CN203310667U

CN203310667U - Microneedle for detecting liquid by quickly extracting liquid in sample

Info

Publication number: CN203310667U
Application number: CN2013205570731U
Authority: CN
Inventors: 张响; 冯维娜; 马将; 王旭; 孙冰丽; 李倩
Original assignee: Zhengzhou University
Current assignee: Zhengzhou University
Priority date: 2013-09-09
Filing date: 2013-09-09
Publication date: 2013-11-27
Anticipated expiration: 2023-09-09

Abstract

The utility model discloses a polymer microneedle for quickly detecting trace sampled liquid. The microneedle consists of a needle head, a base body, a liquid runner and a liquid storage part, wherein the needle head is fixed at the end part of the base body; the liquid runner comprises a branch runner and a main runner; the main runner is arranged along the axial direction of the needle head; the branch runner is perpendicularly communicated with one end of the main runner and is arranged on the front part of the needle head; the other end of the main runner is communicated with the liquid storage part. The microneedle can test corresponding items for various types of detection test paper, and the polymer microneedle can be directly used as a liquid carrier and is observed under test instruments such as a microscope; one-time liquid sampling is realized; the sampled liquid is stored into two or more than two liquid storage slots at the same time and is subjected to corresponding detection respectively; the error probably produced by a reason that the liquid is tested after being sampled for multiple times is avoided.

Description

The micropin of liquid detecting in a kind of rapid extraction sample

Technical field

The utility model relates to a kind of micropin detected for the liquid of rapid extraction sample, is mainly used in the fast detecting of field of food.

Background technology

The liquid Fast Detection Technique is widely used in the every field such as chemistry, chemical industry, biology, medical treatment, food, as in food, cause a disease composition and chemical pollutant fast detecting; Bio-terrorism bacterium and viral field quick detection; Industry organic substance, high analyte, polymkeric substance, RNA (ribonucleic acid), protein, sugar and various microorganism concn detect; Water body volatile organic matter, nitrate, agrochemical pollutant monitoring; Concentration proportioning, microbiotic and the pollutant fast detecting of fruit juice, soft drink, milk and dairy produce, beer and grape wine etc.; Virus, bacterium, biochemical enzymes and drugs field quick detection.That that liquid detecting all needs to have corresponding liquid extraction device and detects reagent, test paper etc.

And existing liquid extraction device is all that separate or distant apart with following pick-up unit usually, the extracted amount of liquid is also larger, extracts comparatively difficulty for the little tissue fluid of amount of liquid; Or manufacturing cost is higher; Or the use of pick-up unit has relatively high expectations to the professional knowledge level, the layman is difficult to operation.

Summary of the invention

For the problem that above-mentioned prior art exists, the utility model provides the micropin of liquid detecting in a kind of novel rapid extraction sample.

This micropin material can adopt metal, carbon fiber or polymkeric substance, as PMMA, PC, COC, ABS, AS, CA, CAB, CAP, CP, EC, EPS, FEP, FRP, EVA, HDPE, HIPS, LCP, LDPE, PA, PBT, PC, PCTFE, PE, PET, PES, PMMA, POM, PP, PPO, PPS, PS, PVA, PVAC, PVB, PVC, PVCA, PVDC, PVFM, SAN etc.

Described in the utility modelly a kind ofly for extracting the micropin of sample liquid detecting, consist of syringe needle, matrix, flow channel for liquids and liquid storing part, syringe needle is fixed on the matrix end; Described flow channel for liquids comprises runner and sprue, and sprue is along needle shaft to setting, an end of runner vertical connection sprue and be arranged on the syringe needle front portion; The other end of sprue is communicated with liquid storing part.Syringe needle can adopt metal or carbon fibre material to make.

Further, canMatrix is provided with the liquid storing part more than 2; Each liquid storing part is connected with sprue by side runner.Liquid storing part is the built-in circular groove of matrix, and the degree of depth is 100 μ m.Described liquid storing part can be also to take out separately microencapsulation or the kit be embedded on matrix, when the liquid in sample need to be delivered to laboratory and detects, can adopt this structure, and getting liquid measure can be greatly to 2ml.In addition, Test paper can be built-in with at liquid storing part, during predetermined substance in detecting sample liquids, testing result can be obtained rapidly. For convenient stable the gripping,On described matrix, can be provided with the section that grips with convex-concave structure.

The syringe needle part diameter of micropin is below 600 μ m, and the kapillary equivalent dimension of syringe needle inside (diameter or the length of side) is below 200 μ m, and the micropin needle length, can be from 10mm to longer according to the difference of extracting sample.The shape in sprue cross section is semicircle, rectangle or U-shaped etc., and side runner is microchannel, can be zero bar or many.

Matrix can be circular or cylindrical for rectangle, can come choice for use to extract sample by making different colors, and the size of matrix is also along with the sample that gets sample has different sizes.If while extracting the fluid sample in vegetables or fruit, the matrix size is less, can make tabular, area is at 1-4cm ²Get final product; As while extracting animal live soma's interstitial fluid, the syringe needle that just need to grow and larger volume be easy to matrix firmly, as use cylindrical base, perhaps flat matrix, the latter half of matrix can include the section that grips or the handle with convex-concave structure, so that increase friction force plays antiskid function, be convenient to manual operations.

Liquid storing part can be the cavity of matrix, gets liquid measure in several to dozens of microlitre magnitudes, and shape is circle, ellipse or rectangle etc., and the general length of side of size is 10mm ~ 20mm, and the degree of depth is below 200 μ m.

The utility model can be placed the test that all kinds Test paper carries out respective item, also can directly this polymer micro needle be placed on as liquid-carrier under the testing tools such as microscope and observe.Micropin described in the utility model can also once be got liquid, is saved in simultaneously in two or more reservoirs, detects accordingly respectively, has avoided repeatedly getting the issuable error of liquid test.

The accompanying drawing explanation

Fig. 1 is polymer micro needle syringe needle schematic diagram described in the utility model;

Fig. 2 is the polymer micro needle schematic diagram that contains cylindrical liquid storing part of the utility model the first embodiment;

Fig. 3 is the polymer micro needle schematic diagram that contains two liquid storing parts of the utility model the second embodiment;

Fig. 4 is a kind of polymer micro needle schematic diagram that contains secondary liquid storing part of the utility model the 3rd embodiment;

Fig. 5 is the poly-compound micropin schematic diagram that contains secondary liquid storing part of the another kind of the utility model the 3rd embodiment.

Wherein, 1----micropin syringe needle, the 2----matrix, 3, the 7----liquid storing part, the 4----runner, the 5----sprue, the 6----side runner, 8----grips section, 9----handle, the secondary liquid storing part of 10----.

Embodiment

Below by specific embodiment, also by reference to the accompanying drawings the utility model is described in detail:

Embodiment mono-

As shown in Figure 2, this micropin consists of integrated metal micro-needle syringe needle 1, polymeric matrix 2 and liquid storing part 3, and liquid storing part 3 is the built-in circular groove of matrix 2, and the degree of depth is 100 μ m.Microneedles 1 punctures the plant tissue epidermis, make runner 4 parts enter organization internal, due to capillarity, tissue fluid enters sprue 5 through runner 4, finally enter liquid storing part 3, directly tissue fluid taken back to analyzing and testing is carried out by instrument in laboratory or in liquid storing part 3, placed Test paper and detect predetermined substance.

Embodiment bis-

As shown in Figure 3, this micropin consists of liquid storing part 3,7 and the side runner 6 of integrated carbon fiber micropin syringe needle 1, plastic cement matrix 2, two rectangles, can get simultaneously in liquid to two liquid storing part.Microneedles 1 punctures the animal meat epidermis, make runner 4 parts enter meat tissue inside, due to capillarity, tissue fluid enters sprue 5 with runner 4, by side runner 6, enter respectively liquid storing part 3 and 7, directly tissue fluid taken back to analyzing and testing is carried out by instrument in laboratory or in liquid storing part 3, placed Test paper and detect simultaneously two kinds of predetermined substances.

Embodiment tri-

As shown in Figure 4, this micropin is by the long aluminium alloy micropin syringe needle 1 of 3cm, plastic cement matrix 2, with the section that grips 8 of convex-concave structure, and the secondary liquid storing part 10 that can take out forms.By gripping section 8, long micropin syringe needle 1 is inserted in ampuliform or bag-shaped drink sample, get liquid in secondary liquid storing part 10, after storing up full liquid, take off secondary liquid storing part 10, sample is taken back to laboratory and detect.This design, by changing secondary liquid storing part, is convenient to continuous several times and is obtained fluid sample.

Claims

1. one kind for extracting the micropin of sample liquid detecting, consists of syringe needle (1), matrix (2), flow channel for liquids and liquid storing part (3), it is characterized in that, syringe needle (1) is fixed on matrix (2) end; Described flow channel for liquids comprises runner (4) and sprue (5), and sprue (5) axially arranges along syringe needle (1), an end of runner (4) vertical connection sprue (5) and be arranged on the syringe needle front portion; The other end of sprue (5) is communicated with liquid storing part (3).

2. micropin according to claim 1, is characterized in that, described syringe needle (1) adopts metal or carbon fibre material to make.

3. micropin according to claim 1, is characterized in that, the liquid storing part (3) more than 2 is arranged on described matrix (2); Each liquid storing part (3) is connected with sprue (5) by side runner (6).

4. micropin according to claim 1, is characterized in that, described liquid storing part (3) is the built-in circular groove of matrix (2), and the degree of depth is 100 μ m.

5. micropin according to claim 1, is characterized in that, described liquid storing part (3) is to take out separately microencapsulation or the kit be embedded on matrix (2).

6. micropin according to claim 4, is characterized in that, described liquid storing part (3) is built-in with Test paper.

7. according to the described described micropin of claim 1-6 any one, it is characterized in that, on described matrix (2), be provided with the section that grips (8) with convex-concave structure.