CN203256181U - Amantadine hydrochloride production equipment for improving production efficiency - Google Patents
Amantadine hydrochloride production equipment for improving production efficiency Download PDFInfo
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- CN203256181U CN203256181U CN 201320159613 CN201320159613U CN203256181U CN 203256181 U CN203256181 U CN 203256181U CN 201320159613 CN201320159613 CN 201320159613 CN 201320159613 U CN201320159613 U CN 201320159613U CN 203256181 U CN203256181 U CN 203256181U
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- amantadine hydrochloride
- pressing device
- tank
- filter
- washing
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Abstract
The utility model discloses amantadine hydrochloride production equipment for improving the production efficiency. The amantadine hydrochloride production equipment comprises a dissolving reaction tank, a filter pressing device, and a washing stewing tank, wherein the dissolving reaction tank is provided with a charging hole, a discharging hole, a mixing motor and an agitator blade, and used for preparing amantadine hydrochloride; the filter pressing device is provided with a feeding hole, a liquid outlet and a filter, and used for filtering amantadine hydrochloride reaction liquid; the washing stewing tank is provided with a liquid inlet, a discharge hole and a saturated salt water inlet, and used for washing the amantadine hydrochloride; the discharging hole of the dissolving reaction tank is communicated with a feeding hole of the filter pressing device via a pipeline; the liquid outlet of the filter pressing device is communicated with the liquid inlet of the washing stewing tank via a pipeline; the filter pressing device is a plate-and-frame filter pressing device; the discharging hole of the dissolving reaction tank is communicated with the feeding hole of the plate-and-frame filter pressing device through a feeding pump via a pipeline. By adopting the amantadine hydrochloride production equipment, the problems that feed liquid in the filter press is stored, and cleaning is not facilitated are solved; and the amantadine hydrochloride production equipment has the advantages that the filter pressing process is full; the work efficiency is improved; loss of the feed liquid is reduced; and the production cost is also reduced.
Description
Technical field
The utility model relates to chemical industry and pharmaceutical industries to the production unit that dry material reacts, filters, washs, and relates in particular to a kind of amantadine hydrochloride production unit of enhancing productivity.
Background technology
Amantadine hydrochloride (Amantadine Hydrochloride) is a kind of three cyclic amine of symmetry, can suppress virus and penetrate host cell, and the shelling of impact virus suppresses its breeding, has the effect for the treatment of preferably and preventing viral infection.The equipment that being used for of generally adopting at present, amantadine hydrochloride produced is as shown in Figure 1: comprise the standing tank 3 of solubilizing reaction tank 1, filter-pressing device and washing; Wherein the solubilizing reaction tank comprises tank body 11, the top of tank body is provided with charging opening 14, the top fixed installation agitator motor 12 of tank body, be provided with stirring rake 13 in tank body, driving stirring rake by agitator motor rotates in tank body, play the effect of stirring material, the bottom of tank body is provided with the drain hole 15 of being controlled by valve 41; Filter-pressing device be pressure-filtering tank 2 ', comprise tank body 21 ', the top of tank body arrange with the opening for feed 22 of solubilizing reaction tank drain hole pipeline connection ' and pressurized nitrogen inlet mouth 26 of being controlled by valve 44 ', the bottom be provided with the carbon outleting port 27 controlled by valve 42 ' and with the liquid outlet 23 of strainer 25 ' by pipeline communication '; Wash standing tank and comprise tank body 31, tank body top is provided with fluid inlet 32 and the saturated common salt water inlet 33 with pressure-filtering tank 2 ' liquid outlet 23 ' pipeline connection, and the bottom is provided with the discharge port 34 of being controlled by valve 43.Technological process is as follows: 1, the top charging opening of amantadine from solubilizing reaction tank 1 dropped into the solubilizing reaction tank that the dilute hydrochloric acid of preparing with purified water is housed, transfer pH with hydrochloric acid, with the heating material in the solubilizing reaction tank and stirring, rear stopped heating reacts completely, open water quench to room temperature, add activated carbon decolorizing and stir; 2, with mixture by the drain hole 15 that is arranged on the solubilizing reaction pot bottom be transferred to pressure-filtering tank 2 ' in, open pressurized nitrogen inlet mouth 26 ' valve 44 to pressurization in tank, strainer by wherein removes by filter gac by carbon outleting port 27 ' discharge, and the filtrate of dissolved salt symmetrel is by strainer 25 ' and pipeline 24 of being communicated with it ' from liquid outlet 23 ' drain into and wash standing tank 3; 3, fill the saturated aqueous common salt of packing into from saturated common salt water inlet 33 in the standing tank 3 of washing, filtrate is carried out cooling standing therein after washing, discharges from discharge port 34 and carries out follow-up treating process.There is following shortcoming in the equipment of production amantadine hydrochloride at present: what 1, solubilizing reaction tank drain hole was emitted is solidliquid mixture, directly open valve, follow-up filter-pressing device charging is easily produced inhomogeneous, affect filter effect, even stop up the pipeline that connects between itself and filter-pressing device when serious, cause filter-pressing device to work, make production efficiency low; 2, be arranged on sidewall rather than the bottom of tank body lower part due to the liquid outlet of pressure-filtering tank, therefore have more feed liquid in this tank and accumulate, be unfavorable for the cleaning of equipment; 3, the carbon outleting port of pressure-filtering tank is arranged on the bottom usually, can discharge together the feed liquid of accumulating when discharging gac, has also caused the loss of product, thereby increases the productive rate that material loss has reduced the final production process; 4, because the pressure of pressurized nitrogen inlet mouth is wayward, reduced the efficient of filtering, in addition, the use of nitrogen has also increased the cost of production process, is unfavorable for scale operation.
The utility model content
Technical problem to be solved in the utility model is to overcome the deficiencies in the prior art, a kind of amantadine hydrochloride production unit of enhancing productivity is provided, thereby reduce feed liquid accumulating in filtering equipment, avoid the loss of feed liquid, be convenient to the cleaning of filtering equipment, reach and reduce production costs, the purpose of enhancing productivity.
The utility model is to be achieved by the following technical programs:
A kind of amantadine hydrochloride production unit of enhancing productivity; Comprise and be provided with charging opening; Drain hole; Agitator motor; The solubilizing reaction tank for the preparation of amantadine hydrochloride of stirring rake; Be provided with opening for feed; The filter-pressing device that is used for filter salts symmetrel reaction solution of liquid outlet and strainer and be provided with fluid inlet; The standing tank of washing that is used for the washing salt symmetrel of discharge port and saturated common salt water inlet; The opening for feed pipeline connection of the drain hole of described solubilizing reaction tank and described filter-pressing device; The fluid inlet pipeline connection of the liquid outlet of described filter-pressing device and the standing tank of described washing; Described filter-pressing device is the filter press device; The drain hole of described solubilizing reaction tank is by the opening for feed pipeline connection of dnockout pump and described filter press device.
Top at the standing tank of described washing is provided with a vacuum extractor.
Described vacuum extractor is vacuum pump.
Described solubilizing reaction tank top is provided with visor mouth, temperature-measuring port, thermometer and tensimeter.
Described stirring rake is anchor formula or frame-type stirring rake.
Compared with prior art, the beneficial effects of the utility model are: provide a kind of amantadine hydrochloride production unit of enhancing productivity 1., between solubilizing reaction tank and filter press device, the dnockout pump is set, can control the speed that material that drain hole emits enters pressure filter, thereby allow material evenly fully filter, reach better filter effect, enhance productivity; 2. pressure-filtering tank is replaced to the filter press device, solved and accumulated the situation of feed liquid in the pressure-filtering tank, and utilized backwashing technology to clean plate and frame filter press easily, easy handling; 3. the gac in plate and frame filter press can together be removed when cleaning equipment, and this moment, feed liquid was all exported by pressure filter, can not cause the loss of feed liquid, thereby has improved the productive rate of producing; 4. wash the vacuum extractor that standing tank top arranges and not only accelerated the filtration velocity of feed liquid in the filter press device, and pressure easily controls, reduced production cost, be conducive to scale operation.
Description of drawings
Fig. 1 is the structural representation of amantadine hydrochloride existing equipment;
Fig. 2 is structural representation of the present utility model.
In figure: 1 solubilizing reaction tank, 11 tank bodies, 12 agitator motors, 13 stirring rakes, 14 charging openings, 15 drain holes, 16 visor mouths, 17 temperature-measuring ports, 18 thermometers, 19 tensimeters
2 filter press devices, 21 tank bodies, 22 opening for feeds, 23 liquid outlets, 24 pipelines, 25 strainers, 26 dnockout pumps
2 ' pressure-filtering tank, 21 ' tank body, 22 ' opening for feed, 23 ' liquid outlet, 24 ' pipeline, 25 ' strainer, 26 ' pressurized nitrogen inlet mouth, 27 ' carbon outleting port
The 3 standing tanks of washing, 31 tank bodies, 32 fluid inlets, 33 saturated common salt water inlets, 34 discharge ports, 35 vacuum extractors
The 41-44 valve.
Embodiment
In order to make those skilled in the art understand better the technical solution of the utility model, the utility model is described in further detail below in conjunction with accompanying drawing and most preferred embodiment.
As shown in Figure 2; The utility model provides a kind of amantadine hydrochloride production unit of enhancing productivity; Comprise and be provided with charging opening 14; Drain hole 15; Agitator motor 12; The solubilizing reaction tank 1 for the preparation of amantadine hydrochloride of stirring rake 13; Be provided with opening for feed 22; The filter-pressing device that is used for filter salts symmetrel reaction solution of liquid outlet 23 and strainer 25 and be provided with fluid inlet 32; The standing tank 3 of washing that is used for the washing salt symmetrel of discharge port 34 and saturated common salt water inlet 33; The drain hole 15 of described solubilizing reaction tank 1 and opening for feed 22 pipeline connections of described filter-pressing device; The liquid outlet 23 of described filter-pressing device and fluid inlet 32 pipeline connections of the standing tank 3 of described washing; Improvement is: described filter-pressing device is filter press device 2; The drain hole 15 of described solubilizing reaction tank is by opening for feed 22 pipeline connections of dnockout pump 26 with described filter press device; The filter press device adopts the commercially available prod; Be widely used in food; Chemical industry; The undercurrent washable filter press device that field of medicaments filters; Adopt the filter press device to substitute traditional pressure-filtering tank; Not only solved the problem that material loses because of the discharge of gac; Also effectively reduced accumulating of feed liquid; By the effect of dnockout pump 26, material is transferred in filtering equipment more swimmingly, thereby makes pressure-filtering process more even, has further improved the purity of product between solubilizing reaction tank 1 and filter press device 2.
Another improvement of this equipment is: be provided with a vacuum extractor 35 at the top of the standing tank 3 of described washing, so significantly improved the efficient of press filtration.
One the improving and to be again of this equipment: described vacuum extractor is vacuum pump, and vacuum pump adopts the commercially available prod, compares nitrogen, and the vacuum pump control pressure more easily operate, and cost is lower, also than nitrogen pot safety, saving space.
The improvement of this equipment also is: described solubilizing reaction tank top is provided with visor mouth 16, temperature-measuring port 17, thermometer 18 and tensimeter 19, convenient like this operator are the observing response situation at any time, control reaction conditions, the monitoring reaction progress, make reaction carry out more thoroughly thereby reach, and timely processing reaction feed liquid, save energy is increased work efficiency.
The improvement of this equipment also is: in order to increase the contact area of stirring rake and material, described stirring rake is anchor formula or frame-type stirring rake, thereby makes reaction more abundant, Reaction time shorten.
The amantadine hydrochloride production unit technological process that the utility model provides is as follows: 1, the top charging opening 14 of amantadine from solubilizing reaction tank 1 dropped into the solubilizing reaction tank 1 that the dilute hydrochloric acid of preparing with purified water is housed, transfer pH with hydrochloric acid, with the heating material in solubilizing reaction tank 1 and stirring, rear stopped heating reacts completely, open water quench to room temperature, add activated carbon decolorizing and stir; 2, mixture controllably is transferred in filter press device 2 by drain hole 15 speed under the effect of dnockout pump 26 that is arranged on solubilizing reaction tank 1 bottom, strainer 25 by wherein removes by filter gac, drains into from liquid outlet 23 more efficiently by strainer 25 and the pipeline 24 that is communicated with it under the effect of the vacuum pump that the filtrate of dissolved salt symmetrel arranges on the standing tank of washing and washs standing tank 3; 3, fill the saturated aqueous common salt of packing into from saturated common salt water inlet 33 in the standing tank of washing, filtrate is carried out therein cooling standing the discharge from discharge port 34 and is carried out follow-up treating process after washing.
The above is only preferred implementation of the present utility model; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the utility model principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection domain of the present utility model.
Claims (5)
1. amantadine hydrochloride production unit of enhancing productivity; Comprise and be provided with charging opening; Drain hole; Agitator motor; The solubilizing reaction tank for the preparation of amantadine hydrochloride of stirring rake; Be provided with opening for feed; The filter-pressing device that is used for filter salts symmetrel reaction solution of liquid outlet and strainer and be provided with fluid inlet; The standing tank of washing that is used for the washing salt symmetrel of discharge port and saturated common salt water inlet; The opening for feed pipeline connection of the drain hole of described solubilizing reaction tank and described filter-pressing device; The fluid inlet pipeline connection of the liquid outlet of described filter-pressing device and the standing tank of described washing; It is characterized in that: described filter-pressing device is the filter press device; The drain hole of described solubilizing reaction tank is by the opening for feed pipeline connection of dnockout pump and described filter press device.
2. amantadine hydrochloride production unit as claimed in claim 1, it is characterized in that: the top at the standing tank of described washing is provided with a vacuum extractor.
3. amantadine hydrochloride production unit as claimed in claim 2, it is characterized in that: described vacuum extractor is vacuum pump.
4. amantadine hydrochloride production unit as described in claim 1-3 any one is characterized in that: described solubilizing reaction tank top is provided with visor mouth, temperature-measuring port, thermometer and tensimeter.
5. amantadine hydrochloride production unit as claimed in claim 1, it is characterized in that: described stirring rake is anchor formula or frame-type stirring rake.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320159613 CN203256181U (en) | 2013-04-02 | 2013-04-02 | Amantadine hydrochloride production equipment for improving production efficiency |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320159613 CN203256181U (en) | 2013-04-02 | 2013-04-02 | Amantadine hydrochloride production equipment for improving production efficiency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203256181U true CN203256181U (en) | 2013-10-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201320159613 Expired - Fee Related CN203256181U (en) | 2013-04-02 | 2013-04-02 | Amantadine hydrochloride production equipment for improving production efficiency |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203256181U (en) |
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2013
- 2013-04-02 CN CN 201320159613 patent/CN203256181U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: 300000 Tianjin District of Jinnan City, Port Industrial Park Patentee after: TIANJIN MINXIANG BIOLOGICAL MEDICINE TECHNOLOGY CO., LTD. Address before: Double town 300000 Tianjin District of Jinnan city (formerly Industrial Park Tianjin Hongxin Chemical Factory) Patentee before: Tianjin Minxiang Biomedical Technology Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131030 Termination date: 20210402 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |