CN202688330U - Temperature compensation module for eliminating temperature fringe effect of gene amplifier - Google Patents
Temperature compensation module for eliminating temperature fringe effect of gene amplifier Download PDFInfo
- Publication number
- CN202688330U CN202688330U CN 201120575385 CN201120575385U CN202688330U CN 202688330 U CN202688330 U CN 202688330U CN 201120575385 CN201120575385 CN 201120575385 CN 201120575385 U CN201120575385 U CN 201120575385U CN 202688330 U CN202688330 U CN 202688330U
- Authority
- CN
- China
- Prior art keywords
- temperature
- compensation module
- temperature compensation
- reaction tubes
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model provides a temperature compensation module for eliminating temperature fringe effect of a gene amplifier, which at least comprises a heating body and a control terminal; the control terminal controls the temperature of the temperature compensation module; heating wires distributed on the heating body is non-uniformly arranged by density or by thickness; and thus different temperature compensation is provided for a reaction tube base of the gene amplifier. The utility model effectively eliminates the position fringe effect of the temperature during the application of the gene amplifier, thus effectively improves the consistency of the temperature of the reaction tube base, and ensures the accurate and reliable running of experiments.
Description
Technical field
The utility model relates to a kind of temperature compensation module for gene-amplificative instrament.
Background technology
Gene-amplificative instrament is the underlying instrument that biomedical sector is used for polymerase chain reaction (PCR), and it can provide stablizes adjustable temperature environment, and the instrument as the dna fragmentation amplification is extensively used by industry.Gene-amplificative instrament can or be cooled to the required accurate temperature of per step reaction with the reaction tubes heating, and in order to guarantee DNA cloning accurately and reliably, the accuracy of temperature control module is extremely important.Now widely used gene-amplificative instrament, mostly adopt Peltier (Peltier, the semiconductor heat electric cooling device) dull and stereotyped type of heating, to be that the reaction tubes pedestal connects one heat sink, Peltier be close to heat sink under, rely on the temperature variation of Peltier to conduct to the reaction tubes pedestal, and then reach the purpose of control reaction tube temperature.This mode temperature control is relatively accurate, warming and cooling rate is fast, but shortcoming is temperature control and is limited to the mid-way in the zone accurately, and the reaction tubes pedestal around since heat sink quick heat radiating on warming and cooling rate and equilibrium temperature, all be starkly lower than region intermediate, the temperature contrast that the fringing effect of this position brings can cause in the PCR reaction process, the primer of fringe region and region intermediate and dna fragmentation hybridization efficiency are inconsistent, and then affect accuracy and the consistence of experimental result.
Summary of the invention
For the problems referred to above, the utility model main purpose provides a kind of temperature compensation module of eliminating the fringing effect of gene amplification temperature.
To achieve these goals, the utility model is by the following technical solutions:
A kind of temperature compensation module for eliminating the fringing effect of gene-amplificative instrament temperature, which comprises at least continuous heating member and control end, described control end carries out temperature control to described heating member, it is inhomogeneous that the density of the heater wire that distributes on the described heating member is arranged inhomogeneous or thickness is arranged, thereby provide different temperature compensations to the reaction tubes pedestal of gene-amplificative instrament.
Aforesaid temperature compensation module, wherein preferably, described temperature compensation module is hollow annular structure or strip structure, be looped around the reaction tubes pedestal edge of gene-amplificative instrament, lip temperature to the reaction tubes pedestal is adjusted compensation, prevents the position fringing effect that reaction tubes susceptor edges quick heat radiating causes.
Aforesaid temperature compensation module, wherein preferably, described heater wire is nichrome wire or printed circuit board (PCB), can arrange or thickness is arranged inhomogeneously realizes inhomogeneous heating by density.
Aforesaid temperature compensation module, wherein preferably, described control end can be subjected to external circuits control and can adopt the variation of different power control temperature.
Aforesaid temperature compensation module, wherein preferably, described heater wire is printed circuit board (PCB), the resin of printed circuit board (PCB) carries out heat insulation as thermal insulation material to described temperature compensation module.
Comprise the temperature control module that is used for gene-amplificative instrament of aforesaid temperature compensation module, it is characterized in that described temperature control module comprises described temperature compensation module, reaction tubes pedestal, Peltier, temperature probe and radiator element;
Described reaction tubes pedestal carrying reaction tubes, described Peltier is close under the reaction tubes pedestal, by conduction heat control reaction tubes base-plate temp, described temperature probe is attached at the reaction tubes base-plates surface, the real time temperature that can measure the reaction tubes pedestal changes, described radiator element is positioned under the Peltier, be used for the Peltier heat radiation to work, described temperature compensation module is looped around reaction tubes pedestal edge, the temperature contrast of described reaction tubes susceptor edges and intermediate portion is adjusted compensation by described temperature compensation module, to improve the temperature uniformity of whole reaction tubes pedestal.
The gene-amplificative instrament that comprises aforesaid temperature compensation module.
The gene-amplificative instrament that comprises aforesaid temperature control module.
The utlity model has following advantage:
The temperature compensation module that the utility model provides has been eliminated the position fringing effect of gene-amplificative instrament temperature of appearance when using effectively.Be positioned at reaction tubes pedestal temperature compensation module all around, can provide thermal environment to the reaction tubes pedestal, it is carried out temperature compensation in real time, prevent the quick heat radiating of reaction tubes susceptor edges position, Effective Raise the consistence of reaction tubes base-plate temp, guarantee that experiment is able to accurately, carries out reliably.
Description of drawings
Fig. 1 is the structural representation of this applied temps compensating module
Fig. 2 is the temperature control module assembling synoptic diagram of using the utility model temperature compensation module
Fig. 3 is the temperature control module structural representation of using the utility model temperature compensation module
Embodiment
Below in conjunction with drawings and Examples, the utility model is described in detail.
In the present embodiment, temperature compensation module 1 is comprised of heating member 11 and control end 12.As shown in Figure 1, heating member 11 can be nichrome wire, and produces different equalising temps everywhere by uneven density arrangement or thickness arrangement; Control end 12 can external circuits, and temperature compensation module 1 is carried out temperature control, and can adopt the variation of different power control temperature.In the present embodiment, temperature compensation module 1 is the hollow annular structure.
Shown in the structural representation of the assembling synoptic diagram of Fig. 2 and Fig. 3, use the temperature control module of the gene-amplificative instrament of the temperature compensation module 1 in this enforcement, wherein: be close at reaction tubes pedestal 2 lower surfaces and be provided with Peltier 3, by the temperature of conduction heat control reaction tubes pedestal 2; Radiator element 4 is set below the Peltier 3, is used for Peltier 3 heat radiations to work; Temperature probe can be positioned between reaction tubes pedestal 2 and the Peltier 3.Peltier 3 adjusts its gradient of temperature by the real time temperature of the reaction tubes pedestal 2 of temperature probe feedback.And temperature compensation module 1 around the ground gland on the edge of reaction tubes pedestal 2, thereby can be to dispelling the heat the faster edge heating of reaction tubes pedestal 2, with the homogeneity of the margin and center temperature that guarantees reaction tubes pedestal 2.
Claims (8)
1. temperature compensation module of be used for eliminating the fringing effect of gene-amplificative instrament temperature, it is characterized in that, which comprises at least continuous heating member and control end, described control end carries out temperature control to described heating member, and it is inhomogeneous that the density of the heater wire that distributes on the described heating member is arranged inhomogeneous or thickness is arranged.
2. temperature compensation module as claimed in claim 1 is characterized in that, described temperature compensation module is hollow annular structure or strip structure, is looped around the reaction tubes pedestal edge of gene-amplificative instrament.
3. temperature compensation module as claimed in claim 1 or 2 is characterized in that, described heater wire is nichrome wire or printed circuit board (PCB).
4. temperature compensation module as claimed in claim 1 or 2 is characterized in that, described control end is subjected to external circuits control and can adopts the variation of different power control temperature.
5. temperature compensation module as claimed in claim 3 is characterized in that, described heater wire is printed circuit board (PCB), and the resin of printed circuit board (PCB) carries out heat insulation as thermal insulation material to described temperature compensation module.
6. comprise the temperature control module that is used for gene-amplificative instrament of temperature compensation module as claimed in claim 1 or 2, it is characterized in that described temperature control module comprises described temperature compensation module, reaction tubes pedestal, Peltier, temperature probe and radiator element;
Described reaction tubes pedestal carrying reaction tubes, described Peltier is close under the reaction tubes pedestal, and described temperature probe is attached at the reaction tubes base-plates surface, and described radiator element is positioned under the Peltier, and described temperature compensation module is looped around reaction tubes pedestal edge.
7. the gene-amplificative instrament that comprises temperature compensation module as claimed in claim 1 or 2.
8. the gene-amplificative instrament that comprises temperature control module as claimed in claim 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120575385 CN202688330U (en) | 2011-12-31 | 2011-12-31 | Temperature compensation module for eliminating temperature fringe effect of gene amplifier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120575385 CN202688330U (en) | 2011-12-31 | 2011-12-31 | Temperature compensation module for eliminating temperature fringe effect of gene amplifier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202688330U true CN202688330U (en) | 2013-01-23 |
Family
ID=47543977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201120575385 Expired - Lifetime CN202688330U (en) | 2011-12-31 | 2011-12-31 | Temperature compensation module for eliminating temperature fringe effect of gene amplifier |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202688330U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110551605A (en) * | 2019-09-02 | 2019-12-10 | 杭州安誉科技有限公司 | Auxiliary control device for porous module |
| CN115505525A (en) * | 2022-11-10 | 2022-12-23 | 鲲鹏基因（北京）科技有限责任公司 | Temperature regulation and control compensation device of PCR instrument and PCR instrument |
-
2011
- 2011-12-31 CN CN 201120575385 patent/CN202688330U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110551605A (en) * | 2019-09-02 | 2019-12-10 | 杭州安誉科技有限公司 | Auxiliary control device for porous module |
| CN115505525A (en) * | 2022-11-10 | 2022-12-23 | 鲲鹏基因（北京）科技有限责任公司 | Temperature regulation and control compensation device of PCR instrument and PCR instrument |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10835901B2 (en) | Apparatuses, systems and methods for providing thermocycler thermal uniformity | |
| US8795592B2 (en) | Sample thermal cycling | |
| JP2018511314A5 (en) | ||
| Feng et al. | Natural convection in metal foam heat sinks with open slots | |
| JP2008035859A (en) | Instrument for heating and cooling | |
| CN204795648U (en) | Novel 3D printer heating bottom plate | |
| CN202688330U (en) | Temperature compensation module for eliminating temperature fringe effect of gene amplifier | |
| CN210481399U (en) | Auxiliary heating device for gene amplification instrument module | |
| Somasundaram et al. | A study of intermittent spray cooling process through application of a sequential function specification method | |
| CN107871700A (en) | A kind of heating system | |
| Walunj et al. | Experimental analysis of inclined narrow plate-fins heat sink under natural convection | |
| US20150165438A1 (en) | Microfluidic device and temperature control method for microfluidic device | |
| CN105670924A (en) | Natural convection PCR (Polymerase Chain Reaction) microsystem | |
| US20180312958A1 (en) | Vapor deposition apparatus and method for manufacturing film | |
| KR101261399B1 (en) | Emperature control system of heating system and temperature control method using the same | |
| CN203758634U (en) | Cold face temperature uniformity testing apparatus for thermoelectric refrigeration components | |
| JP2012059872A5 (en) | ||
| CN101924016B (en) | Heating method, device and substrate processing equipment | |
| CN203719098U (en) | Precise temperature control electric heating sleeve | |
| CN203465134U (en) | Novel spontaneous heating device for zirconium alloy tube fatigue test | |
| KR20150024050A (en) | Apparatus for gene alplification and mamufacture method thereof | |
| CN108520868A (en) | Conductive structure | |
| Lama et al. | Choice of metal heaters for measuring thermal conductivity using 3ω method | |
| JPH03237345A (en) | Method for measuring thermal conductivity | |
| CN105332059A (en) | Heating device applied in low-temperature polysilicon heating technology and heating method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: BEIJING BEITAI SCIENCE + TECHNOLOGY CO., LTD. Effective date: 20121220 |
|
| C14 | Grant of patent or utility model | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20121220 Address after: Room B201-206, Zhongguancun development building No. 12 Beijing 100085 Haidian District shangdixinxi Road Patentee after: Beijing Eastwin Scientific, Inc. Address before: Room B201-206, Zhongguancun development building No. 12 Beijing 100085 Haidian District shangdixinxi Road Patentee before: Beijing Eastwin Scientific, Inc. Patentee before: BEIJING BEITAI TECHNOLOGY CO., LTD. |
|
| ASS | Succession or assignment of patent right |
Owner name: SUZHOU DONGSHENG XINGYE SCIENTIFIC INSTRUMENT CO., Free format text: FORMER OWNER: BEIJING EASTWIN SCIENTIFIC, INC. Effective date: 20130207 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100085 HAIDIAN, BEIJING TO: 215123 SUZHOU, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130207 Address after: Xinghu street Suzhou Industrial Park in Jiangsu province 215123 BioBAY No. 218 building 506 unit B2 Patentee after: Suzhou Dongsheng Xingye Scientific Instrument Co., Ltd. Address before: Room B201-206, Zhongguancun development building No. 12 Beijing 100085 Haidian District shangdixinxi Road Patentee before: Beijing Eastwin Scientific, Inc. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20130123 |