CN202605532U - Electroporation medicine importing instrument - Google Patents
Electroporation medicine importing instrument Download PDFInfo
- Publication number
- CN202605532U CN202605532U CN 201220200990 CN201220200990U CN202605532U CN 202605532 U CN202605532 U CN 202605532U CN 201220200990 CN201220200990 CN 201220200990 CN 201220200990 U CN201220200990 U CN 201220200990U CN 202605532 U CN202605532 U CN 202605532U
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- circuit
- control chip
- electroporation
- amplifying circuit
- relay
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Abstract
The utility model discloses an electroporation medicine importing instrument comprising a shell, wherein a control chip, a D/A converter, a wave filter, a stored program control amplifying circuit and a power amplifying circuit, which are sequentially connected together, are installed in the shell, a liquid crystal display screen and a parameter adjusting pushbutton are arranged on the front panel of the shell, and the liquid crystal display screen and the parameter adjusting pushbutton are respectively connected with the control chip. The medicine importing instrument disclosed by the utility model can provide the following four pulse wave shapes of sine wave, triangular wave, square wave and sawtooth wave, and furthermore, the medicine importing instrument can regulate and control the following parameters of the pulse in real time: amplitude, interval, width and waveform category.
Description
Technical field
This utility model relates to a kind of medicine introducing apparatus, is specifically related to a kind of exportable multiple electric pulse waveform and parameter and changes adjustable electroporation medicine introducing apparatus flexibly.
Background technology
The parameters such as electric pulse shape, amplitude and persistent period of electroporation medicine introducing apparatus all have influence in various degree to administering effect; Simultaneously since size, structure, the chemical characteristic of different biological cells have nothing in common with each other, so it is also inequality that a certain specific medication is carried out the required electric pulse parameter of effective electroporation; So just need according to by administration person and select suitable electric pulse to medicine.And the pulse parameter that existing electroporation medicine introducing apparatus provides is all more single, most of instrument be confined to a kind of impulse waveform or parameter variation range little.
Summary of the invention
To the shortcomings and deficiencies of prior art, the purpose of this utility model is to provide a kind of exportable multiple electric pulse waveform and parameter to change adjustable electroporation medicine introducing apparatus flexibly.
For realizing above-mentioned technical assignment, this utility model is taked following technical solution:
A kind of electroporation medicine introducing apparatus; Comprise housing; It is characterized in that, the control chip, D/A converter, wave filter, programmable amplifying circuit and the power amplification circuit that connect successively are installed in the said housing, the front panel of said housing is provided with LCDs and parameter regulation and control button;
Said programmable amplifying circuit comprises relay control chip, amplifier and at least two relays; Said each relay is connected with wave filter through resistance respectively; Each relay all is connected with the relay control chip; Each relay all is connected with amplifier, and said relay control chip is connected with control chip;
Said power amplification circuit comprises first amplifying circuit, complementary circuit, pulse transformer drivers and the pulse transformer that connects successively; Be connected with feedback circuit in the said power amplification circuit; This feedback circuit comprises second amplifying circuit and the filter circuit that is connected; Said second amplifying circuit is connected with pulse transformer drivers through sampling resistor, and said filter circuit is connected with the input of complementary circuit, and said first amplifying circuit is connected with amplifier;
Said LCDs all is connected with control chip with the parameter adjustment button.
The other technologies of this utility model are characterized as:
Said control chip adopts the EP2C8Q208C8 chip.
Said wave filter adopts 7 rank elliptic filters.
Described first amplifying circuit is a single-valve amplification circuit.
Said relay control chip adopts the ULN2001 chip.
Described pulse transformer drivers adopts IRF740 MOSFET.
The medicine introducing apparatus of this utility model is a kind of total function waveform burst pulse medicine introducing apparatus; This introducing apparatus can provide sine wave, triangular wave, square wave and four kinds of impulse waveforms of sawtooth waveforms, parameter that in addition can also paired pulses: amplitude, at interval, width and type of waveform carry out real-time monitoring.
Description of drawings
Fig. 1 is the internal structure sketch map of this utility model;
Fig. 2 is the structural representation of the programmable amplifying circuit of this utility model;
Fig. 3 is the structural representation of the power amplification circuit of this utility model.
Below in conjunction with embodiment and accompanying drawing this utility model is done further explain.
The specific embodiment
As illustrated in fig. 1 and 2; Technical scheme according to this utility model; The electroporation medicine introducing apparatus of this embodiment comprises housing; The control chip, D/A converter, wave filter, programmable amplifying circuit and the power amplification circuit that connect successively are installed in this housing, and the front panel of said housing is provided with LCDs and parameter regulation and control button; Said programmable amplifying circuit comprises relay control chip, amplifier and ten relays; Each relay is connected with wave filter through resistance respectively; Each relay all is connected with the relay control chip, and each relay all is connected with amplifier, and the relay control chip is connected with control chip; Said power amplification circuit comprises first amplifying circuit, complementary circuit, pulse transformer drivers and the pulse transformer that connects successively; Also be connected with feedback circuit in this power amplification circuit; This feedback circuit comprises second amplifying circuit and the filter circuit that is connected; Second amplifying circuit is connected with pulse transformer drivers through sampling resistor, and filter circuit is connected with the input of complementary circuit, and first amplifying circuit is connected with amplifier; Said LCDs is connected respectively at control chip with the parameter adjustment button.
Control chip is wherein selected the EP2C8Q208C8 chip of the Cyclone II series of altera company for use; For realizing the technical purpose of this utility model; Adopt the SOPC embedded technology in fpga chip, to embed Nios II soft-core processor, to realize control to system; And revise direct frequency synthesis technique principle, in fpga chip, adopt hardware description language to realize four kinds of impulse waveform generation circuit; Wave filter adopts 7 rank elliptic filters; First amplifying circuit is a single-valve amplification circuit; The relay control chip adopts the ULN2001 chip.
During system works; At first send the pulse signal parameter of output through touch screen and the Nios II soft-core processor of knob in fpga chip; After Nios II soft-core processor receives the pulse parameter instruction; Through Nios II soft-core processor routine processes control instruction is sent to the pulse signal generator in the fpga chip; Pulse signal generator produces the numeric type pulse signal of relevant parameter, converts the numeric type pulse signal into analog pulse signal through D/A converter, this analog pulse signal be system final the basic pulse signal of the pulse signal that will export; Then the basic pulse signal is weeded out HF noise signal through filter circuit, the power amplification circuit through programmable amplifying circuit and back level obtains the pulse voltage signal that finally need export.LCDs shows the parameters of pulse signal simultaneously.
Connection design principle for the programmable amplifying circuit in the device is according to T type weighted resistance network principle in the D/A converter, adopts relay and resistance to realize the regulating circuit of pulse amplitude.Use relay to replace the analog switch in the D/A converter T type weighted resistance network; Eliminated the influence of analog switch parasitic parameter pulse signals waveform; Realize the control to it through the Nios II soft-core processor among the FPGA, the relay model can be the G6S-2-Y of Omron.In conjunction with shown in Figure 3, be example with N level T type weighted resistance network, resistance R A1 one termination first order network input (first order network input is as the programmable amplifying circuit pulse signal input terminal), network input in the second level under another termination; Resistance R B1 one termination first order network input, the public electric shock of another relay termination 1 can constitute first order T type weighted resistance network.Resistance R A2 one termination second level network input (second level network input is the outfan of first order network just), third level network input under another termination; Resistance R B2 one termination second level network input, the public electric shock of another relay termination 2 can constitute second level T type weighted resistance network.According to this annexation backward cascade constitute N level T type weighted resistance network, the network annexation of afterbody is the outfan that resistance R BN and RB (N+1) connect the N-1 network, wherein resistance R BN succeeds the common of electrical equipment N, resistance R B (N+1) ground connection gets final product.The normally opened contact of all relays connects the end of oppisite phase of amplifier in addition, and the normally-closed contact of each relay connects the in-phase end of amplifier, and the outfan of amplifier is the outfan of pulse signal; The positive termination 5V voltage of the line bag of relay, negative terminal is received the outfan of chip ULN2001, and the input of ULN2001 is received fpga chip.Adopt the ULN2001 chip as buffer, prevent the destruction that the back-emf of generation caused the I/O mouth of FPGA when relay switched.Wherein the effect of outfan amplifier is to realize the pulse signal summation operation, and the amplifier model is AD8009.The size of N depends on control accuracy, and minima is 2; RA series resistance and RB series resistance are the 1:2 relation, need N-1 RA series resistance in the network, N+1 RB series resistance.N gets 10 in the present embodiment, promptly needs 9 51 ohm of RA series resistance of 10 relays, 11 100 ohm of RB series resistance.
Power amplification circuit wherein is by single-valve amplification circuit, and pulse transformer drive circuit, back level pulse transformer amplify and the feedback circuit composition.
Single-valve amplification circuit is with the pulse signal process buffering of programmable amplifying circuit output and amplifies, to satisfy the requirement that back grade MOSFET is operated in linear zone.Because of system's output pulse width and interval variation wider range, amplifying circuit must be realized the gain stability of broad frequency band scope, has enough big bandwidth range in order to guarantee circuit.Circuit uses single transistor to realize that circuit amplifies, and selecting the transistor model for use is 2N5551.
The pulse transformer drivers part adopts MOSFET, and in order to improve the linearity scope of drive circuit, the biasing of MOSFET and promotion have adopted the Darlington pair pipe to realize the complementary output circuit.It is IRF740 that MOSFET selects model for use; The Darlington pair pipe selects for use TIP120/125 to pipe.
The effect of feedback circuit is a DC operation state of stablizing MOSFET, makes pulse transformer drivers when static state, be in the lightly conducting state, prevents the operating point drift that variations in temperature causes simultaneously.Principle is to convert the MOSEFT source-drain current to voltage through the sampling resistor that is connected MOSFET drain electrode, and the feedback voltage after amplifying through filtering is applied to the input of MOSFET drive circuit, the purpose when playing the stable DC state.Amplifying circuit and filter circuit are realized that by an integrated transporting discharging amplifier model is LM324.
Pulse transformer boosts to the pulse signal of output, realizes the amplification of pulse amplitude, and the step-up ratio of used pulse transformer is 1:20.
Claims (6)
1. electroporation medicine introducing apparatus; Comprise housing; It is characterized in that, the control chip, D/A converter, wave filter, programmable amplifying circuit and the power amplification circuit that connect successively are installed in the said housing, the front panel of said housing is provided with LCDs and parameter regulation and control button;
Said programmable amplifying circuit comprises relay control chip, amplifier and at least two relays; Said each relay is connected with wave filter through resistance respectively; Each relay all is connected with the relay control chip; Each relay all is connected with amplifier, and said relay control chip is connected with control chip;
Said power amplification circuit comprises first amplifying circuit, complementary circuit, pulse transformer drivers and the pulse transformer that connects successively; Be connected with feedback circuit in the said power amplification circuit; This feedback circuit comprises second amplifying circuit and the filter circuit that is connected; Said second amplifying circuit is connected with pulse transformer drivers through sampling resistor, and said filter circuit is connected with the input of complementary circuit, and said first amplifying circuit is connected with amplifier;
Said LCDs all is connected with control chip with the parameter adjustment button.
2. electroporation medicine introducing apparatus as claimed in claim 1 is characterized in that, said control chip adopts the EP2C8Q208C8 chip.
3. electroporation medicine introducing apparatus as claimed in claim 1 is characterized in that said wave filter adopts 7 rank elliptic filters.
4. electroporation medicine introducing apparatus as claimed in claim 1 is characterized in that described first amplifying circuit is a single-valve amplification circuit.
5. electroporation medicine introducing apparatus as claimed in claim 1 is characterized in that, said relay control chip adopts the ULN2001 chip.
6. electroporation medicine introducing apparatus as claimed in claim 1 is characterized in that, described pulse transformer drivers adopts IRF740 MOSFET.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220200990 CN202605532U (en) | 2012-05-07 | 2012-05-07 | Electroporation medicine importing instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220200990 CN202605532U (en) | 2012-05-07 | 2012-05-07 | Electroporation medicine importing instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202605532U true CN202605532U (en) | 2012-12-19 |
Family
ID=47339268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220200990 Expired - Fee Related CN202605532U (en) | 2012-05-07 | 2012-05-07 | Electroporation medicine importing instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202605532U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106153997A (en) * | 2016-08-29 | 2016-11-23 | 株洲中车时代电气股份有限公司 | A kind of pulse outputting unit for the test of rail vehicle charger |
| CN111237228A (en) * | 2018-11-28 | 2020-06-05 | 明纬(广州)电子有限公司 | Control circuit with speed regulation function |
-
2012
- 2012-05-07 CN CN 201220200990 patent/CN202605532U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106153997A (en) * | 2016-08-29 | 2016-11-23 | 株洲中车时代电气股份有限公司 | A kind of pulse outputting unit for the test of rail vehicle charger |
| CN111237228A (en) * | 2018-11-28 | 2020-06-05 | 明纬(广州)电子有限公司 | Control circuit with speed regulation function |
| CN111237228B (en) * | 2018-11-28 | 2022-06-07 | 明纬(广州)电子有限公司 | Control circuit with speed regulation function |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121219 Termination date: 20170507 |