CN203074928U - Artificial self-simulation endothelium vascular structure - Google Patents
Artificial self-simulation endothelium vascular structure Download PDFInfo
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- CN203074928U CN203074928U CN2013201017405U CN201320101740U CN203074928U CN 203074928 U CN203074928 U CN 203074928U CN 2013201017405 U CN2013201017405 U CN 2013201017405U CN 201320101740 U CN201320101740 U CN 201320101740U CN 203074928 U CN203074928 U CN 203074928U
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- blood vessel
- artificial blood
- artificial
- endothelium
- simulation
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Abstract
The utility model discloses an artificial self-simulation endothelium vascular structure which comprises an artificial blood vessel, the diameter of the artificial blood vessel is smaller than 6mm, and a neurogenic factor layer is crosslinked on the surface of the inner wall of the artificial blood vessel. In the technical scheme, the artificial self-simulation endothelium vascular structure is researched aiming at the artificial blood vessel with the diameter of smaller than 6mm, the neurogenic factor NGF capable of capturing the endothelial progenitor cells in a human body can be screened out, the endothelial progenitor cells in blood can be induced through the neurogenic factor to be enriched at the area and further adhere and differentiate the endothelial progenitor cells, thus realizing the endothelialization of the blood vessels, and achieving an antithrombosis effect. The large-scale production of the artificial blood vessel made of synthetic materials can be more easily realized, the modification on the surface cell factor can be carried by the ePTFE artificial blood vessel, and the artificial blood vessel is planted in a biological body, thus realizing the self raising on the surface of the artificial blood vessel and achieving the endothelialization.
Description
Technical field
This utility model relates to area of medical devices, especially relates to a kind of from raising endothelium artificial blood vessel structure.
Background technology
Be accompanied by the transformation of social progress and people life, diet style, the sickness rate of tremulous pulse ischemic diseases is up to 17～20%, and the unexpected blood vessel injury every year that causes because of traffic, industry, motion etc. is also with 7.3% speed increase.The method of clinical treatment tremulous pulse ischemic diseases is the most definite with artery reconstruction art effect, synthetic blood vessel commonly used is rebuild tremulous pulse as the tremulous pulse substitute, commercial heavy caliber artificial blood vessel long-term patency rates is satisfied, but small-bore at present (bore is less than 6mm) artificial blood vessel is because the blood vessel endothelium disappearance, patency rate is difficult to reach requirement, very easily in the artificial blood vessel, form thrombosis, occluding vascular.
Summary of the invention
In order to remedy above-mentioned small-caliber artificial blood vessel endothelial loss, be difficult to meet the requirements of defective, the utility model proposes a kind of from raising endothelium artificial blood vessel structure.
The technical scheme that realizes above-mentioned beneficial effect is, a kind ofly comprises the artificial blood vessel from raising endothelium artificial blood vessel structure, and described artificial blood vessel's diameter is less than 6 millimeters, neurogenic factor layer arranged in that artificial blood vessel's inner wall surface is crosslinked.In the technical program, research and develop at the artificial blood vessel of diameter specially less than 6MM, having filtered out can be at the neurogenic factor NGF of human body IT endothelial progenitor cells, adopt the neurogenic factor to induce endothelial progenitor cells in the blood in this regional enrichment, and then adhesion is divided into endotheliocyte, realize the endothelialization of blood vessel, play antithrombotic effect.Because the easier realization of artificial blood vessel of synthetic material has the commercialization of scale, we select the ePTFE artificial blood vessel to carry out the modification of the superficial cell factor, and in the implantable bioartificial body, the realization endothelial progenitor cells is independently raised the artificial blood vessel surface, reaches endothelialization.In the technical program, the artificial blood vessel has elasticity, and the artificial blood vessel can carry out corresponding crooked deformation according to human motion in the time of human motion or different attitude, and anti-breaking of hemostatic tube interface falls.
Described artificial blood vessel is corrugated tube shape, and neurogenic factor layer closely is connected artificial blood vessel's inwall.In the technical program, the artificial blood vessel is made into corrugated tube shape, increases its elasticity, guarantees that patient's blood vessel when the bending activity can not rupture.
Described neurogenic factor layer thickness is 0.1-0.5mm.In the technical program, the general crosslinked thickness of neurogenic factor layer is 0.1-0.5mm, is guaranteeing that it satisfies the internal diameter of as far as possible expanding blood vessel on the prerequisite of later stage to the endotheliocyte seizure.
Description of drawings
Fig. 1 is the structural representation of a kind of embodiment of the present utility model;
Fig. 2 is the structural representation of the another kind of embodiment of this utility model;
Among the figure, 1, the artificial blood vessel; 2, neurogenic factor layer.
The specific embodiment
Below in conjunction with accompanying drawing this utility model is described further.
In conjunction with Fig. 1, a kind ofly comprise artificial blood vessel 1 from the endothelium artificial blood vessel structure of raising, described artificial blood vessel's diameter is less than 6 millimeters, neurogenic factor layer 2 arranged in that artificial blood vessel's inner wall surface is crosslinked.The blood vessel of present embodiment is applicable under the thinner blood vessel situation that the length of vessel of present embodiment can be carried out cutting with the need, and length is grasped easily.
In conjunction with Fig. 2, another kind of embodiment of the present utility model in the present embodiment, is made corrugated tube shape at the situation decline blood vessel pipe shaft that blood vessel is thicker, and nozzle position is still pipe, is convenient to be connected with human vas, and corrugated tube shape is convenient to bending.In the present embodiment, described neurogenic factor layer thickness is 0.1-0.5mm, guarantees the mobile unimpeded of blood vessel in the later stage seizure growth that is guaranteeing under this thickness endotheliocyte.
Present embodiment when in use, select the ePTFE artificial blood vessel of suitable diameter, adopting neurogenic factor NGF to carry out intracavity to internal blood vessel modifies, blood vessel and the neurogenic factor and blood vessel are carried out the photo-crosslinking certain hour in super-clean bench, crosslinked good artificial blood vessel directly applies to clinical.
The above; be general case study on implementation of the present utility model; be not that this utility model is imposed any restrictions; everyly any simple modification that above embodiment did, change and equivalent structure are changed, all still belong in the protection domain of technical solutions of the utility model according to this utility model technical spirit.
Claims (3)
1. one kind from the endothelium artificial blood vessel structure of raising, and comprises elasticity artificial blood vessel (1), it is characterized in that, described artificial blood vessel's diameter is less than 6 millimeters, neurogenic factor layer (2) is arranged in that artificial blood vessel's inner wall surface is crosslinked.
2. the endothelium artificial blood vessel structure of raising certainly according to claim 1 is characterized in that described artificial blood vessel is corrugated tube shape, and neurogenic factor layer closely is connected artificial blood vessel's inwall.
3. according to claim 1 from raising endothelium artificial blood vessel structure, it is characterized in that described neurogenic factor layer thickness is 0.1-0.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013201017405U CN203074928U (en) | 2013-03-06 | 2013-03-06 | Artificial self-simulation endothelium vascular structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013201017405U CN203074928U (en) | 2013-03-06 | 2013-03-06 | Artificial self-simulation endothelium vascular structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203074928U true CN203074928U (en) | 2013-07-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2013201017405U Expired - Fee Related CN203074928U (en) | 2013-03-06 | 2013-03-06 | Artificial self-simulation endothelium vascular structure |
Country Status (1)
| Country | Link |
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| CN (1) | CN203074928U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771783A (en) * | 2015-04-29 | 2015-07-15 | 广州宏畅生物科技有限公司 | Small-caliber biotic artificial blood vessel with anti-thrombus formation and anti-intimal hyperplasia functions |
| CN104826164A (en) * | 2015-04-24 | 2015-08-12 | 广州宏畅生物科技有限公司 | Biological artificial blood vessel able to realize in vivo self-reconstruction |
-
2013
- 2013-03-06 CN CN2013201017405U patent/CN203074928U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104826164A (en) * | 2015-04-24 | 2015-08-12 | 广州宏畅生物科技有限公司 | Biological artificial blood vessel able to realize in vivo self-reconstruction |
| CN104826164B (en) * | 2015-04-24 | 2018-05-22 | 广州宏畅生物科技有限公司 | The biological artificial blood vessel of self remodeling can be realized in body |
| CN104771783A (en) * | 2015-04-29 | 2015-07-15 | 广州宏畅生物科技有限公司 | Small-caliber biotic artificial blood vessel with anti-thrombus formation and anti-intimal hyperplasia functions |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130724 Termination date: 20140306 |