CN202681955U - Noninvasive tumor locating system - Google Patents

Abstract

The utility model relates to a noninvasive tumor locating system. In the system, a time concept is introduced on the basis of a three-dimensional radiotherapy technology; situations that motions and displacement errors among fractionated treatments for anatomy tissues in the treatment process, such as breath peristalsis motions, daily setup errors, target section contraction and the like, casus changes of radiotherapy dose distribution and influence treatment plans are considered sufficiently; and various advanced imaging equipment is utilized for monitoring tumors and normal organs in real time before and during a user suffers from the treatment, and the treatment conditions can be adjusted in accordance with changes of organ positions so that target sections can be radiated closely, and further the real accurate treatment is achieved.

Description

A kind of noinvasive tumor-localizing system

Technical field

This utility model relates to a kind of noinvasive tumor-localizing system, relates in particular to a kind of noinvasive tumor-localizing system that reduces shift error by telltale mark point.

Background technology

Tumor more and more becomes the biggest threat of modern society's health of people, and along with the development of science and technology, the oncotherapy technology has also had significant progress.Because tumor is positioned at health mostly, therefore, accurately remain the difficult point place in the location for tumor.Because the skin of body surface is mobile easily, therefore, only positioning by skin surface is to have larger error.In the prior art, usually external devices is fixed on the health and positions, but like this can be painful greatly to the sufferer band.Because the patient is after carrying out tumor-localizing at bat CT image, therapy system is formulated treatment plan according to the position of this CT image tumor usually, but usually clap the CT image and formal on the therapeutic bed treatment for some time, again after going up therapeutic bed, its body position all can some variation, can not be when clapping the CT image position just the same, therefore, have larger position error.

The utility model content

The technical problem that this utility model solves is: make up a kind of noinvasive tumor-localizing system, overcome prior art in the tumor-localizing process, the location inaccuracy exists larger position error to affect the technical problem of therapeutic effect.

The technical solution of the utility model is: make up a kind of noinvasive tumor-localizing system, the positioning unit that comprises telltale mark point for the position patient tumor, takes the shooting unit of patient tumors zone DR image, tumor is reorientated, described telltale mark point is arranged on patient body-surface, described shooting unit is taken respectively at least two the DR images in patient tumors zone from different perspectives, and described positioning unit is reorientated tumor according to described DR image.

Further technical scheme of the present utility model is: described telltale mark point is for a plurality of, and described a plurality of telltale mark points are separately fixed at patient's diverse location with it, does not overlap mutually at many above telltale mark point of DR image of described shooting unit photographs.

Further technical scheme of the present utility model is: also comprise the pedestal of fixing described telltale mark point, described pedestal is fixed on it the described patient.

Further technical scheme of the present utility model is: described pedestal comprises dens supporter, described dens supporter and patient's dental articulation.

Technique effect of the present utility model is: make up a kind of noinvasive tumor-localizing system, introduced the concept of time on the basis of three-dimensional radiotherapy technology, taken into full account and dissected the motion that is organized in the therapeutic process and displacement error between interval procedure, as breathe vermicular movement, daily pendulum bit error, target area contraction etc. causes variation that Radiotherapy dosimetry distributes and on the situation of the aspects such as impact for the treatment of plan, before patient treatment, utilize various advanced persons' image documentation equipment that tumor and normal organ are carried out real-time monitoring in the treatment, and can make irradiation field follow the target area closely according to the variation adjustment treatment condition of organ site, make it to accomplish accurate treatment truly.

Description of drawings

Fig. 1 is structural representation of the present utility model.

Fig. 2 is base construction figure of the present utility model.

Fig. 3 is flow chart of the present utility model.

The specific embodiment

Below in conjunction with specific embodiment, technical solutions of the utility model are further specified.

As shown in Figure 1, the specific embodiment of the present utility model is: make up a kind of noinvasive tumor-localizing system, comprise the telltale mark point for the position patient tumor, generate the image reconstruction unit 1 of DDR image according to patient's CT image reconstruction, take the shooting unit 2 of patient tumors zone DR image, DR image and DDR image are mated the matching unit 3 of calculating, obtain the acquiring unit 4 of positional parameter, the positioning unit 5 that tumor is reorientated, described shooting unit 2 is taken respectively at least two the DR images in patient tumors zone from different perspectives, the DDR image that described image reconstruction unit 1 is rebuild contains the mark of described telltale mark point, at least two DR images of described matching unit 3 bases are the treatment coordinate with the Coordinate Conversion of telltale mark point, then the coordinate that will treat the DDR framing gauge point of coordinate and described corresponding angle mates calculating, result and the definite tumor coordinate of described treatment plan that described acquiring unit 4 calculates according to coupling obtain positional parameter, described positioning unit 5 is reorientated tumor according to the positional parameter that described acquiring unit 4 obtains, and described positioning unit is computer.

As described in Figure 1, specific implementation process of the present utility model is as follows: treatment planning systems receives patient's CT image by network or alternate manner, image reconstruction unit 1 generates the DRR image with patient's CT image calculation, and described image reconstruction unit 1 is carried out the DDR image reconstruction with the central point of described CT image as the center of DRR image.Patient's telltale mark dot information is arranged on the described DRR image.When the patient positioned, the unit 2 of taking pictures on the therapy apparatus was taken the DR image of two angles of patient's patient part in real time.In the specific embodiment, the described unit 2 of taking pictures comprises flat panel detector and sends the photosphere pipe of X-ray line.During treatment, send ray by the radiation head focusing.

Described matching unit 3 mates calculating with the DRR image of corresponding angle respectively with these two DR images, and detailed process is as follows:

At least two DR images of described matching unit 3 bases are the treatment coordinate with the Coordinate Conversion of telltale mark point:

$x=\frac{(x_3\×\cos \mathrm{\α}-a\×\sin \mathrm{\α})\×(z-a\×\cos \mathrm{\α})}{a\×\sin \mathrm{\α}-x_3\×\sin \mathrm{\α}-b\×\cos \mathrm{\α}}$

$y=\frac{y_3\×(x-a\×\sin \mathrm{\α})}{x_3\×\cos \mathrm{\α}-b\×\sin \mathrm{\α}}$

$z=\frac{(x_3\×\sin \mathrm{\α}+b\×\cos \mathrm{\α})\×(X_3\×\sin \mathrm{\β}+b\×\cos \mathrm{\β})\×(a\×\sin \mathrm{\α}-a\×\sin \mathrm{\β})+a\×\cos \mathrm{\α}\×}{(x_3\×\cos \mathrm{\α}-b\×\sin \mathrm{\α})\×(X_3\sin \mathrm{\β}+b\×\cos \mathrm{\β})-(X_3\×\cos \mathrm{\β}-a\×\sin \mathrm{\β})\×}$

$\frac{(x_3\×\cos \mathrm{\α}-b\×\sin \mathrm{\α})\×(X_3\×\sin \mathrm{\β}+b\×\cos \mathrm{\β})-a\×\cos \mathrm{\β}\×(X_3\×\cos \mathrm{\β}-b\×\sin \mathrm{\β})\×}{(x_3\×\sin \mathrm{\α}+b\×\cos \mathrm{\α})}$

$\frac{(x_3\×\sin \mathrm{\α}+b\×\cos \mathrm{\α})}{\mathrm{}}$

Wherein: a is for treating focus to the distance between the flat panel detector, and b is the distance between radiation head and the flat panel detector.(this local sensation or improper.)

(x ₃, y ₃) for the point coordinates conversion in the DR image under angle [alpha] of telltale mark point comes, its coordinate system is to the right the x axle take picture centre as initial point, upwards is the y axle;

$\left\{\begin{array}{c}{x}_3=x_1-\frac{\mathrm{imagewidth}}{2}\\ y_3=y_1-\frac{\mathrm{<figure-callout\; id="2"\; label="imagelength"\; filenames="120516150752.png"\; state="\{\{state\}\}">imagelength</figure-callout>}}{2}\end{array}\right.$

(x ₁, y ₁) be the coordinate of telltale mark point DR image mid point under angle [alpha];

(X ₃, Y ₃) for the DR image mid point coordinate transform under angle beta of telltale mark point comes, its coordinate system is to the right the x axle take picture centre as initial point, upwards is the y axle:

$\left\{\begin{array}{c}{X}_3=X_1-\frac{\mathrm{imagewidth}}{2}\\ Y_3=Y_1-\frac{\mathrm{<figure-callout\; id="2"\; label="imagelength"\; filenames="120516150752.png"\; state="\{\{state\}\}">imagelength</figure-callout>}}{2}\end{array}\right.$

(X ₁, Y ₁) be the coordinate of telltale mark point DR image mid point under angle beta.

Thus, obtain the treatment coordinate (x, y, z) of this telltale mark point.DDR image according to this telltale mark point, the treatment coordinate (x, y, z) of this telltale mark point three-dimensional coordinate with the DDR image of this telltale mark point is subtracted each other respectively, obtain the coordinate difference of this telltale mark point treatment coordinate (x, y, z) and the three-dimensional coordinate of the DDR image of this telltale mark point, it is patient's positional parameter, then, described positioning unit 5 is increased to this positional parameter on the corresponding coordinate of DDR image tumor coordinate, obtain the new treatment coordinate of tumor, with the treatment coordinate that tumor is new tumor is reorientated.

In this utility model preferred implementation, described telltale mark point is for a plurality of, and described a plurality of telltale mark points are separately fixed at patient's diverse location with it, and 2 many above telltale mark point of DR image taking do not overlap mutually in described shooting unit.Described matching unit 3 with a plurality of telltale mark points respectively the coupling result of calculation of the telltale mark point corresponding with described DDR image average, get its average as final coupling result of calculation.Detailed process is as follows: if telltale mark point is for a plurality of, then calculate respectively, obtained the treatment coordinate of this point by each telltale mark point, then draw respectively the separately coordinate difference of telltale mark point, get the average of coordinate difference as positional parameter, then, described positioning unit 5 is increased to this positional parameter on the corresponding coordinate of DDR image tumor coordinate, obtain the new treatment coordinate of tumor, with the treatment coordinate that tumor is new tumor is reorientated.Can obtain like this locating more accurately.

As shown in Figure 2, in this utility model preferred implementation, also comprise the pedestal A of fixing described telltale mark point, described pedestal A is fixed on it the described patient.In the specific embodiment, described pedestal A comprises dens supporter C, described dens supporter C and patient's dental articulation.Because dens supporter C and patient's dental articulation can play well fixation, avoided the technical problem that contact built on the sand or to patient bring misery of pedestal with the person.

As shown in Figure 3, the specific embodiment of the present utility model is: a kind of tumor-localizing method is provided, and described tumor-localizing system comprises the telltale mark point for the position patient tumor, and described tumor-localizing method comprises the steps:

Step 100: the telltale mark point is set, that is, the telltale mark point is fixedly installed on patient body-surface.

Step 200: rebuild the DDR image: the CT image reconstruction that contains telltale mark point according to shooting generates the DDR image.Detailed process is as follows: because the telltale mark point is fixedly installed on patient body-surface, contain the telltale mark point in the CT image, make up three-dimensional system of coordinate, the CT image reconstruction that contains telltale mark point according to shooting generates the DDR image, it is rebuild on the DDR image that generates, telltale mark point and knub position obtain respectively its coordinate in this three-dimensional system of coordinate, then treatment planning systems is made treatment plan, namely the obtain medical treatment three-dimensional coordinate of target spot, telltale mark point also has the three-dimensional coordinate in this three-dimensional system of coordinate.In the process of reconstruction, carry out the DDR image reconstruction with the central point of described CT image as the center of DRR image.

Step 300: take the DR image, that is: take from different perspectives respectively at least two the DR images in patient tumors zone.

Step 400: coupling is calculated, that is: the Coordinate Conversion according at least two DR framing gauge points is the treatment coordinate, and the coordinate that then will treat the DDR framing gauge point of coordinate and described corresponding angle mates and calculates coupling result of calculation.

Detailed process is as follows: according at least two DR images the Coordinate Conversion of telltale mark point is the treatment coordinate:

$x=\frac{(x_3\&times;\cos \mathrm{\&alpha;}-a\&times;\sin \mathrm{\&alpha;})\&times;(z-a\&times;\cos \mathrm{\&alpha;})}{a\&times;\sin \mathrm{\&alpha;}-x_3\&times;\sin \mathrm{\&alpha;}-b\&times;\cos \mathrm{\&alpha;}}$

$y=\frac{y_3\&times;(x-a\&times;\sin \mathrm{\&alpha;})}{x_3\&times;\cos \mathrm{\&alpha;}-b\&times;\sin \mathrm{\&alpha;}}$

$z=\frac{(x_3\&times;\sin \mathrm{\&alpha;}+b\&times;\cos \mathrm{\&alpha;})\&times;(X_3\&times;\sin \mathrm{\&beta;}+b\&times;\cos \mathrm{\&beta;})\&times;(a\&times;\sin \mathrm{\&alpha;}-a\&times;\sin \mathrm{\&beta;})+a\&times;\cos \mathrm{\&alpha;}\&times;}{(x_3\&times;\cos \mathrm{\&alpha;}-b\&times;\sin \mathrm{\&alpha;})\&times;(X_3\sin \mathrm{\&beta;}+b\&times;\cos \mathrm{\&beta;})-(X_3\&times;\cos \mathrm{\&beta;}-a\&times;\sin \mathrm{\&beta;})\&times;}$

$\frac{(x_3\&times;\cos \mathrm{\&alpha;}-b\&times;\sin \mathrm{\&alpha;})\&times;(X_3\&times;\sin \mathrm{\&beta;}+b\&times;\cos \mathrm{\&beta;})-a\&times;\cos \mathrm{\&beta;}\&times;(X_3\&times;\cos \mathrm{\&beta;}-b\&times;\sin \mathrm{\&beta;})\&times;}{(x_3\&times;\sin \mathrm{\&alpha;}+b\&times;\cos \mathrm{\&alpha;})}$

$\frac{(x_3\&times;\sin \mathrm{\&alpha;}+b\&times;\cos \mathrm{\&alpha;})}{\mathrm{}}$

Wherein: a is for treating focus to the distance between the flat panel detector, and b is the distance between radiation head and the flat panel detector.

(x ₃, y ₃) for the point coordinates conversion in the DR image under angle [alpha] of telltale mark point comes, its coordinate system is to the right the x axle take picture centre as initial point, upwards is the y axle,

$\left\{\begin{array}{c}{x}_3=x_1-\frac{\mathrm{imagewidth}}{2}\\ y_3=y_1-\frac{\mathrm{<figure-callout\; id="2"\; label="imagelength"\; filenames="120516150752.png"\; state="\{\{state\}\}">imagelength</figure-callout>}}{2}\end{array}\right.$

(x ₁, y ₁) be the coordinate of telltale mark point DR image mid point under angle [alpha];

(X ₃, Y ₃) for the DR image mid point coordinate transform under angle beta of telltale mark point comes, its coordinate system is to the right the x axle take picture centre as initial point, upwards is the y axle:

$\left\{\begin{array}{c}{X}_3=X_1-\frac{\mathrm{imagewidth}}{2}\\ Y_3=Y_1-\frac{\mathrm{<figure-callout\; id="2"\; label="imagelength"\; filenames="120516150752.png"\; state="\{\{state\}\}">imagelength</figure-callout>}}{2}\end{array}\right.$

(X ₁, Y ₁) be the coordinate of telltale mark point DR image mid point under angle beta.

Step 500: obtain positional parameter, that is: obtain positional parameter according to coupling result of calculation and the definite tumor coordinate of described treatment plan.Detailed process is as follows: the treatment coordinate (x, y, z) that obtains this telltale mark point.DDR image according to this telltale mark point, the treatment coordinate (x, y, z) of this telltale mark point three-dimensional coordinate with the DDR image of this telltale mark point is subtracted each other respectively, obtain the coordinate difference of this telltale mark point treatment coordinate (x, y, z) and the three-dimensional coordinate of the DDR image of this telltale mark point, i.e. patient's positional parameter.

Step 600: location: tumor is reorientated according to described positional parameter.Detailed process is as follows: this positional parameter is increased on the corresponding coordinate of DDR image tumor coordinate, obtains the new treatment coordinate of tumor, with the treatment coordinate that tumor is new tumor is reorientated.

In this utility model preferred implementation, described telltale mark point is for a plurality of, and described a plurality of telltale mark points are separately fixed at patient's diverse location with it, and 2 many above telltale mark point of DR image taking do not overlap mutually in described shooting unit.Described matching unit 3 with a plurality of telltale mark points respectively the coupling result of calculation of the telltale mark point corresponding with described DDR image average, get its average as final coupling result of calculation.Detailed process is as follows: if telltale mark point is for a plurality of, then calculate respectively, obtained the treatment coordinate of this point by each telltale mark point, then draw respectively the separately coordinate difference of telltale mark point, get the average of coordinate difference as positional parameter, then, described positioning unit 5 is increased to this positional parameter on the corresponding coordinate of DDR image tumor coordinate, obtain the new treatment coordinate of tumor, with the treatment coordinate that tumor is new tumor is reorientated.Can obtain like this locating more accurately.

Technique effect of the present utility model is: make up a kind of noinvasive tumor-localizing system, introduced the concept of time on the basis of three-dimensional radiotherapy technology, taken into full account and dissected the motion that is organized in the therapeutic process and displacement error between interval procedure, as breathe vermicular movement, daily pendulum bit error, target area contraction etc. causes variation that Radiotherapy dosimetry distributes and on the situation of the aspects such as impact for the treatment of plan, before patient treatment, utilize various advanced persons' image documentation equipment that tumor and normal organ are carried out real-time monitoring in the treatment, and can make irradiation field follow the target area closely according to the variation adjustment treatment condition of organ site, make it to accomplish accurate treatment truly.

Above content is in conjunction with concrete preferred implementation further detailed description of the utility model, can not assert that implementation of the present utility model is confined to these explanations.For this utility model person of an ordinary skill in the technical field, without departing from the concept of the premise utility, can also make some simple deduction or replace, all should be considered as belonging to protection domain of the present utility model.

Claims (4)

1. noinvasive tumor-localizing system, it is characterized in that, the positioning unit that comprises telltale mark point for the position patient tumor, takes the shooting unit of patient tumors zone DR image, tumor is reorientated, described telltale mark point is arranged on patient body-surface, described shooting unit is taken respectively at least two the DR images in patient tumors zone from different perspectives, and described positioning unit is reorientated tumor according to described DR image.

2. noinvasive tumor-localizing according to claim 1 system, it is characterized in that, described telltale mark point is for a plurality of, and described a plurality of telltale mark points are separately fixed at patient's diverse location with it, does not overlap mutually at many above telltale mark point of DR image of described shooting unit photographs.

3. noinvasive tumor-localizing according to claim 1 system is characterized in that, also comprises the pedestal of fixing described telltale mark point, and described pedestal is fixed on it the described patient.

4. noinvasive tumor-localizing according to claim 3 system is characterized in that described pedestal comprises dens supporter, described dens supporter and patient's dental articulation.

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