CN203123956U - Automatic derivatization reaction treatment equipment - Google Patents
Automatic derivatization reaction treatment equipment Download PDFInfo
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- CN203123956U CN203123956U CN 201320052394 CN201320052394U CN203123956U CN 203123956 U CN203123956 U CN 203123956U CN 201320052394 CN201320052394 CN 201320052394 CN 201320052394 U CN201320052394 U CN 201320052394U CN 203123956 U CN203123956 U CN 203123956U
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Abstract
The utility model discloses automatic derivatization reaction treatment equipment. The automatic derivatization reaction treatment equipment comprises N derivatization reaction units, wherein each derivatization reaction unit comprises a solvent bottle, a cleaning bottle, a sample bottle, a reaction bottle, a first control valve, a second control valve, a third control valve, a first one-way valve, a second one-way valve, a third one-way valve, a first quantification pump, a second quantification pump, a third quantification pump, a constant volume sensor, a temperature sensor, a heater, an electromagnetic stirrer, a timer and a control module; each control module comprises a master controller, a valve controller, a temperature controller, a stirring controller, a time controller, a constant volume sensor and a pump controller; and the valve controller, the temperature controller, the time controller, the constant volume sensor and the pump controller are connected with the master controller respectively. All parts can be controlled in real time by the control modules according to the reaction process of a derivatization reaction, so that the whole reaction process is automatically completed; and the labor intensity can be reduced, and derivation time and derivation temperature are accurately controlled, so that the derivatization test of batch samples is high in accuracy, and high in parallelism.
Description
Technical field
The utility model relates to a kind of automatic derivative reaction treatment facility.
Background technology
Derivatization is a kind of material that utilizes chemical transformation compound to be changed into similar chemical constitution.In general, the compound of a specific function participates in derivatization reaction, solubility, and boiling point, fusing point, state of aggregation or chemical composition can produce and depart from, and consequent new chemical property can be used for quantizing or separating.The effect of analyte derivativeization mainly is that the material that is difficult to analyze is converted into material similar to its chemical constitution but that be easy to analyze, is convenient to quantize and separate, and as when detection material does not have UV absorption, it can be added chromophore, the material that generation can be detected.
Chemical derivatization is widely used in Instrumental Analysis.The applied chemistry derivatization reaction is volatility or the raising detection sensitivity in order to increase sample in the gas-chromatography, and the chemical derivatization of high performance liquid chromatography refers to utilize certain reagent (being generally called chemically derived reagent or labelled reagent) and sample component to carry out chemical reaction under certain condition, and the product of reaction is conducive to the chromatogram detection or separates.General chemical derivatization mainly contains following purpose: the sensitivity that improves sample detection; Improve the separating degree of sample mixture; Be suitable for further doing structure and identify, as mass spectrum, infrared or nuclear magnetic resonance etc.Carry out chemically derived reaction and should satisfy following requirement: reaction condition is required not harsh, and can be rapidly, carry out quantitatively; Certain component in the sample is only generated a kind of derivative, and byproduct of reaction and excessive derivative reagent do not disturb separation and the detection of sample; Chemically derived reagent conveniently is easy to get, and versatility is good.
At present, laboratory derivative reaction utensil commonly used has volumetric flask, water-bath etc., some problems below existing when carrying out common derivatization test: 1, the visual constant volume of volumetric flask can cause volumetric errors, perhaps causes the constant volume error because of the volumetric flask quality problems; 2, water-bath is in the derivatization process of batch sample, and temperature control has certain deviation, and can't realize the derivative reaction more than 100 ℃; 3, in batch analyte derivative process, because artificial origin's (as operating time, timing error etc.) causes that the derivatization process of each sample is not quite similar, and exists experimental error; 4, derivative reaction is subject to the influence of operating personnel's level.
Therefore, be to reduce the experimental error of derivative reaction, be badly in need of providing a kind of derivatization reaction equipment of automation, can control the time of deriving accurately, the temperature of deriving, make that analyte derivative experiment accuracy is higher in batches, collimation is better.
The utility model content
A kind of automatic derivative reaction treatment facility of the utility model, its purpose is to provide the chemical derivatization reaction treatment equipment of a kind of automation, sequencing, overcomes accuracy and the not high problem of operating efficiency of manually carrying out the analyzing and testing experiment in the prior art.
A kind of automatic derivative reaction treatment facility, comprise N derivative reaction unit, the derivative reaction unit is connected in parallel, and each derivative reaction unit comprises solvent bottle, washer bottle, sample bottle, reaction bulb, first control valve, second control valve, the 3rd control valve, first check valve, second check valve, the 3rd check valve, first constant displacement pump, second constant displacement pump, the 3rd constant displacement pump, constant volume sensor, temperature sensor, heater, magnetic stirrer, timer and control module;
Described control module comprises master controller, valve control, temperature controller, stirring controller, time controller, constant volume sensor and pump controller; Valve control, temperature controller, time controller, constant volume sensor and pump controller all link to each other with main controller; Wherein N is the integer more than or equal to 1;
Wherein, valve control is used for the valve control of control first control valve, second control valve, the 3rd control valve, first check valve, second check valve and the 3rd check valve;
Temperature controller is used for control heater;
Stir controller and be used for the control magnetic stirrer;
Pump controller is used for the pump controller of control first constant displacement pump, second constant displacement pump and the 3rd constant displacement pump;
Wherein, first control valve and second control valve are three-way control valve, and the 3rd control valve is two logical control valves;
Described solvent bottle, first check valve, first constant displacement pump, first control valve and reaction bulb connect by pipeline successively;
Described washer bottle all links to each other with second control valve with sample bottle, and second control valve, second check valve, second constant displacement pump and reaction bulb connect by pipeline successively;
Described reaction bulb, the 3rd check valve, the 3rd constant displacement pump and checkout gear connect by pipeline successively;
Described reaction bulb also links to each other with the 3rd control valve by pipeline;
Described reaction bulb is provided with constant volume sensor and temperature sensor, and heater and magnetic stirrer all are located at the reaction bulb bottom.
Described solvent bottle quantity is M, and M be the integer more than or equal to 1, when M more than or equal to 2 the time, by the connection of first mixing valve, first mixing valve links to each other with first check valve between the solvent bottle.
Described washer bottle quantity is P, and P is integer more than or equal to 1, when P more than or equal to 2 the time, be communicated with by second mixing valve between the washer bottle, second mixing valve links to each other with second control valve.
Described pipeline is the PEEK pipe.
Beneficial effect
The utility model provides a kind of automatic derivative reaction treatment facility, this equipment comprises N derivative reaction unit, the derivative reaction unit is connected in parallel, and each derivative reaction unit comprises solvent bottle, washer bottle, sample bottle, reaction bulb, first control valve, second control valve, the 3rd control valve, first check valve, second check valve, the 3rd check valve, first constant displacement pump, second constant displacement pump, the 3rd constant displacement pump, constant volume sensor, temperature sensor, heater, magnetic stirrer, timer and control module; Described control module comprises master controller, valve control, temperature controller, stirring controller, time controller, constant volume sensor and pump controller; Valve control, temperature controller, time controller, constant volume sensor and pump controller all link to each other with main controller; Wherein N is the integer more than or equal to 1; Wherein, valve control is used for the valve control of control first control valve, second control valve, the 3rd control valve, first check valve, second check valve and the 3rd check valve; Temperature controller is used for control heater; Stir controller and be used for the control magnetic stirrer; Pump controller is used for the pump controller of control first constant displacement pump, second constant displacement pump and the 3rd constant displacement pump; This apparatus structure is simple, realizes that easily suitable batchization is carried out derivative reaction; Utilize control module to control each parts in real time according to the course of reaction of derivative reaction, make entire reaction course finish automatically; Utilize constant displacement pump, make and quantitatively to extract solution, the error in reducing to produce in batches in the course of reaction in the derivative reaction process; Adopt the constant volume sensor to improve the constant volume precision; Adopt automatic derivative reaction pre-processing device and method, can reduce hand labor intensity, control the time of deriving and the temperature of deriving accurately, make batch analyte derivative experiment accuracy higher, collimation is better.
Description of drawings
Fig. 1 is electric control structure figure of the present utility model;
Fig. 2 is working cell of the present utility model mechanical construction drawing;
Fig. 3 is workflow schematic diagram of the present utility model.
The specific embodiment
Below in conjunction with accompanying drawing the utility model being described further, is example with 6 working cells.
As depicted in figs. 1 and 2, a kind of automatic derivative reaction treatment facility, comprise 6 derivative reaction unit, each derivative reaction unit comprises solvent bottle, washer bottle, sample bottle, reaction bulb, first control valve, second control valve, the 3rd control valve, first check valve, second check valve, the 3rd check valve, first constant displacement pump, second constant displacement pump, the 3rd constant displacement pump, constant volume sensor, temperature sensor, heater, magnetic stirrer, timer and control module; Described control module comprises master controller, the valve control that is used for control first control valve, second control valve, the 3rd control valve, first check valve, second check valve and the 3rd check valve, the temperature controller that is used for control heater, the stirring controller that is used for the control magnetic stirrer, time controller, constant volume sensor and control the pump controller of first constant displacement pump, second constant displacement pump and the 3rd constant displacement pump; Valve control, temperature controller, time controller, constant volume sensor and pump controller all link to each other with main controller;
Wherein, first control valve and second control valve are three-way control valve, and the 3rd control valve is two logical control valves;
Described solvent bottle comprises solvent bottle A and solvent bottle B, and solvent bottle A all links to each other with first mixing valve with solvent bottle B, and first mixing valve, first check valve, first constant displacement pump, first control valve link to each other by pipeline successively with reaction bulb;
Described washer bottle and sample bottle all are connected to reaction bulb with second control valve, second check valve and second constant displacement pump successively by pipeline; Wherein, washer bottle comprises washer bottle C and washer bottle D, and washer bottle C all links to each other with second mixing valve with washer bottle D, and second mixing valve links to each other with second control valve;
Described reaction bulb is connected to checkout gear with the 3rd check valve and the 3rd constant displacement pump successively by pipeline;
Described reaction bulb also links to each other with the 3rd control valve by pipeline;
Described reaction bulb is provided with constant volume sensor and temperature sensor, and heater and magnetic stirrer all are located at the reaction bulb bottom.
The course of work based on the said equipment is as follows:
Step 1: open first check valve, start first constant displacement pump, with the pipeline between liquid A or B or solvent bottle of AB rinse and first constant displacement pump of deriving in the solvent bottle;
Step 2: start second constant displacement pump, the pipeline between the second control valve gating sample bottle and second check valve extracts the 2ml sample solution to reaction bulb, and first constant displacement pump extracts the 5ml derivative solution and cut out first control valve to reaction bulb;
Step 3: utilize the temperature sensor control heater to make that solution temperature rises to design temperature in the reaction bulb, start the timer timing then to setting-up time, stir controller and start magnetic stirrer work;
Step 4: the setting-up time for the treatment of timer is to being derivative reaction when finishing, and timer, heater and agitator quit work, and allow the solution after deriving be cooled to room temperature;
Step 5: start the constant volume sensor, reaction solution in the reaction bulb is settled to set volume 10ml, the residue reaction solution is discharged by first control valve, if the reaction solution volume is less than set volume in the reaction bulb, then open first control valve, extract liquid to the reaction bulb of deriving by second constant displacement pump and be settled to 10ml, start agitator mixing time T, wherein T is 10 seconds;
Step 6: start the 3rd constant displacement pump, the solution after quantitatively extracting 2ml and deriving is to checkout gear;
Step 7: pipeline cleans, open the 3rd control valve, to remain behind the derivatization reaction solution and discharge, the second control valve gating detergent line, second constant displacement pump extracts closes the 3rd control valve after cleaning solution C or D or CD clean pipeline between second control valve to the, three control valves.
Claims (4)
1. automatic derivative reaction treatment facility, it is characterized in that, comprise N derivative reaction unit, the derivative reaction unit is connected in parallel, and each derivative reaction unit comprises solvent bottle, washer bottle, sample bottle, reaction bulb, first control valve, second control valve, the 3rd control valve, first check valve, second check valve, the 3rd check valve, first constant displacement pump, second constant displacement pump, the 3rd constant displacement pump, constant volume sensor, temperature sensor, heater, magnetic stirrer, timer and control module;
Described control module comprises master controller, valve control, temperature controller, stirring controller, time controller, constant volume sensor and pump controller; Valve control, temperature controller, time controller, constant volume sensor and pump controller all link to each other with main controller; Wherein N is the integer more than or equal to 1;
Wherein, valve control is used for the valve control of control first control valve, second control valve, the 3rd control valve, first check valve, second check valve and the 3rd check valve;
Temperature controller is used for control heater;
Stir controller and be used for the control magnetic stirrer;
Pump controller is used for the pump controller of control first constant displacement pump, second constant displacement pump and the 3rd constant displacement pump;
Wherein, first control valve and second control valve are three-way control valve, and the 3rd control valve is two logical control valves;
Described solvent bottle, first check valve, first constant displacement pump, first control valve and reaction bulb connect by pipeline successively;
Described washer bottle all links to each other with second control valve with sample bottle, and second control valve, second check valve, second constant displacement pump and reaction bulb connect by pipeline successively;
Described reaction bulb, the 3rd check valve, the 3rd constant displacement pump and checkout gear connect by pipeline successively;
Described reaction bulb also links to each other with the 3rd control valve by pipeline;
Described reaction bulb is provided with constant volume sensor and temperature sensor, and heater and magnetic stirrer all are located at the reaction bulb bottom.
2. automatic derivative reaction treatment facility according to claim 1 is characterized in that, described solvent bottle quantity is M, M is the integer more than or equal to 1, when M more than or equal to 2 the time, be communicated with by first mixing valve between the solvent bottle, first mixing valve links to each other with first check valve.
3. automatic derivative reaction treatment facility according to claim 1 is characterized in that, described washer bottle quantity is P, P is integer more than or equal to 1, when P more than or equal to 2 the time, be communicated with by second mixing valve between the washer bottle, second mixing valve links to each other with second control valve.
4. according to each described automatic derivative reaction treatment facility of claim 1-3, it is characterized in that described pipeline is the PEEK pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320052394 CN203123956U (en) | 2013-01-30 | 2013-01-30 | Automatic derivatization reaction treatment equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320052394 CN203123956U (en) | 2013-01-30 | 2013-01-30 | Automatic derivatization reaction treatment equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203123956U true CN203123956U (en) | 2013-08-14 |
Family
ID=48931983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201320052394 Expired - Lifetime CN203123956U (en) | 2013-01-30 | 2013-01-30 | Automatic derivatization reaction treatment equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203123956U (en) |
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2013
- 2013-01-30 CN CN 201320052394 patent/CN203123956U/en not_active Expired - Lifetime
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20130814 |