CN103408479A - Preparation device of retinol acetate - Google Patents
Preparation device of retinol acetate Download PDFInfo
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- CN103408479A CN103408479A CN2013103288213A CN201310328821A CN103408479A CN 103408479 A CN103408479 A CN 103408479A CN 2013103288213 A CN2013103288213 A CN 2013103288213A CN 201310328821 A CN201310328821 A CN 201310328821A CN 103408479 A CN103408479 A CN 103408479A
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- main reaction
- liquid nitrogen
- reaction kettle
- preparation device
- reaction still
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Abstract
The invention discloses a preparation device of retinol acetate. According to the preparation device, a main reaction kettle, a water washing kettle, a wiped film evaporator, a distillation kettle and a finished product collecting tank are connected with one another through pipelines in the reaction direction, wherein NN-dimethylformamide, sodium tert-butoxide, pentadecane phosphate ester and valeraldehyde are placed in the main reaction kettle. The preparation device is characterized in that the main reaction kettle is connected with the liquid nitrogen container through a pipeline. According to the preparation device, the main reaction kettle is connected with the liquid nitrogen container externally, and liquid nitrogen is used for cooling materials in the main reaction kettle, so as to enable the materials in the main reaction kettle to be subjected to full reactions and reduce side reactions. Therefore, the content and the yield of the retinol acetate are improved.
Description
Technical field
The present invention relates to a kind of preparation facilities of, especially a kind of preparation facilities for preparing of high-content and high yield.
Background technology
Is as medicine simply, and what have the health that maintains the normal vision function, safeguard Epithelial cell and Promote immunity sphaeroprotein synthesizes, maintains the effect that the bone normal growth is grown, promoted growth and reproduction, suppresses tumor growth, accessory substance.By nitrogen dimethylformamide, sodium tert-butoxide, carbon 15 phosphoric acid ester and five-carbon ring aldehydo are reacted, and through a series of washing, evaporation, distillation, thereby finally obtain finished product, in reaction process, can produce a large amount of heats, the brine refrigeration of generally using at present, because the temperature of salt solution is low not, thereby heat transfer effect is bad, cause the material reaction in the end reaction still incomplete, thereby make by product obviously increase, the yield of and content are not high, are unfavorable for scale operation.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of preparation facilities, prepares high-content, of high yield.
For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of preparation facilities of, along the Direction of Reaction pipeline successively, be connected with main reaction still, washing kettle, luwa evaporator, still kettle and finished product receiving tank, in described main reaction still, be placed with nitrogen dimethylformamide, sodium tert-butoxide, carbon 15 phosphoric acid ester and five-carbon ring aldehydo, its innovative point is: described main reaction still pipeline is connected with liquid nitrogen container.
Further, the liquid nitrogen in described liquid nitrogen container keeps the temperature of main reaction still to be controlled at-45 ℃～-50 ℃.
Further, the liquid nitrogen in described liquid nitrogen container keeps the temperature optimum control of main reaction still at-48 ℃.
The invention has the advantages that: by the external liquid nitrogen container of main reaction still, utilize the lower liquid nitrogen of temperature in liquid nitrogen container, to the material in the main reaction still, carry out cooling, thereby make the material in the main reaction still fully react, reduce the generation of side reaction, thereby improve content and the yield of.
Practical using result shows, with liquid nitrogen in liquid nitrogen container, the temperature of reaction is controlled to-45 ℃～-50 ℃, can meet normal user demand, and the temperature optimum control is at-48 ℃, and reaction effect is better.
The accompanying drawing explanation
The present invention is further detailed explanation below in conjunction with the drawings and specific embodiments.
Diagram is the structural representation of the preparation facilities of a kind of of the present invention.
In figure: 1-main reaction still, 2-washing kettle, 3-luwa evaporator, 4-still kettle, 5-finished product receiving tank, 6-liquid nitrogen container.
Embodiment
The preparation facilities of of the present invention, along the Direction of Reaction pipeline successively, be connected with main reaction still 1, washing kettle 2, luwa evaporator 3, still kettle 4 and finished product receiving tank 5, in main reaction still 1, be placed with nitrogen dimethylformamide, sodium tert-butoxide, carbon 15 phosphoric acid ester and five-carbon ring aldehydo.For guaranteeing that in the main reaction still, material fully reacts, main reaction still 1 pipeline is connected with liquid nitrogen container 6.
By at the external liquid nitrogen container 6 of main reaction still 1, utilize the lower liquid nitrogen of phase temperature in liquid nitrogen container 6, the material in main reaction still 1 is carried out cooling, thereby make in the material in main reaction still 1 a minute reaction, reduce the generation of side reaction, thereby improve content and the yield of.
Practical using result shows, utilizes the liquid nitrogen in liquid nitrogen container 6 that the temperature of reaction is controlled to-45 ℃～-50 ℃, can meet normal user demand, and the temperature optimum control is at-48 ℃, and reaction effect is better.
An above embodiment to the invention has been described in detail, but described content only is the preferred embodiment of the invention, can not be considered to be used to limiting the practical range of the invention.All equalizations of doing according to the invention application range change and improve etc., within all should belonging to the patent covering scope of the invention.
Claims (3)
1. the preparation facilities of, along the Direction of Reaction pipeline successively, be connected with main reaction still, washing kettle, luwa evaporator, still kettle and finished product receiving tank, in described main reaction still, be placed with nitrogen dimethylformamide, sodium tert-butoxide, carbon 15 phosphoric acid ester and five-carbon ring aldehydo, it is characterized in that: described main reaction still pipeline is connected with liquid nitrogen container.
2. a kind of preparation facilities as claimed in claim 1 is characterized in that: the liquid nitrogen in described liquid nitrogen container keeps the temperature of main reaction still to be controlled at-45 ℃～-50 ℃.
3. a kind of preparation facilities as claimed in claim 2, is characterized in that, the liquid nitrogen in described liquid nitrogen container keeps the temperature optimum control of main reaction still at-48 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103288213A CN103408479A (en) | 2013-07-31 | 2013-07-31 | Preparation device of retinol acetate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103288213A CN103408479A (en) | 2013-07-31 | 2013-07-31 | Preparation device of retinol acetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103408479A true CN103408479A (en) | 2013-11-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013103288213A Pending CN103408479A (en) | 2013-07-31 | 2013-07-31 | Preparation device of retinol acetate |
Country Status (1)
| Country | Link |
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| CN (1) | CN103408479A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2497861Y (en) * | 2001-09-07 | 2002-07-03 | 宁波明欣化工机械有限责任公司 | Low-temperature reactor device |
| CN1363553A (en) * | 2001-01-05 | 2002-08-14 | 浙江医药股份有限公司新昌制药厂 | Process for preparing VA derivative |
| CN101219983A (en) * | 2007-12-29 | 2008-07-16 | 安徽智新生化有限公司 | Method for producing improved vitamin A acetic ester |
| CN202606136U (en) * | 2012-04-17 | 2012-12-19 | 太仓浦源医药原料有限公司 | 7-chlorine-2-oxoethyl oenanthate reacting device system |
-
2013
- 2013-07-31 CN CN2013103288213A patent/CN103408479A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1363553A (en) * | 2001-01-05 | 2002-08-14 | 浙江医药股份有限公司新昌制药厂 | Process for preparing VA derivative |
| CN2497861Y (en) * | 2001-09-07 | 2002-07-03 | 宁波明欣化工机械有限责任公司 | Low-temperature reactor device |
| CN101219983A (en) * | 2007-12-29 | 2008-07-16 | 安徽智新生化有限公司 | Method for producing improved vitamin A acetic ester |
| CN202606136U (en) * | 2012-04-17 | 2012-12-19 | 太仓浦源医药原料有限公司 | 7-chlorine-2-oxoethyl oenanthate reacting device system |
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Application publication date: 20131127 |