CN202606136U - 7-chlorine-2-oxoethyl oenanthate reacting device system - Google Patents
7-chlorine-2-oxoethyl oenanthate reacting device system Download PDFInfo
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- CN202606136U CN202606136U CN 201220162210 CN201220162210U CN202606136U CN 202606136 U CN202606136 U CN 202606136U CN 201220162210 CN201220162210 CN 201220162210 CN 201220162210 U CN201220162210 U CN 201220162210U CN 202606136 U CN202606136 U CN 202606136U
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- reaction
- storage tank
- liquid nitrogen
- oenanthate
- oxoethyl
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Abstract
The utility model discloses a 7-chlorine-2-oxoethyl oenanthate reacting device system. The system comprises a reaction kettle, a Ringer's solution storage kettle, a diethyl oxalate storage tank, and a liquid nitrogen storage tank, wherein the Ringer's solution storage kettle and the diethyl oxalate storage tank are connected to the reaction kettle; a reaction material is added into the reaction kettle; the liquid nitrogen storage tank is connected with the reaction kettle by a pipeline. The 7-chlorine-2-oxoethyl oenanthate reacting device system has the advantages rapid temperature reduction is realized by introducing low-temperature liquid nitrogen in the reaction kettle, and nitrogen can accurately control low-temperature reaction, so that the effective reaction and the high yield of target product are realized; and therefore, the 7-chlorine-2-oxoethyl oenanthate reacting device system is particularly suitable for reactants with large heating amount, and the reaction yield is improved to a large extent.
Description
Technical field
The utility model relates to a kind of reaction system of chemical products, particularly a kind of 7-chloro-2-oxoheptanoate reaction unit system.
Background technology
7-chloro-2-oxoheptanoate is the key intermediate of cilastatin, and its Grignard production needs cryogenic conditions, and general refrigeration plant is difficult to satisfy it and produces needs, and the dropping time is long, side reaction is many, yield is low.
The utility model content
The utility model purpose: to the problems referred to above, the purpose of the utility model provides a kind of 7-chloro-2-oxoheptanoate reaction unit system, satisfies Grignard and produces required cryogenic conditions, improves yield.
Technical scheme: a kind of 7-chloro-2-oxoheptanoate reaction unit system; Comprise that agitated reactor, Grignard solution store still, diethy-aceto oxalate storage tank; Said Grignard solution stores still, said diethy-aceto oxalate storage tank all is connected to said agitated reactor and adds reaction mass; Also comprise liquid nitrogen storage tank, said liquid nitrogen storage tank is connected with said agitated reactor through pipeline.
Said pipeline outerwrap heat-insulation layer, the low temperature of maintenance liquid nitrogen makes it effectively lower the temperature to reaction system, prevents that liquid nitrogen gasification from influencing cooling effect.
On the said agitated reactor blow-down pipe is set.
Beneficial effect: compared with prior art; The utility model has the advantages that through low temperature liquid nitrogen and lead to fast cooling in the agitated reactor; Nitrogen can accurately be controlled low-temp reaction simultaneously; Realize effectively reaction and the high yield of target product, be particularly useful for reactant, can improve reaction yield largely with a large amount of heatings.
Description of drawings
Accompanying drawing is the utility model system architecture sketch map.
The specific embodiment
Below in conjunction with accompanying drawing and specific embodiment; Further illustrate the utility model; Should understand these embodiment only be used to the utility model is described and be not used in the restriction the utility model scope; After having read the utility model, those skilled in the art all fall within the application's accompanying claims institute restricted portion to the modification of the various equivalent form of values of the utility model.
Shown in accompanying drawing; A kind of 7-chloro-2-oxoheptanoate reaction unit system; Comprise that agitated reactor 1, Grignard solution store still 2, diethy-aceto oxalate storage tank 3, liquid nitrogen storage tank 4, Grignard solution stores still 2, diethy-aceto oxalate storage tank 3 all is connected to agitated reactor 1, in agitated reactor 1, adds reaction mass; Liquid nitrogen storage tank 4 is connected with agitated reactor 1 through pipeline 5, through the cooled with liquid nitrogen reaction system.Pipeline 5 outerwrap heat-insulation layers 6 are provided with blow-down pipe 7 on the agitated reactor 1.
Claims (3)
1. 7-chloro-2-oxoheptanoate reaction unit system; Comprise that agitated reactor (1), Grignard solution store still (2), diethy-aceto oxalate storage tank (3); Said Grignard solution stores still (2), said diethy-aceto oxalate storage tank (3) all is connected to said agitated reactor (1) and adds reaction mass; It is characterized in that: also comprise liquid nitrogen storage tank (4), said liquid nitrogen storage tank (4) is connected with said agitated reactor (1) through pipeline (5).
2. a kind of 7-chloro-2-oxoheptanoate reaction unit according to claim 1 system is characterized in that: said pipeline (5) outerwrap heat-insulation layer (6).
3. a kind of 7-chloro-2-oxoheptanoate reaction unit according to claim 1 system is characterized in that: blow-down pipe (7) is set on the said agitated reactor (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220162210 CN202606136U (en) | 2012-04-17 | 2012-04-17 | 7-chlorine-2-oxoethyl oenanthate reacting device system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220162210 CN202606136U (en) | 2012-04-17 | 2012-04-17 | 7-chlorine-2-oxoethyl oenanthate reacting device system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202606136U true CN202606136U (en) | 2012-12-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220162210 Expired - Fee Related CN202606136U (en) | 2012-04-17 | 2012-04-17 | 7-chlorine-2-oxoethyl oenanthate reacting device system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202606136U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103408479A (en) * | 2013-07-31 | 2013-11-27 | 安徽智新生化有限公司 | Preparation device of retinol acetate |
| CN106955643A (en) * | 2017-04-18 | 2017-07-18 | 成都绿林科技有限公司 | The synthesis reactor reacted suitable for ultralow temperature anaerobic |
-
2012
- 2012-04-17 CN CN 201220162210 patent/CN202606136U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103408479A (en) * | 2013-07-31 | 2013-11-27 | 安徽智新生化有限公司 | Preparation device of retinol acetate |
| CN106955643A (en) * | 2017-04-18 | 2017-07-18 | 成都绿林科技有限公司 | The synthesis reactor reacted suitable for ultralow temperature anaerobic |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121219 Termination date: 20150417 |
|
| EXPY | Termination of patent right or utility model |