis method
CN104849322B (en) * 2015-04-22 2017-10-24 中国农业大学 A kind of impedance biosensor and bio-impedance determination method

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