CN103159631A - Adamantanamine hydrochloride production device for improving production efficiency - Google Patents
Adamantanamine hydrochloride production device for improving production efficiency Download PDFInfo
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- CN103159631A CN103159631A CN 201310112159 CN201310112159A CN103159631A CN 103159631 A CN103159631 A CN 103159631A CN 201310112159 CN201310112159 CN 201310112159 CN 201310112159 A CN201310112159 A CN 201310112159A CN 103159631 A CN103159631 A CN 103159631A
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- filter press
- amantadine hydrochloride
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Abstract
The invention discloses an adamantanamine hydrochloride production device for improving production efficiency. The adamantanamine hydrochloride production device for improving production efficiency comprises a dissolving reaction tank, a filter press and a washing stewing tank, wherein the dissolving reaction tank is provided with a charging pot, a discharging port, a stirring motor and a stirring paddle and is used for preparing adamantanamine hydrochloride; the filter press is provided with a feeding port, a liquid outlet and a filter and is used for filtering an adamantanamine hydrochloride reaction liquid; the washing stewing tank is provided with a liquid inlet, a material outlet and a statured saline solution inlet and is used for washing adamantanamine hydrochloride; the discharging pot of the dissolving reaction tank is communicated with a feeding port pipeline of the filter press; the liquid outlet of the filter press is communicated with a liquid inlet pipeline of the washing stewing tank; the filter press is a plate frame filter press; and the discharging port of the dissolving reaction tank is communicated with a feeding port pipeline of the plate frame filter press by a feeding pump. According to the adamantanamine hydrochloride production device for improving production efficiency disclosed by the invention, the problems that the filter device is accumulated with feed liquid and is unbeneficial to cleaning are solved; moreover, the adamantanamine hydrochloride production device has the advantages of enabling the filter pressing process to be more sufficient, improving the working efficiency, reducing the feed liquid loss and reducing the production cost.
Description
Technical field
the present invention relates to the production unit that chemical industry and pharmaceutical industries are reacted, filter, washed dry material, relate in particular to a kind of amantadine hydrochloride production unit of enhancing productivity.
Background technology
amantadine hydrochloride (Amantadine Hydrochloride) is a kind of three cyclic amine of symmetry, can suppress virus and penetrate host cell, and affect viral shelling and suppress its breeding, has preferably the effect for the treatment of and preventing viral infection.The equipment of producing for amantadine hydrochloride generally adopted at present is as shown in Figure 1: comprise the standing tank 3 of solubilizing reaction tank 1, filter-pressing device and washing; Wherein the solubilizing reaction tank comprises tank body 11, the top of tank body is provided with charging opening 14, the top fixed installation agitator motor 12 of tank body, be provided with stirring rake 13 in tank body, drive stirring rake by agitator motor rotates in tank body, play the effect of stirring material, the bottom of tank body is provided with the drain hole 15 of being controlled by valve 41; Filter-pressing device be pressure-filtering tank 2 ', comprise tank body 21 ', the top of tank body arrange with the opening for feed 22 of solubilizing reaction tank drain hole pipeline connection ' and pressurized nitrogen inlet mouth 26 of being controlled by valve 44 ', bottom be provided with the carbon outleting port 27 controlled by valve 42 ' and with the liquid outlet 23 of strainer 25 ' by pipeline communication '; Wash standing tank and comprise tank body 31, tank body top is provided with fluid inlet 32 and the saturated common salt water inlet 33 with pressure-filtering tank 2 ' liquid outlet 23 ' pipeline connection, and bottom is provided with the discharge port 34 of being controlled by valve 43.Technological process is as follows: 1, amantadine is dropped into the solubilizing reaction tank that the dilute hydrochloric acid of preparing by purified water is housed from the top charging opening of solubilizing reaction tank 1, adjust pH with hydrochloric acid, by the heating material in the solubilizing reaction tank stirring, stop heating after reacting completely, open water quench to room temperature, add activated carbon decolorizing and stir; 2, by mixture by the drain hole 15 that is arranged on the solubilizing reaction pot bottom be transferred to pressure-filtering tank 2 ' in, open pressurized nitrogen inlet mouth 26 ' valve 44 to pressurization in tank, strainer by wherein removes by filter gac by carbon outleting port 27 ' discharge, and the filtrate of dissolved salt symmetrel is by strainer 25 ' and pipeline 24 of being communicated with it ' from liquid outlet 23 ' drain into and wash standing tank 3; 3, wash in standing tank 3 and fill the saturated aqueous common salt of packing into from saturated common salt water inlet 33, filtrate is carried out cooling standing therein after washing, from discharge port 34, discharges and carries out follow-up treating process.There is following shortcoming in the equipment of production amantadine hydrochloride at present: what 1, solubilizing reaction tank drain hole was emitted is solidliquid mixture, directly open valve, follow-up filter-pressing device charging is easily produced inhomogeneous, affect filter effect, even stop up the pipeline connected between itself and filter-pressing device when serious, cause filter-pressing device to work, make production efficiency low; 2, be arranged on sidewall rather than the bottom of tank body lower part due to the liquid outlet of pressure-filtering tank, therefore have more feed liquid in this tank and accumulate, be unfavorable for the cleaning of equipment; 3, the carbon outleting port of pressure-filtering tank is arranged on bottom usually, when discharging gac, can discharge together the feed liquid of accumulating, and has also caused the loss of product, thereby increases the productive rate that material loss has reduced the final production process; 4, because the pressure of pressurized nitrogen inlet mouth is wayward, reduced the efficiency of filtering, in addition, the use of nitrogen has also increased the cost of production process, is unfavorable for scale operation.
Summary of the invention
technical problem to be solved by this invention is to overcome the deficiencies in the prior art, a kind of amantadine hydrochloride production unit of enhancing productivity is provided, thereby reduce feed liquid accumulating in filtering equipment, avoid the loss of feed liquid, be convenient to the cleaning of filtering equipment, reach and reduce production costs, the purpose of enhancing productivity.
the present invention is achieved by the following technical programs:
a kind of amantadine hydrochloride production unit of enhancing productivity, comprise and be provided with charging opening, drain hole, agitator motor, solubilizing reaction for the preparation of the amantadine hydrochloride tank of stirring rake, be provided with opening for feed, the filter-pressing device for filter salts symmetrel reaction solution of liquid outlet and strainer and be provided with fluid inlet, the standing tank of washing for the washing salt symmetrel of discharge port and saturated common salt water inlet, the opening for feed pipeline connection of the drain hole of described solubilizing reaction tank and described filter-pressing device, the fluid inlet pipeline connection of the liquid outlet of described filter-pressing device and the standing tank of described washing, described filter-pressing device is the filter press device, the drain hole of described solubilizing reaction tank is by the opening for feed pipeline connection of dnockout pump and described filter press device.
top at the standing tank of described washing is provided with a vacuum extractor.
described vacuum extractor is vacuum pump.
described solubilizing reaction tank top is provided with visor mouth, temperature-measuring port, thermometer and tensimeter.
described stirring rake is anchor formula or frame-type stirring rake.
compared with prior art, the invention has the beneficial effects as follows: 1. provide a kind of amantadine hydrochloride production unit of enhancing productivity, between solubilizing reaction tank and filter press device, the dnockout pump is set, can control the speed that material that drain hole emits enters pressure filter, thereby allow material evenly fully filter, reach better filter effect, enhance productivity; 2. pressure-filtering tank is replaced to the filter press device, solved and accumulated the situation of feed liquid in the pressure-filtering tank, and utilize backwashing technology to be cleaned plate and frame filter press easily, easy handling; 3. the gac in plate and frame filter press can together be removed when cleaning equipment, and now feed liquid is all exported by pressure filter, can not cause the loss of feed liquid, thereby has improved the productive rate of producing; 4. wash the vacuum extractor that standing tank top arranges and not only accelerated the filtration velocity of feed liquid in the filter press device, and pressure easily controls, reduced production cost, be conducive to scale operation.
The accompanying drawing explanation
fig. 1 is the structural representation of amantadine hydrochloride existing equipment;
fig. 2 is structural representation of the present invention.
in figure: 1 solubilizing reaction tank, 11 tank bodies, 12 agitator motors, 13 stirring rakes, 14 charging openings, 15 drain holes, 16 visor mouths, 17 temperature-measuring ports, 18 thermometers, 19 tensimeters
2 filter press devices, 21 tank bodies, 22 opening for feeds, 23 liquid outlets, 24 pipelines, 25 strainers, 26 dnockout pumps
2 ' pressure-filtering tank, 21 ' tank body, 22 ' opening for feed, 23 ' liquid outlet, 24 ' pipeline, 25 ' strainer, 26 ' pressurized nitrogen inlet mouth, 27 ' carbon outleting port
the standing tank of 3 washing, 31 tank bodies, 32 fluid inlets, 33 saturated common salt water inlets, 34 discharge ports, 35 vacuum extractors
the 41-44 valve.
Embodiment
in order to make those skilled in the art understand better technical scheme of the present invention, below in conjunction with accompanying drawing and most preferred embodiment, the present invention is described in further detail.
as shown in Figure 2, the invention provides a kind of amantadine hydrochloride production unit of enhancing productivity, comprise and be provided with charging opening 14, drain hole 15, agitator motor 12, solubilizing reaction for the preparation of the amantadine hydrochloride tank 1 of stirring rake 13, be provided with opening for feed 22, the filter-pressing device for filter salts symmetrel reaction solution of liquid outlet 23 and strainer 25 and be provided with fluid inlet 32, the standing tank 3 of the washing for the washing salt symmetrel of discharge port 34 and saturated common salt water inlet 33, the drain hole 15 of described solubilizing reaction tank 1 and opening for feed 22 pipeline connections of described filter-pressing device, the liquid outlet 23 of described filter-pressing device and fluid inlet 32 pipeline connections of the standing tank 3 of described washing, improvement is: described filter-pressing device is filter press device 2, the drain hole 15 of described solubilizing reaction tank is opening for feed 22 pipeline connections with described filter press device by dnockout pump 26, the filter press device adopts commercially available prod, be widely used in food, chemical industry, the undercurrent washable filter press device that field of medicaments filters, adopt the filter press device to substitute traditional pressure-filtering tank, not only solved the problem that material loses because of the discharge of gac, also effectively reduced accumulating of feed liquid, between solubilizing reaction tank 1 and filter press device 2, by the effect of dnockout pump 26, material is transferred in filtering equipment more swimmingly, thereby makes pressure-filtering process more even, has further improved the purity of product.
another improvement of this equipment is: be provided with a vacuum extractor 35 at the top of the standing tank 3 of described washing, so significantly improved the efficiency of press filtration.
an improvement again of this equipment is: described vacuum extractor is vacuum pump, and vacuum pump adopts commercially available prod, compares nitrogen, and the vacuum pump control pressure more easily operates, and cost is lower, also than nitrogen pot safety, saving space.
the improvement of this equipment also is: described solubilizing reaction tank top is provided with visor mouth 16, temperature-measuring port 17, thermometer 18 and tensimeter 19, convenient like this operator are the observing response situation at any time, control reaction conditions, the monitoring reaction progress, thereby reach, make reaction carry out more thoroughly, and processing reaction feed liquid in time, save energy, increase work efficiency.
the improvement of this equipment also is: in order to increase the contact area of stirring rake and material, described stirring rake is anchor formula or frame-type stirring rake, thereby makes reaction more abundant, Reaction time shorten.
amantadine hydrochloride production unit technological process provided by the invention is as follows: 1, amantadine is dropped into the solubilizing reaction tank 1 that the dilute hydrochloric acid of preparing by purified water is housed from the top charging opening 14 of solubilizing reaction tank 1, adjust pH with hydrochloric acid, by the heating material in solubilizing reaction tank 1 stirring, stop heating after reacting completely, open water quench to room temperature, add activated carbon decolorizing and stir; 2, mixture controllably is transferred in filter press device 2 by drain hole 15 speed under the effect of dnockout pump 26 that is arranged on solubilizing reaction tank 1 bottom, strainer 25 by wherein removes by filter gac, draining into from liquid outlet 23 more efficiently and wash standing tank 3 by strainer 25 and the pipeline 24 that is communicated with it under the effect of the vacuum pump that the filtrate of dissolved salt symmetrel arranges on the standing tank of washing; 3, wash in standing tank and fill the saturated aqueous common salt of packing into from saturated common salt water inlet 33, filtrate carries out coolingly standingly from discharge port 34, discharging and carrying out follow-up treating process therein after washing.
the above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (5)
1. an amantadine hydrochloride production unit of enhancing productivity, comprise and be provided with charging opening, drain hole, agitator motor, solubilizing reaction for the preparation of the amantadine hydrochloride tank of stirring rake, be provided with opening for feed, the filter-pressing device for filter salts symmetrel reaction solution of liquid outlet and strainer and be provided with fluid inlet, the standing tank of washing for the washing salt symmetrel of discharge port and saturated common salt water inlet, the opening for feed pipeline connection of the drain hole of described solubilizing reaction tank and described filter-pressing device, the fluid inlet pipeline connection of the liquid outlet of described filter-pressing device and the standing tank of described washing, it is characterized in that: described filter-pressing device is the filter press device, the drain hole of described solubilizing reaction tank is by the opening for feed pipeline connection of dnockout pump and described filter press device.
2. amantadine hydrochloride production unit as claimed in claim 1, it is characterized in that: the top at the standing tank of described washing is provided with a vacuum extractor.
3. amantadine hydrochloride production unit as claimed in claim 2, it is characterized in that: described vacuum extractor is vacuum pump.
4. amantadine hydrochloride production unit as described as claim 1-3 any one, it is characterized in that: described solubilizing reaction tank top is provided with visor mouth, temperature-measuring port, thermometer and tensimeter.
5. amantadine hydrochloride production unit as claimed in claim 1, it is characterized in that: described stirring rake is anchor formula or frame-type stirring rake.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310112159 CN103159631A (en) | 2013-04-02 | 2013-04-02 | Adamantanamine hydrochloride production device for improving production efficiency |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310112159 CN103159631A (en) | 2013-04-02 | 2013-04-02 | Adamantanamine hydrochloride production device for improving production efficiency |
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| CN103159631A true CN103159631A (en) | 2013-06-19 |
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| CN 201310112159 Pending CN103159631A (en) | 2013-04-02 | 2013-04-02 | Adamantanamine hydrochloride production device for improving production efficiency |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112657449A (en) * | 2019-10-15 | 2021-04-16 | 立邦涂料（中国）有限公司 | Continuous production method and equipment of aqueous electrophoretic resin |
| CN114602353A (en) * | 2022-04-13 | 2022-06-10 | 铜陵瑞莱科技有限公司 | Washing device for obtaining low-viscosity iron oxide yellow |
-
2013
- 2013-04-02 CN CN 201310112159 patent/CN103159631A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112657449A (en) * | 2019-10-15 | 2021-04-16 | 立邦涂料（中国）有限公司 | Continuous production method and equipment of aqueous electrophoretic resin |
| CN114602353A (en) * | 2022-04-13 | 2022-06-10 | 铜陵瑞莱科技有限公司 | Washing device for obtaining low-viscosity iron oxide yellow |
| CN114602353B (en) * | 2022-04-13 | 2024-04-05 | 铜陵瑞莱科技有限公司 | Washing device for obtaining low-viscosity iron oxide yellow |
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Application publication date: 20130619 |