CN202994658U - Detecting system based on surface plasmon resonance (SPR) - Google Patents
Detecting system based on surface plasmon resonance (SPR) Download PDFInfo
- Publication number
- CN202994658U CN202994658U CN 201220543532 CN201220543532U CN202994658U CN 202994658 U CN202994658 U CN 202994658U CN 201220543532 CN201220543532 CN 201220543532 CN 201220543532 U CN201220543532 U CN 201220543532U CN 202994658 U CN202994658 U CN 202994658U
- Authority
- CN
- China
- Prior art keywords
- light
- spr
- polarized light
- successively
- sensitive face
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The utility model belongs to the technical field of photoelectric detection, and provides a detection system based on surface plasmon resonance (SPR). The detection system based on the SPR combines spectral scanning technology with angle detection technology or phase detection technology, uses angle detection technology or phase detection technology to obtain a SPR angle, lightens point light sources at corresponding positions in array light sources and turns off point light sources at other positions, then scans spectra of the lightened point light sources by means of spectral scanning technology, obtains spectral location in the best linear region, and sets a wavelength corresponding to the spectral location as an operating wavelength of the spectral filter. By means of the detection system based on SPR, SPR positions of the spectra are changed, small-angle high-precision continuous scanning is achieved, and light source spectral width is taken full advantage. Compared with the prior art, the problems that point light sources are arranged densely in the array light sources and light source spectral use rate is low are solved, conflict between the density degree of the point light sources in the array light sources and the scanning angles is solved, product cost is reduced, and processes are simplified.
Description
Technical field
The utility model belongs to photoelectric detection technology field, relates in particular to a kind of detection system based on SPR.
Background technology
Surface plasma body resonant vibration (Surface Plasmon Resonance, SPR) phenomenon refers to, the evanescent wave that incident light produces when glass interface generation total reflection excites the free electron of metal surface, form surface plasma, produce plasma wave, under certain condition, evanescent wave and plasma wave resonate, the Energy Coupling of incident light makes energy of reflection light obviously decay in surface plasma.This phenomenon is used in the detection field of biology, medicine, chemistry, mainly for detection of the interaction between biomacromolecule, obtains the bonding information in each step between reactant molecule, measures kinetic constant, have highly sensitive, need not the advantage such as mark.
Known ground, the present detection method based on SPR divide and mainly contain two classes: the one, take the angle detection method of detection of reflected light intensity as the basis; The 2nd, take the phase place of the detection of reflected light phase-detection method as the basis.This two classes detection method all need utilize extraneous mechanical hook-up to carry out position modulation to light source, and degree of accuracy is relatively poor, complex operation, and the dynamic range of phase-detection method is little or sensitivity is inconsistent.
For this reason, prior art has proposed a kind of detection system based on SPR, this system adopts array light source, some light sources is arranged on the focal plane of lens, and sequentially lights, make polarized light sequentially shine on the sensitive face of sample cell with different angles, real time record is obtained SPR angle scanning curve from the reflective light intensity of sensitive face reflection, and this mode is with respect to traditional angle detection method, need not mechanical hook-up and control, accuracy of detection is high.
Yet, existing said detecting system has only been utilized the position distribution of light source, wasted spectral energy, and in order to obtain high precision SPR angle curve, interval in the requirement array light source between each pointolite is as far as possible little, namely need the pointolite of very dense to arrange, could obtain high-precision SPR angle scanning curve, make that cost of products is high, complex process.
The utility model content
The purpose of this utility model is to provide a kind of detection system based on SPR, is intended to solve in existing detection system based on SPR, and the pointolite dense arrangement in array light source causes that cost of products is high, the problem of complex process.
The utility model is achieved in that a kind of detection system based on SPR, and described system comprises:
Arrange by some pointolites that produce respectively sense light the array light source that forms;
Be placed on the transmission light path of described sense light, to obtaining polarized light and make described polarized light incide the optical module of sensitive face after described sense light collimation;
Connect described array light source, control that each described pointolite is lighted successively so that each described polarized light shines the controller of described sensitive face successively with different angles;
Connect described controller, record interference image corresponding to each described pointolite or the intensity of reflected light of described polarized light after described sensitive face to obtain SPR angle curve, obtain the SPR resonance angle and by described controller control in described array light source, the pointolite of described SPR resonance angle correspondence position is lighted and planar array detector that other location point light source is closed;
The pointolite that described controller is lighted carries out spectral scan, the corresponding wavelength that described spectral position is set after obtaining the spectral position in optimum linear district, by described controller is the spectral filter of operation wavelength, described spectral filter is arranged on described polarized light on the reflected light light path after described sensitive face, and described spectral filter connects described controller.
In one case, described optical module can also comprise:
The described sense light that each described pointolite is produced successively collimates, and forms the first lens of different angles emergent light, and each described pointolite is placed on the focal plane of described first lens;
Be placed on the light path of the described sense light after described first lens collimation, obtain successively first polarizer of each polarized light from the described sense light after described first lens collimation;
Be placed on the light path of the described polarized light after described first polarizer, receive each described polarized light that described first polarizer obtains and each described polarized light is shone the first prism on the first sensitive face with different angles successively, be placed with the first sample cell on described the first sensitive face;
Be placed on the catoptrical light path of described the first sensitive face second lens that will collimate through the reflected light of described the first sensitive face successively;
Be placed on the described catoptrical light path after described the second collimated, obtain successively the first analyzer of each polarized light from the reflected light after described the second collimated;
Be placed on the light path of the described polarized light after described the first analyzer, the described polarized light in each described reflected light focused on the 3rd lens of described planar array detector.
In another case, described optical module can also comprise:
The 4th lens that the described sense light that each described pointolite is produced successively collimates, each described pointolite is placed on the focal plane of described the 4th lens;
Be placed on the light path of the described sense light after described the 4th collimated, obtain successively second polarizer of each polarized light from the described sense light after described the 4th collimated;
Be placed on the light path of the described polarized light after described second polarizer phase-modulator that each the described polarized light that successively the described polarizer is obtained is modulated;
Be placed on the light path of the described polarized light after described phase-modulator, receive successively each the described polarized light after the modulation of described phase-modulator and will modulate after each described polarized light shine the second prism on the second sensitive face with different angles, be placed with the second sample cell on described the second sensitive face;
Be placed on the catoptrical light path of described the second sensitive face the 5th lens that will collimate through the reflected light of described the second sensitive face successively;
Be placed on the described catoptrical light path after described the 5th collimated, obtain successively the second analyzer of each described polarized light from the reflected light after described the 5th collimated;
Be placed on the light path of the described polarized light after described the second analyzer, the described polarized light in each described reflected light focused on the 6th lens of described planar array detector.
Wherein, described the first sensitive face and described the second sensitive face can be the SPR sensing membrane, for example golden film or silverskin.
Wherein, described array light source can be the array broadband light source.
Further, described array broadband light source can be the linear array light emitting diode of linear array light emitting diode, Linear array fiber coupling or with the wideband light source of the Linear array fiber coupling of electric-controlled switch.
Wherein, described spectral filter can adopt adjustable optical filter, and described adjustable optical filter is liquid crystal adjustable optical filter or adjustable F-P optical filter.
The detection system based on SPR that the utility model provides is that the spectral scan technology is combined with angle detection technique or phase-detection technology, after utilizing angle detection technique or phase-detection technology to obtain low precision SPR resonance angle, the pointolite of correspondence position in array light source is lighted and the pointolite of other position is closed, utilize afterwards the spectral scan technology to carry out the spectrum fine scanning to this pointolite, obtain the spectral position in optimum linear district, the corresponding wavelength of this spectral position is set to the spectral filter operation wavelength.This system realizes the high-precision continuous sweep of low-angle by the change of spectrum to the SPR resonant position, take full advantage of the spectrum width of light source, has avoided pointolite intensive in the array light source to arrange, thereby can reduce cost of products, simplifies technique.
Description of drawings
Fig. 1 is the structural drawing based on the detection system of SPR that the utility model the first embodiment provides;
Fig. 2 is existing graph of a relation based on the resulting refraction angle of the detection system of SPR and phase place;
Fig. 3 is the structural drawing based on the detection system of SPR that the utility model the second embodiment provides;
Fig. 4 is in the utility model the second embodiment, the graph of a relation of refraction angle and phase relation.
Embodiment
In order to make the purpose of this utility model, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the utility model is further elaborated.Should be appreciated that specific embodiment described herein only in order to explaining the utility model, and be not used in restriction the utility model.
The detection system based on SPR that the utility model provides is that the spectral scan technology is combined with angle detection technique or phase-detection technology, after utilizing angle detection technique or phase-detection technology to obtain the SPR resonance angle, corresponding point light source igniting in array light source is closed other pointolite, utilize afterwards the spectral scan technology to carry out the spectrum fine scanning to this pointolite, obtain the spectral position in optimum linear district, the corresponding wavelength of this spectral position is set to the spectral filter operation wavelength.
Particularly, the detection system based on SPR that the utility model provides comprises: arranged the array light source that forms by some pointolites, for generation of sense light; Optical module is used for obtaining polarized light, and making polarized light incide sensitive face after the sense light collimation; Controller is used for controlling each pointolite and lights successively, makes each polarized light shine sensitive face with different angles successively; Planar array detector, be used for recording interference image corresponding to each pointolite or the intensity of reflected light of polarized light after sensitive face, obtain SPR angle curve, obtain the SPR resonance angle from SPR angle curve, and control in array light source that the correspondence position pointolite is lighted and other location point light source is closed by controller; Be included in the spectral filter in optical module, this spectral filter is arranged on polarized light on the reflected light light path after sensitive face, the pointolite that is used for controller is lighted carries out spectral scan, obtain the spectral position in optimum linear district, the corresponding wavelength that by controller this spectral position is set afterwards is the operation wavelength of spectral filter.
Below be combined with the angle detection technique with the spectral scan technology respectively and spectral scan technology and phase-detection technology are integrated as example, describe formation and the principle of work of above-mentioned detection system based on SPR in detail:
Embodiment one
The structure based on the detection system of SPR that Fig. 1 shows that the utility model the first embodiment provides for convenience of explanation, only shows the part relevant to the utility model the first embodiment.
In the utility model the first embodiment, comprise based on the detection system of SPR: first surface array detector 111; Arranged the first array light source 101 that forms by some pointolites, be used for producing successively sense light; First lens 102 is used for successively each sense light being collimated, and each pointolite is placed on the focal plane of first lens 102; First polarizer 103, the sense light after being used for collimating from first lens 102 is successively obtained each polarized light; The first prism 104 is used for receiving each polarized light that first polarizer obtains, and each polarized light is shone on the first sensitive face 105 with different angles successively, is placed with the first sample cell 106 on the first sensitive face 105; The second lens 107 are used for collimating through the reflected light of the first sensitive face 105 successively; The first analyzer 108 is for polarized light the reflected light after the second lens 107 collimations obtains successively; The 3rd lens 110 are used for the polarized light of each reflected light is focused on first surface array detector 111, obtain SPR angle scanning curve by first surface array detector 111, and obtain the SPR resonance angle from SPR angle curve; The first controller 112 is used for the reference mark light source and produces successively sense light, and control in the first array light source 101, the pointolite of SPR resonance angle correspondence position is lighted and other location point light source is closed; The first spectral filter 109, the pointolite that is used for the first controller 112 is lighted carries out spectral scan, obtain the spectral position in optimum linear district, the corresponding wavelength that by the first controller 112 this spectral position is set afterwards is the operation wavelength of the first spectral filter 109.
Wherein, the first array light source 101 is array broadband light sources, as the linear array light emitting diode of linear array light emitting diode, Linear array fiber coupling, with the white light source of the Linear array fiber coupling of electric-controlled switch etc.; The first sensitive face 105 refers to the SPR sensing membrane, as golden film, silverskin etc.; The first spectral filter 109 adopts adjustable optical filter, as liquid crystal adjustable optical filter, adjustable F-P optical filter, monochromator etc.
This system is when work, in first controller 112 control the first array light sources 101, each pointolite produces sense light successively, sense light is after first lens 102 collimations, first polarizer 103 obtains wherein each polarized light, each polarized light with different angles from the plane of incidence incident of the first prism 104 and shine the surface of the first sensitive face 105, in order to form resonance with realizing the first sensitive face 105 ionic medium ripples; Afterwards, first surface array detector 111 records the light intensity of the polarized light that is reflected back from the first sensitive face 105 successively, obtains SPR angle scanning curve, obtains the SPR resonance angle; Afterwards, the first controller 112 controls that pointolites corresponding to SPR resonance angle are lighted and other pointolite is closed, the pointolite of being lighted by 109 pairs of the first controllers 112 of the first spectral filter carries out spectral scan, record simultaneously the SPR spectral information of a series of correspondences, obtain the spectral position in optimum linear district; Afterwards, the corresponding wavelength of first controller 112 these spectral positions is set to the operation wavelength of the first spectral filter 109, obtain high-precision SPR optimum position, and whole measurement range has all guaranteed maximum sensitivity, and in can not occurring usually as shown in Figure 2, the problem that spectrum SPR sensitivity reduces with wavelength shift.Afterwards, pass into sample in the first sample cell 106, the SPR strength information of real time record the first sensitive face 105 obtains the information such as bioanalysis interaction on whole the first sensitive face 105.
Embodiment two
The structure based on the detection system of SPR that Fig. 3 shows that the utility model the second embodiment provides for convenience of explanation, only shows the part relevant to the utility model the second embodiment.
In the utility model the second embodiment, comprise based on the detection system of SPR: the second planar array detector 222; Arranged the second array light source 201 that forms by some pointolites, be used for producing successively sense light; The 4th lens 202, the sense light that is used for successively each pointolite being produced successively collimates, and each pointolite is placed on the focal plane of the 4th lens 202; Second polarizer 203, the sense light after being used for collimating from the 4th lens 202 is successively obtained each polarized light; Phase-modulator 204, each polarized light that is used for successively the polarizer 203 being obtained is modulated; The second prism 205 is used for each polarized light after receiving phase modulator 204 is modulated successively, and each polarized light after modulation is shone on the second sensitive face 206 with different angles, is placed with the second sample cell 207 on the second sensitive face 206; The 5th lens 208 are used for collimating through the reflected light of the second sensitive face 206 successively; The second analyzer 209, the reflected light after being used for collimating from the 5th lens 208 successively obtains each polarized light; The 6th lens 221 are used for the polarized light of each reflected light is focused on the second planar array detector 222, obtain SPR angle scanning curve by the second planar array detector 222, and obtain the SPR resonance angle from SPR angle curve; Second controller 223 be used for to control that the second array light source 201 correspondence position pointolites are lighted and other location point light source is closed; The second spectral filter 220, the pointolite that is used for second controller 223 is lighted carries out spectral scan, obtain the spectral position in optimum linear district, the corresponding wavelength that by second controller 223 this spectral position is set afterwards is the operation wavelength of the second spectral filter 220.
Similarly, the second array light source 201 is array broadband light sources, as the linear array light emitting diode of linear array light emitting diode, Linear array fiber coupling, with the white light source of the Linear array fiber coupling of electric-controlled switch etc.; The second sensitive face 206 refers to the SPR sensing membrane, as golden film, silverskin etc.; The second spectral filter 220 is adjustable optical filters, as liquid crystal adjustable optical filter, adjustable F-P optical filter etc.
This system is when work, in second controller 223 control the second array light sources 201, each pointolite produces sense light successively, sense light is after the 4th lens 202 collimations, second polarizer 203 obtains wherein each polarized light, each polarized light is after phase-modulator 204 modulation, with different angles from the plane of incidence incident of the second prism 205 and shine the surface of the second sensitive face 206, in order to form resonance with realizing the second sensitive face 206 ionic medium ripples; Afterwards, the second planar array detector 222 records the polarized light that is reflected back from the second sensitive face 206 successively, and demodulation extraction phase place, obtains SPR angle scanning curve, obtains the SPR resonance angle; Afterwards, second controller 223 controls that pointolites corresponding to SPR resonance angle are lighted and other pointolite is closed, the pointolite of being lighted by 220 pairs of second controllers 223 of the second spectral filter carries out spectral scan, record simultaneously the SPR spectral information of a series of correspondences, obtain the spectral position in optimum linear district; Afterwards, the corresponding wavelength of second controller 223 these spectral positions is set to the operation wavelength of the second spectral filter 220, obtain high-precision SPR optimum position, and whole measurement range all guaranteed maximum sensitivity (as shown in Figure 4), and reduces (as shown in Figure 2) unlike the phase place SPR sensitivity of usually simple spectral scan with wavelength shift.Afterwards, pass into sample in the second sample cell 207, the SPR interference image of real time record the second sensitive face 206 obtains the information such as bioanalysis interaction on whole the second sensitive face 206.
The detection system based on SPR that the utility model provides is that the spectral scan technology is combined with angle detection technique or phase-detection technology, after utilizing angle detection technique or phase-detection technology to obtain the SPR resonance angle, the pointolite of correspondence position in array light source is lighted and the pointolite of other position is closed, utilize afterwards the spectral scan technology to carry out spectral scan to this pointolite, obtain the spectral position in optimum linear district, the corresponding wavelength of this spectral position is set to the spectral filter operation wavelength.This system is by the change of spectrum to the SPR resonant position, realize the high-precision continuous sweep of low-angle, take full advantage of the spectrum width of light source, avoided pointolite intensive in the array light source to arrange, solve the contradiction between angle high resolving power and light source reticular density, thereby can reduce cost of products, simplification technique.In addition, with respect to existing narrow-band light source SPR technology, can improve dynamic range, the eliminate laser speckle noise; With respect to existing wideband light source SPR technology, improved system's detection sensitivity, angle, phase place are combined with spectral technique, can guaranteeing to obtain maximum dynamic range under the peak response condition, can cover the scope of whole SPR.
The above is only preferred embodiment of the present utility model; not in order to limit the utility model; all any modifications of doing within spirit of the present utility model and principle, be equal to and replace and improvement etc., within all should being included in protection domain of the present utility model.
Claims (8)
1. the detection system based on SPR, is characterized in that, described system comprises:
Arrange by some pointolites that produce respectively sense light the array light source that forms;
Be placed on the transmission light path of described sense light, to obtaining polarized light and make described polarized light incide the optical module of sensitive face after described sense light collimation;
Connect described array light source, control that each described pointolite is lighted successively so that each described polarized light shines the controller of described sensitive face successively with different angles;
Connect described controller, record interference image corresponding to each described pointolite or the intensity of reflected light of described polarized light after described sensitive face to obtain SPR angle curve, obtain the SPR resonance angle and by described controller control in described array light source, the pointolite of described SPR resonance angle correspondence position is lighted and planar array detector that other location point light source is closed;
The pointolite that described controller is lighted carries out spectral scan, the corresponding wavelength that described spectral position is set after obtaining the spectral position in optimum linear district, by described controller is the spectral filter of operation wavelength, described spectral filter is arranged on described polarized light on the reflected light light path after described sensitive face, and described spectral filter connects described controller.
2. the detection system based on SPR as claimed in claim 1, is characterized in that, described optical module also comprises:
The described sense light that each described pointolite is produced successively collimates, and forms the first lens of different angles emergent light, and each described pointolite is placed on the focal plane of described first lens;
Be placed on the light path of the described sense light after described first lens collimation, obtain successively first polarizer of each polarized light from the described sense light after described first lens collimation;
Be placed on the light path of the described polarized light after described first polarizer, receive each described polarized light that described first polarizer obtains and each described polarized light is shone the first prism on the first sensitive face with different angles successively, be placed with the first sample cell on described the first sensitive face;
Be placed on the catoptrical light path of described the first sensitive face second lens that will collimate through the reflected light of described the first sensitive face successively;
Be placed on the described catoptrical light path after described the second collimated, obtain successively the first analyzer of each polarized light from the reflected light after described the second collimated;
Be placed on the light path of the described polarized light after described the first analyzer, the described polarized light in each described reflected light focused on the 3rd lens of described planar array detector.
3. the detection system based on SPR as claimed in claim 1, is characterized in that, described optical module also comprises:
The 4th lens that the described sense light that each described pointolite is produced successively collimates, each described pointolite is placed on the focal plane of described the 4th lens;
Be placed on the light path of the described sense light after described the 4th collimated, obtain successively second polarizer of each polarized light from the described sense light after described the 4th collimated;
Be placed on the light path of the described polarized light after described second polarizer phase-modulator that each the described polarized light that successively the described polarizer is obtained is modulated;
Be placed on the light path of the described polarized light after described phase-modulator, receive successively each the described polarized light after the modulation of described phase-modulator and will modulate after each described polarized light shine the second prism on the second sensitive face with different angles, be placed with the second sample cell on described the second sensitive face;
Be placed on the catoptrical light path of described the second sensitive face the 5th lens that will collimate through the reflected light of described the second sensitive face successively;
Be placed on the described catoptrical light path after described the 5th collimated, obtain successively the second analyzer of each described polarized light from the reflected light after described the 5th collimated;
Be placed on the light path of the described polarized light after described the second analyzer, the described polarized light in each described reflected light focused on the 6th lens of described planar array detector.
4. the detection system based on SPR as claimed in claim 2, is characterized in that, described the first sensitive face is the SPR sensing membrane, and described SPR sensing membrane is golden film or silverskin.
5. the detection system based on SPR as claimed in claim 3, is characterized in that, described the second sensitive face is the SPR sensing membrane, and described SPR sensing membrane is golden film or silverskin.
6. as claim 1,2 or 3 described detection systems based on SPR, it is characterized in that, described array light source is the array broadband light source.
7. the detection system based on SPR as claimed in claim 6, is characterized in that, described array broadband light source is the linear array light emitting diode of linear array light emitting diode, Linear array fiber coupling or with the wideband light source of the Linear array fiber coupling of electric-controlled switch.
8. as claim 1,2 or 3 described detection systems based on SPR, it is characterized in that, described spectral filter adopts adjustable optical filter, and described adjustable optical filter is liquid crystal adjustable optical filter or adjustable F-P optical filter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220543532 CN202994658U (en) | 2012-10-23 | 2012-10-23 | Detecting system based on surface plasmon resonance (SPR) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220543532 CN202994658U (en) | 2012-10-23 | 2012-10-23 | Detecting system based on surface plasmon resonance (SPR) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202994658U true CN202994658U (en) | 2013-06-12 |
Family
ID=48565829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220543532 Expired - Fee Related CN202994658U (en) | 2012-10-23 | 2012-10-23 | Detecting system based on surface plasmon resonance (SPR) |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202994658U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102944537A (en) * | 2012-10-23 | 2013-02-27 | 深圳大学 | Detection system and detection method based on SPR |
| CN103792212A (en) * | 2014-02-18 | 2014-05-14 | 深圳大学 | Optical fiber surface plasma resonance sensor, detection system and method |
| CN113063735A (en) * | 2021-04-21 | 2021-07-02 | 大连理工大学 | Surface plasmon resonance sensing system based on chromatic dispersion |
-
2012
- 2012-10-23 CN CN 201220543532 patent/CN202994658U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102944537A (en) * | 2012-10-23 | 2013-02-27 | 深圳大学 | Detection system and detection method based on SPR |
| CN102944537B (en) * | 2012-10-23 | 2016-04-06 | 深圳大学 | A kind of detection system based on SPR and detection method thereof |
| CN103792212A (en) * | 2014-02-18 | 2014-05-14 | 深圳大学 | Optical fiber surface plasma resonance sensor, detection system and method |
| CN103792212B (en) * | 2014-02-18 | 2017-01-04 | 深圳大学 | A kind of Fiber Optic Sensor Based on Surface Plasmon Resonance, detecting system and method |
| CN113063735A (en) * | 2021-04-21 | 2021-07-02 | 大连理工大学 | Surface plasmon resonance sensing system based on chromatic dispersion |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10578554B2 (en) | Spectrum-scanned SPR imaging detection system | |
| CN101371129B (en) | Surface plasmon resonance sensors and methods for detecting samples using the same | |
| CN108827172B (en) | Non-contact laser thickness measuring device and method based on solid zoom lens | |
| CN102749627B (en) | Full-height laser radar for detecting atmosphere wind field, temperature and density | |
| CN100451678C (en) | High spectrum full polarization three dimension imaging integrate detecting system | |
| CN103543135B (en) | A kind of nano-precision hot spot alignment methods based on Fluorescence lifetime distribution and device | |
| CN106441125B (en) | A kind of measured film thickness method and system | |
| CN102692394B (en) | Two-dimensional imaging method and device based on thermal lens effect | |
| CN102721673B (en) | Multi-beam array light-induced reflectivity imaging device and method | |
| CN101907513B (en) | Diffraction property low-light test system and method of acousto-optic tunable filter (AOTF) | |
| CN110927121B (en) | Phase type SPR detection device and method based on white light interference spectrum | |
| CN102253014A (en) | System and method for surface plasmon resonance sensing detection | |
| US20190219505A1 (en) | Device for analysing a specimen using the goos-hänchen surface plasmon resonance effect | |
| CN202994658U (en) | Detecting system based on surface plasmon resonance (SPR) | |
| CN102944537B (en) | A kind of detection system based on SPR and detection method thereof | |
| CN104737000A (en) | Arrangement for an analysis system, analysis system having the arrangement and method for use of the arrangement | |
| CN102362146A (en) | Reflectance distribution curve modeling method, thickness measurement scheme and thickness measurement reflectometer using same | |
| CN103389284A (en) | Surface plasma resonance system and detection method thereof | |
| CN104634766A (en) | Super-resolution device and method based on pumping-probe technology | |
| CN103454247B (en) | A kind of apparatus for measuring refractive index of machine with wide range and method | |
| CN101832910B (en) | Reverse collinear transient heat reflection measurement system | |
| CN102253005A (en) | Surface plasmon resonance sensing detection system and method | |
| CN103439294A (en) | Angle modulation and wavelength modulation surface plasmon resonance (SPR) sharing system | |
| CN101408680B (en) | Four-range multiplication system far-field monitoring device and collimating method thereof | |
| CN201749021U (en) | Dim light test device of diffraction performance of acousto-optic turnable filter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130612 Termination date: 20141023 |
|
| EXPY | Termination of patent right or utility model |