CN202933048U - Heterograft rat abdominal aortic aneurysm model built by using sleeve - Google Patents
Heterograft rat abdominal aortic aneurysm model built by using sleeve Download PDFInfo
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- CN202933048U CN202933048U CN 201220343949 CN201220343949U CN202933048U CN 202933048 U CN202933048 U CN 202933048U CN 201220343949 CN201220343949 CN 201220343949 CN 201220343949 U CN201220343949 U CN 201220343949U CN 202933048 U CN202933048 U CN 202933048U
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Abstract
The utility model relates to a heterograft rat abdominal aortic aneurysm model built by using a sleeve and belongs to the field of medical experimental animals. The core technology of the model is that the system sleeve is used for achieving end-to-end connection between blood vessels. Detailed steps include that first, the sleeve which is 2mm in a main body and 1mm in the handle length and provided with an annular clamping groove at the axial middle point of an outer wall of the main body is prepared. A blood vessel of a receptor penetrates through the sleeve and is turned over, a silk thread binds the blood vessel of the receptor on the sleeve along the clamping groove, the blood vessel of the receptor is fixed on the sleeve and inserted into a blood vessel of a donor, the blood vessel of the donor and the receptor blood vessel fixed through the sleeve are bound through the silk thread along the clamping groove, end-to-end connection of the blood vessels is finished, and the forming condition of heterograft abdominal aortic aneurysm is evaluated by opening an abdomen two weeks later. The heterograft rat abdominal aortic aneurysm model is achieved through a new method and is simple in operation compared with a common blood vessel end-to-end matching method, required time of operation is short, operation complications are fewer, success rate of model building is high, and homogeneity of the model is good.
Description
Technical field
The present invention relates to build the method for abdominal aortic aneurysms model, belong to medical experiment animal field.
Background technology
Abdominal aortic aneurysm is a kind of arotic disease of high danger, is called as the stealthy killer of middle-aged and elderly people.The pathological characters of abdominal aortic aneurysm is the regression of abdominal aorta wall elastic force flaggy, and the ventral aorta diameter increases gradually and surpasses more than 1.5 times of normal diameter, the tumor wall finally occurs break hemorrhagely, causes death.Along with countries in the world enter aging society, the sickness rate of abdominal aortic aneurysm is more and more higher, and the statistical data of 2000 shows, in the U.S., the sickness rate of abdominal aortic aneurysm reaches 2%～7%, and 15000 people that have an appointment every year are dead because of abdominal aortic aneurysm, accounts for the 11st of the disease cause of the death; Europe general population formation of abdominal aortic aneurysms rate is 4.5%～5.9%, far surpasses general malignant tumor, accounts for the 13rd of the disease cause of the death; In China, the incidence rate of the abdominal aortic aneurysm of 2005 is 3 ‰-6.6 ‰ according to incompletely statistics, and in the past 30 years, sickness rate has risen 3 times.Based on above-mentioned present situation, the research of abdominal aortic aneurysm etiology mechanism is become more and more important.Due to the particularity of medical research, rat becomes medical circle to the most frequently used modeling object of various diseases research, and therefore the model of abdominal aortic aneurysm of rat also becomes the classical model of research formation of abdominal aortic aneurysms mechanism.With the Cavia porcellus aorta transplantation to rat aorta, the xenotransplantation abdominal aortic aneurysms model that rejection by heteroplasm builds, because its tumor formation rate is high, tumor volume morphing, organizational structure and law of development and mankind's abdominal aortic aneurysm similarity are high, become the outstanding person in the abdominal aortic aneurysms model.
Build at present xenotransplantation abdominal aortic aneurysms model, the method that adopts is with the blood vessel suture, Cavia porcellus ventral aorta and rat aorta to be carried out end to end anastomosis, due to the anastomotic stoma diameter in 1.5mm, need to could complete smoothly at operated under microscope, and the technical merit to the operator is had relatively high expectations, and abecedarian's learning curve is longer.In addition, the complication of vascular anastomosis comprises intraoperative hemorrhage, anastomotic stenosis after surgery or anastomotic stoma thrombosis, and these problems all can affect the success of modeling.
Summary of the invention
A kind of with sleeve pipe structure xenotransplantation abdominal aortic aneurysms model, it is characterized in that: the long 2mm of casing main body, main body outer wall axial midpoint has the annular slot perpendicular to the sleeve pipe axis, and main body one end has handle, long 1mm, the cross-sectional length of handle is no more than the semi-ring of sleeve pipe; The sleeve pipe external diameter is no more than 1.5mm, and internal diameter is in the 1mm left and right.
The invention provides a kind of xenotransplantation abdominal aortic aneurysms modeling of adopting new method, can make operation simpler, the operation required time shorter, the complication of operation still less, modeling has higher success rate, the homogeneity of model is better.
Model of the present invention is realized as follows: 1, make sleeve pipe; 2, the receptor ends of vessels is fixed on sleeve pipe; 3, donor blood vessel is connected with the receptor blood vessel that is connected sleeve pipe; 4, observed result after 2 weeks.
Description of drawings
The schematic diagram of Fig. 1 sleeve pipe of the present invention.
The implementing procedure of Fig. 2 new method of the present invention
The specific embodiment
1, adopt Cordis subsidiary of Johnson Co. commercially available 4F angiography conduit (external diameter 1.35mm, internal diameter 0.97mm), this conduit is medical high rigidity polyester material, be difficult for subsiding, external diameter is no more than 1.5mm, and internal diameter is fit to the anatomical features of abdominal aortic aneurysms in the 1mm left and right.This conduit is made sleeve pipe, the long 2mm of its main body (1.1), the outer wall axial midpoint is carved into annular slot (1.2) perpendicular to the sleeve pipe axis with blade, and main body one end has the long handle (1.3) of 1mm, the cross-sectional length of handle is no more than the semi-ring of sleeve pipe, is convenient to the tweezers clamping when operation.2, after rat laparotomy, appear the long 2cm of renal artery ventral aorta below horizontal, all lumbar arteries of ligation, block with vascular clamp at the ventral aorta two ends, cross-section at the mid point of free aortic segment, with the ventral aorta broken ends of fractured bone as the receptor blood vessel, the receptor blood vessel is passed inside pipe casing (2.1), inner membrance outwards overturns, and ties up the sessile receptor blood vessel with the 8-0 silk thread along casing clamp grooved ring shape, and ligation power is with the diameter that does not dwindle sleeve pipe be as the criterion (2.2).3, it is fixing that same method is completed tying up of another broken ends of fractured bone of rat aorta with sleeve pipe.4, get the long Cavia porcellus ventral aorta of 3cm as donor blood vessel, be fixed on two the two ends that on sleeve pipe, the receptor blood vessel inserts respectively donor blood vessel, tie up donor blood vessel and by the receptor blood vessel (2.3) that sleeve pipe is fixed with the 8-0 silk thread along casing clamp grooved ring shape, complete donor blood vessel and be connected the end end with the receptor blood vessel and connect.5, open the situation of abdomen assessment xenotransplantation ventral aorta neoplasia after 2 weeks.
Claims (2)
1. one kind builds xenotransplantation abdominal aortic aneurysms model with sleeve pipe, it is characterized in that: the long 2mm of casing main body, main body outer wall axial midpoint has the annular slot perpendicular to the sleeve pipe axis, and main body one end has handle, long 1mm, the cross-sectional length of handle is no more than the semi-ring of sleeve pipe; The sleeve pipe external diameter is no more than 1.5mm, and internal diameter is in the 1mm left and right.
2. according to claim 1 with sleeve pipe structure xenotransplantation abdominal aortic aneurysms model, it is characterized in that: this shell material is medical high rigidity polyester material, is difficult for subsiding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220343949 CN202933048U (en) | 2012-07-06 | 2012-07-06 | Heterograft rat abdominal aortic aneurysm model built by using sleeve |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220343949 CN202933048U (en) | 2012-07-06 | 2012-07-06 | Heterograft rat abdominal aortic aneurysm model built by using sleeve |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202933048U true CN202933048U (en) | 2013-05-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220343949 Expired - Fee Related CN202933048U (en) | 2012-07-06 | 2012-07-06 | Heterograft rat abdominal aortic aneurysm model built by using sleeve |
Country Status (1)
| Country | Link |
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| CN (1) | CN202933048U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596082A (en) * | 2016-01-29 | 2016-05-25 | 四川大学 | Abdominal aorta aneurysm growth process modeling method |
| CN110123478A (en) * | 2019-06-12 | 2019-08-16 | 西南医科大学附属医院 | A kind of vessel cannula and application method with anchoring knot |
| CN112294381A (en) * | 2020-10-27 | 2021-02-02 | 中南大学湘雅医院 | Sleeve device for microsurgery blood vessel and lymphatic vessel anastomosis |
-
2012
- 2012-07-06 CN CN 201220343949 patent/CN202933048U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596082A (en) * | 2016-01-29 | 2016-05-25 | 四川大学 | Abdominal aorta aneurysm growth process modeling method |
| CN110123478A (en) * | 2019-06-12 | 2019-08-16 | 西南医科大学附属医院 | A kind of vessel cannula and application method with anchoring knot |
| CN112294381A (en) * | 2020-10-27 | 2021-02-02 | 中南大学湘雅医院 | Sleeve device for microsurgery blood vessel and lymphatic vessel anastomosis |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130515 Termination date: 20150706 |
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| EXPY | Termination of patent right or utility model |