CN202568214U - Wireless passive type oral electronic capsule adopting quartz tuning fork sensor - Google Patents
Wireless passive type oral electronic capsule adopting quartz tuning fork sensor Download PDFInfo
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- CN202568214U CN202568214U CN 201220206717 CN201220206717U CN202568214U CN 202568214 U CN202568214 U CN 202568214U CN 201220206717 CN201220206717 CN 201220206717 CN 201220206717 U CN201220206717 U CN 201220206717U CN 202568214 U CN202568214 U CN 202568214U
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Abstract
The utility model discloses a wireless passive type oral electronic capsule adopting a quartz tuning fork sensor, belongs to the field of intelligent medical apparatus and instruments, and has the advantages of low cost, and capability of measuring a human body temperature precisely, wirelessly and passively, accurately diagnosing the focus position, staying at the sick part for any set time period, and automatically and continuously spraying while sampling a body fluid. The wireless passive type oral electronic capsule adopts a wireless sensor unit namely a quartz tuning fork sensor which can work in a human body without a power supply, and an inductive coil as core parts, uses a miniature bellows as an actuating controller, adopts a magnet and a signal receiving controller arranged in vitro and required for a power source for power supply as key components, uses ultrasonic wave to transmit sensitive signals in a wireless mode, and adopts electromagnetic waves to supply energy for the quartz tuning fork temperature sensor in vitro in a wireless mode. The capsule is high in body temperature measurement precision, obvious in medical care effect, low in cost and good in reliability, and is a low-cost multifunctional high-tech medical care product.
Description
Technical field
This utility model relates to a kind of medical oral electronic capsule, particularly relates to a kind of oral electronic capsule of wireless and passive type that adopts the quartz tuning-fork pick off.It belongs to intelligent medical technique with the apparatus field.It not only can high-accuracy, wireless, no seedbed, directly measure the temperature of human consumption organ; Critically confirm lesions position (for example: carninomatosis becomes); And can rest on any sufferer district that needs treatment; Spray medicine automatically, directly, continuously, simultaneously can also be to the sampling bodily fluids at this place.In other words; The oral electronic capsule of this wireless and passive type be with need not at inside of human body that power supply can work the wireless senser parts---the temperature sensor of resonance type quartz crystal tuning fork, inductance coil are core; Miniature corrugated tube as the executor; And the one-chip computer that utilize microminiature neodymium iron boron magnetic iron, is positioned at human external is soft, hardware, electric magnet contact etc. is as critical component; Adopt the ultrasonic transmission sensitive signal, utilize electromagnetic wave energy to be provided for the quartz tuning-fork temperature sensor from external with wireless mode.
This medical capsule result of use is remarkable, cost is low, stablize, reliability high, is a kind of low cost, multi-functional high-tech medical device product.
Background technology
Medical oral electronic capsule has become one of heat subject of international medical device research at present.Many knowledges that are total to utilize medical oral capsule dispensing, can be directly to the administrations of sufferer district, and not only medical effect is good, and gets instant result, and side effect is little.In addition, can also add the bodily fluid sampling function, in real time institute's allocation focus carried out optionally bodily fluid sampling, so that accurately carry out online pathological changes check, diagnosis rate is high.
Most of medical capsules require in device, to have the cellular zone and the bodily fluid sampling memory cell areas of deposit medicament.When the patient swallowed and arrive institute's allocation to medical oral capsule, then the medicament in the capsule can automatically discharge to the sufferer district, and automatically to the sampling bodily fluids at this place, took in capsule body fluid cellular zone to sampling body fluid then.In other words, can be to the limit administration of sufferer district, bodily fluid sampling is carried out on the limit.China is existing a lot of about the patent of medical capsule, for example: and Chinese patent 201010581410.1 and 03223480.5 etc., but their technical performance also far can not satisfy present clinical needs.
According to investigations; Urgent clinical needs now a kind of can either wireless, no seedbed measurement inside of human body key parameter (for example: temperature); So that accurately confirm lesions position (for example: carninomatosis becomes); And can rest on this sufferer district, spray medicine automatically, directly, continuously, simultaneously to the device of the sampling bodily fluids at this place.Regrettably the home and abroad does not also have this wireless, passive medical oral electronic capsule at present.
Consult the home and abroad scientific and technical literature recently and show, about parameter capsules such as wireless and passive ground take temperatures, more existing patents, for example: Chinese patent 201010510366.5,201020565302.0 and United States Patent (USP) 5395366,3739279.Chinese patent 201010510366.5 discloses some and has comprised the measuring method and the circuit of the wireless and passive of wireless sourceless sensor part and peripheral control unit part.Wherein the wireless sourceless sensor part is made up of an electric capacity (C) and a coil (L); In electric capacity or the coil one of them as pick off; And need not power supply and get final product work; Have characteristics such as simple, that volume is little, in light weight, but the Q of lc circuit (quality factor) is very low, so the precision of this pick off is not high.Chinese patent 201010183011.X discloses a kind of wireless sensing device and method.This wireless sensing device comprises antenna, voltage controlled oscillator and processing unit.Antenna receives first wireless signal and produces the signal of telecommunication according to this, and wherein first wireless signal is to be reflected second wireless signal and produced by determinand.Voltage controlled oscillator couples antenna, under the interference of the signal of telecommunication, produces oscillator signal, and wherein oscillator signal changes with the change of the signal of telecommunication.Processing unit couples voltage controlled oscillator, assesses the parameter of determinand according to the variation of oscillator signal.
Above-mentioned patent all is to adopt electromagnetic wave that parameters such as human body internal body temperature are detected and use electromagnetic transmission, but the greatest weakness of electromagnetic wave signal is that decay is very big in human body, and quite is subject to disturb.Therefore, this kind wireless sensing device must with the close of pick off, be no more than more than 10 centimetres usually.Compare with resonance type quartz crystal crystal temperature effect pick off, the Q of lc circuit (quality factor) is very low, and also low 2～3 one magnitude of its repeatability, long-time stability.Therefore, the ratio of precision quartz temperature sensor of LC pick off hangs down 2～3 one magnitude, and highest resolution also differs from 3～4 one magnitude.
Though U.S. Pat 4689621 has also been announced a kind of pill that utilizes resonance type quartz crystal temperature sensor monitors human consumption organ temperature with US4844076; But these patent pills all adopt the internal battery power supply, also do not have bodily fluid sampling, medicament in addition and spurt trouble district function automatically.Obviously, they can not list the oral electronic capsule category of wireless and passive type in.The medical oral electronic capsule of wireless and passive type is that a specific character is good, and there are a lot of Radix Clematidis Clarkeanaes in the high-tech medical device product that cost is low, and they are:
1, adopt the electronic capsule of wireless means to have bigger difficulty
Routine techniques is to utilize electromagnetic wave that parameters such as human body internal body temperature are detected and transmit sensitive signal, but regrettably electromagnetic wave decay very big in human body and electromagnetic wave signal quite is subject to interference.Therefore the distance of wireless sensing device and pick off can not surpass 10cm usually.More about this technological patent, for example: Chinese patent 201010510366.5 and 201020565302.0, U.S. Pat 7187960 etc.It may be noted that especially conventional medical oral electronic capsule can not adopt metal shell, otherwise utilize sensitive to electromagnetic waves and transmission signal, difficulty is very big.
2, utilize the electronic capsule of the passive method bottleneck that possesses skills at present
The technological door of the medical oral electronic capsule of wireless and passive type of the no battery of employing is very high.Routine techniques is miniature lithium battery to be installed as power supply in capsule, for example U.S. Pat 8036842, US4689621 and US4844076.Their shortcoming is that not only volume is big, cost is high, and when high temperature, is prone to blast.Therefore, the storage of this medical oral electronic capsule and transportation are all cumbersome.
3, it is many accurately to make a definite diagnosis the lesions position difficult point
Routine techniques is to utilize X ray or CT machine to confirm lesions position, for example U.S. Pat 7187960, US5395366.
Their shortcoming not only cost is high, and accuracy is low, and X ray kills and wounds leukocyte, and is quite harmful to human body.
4, make oral electronic capsule exactly, stably rest on gastral focal zone, its technological door is very high usually, unpowered device in the capsule, and for example U.S. Pat 6582365.Therefore capsule can not move in digestive tract voluntarily, can not drive in the wrong direction or stagnate, and can only move along with the wriggling of intestinal, stomach.Obviously, make medical oral electronic capsule in the time of setting arbitrarily, rest on certain one place, sufferer district exactly, its technical difficulty is very big.
5, require medical oral electronic capsule can realize at low cost automatically, directly, continuously to sufferer district spray medicine, the body fluid to this place carries out in good time sampling simultaneously, needs some technical know-how
Usually, oral electronic capsule receives the restriction of volume and cost, in the capsule executor, power set and microcomputer etc. can not be installed, and for example U.S. Pat 5395366.Therefore requirement can be sprayed medicine automatically, directly, continuously to any sufferer district and carried out body fluid and sample in good time, and its technical difficulty is quite big.
The medical oral electronic capsule of wireless and passive type of the employing quartz tuning-fork pick off of this utility model is just in order to satisfy above-mentioned requirements development.It adopts ultrasound wave to transmit sensitive signal with wireless mode, and utilizes electromagnetic wave energy to be provided for the quartz tuning-fork temperature sensor that is positioned at digestive tract internal electron capsule ball with wireless mode from external.Therefore it be a kind of can either low-cost, wireless, no seedbed, the key parameter of interference-free measurement inside of human body (for example: temperature); So that (for example: cancer), can rest in the time of setting arbitrarily again that medicine is directly sprayed to the sufferer district automatically, continuously in this sufferer district and accurately seek lesions position to the medical oral electronic capsule of wireless and passive of the sampling bodily fluids at this place.
The utility model content
The purpose of this utility model provides a kind of medical oral electronic capsule of wireless and passive type that adopts the temperature sensor of resonance type quartz crystal tuning fork; It not only can low-cost, high-accuracy, wireless, no seedbed, interference-free is measured temperature in the human body body; Accurately make a definite diagnosis lesions position (for example: carninomatosis becomes); And can in the time of setting arbitrarily, rest on this sufferer district and spray medicine automatically, continuously, to the sampling bodily fluids at this place, be stored in the capsule then simultaneously.
The purpose of this utility model is achieved in that shown in Fig. 1 (a) and Fig. 1 (b), and a kind of to adopt the oral electronic capsule of wireless and passive type of quartz tuning-fork pick off be to be made up of oral capsule ball and external reception controller two large divisions.Wherein, the structure of oral capsule ball is as shown in Figure 2, and it comprises following zero, parts:
The outermost layer of oral capsule ball is by stainless iron (1Cr17, the ferritic stainless steel) capsule housing of gel parcel, and its inside is divided into the two large divisions---fore-end and rear end part.Comprise the temperature sensor of resonance type quartz crystal tuning fork, inductance coil, medical pharmacy floss hole, microtubule and microminiature neodymium iron boron magnetic iron at fore-end; Comprise body fluid suction port, medicament deposit unit, medicament exhaust unit, bodily fluid sampling memory element at rear end part, miniature corrugated tube, superabsorbent volumetric expansion polymeric material granule, diaphragm seal (fatty sorrel or gelatin film), the drainage screen made from strike, the medicament that is positioned at medicament deposit unit etc.
But its fore-end is separated into two parts again---upper part and end portion, and upper and lower end part state axisymmetricly, medical pharmacy floss hole and microtubule all place on its axis of symmetry.The temperature sensor of resonance type quartz crystal tuning fork is connected with the miniature inductance coil, constitutes a closed loop oscillation circuit, place the upper part and be close to capsule housing, and microminiature neodymium iron boron magnetic iron places end portion.
One end of capsule ball fore-end is provided with the medical pharmacy floss hole, and its aperture is less, is under the gi system pressure condition, and internal drug can not flow out, and its aperture should be less than 0.01mm usually; And an end of capsule ball rear end part is provided with the body fluid suction port; Its aperture is greater than the medicament floss hole, and under normal gi system pressure condition, body fluid can get into; But for the sufferer district bodily fluid sampling that need are made a definite diagnosis, treated; Outermost layer is equipped with fatty acid diaphragm seal or gelatin-sealed film at body fluid suction port place, prevents the non-body fluid intrusion that needs the treatment organ, causes the unnecessary discharging of medicament.The suit disease patient of large intestine, small intestinal etc. of the former fatty acid diaphragm seal uses, and patients such as the suitable gastric disease of the latter's gelatin-sealed film use.In addition, in the inside of body fluid suction port diaphragm seal drainage screen is installed, after preventing that diaphragm seal from dissolving fully, the volumetric expansion polymeric material granule with superabsorbent spills.
At the internal equipment of oral capsule ball rear end part the miniature corrugated tube made from strike, its opening is connected with the body fluid suction port.In the bodily fluid sampling memory element of this bellows interior, fill some and had the volumetric expansion polymer beads or the dusty material of super absorption characteristic, for example sodium polyacrylate series polymer, starch-acrylate graft copolymer series polymer etc.When body fluid flows into the volumetric expansion polymeric material granule from above-mentioned body fluid suction port, and after being absorbed, then its volume can expand tens of times～hundreds of times.Because miniature corrugated tube is the nickel corrugated tube that utilizes strike to make, thus volume very little (external diameter can be Φ 1mm, and wall thickness can reach 10 μ m) not only, and also the elasticity of corrugated tube is strong, and stable in the displacement of telescopic direction, linear good.Obviously; Violent expansion will take place in bodily fluid sampling memory element volume, and this expansive force will cause inside medicament to be housed (for example after transmitting medicament deposit unit; Cancer agent extremely) the intensive contraction of medicament deposit unit volume, thus make the medicament in the medicament deposit unit almost all emit.
The function of neodymium iron boron magnetic iron is following: can with cooperatings such as soft, the hardware of one-chip computer in the electric magnet contact of outside, the signal processing controller unit; Make the oral capsule ball stably rest on the inner any focal zone of digestive tract, and automatically, directly, draw body fluid and spray medicine continuously.
The external reception controller of this electronic capsule is shown in Fig. 1 (b), and it comprises: voltage controlled oscillator, character display, ultrasound wave receiving transducer, one-chip computer, derailing switch, miniature antenna, power supply and electric magnet contact etc.Its ultrasound wave receiving transducer and one-chip computer link, and a line conductor of one-chip computer and derailing switch connect, and derailing switch is connecting the electric magnet contact.Power supply links with one-chip computer, voltage controlled oscillator respectively, and voltage controlled oscillator and miniature antenna link.
As shown in Figure 3, the quartz tuning-fork temperature sensor comprises: metal pipe cap, temperature-sensitive quartz tuning-fork, metal base, kovar alloy pin, glass insulator and the excellent helium of thermal conduction characteristic.The body of quartz tuning-fork temperature sensor is very little, and its overall dimensions is merely Φ 2 * 6mm.Usually its mode of operation is twisting vibration pattern or beam mode.Therefore, its response speed is fast, and resolution is good, can reach 0.001～0.0001 ℃, and accuracy is high, can reach 0.1～0.02 ℃.In brief, the technical essential of this wireless and passive type electronic capsule is: 1, need not at inside of human body that power supply can work wireless sensor unit---the temperature sensor of resonance type quartz crystal tuning fork, inductance coil are as core component; 2, utilize with the miniature corrugated tube of strike making and cooperatively interacting of superabsorbent volumetric expansion polymeric material, constitute the executor who does not need the additionaling power control device; 3, the signal that utilizes small neodymium iron boron magnetic iron in the capsule ball and be positioned at the need power supply power supply of human external receives cooperatively interacting of controller and outside electric magnet contact, as the capsule ball at the inner any focal zone location of digestive tract and the critical component of random time stop; 4, the conduct of employing ultrasound wave with the means of wireless mode transmission sensitive signal, utilizes electromagnetic wave as the method that energy is provided from external quartz tuning-fork temperature sensor to the capsule ball in digestive tract inside with wireless mode between the device of inner capsule ball of digestive tract and human external.
The working mechanism of the electronic capsule of this utility model is following:
Shown in Fig. 1 (a), its suitable gi system uses, for example: diseases such as stomach, large intestine, small intestinal.The film of the capsule ball of suitable treatment intestinal diseases is to be made up of fatty sorrel etc., and the film of the capsule ball of suitable treatment gastric disease is to be made up of gelatin film etc.
After the patient had swallowed the capsule ball of treatment intestinal diseases, because the material of this capsule ball diaphragm seal is a fatty acid, so the fatty acid diaphragm seal all can not dissolve in the esophagus stomach function regulating, promptly the body fluid of above-mentioned zone can not flow in the capsule ball., this moment, temp measuring system but can normally be worked:
Shown in Fig. 1 (b); Because the quartz tuning-fork pick off is connected with the miniature inductance coil; Constitute a closed loop, voltage controlled oscillator and miniature antenna have also constituted a closed loop, so can utilize the electromagnetic coupled in these two loops; Utilize electromagnetic wave to pass to quartz tuning-fork temperature sensor (referring to Fig. 3) to energy from human external, thereby produce vibration by the closed loop that tuning fork pick off and miniature inductance coil constitute with wireless mode.When the natural frequency of the closed loop that constitutes when electromagnetic frequency and quartz tuning-fork temperature sensor and miniature inductance coil equated, resonance then took place.Its resonant frequency is strictly corresponding one by one with this place's temperature, and linear with dut temperature.Obviously, if can measure its resonant frequency, just known the temperature value at this place.At this moment, the vibration of quartz tuning-fork temperature sensor itself is a kind of mechanical vibration during resonance, or is called supersonic vibration.Utilize the ultrasound wave receiving transducer can be at the external quartz tuning-fork temperature sensor ultrasonic waves transmitted vibration signal that receives.Then, utilize soft, the hardware technology of one-chip computer again, can on character display, demonstrate swallowing the time etc. of dut temperature value, resonant frequency, capsule ball; Cooperate voltage controlled oscillator can adjust the frequency of the closed loop that constitutes by voltage controlled oscillator and miniature antenna, also can control starting or stoping of quartz tuning-fork temperature sensor; In addition, cooperate microminiature neodymium iron boron magnetic iron in electric magnet contact and the capsule ball can also control the capsule ball in any one time of staying etc. of digestive tract.
When the capsule ball arrived small intestinal, because the effect of intestinal juice, the diaphragm seal that fatty acid etc. constitute can dissolved and digestion.At this moment, the intestinal juice as body fluid gets into the inner miniature corrugated tube of electronic capsule through drainage screen, body fluid suction port.Therefore the graininess or the pulverous superabsorbent volumetric expansion polymeric material granule that are filled in the bodily fluid sampling memory element of corrugated tube will constantly absorb intestinal juice, and produce volumetric expansion rapidly.Obviously, the volume of volumetric expansion polymeric material expands rapidly, and the medicament that causes being positioned at medicament deposit unit receives the extruding of corrugated tube, thereby emits from the medical pharmacy floss hole.
The beneficial effect of this utility model is following:
The oral electronic capsule of wireless and passive type of the employing quartz tuning-fork pick off of this utility model comprises the two large divisions---oral capsule ball and external reception controller.The oral electronic capsule of this utility model utilizes accurate digital sensor---and the temperature sensor of resonance type quartz crystal tuning fork is as core; Cooperate inductance coil to become again and need not the wireless sensor unit that power supply gets final product work at inside of human body; Not only can be low-cost, high-accuracy, wireless and passive ground measures temperature in the human body body, accurately seeks lesions position.Particularly the temperature of cancerous cell is higher about 0.1 ℃ than the temperature of healthy cell, and the resolution of resonance type quartz crystal tuning fork temperature sensor can reach 0.001～0.0001 ℃, therefore cooperates the CT image, can make a definite diagnosis the carninomatosis district fully.The oral electronic capsule of this utility model utilizes small neodymium iron boron magnetic iron in the oral capsule ball with outside electric magnet contact and be positioned at the human external signal and receive cooperatively interacting of controller; Can make the capsule ball stop random time at the inner any focal zone of digestive tract; Therefore the capsule ball can utilize limited resources well, exactly to the administration of sufferer district, not only good effect; And side effect is little, holds steel and is used on the blade.The oral electronic capsule of this utility model utilizes cooperatively interacting of extraordinary miniature corrugated tube and superabsorbent volumetric expansion polymeric material dexterously, constitutes the executor who does not need the additionaling power control device, thereby realizes automatic chemical feeding.The oral electronic capsule of this utility model utilizes ultrasound wave and electromagnetic wave loop neatly, has solved the difficult problem that the metal shell electronic capsule is difficult to carry out simultaneously inside and outside sensitive signal transmission of body and feed.
In brief; This utility model utilizes quartz tuning-fork pick off, permanent magnetism iron, electric magnet contact, extraordinary miniature corrugated tube, superabsorbent volumetric expansion polymeric material, one-chip computer, ultrasound wave and electromagnetic wave loop; Having solved some difficult problems of the oral electronic capsule of present wireless and passive type---low cost, high accuracy, wireless, no seedbed, interference-free are measured temperature in the human body body; Make a definite diagnosis lesions position (for example: carninomatosis becomes); And can rest on this sufferer district in the time of setting arbitrarily and spray medicine automatically, continuously, can also add the bodily fluid sampling function simultaneously, in real time institute's allocation focus carried out optionally bodily fluid sampling.
Description of drawings
The sketch map of the oral electronic capsule structure of wireless and passive type of the employing quartz tuning-fork pick off that Fig. 1 (a) is made up of oral capsule ball and external reception controller two large divisions.
Fig. 1 (b) adopts the operation principle block chart of the oral electronic capsule of wireless and passive type of quartz tuning-fork pick off.
Fig. 2 adopts the oral capsule ball structural representation of the oral electronic capsule of wireless and passive type of quartz tuning-fork pick off.
The structural representation of the quartz tuning-fork temperature sensor that Fig. 3 this utility model uses.
The specific embodiment
Below in conjunction with accompanying drawing 1 (a), Fig. 1 (b), accompanying drawing 2 and accompanying drawing 3 and embodiment this utility model is done and to be further described; Present embodiment is being that prerequisite is implemented with this utility model technical scheme, though provided detailed embodiment, the protection domain of this utility model is not limited to following embodiment.
Shown in Fig. 1 (a) and Fig. 1 (b), a kind of oral electronic capsule of wireless and passive type that adopts the quartz tuning-fork pick off is to be made up of with external reception controller 102 two large divisions oral capsule ball 101.Usually, oral capsule ball 101 is swallowed works in the digestive tract 104 of human body 103, and it comprises following zero, parts:
By stainless iron (1Cr17, the ferritic stainless steel) capsule housing 10 of gel parcel, resonance type quartz crystal tuning fork temperature sensor 205, inductance coil 208, medical pharmacy floss hole 2, medicament deposit unit 18, medicament exhaust unit 16, microtubule 11, bodily fluid sampling memory element 17, body fluid suction port 3, miniature corrugated tube 4, superabsorbent volumetric expansion polymeric material granule 6, diaphragm seal (fatty sorrel or gelatin film) 14, drainage screen 9, the medicament 5 that is positioned at medicament deposit unit and microminiature neodymium iron boron magnetic iron 12 etc. with the strike making.
The outermost layer of oral capsule ball 101 is by stainless iron (1Cr17, the ferritic stainless steel) capsule housing 10 of gel parcel, and its inside is divided into the two large divisions---fore-end 7 and rear end part 8.Comprise resonance type quartz crystal tuning fork temperature sensor 205, miniature inductance coil 208, microtubule 11, medical pharmacy floss hole 2 and microminiature neodymium iron boron magnetic iron 12 at fore-end 7; Comprise body fluid suction port 3, medicament deposit unit 18, medicament exhaust unit 16, bodily fluid sampling memory element 17 at rear end part 8, miniature corrugated tube 4, superabsorbent volumetric expansion polymeric material granule 6, diaphragm seal (fatty sorrel or gelatin film) 14, the drainage screen made from strike 9, the medicament 5 that is positioned at medicament deposit unit etc.
Fore-end 7 is divided into two parts again---and upper part 13 and end portion 15, and upper part 13, end portion 15 state axisymmetricly, medical pharmacy floss hole 2, microtubule 11 place on the line of symmetry.Quartz tuning-fork temperature sensor 205 and connect with miniature inductance coil 208 constitutes a closed loop oscillation circuit, places upper part 13 and is close to capsule housing 10; Microminiature neodymium iron boron magnetic iron 12 places end portion 15.
As shown in Figure 2; An end of end parts 7 is provided with medical pharmacy floss hole 2 before the oral capsule ball 101 of the oral electronic capsule of wireless and passive type that adopts quartz tuning-fork pick off 205; Its aperture is under the gi system pressure condition less than 0.01mm, and internal drug can not flow out; And an end of capsule ball rear end part is provided with body fluid suction port 3; Its aperture is greater than the medicament floss hole; Be under the gi system pressure condition, body fluid can flow into, but at body fluid suction port 3 place's outermost layers fatty acid diaphragm seal or gelatin-sealed film 14 is installed; Prevent that the non-body fluid of treatment organ that needs from invading miniature corrugated tube 4, cause the unnecessary discharging of medicament 5.The former---the suit disease of large intestine, small intestinal of fatty acid diaphragm seal is used uses such as the suitable gastric disease of the latter---gelatin-sealed film.In addition, near the inside of the diaphragm seal 14 body fluid suction port 3 places is equipped with drainage screen 9, spills to prevent the volumetric expansion polymeric material granule 6 that has superabsorbent after diaphragm seal 14 dissolves fully.
At the internal equipment of the rear end part 8 of oral capsule ball 101 the miniature corrugated tube made from strike 4, its opening is connected with body fluid suction port 3.The inside of this corrugated tube 4 has been filled some and has been had the volumetric expansion polymer beads material 6 of super absorption characteristic in bodily fluid sampling memory element 17, for example, and sodium polyacrylate series polymer, starch one acrylic acid graft copolymer series polymer etc.When body fluid flows into the volumetric expansion polymeric material granules 6 from above-mentioned body fluid suction port 3, and after being absorbed, then its volume can expand tens of times～hundreds of times.Because miniature corrugated tube 4 is the nickel corrugated tubes that utilize strike to make, thus volume very little (external diameter can be Φ 1mm, and wall thickness can reach 10 μ m) not only, and also the elasticity of corrugated tube is strong, and stable in the displacement of telescopic direction, linear good.Obviously; The volumetric expansion of bodily fluid sampling memory element 17 will produce huge expansive force; This expansive force passes to medicament deposit unit 16; To cause inside that the violent contraction of medicament deposit unit 16 volumes of medicament 5 (for example, killing the cancer agent) is housed, thereby make the medicament 5 in the medicament deposit unit 16 almost all emit.
The function of neodymium iron boron magnetic iron 12 is following: can with cooperatings such as soft, the hardware of one-chip computer 204 in the electric magnet contact 211 of outside, the signal processing controller unit; Make capsule ball 101 stably rest on the inner any focal zone of digestive tract, and automatically, directly, draw body fluid and spray medicine continuously.
Shown in Fig. 1 (b); Shown in, the external reception controller 102 of this electronic capsule comprises: voltage controlled oscillator 201, character display 202, ultrasound wave receiving transducer 203, one-chip computer 204, derailing switch 212, miniature antenna 209, power supply 210 and electric magnet contact 211 etc.Its ultrasound wave receiving transducer 203 and one-chip computer 204 link, and a line conductor of one-chip computer 204 and derailing switch 212 connect, and derailing switch 212 is connecting electric magnet contact 211.Power supply 210 links with one-chip computer 204, voltage controlled oscillator 201 respectively, and voltage controlled oscillator 201 links with miniature antenna 209.
As shown in Figure 3, quartz tuning-fork temperature sensor 205 comprises: metal pipe cap 301, temperature-sensitive quartz tuning-fork 302, glass insulator 304, metal base 305, excellent helium 306, the kovar alloy pin 307 of thermal conduction characteristic.The volume of resonance type quartz crystal tuning fork temperature sensor 205 is very little, and its overall dimensions is merely Φ 2 * 6mm.Usually, its vibration mode of operation is twisting vibration or beam mode.Therefore, its response speed is fast, and resolution is good, accuracy is high, can reach 0.1～0.02 ℃.
In brief, the technical essential of this wireless and passive type electronic capsule is: 1), need not at inside of human body that power supply can work wireless sensor unit---the temperature sensor of resonance type quartz crystal tuning fork, inductance coil are as core component; 2), the miniature corrugated tube made from strike as the executor who does not need the additionaling power control device; 3), the signal that utilizes small neodymium iron boron magnetic iron in the capsule and be positioned at the need power supply power supply of human external receives cooperatively interacting of controller and outside electric magnet contact electric magnet, as wireless and passive type oral capsule ball at the inner any focal zone location of digestive tract and the critical component of random time stop; 4), adopt ultrasound wave as between the device of the inner capsule ball of digestive tract and human external with the means of wireless mode transmission sensitive signal, utilize electromagnetic wave as with wireless mode from external method of energy being provided for quartz tuning-fork temperature sensor the capsule ball of digestive tract inside.
The working mechanism of the electronic capsule of this utility model is following:
Shown in Fig. 1 (a), its suitable gi system uses, for example: diseases such as stomach, large intestine, small intestinal.The film 14 of the oral capsule ball 101 of suitable treatment intestinal diseases is to be made up of fatty sorrel etc., and the film 14 of the electronic capsule 101 of suitable treatment gastric disease is to be made up of gelatin film etc.
After the patient had swallowed the oral capsule ball 101 of treatment gastric disease, because this capsule diaphragm seal 14 is gelatin films, so have only under one's belt, gelatin-sealed film 14 could dissolve.So the body fluid of above-mentioned zone flows in the oral capsule ball 101 under one's belt.In contrast, temp measuring system just can normally be worked from swallowable capsule ball 101 backs:
Shown in Fig. 1 (b); Because quartz tuning-fork pick off 205 is connected with miniature inductance coil 208; Constitute a closed loop, voltage controlled oscillator 201 has also constituted a closed loop with miniature antenna 209, so can utilize the electromagnetic coupled in these two loops; Pass to quartz tuning-fork temperature sensor 205 (referring to Fig. 3) to energy from human external through electromagnetic wave 206 with wireless mode, thereby the closed loop that causes being made up of tuning fork pick off 205 and miniature inductance coil 208 produces vibration.When the frequency of electromagnetic wave 206 equated with the natural frequency of the closed loop that is made up of quartz tuning-fork temperature sensor 205 and miniature inductance coil 208, resonance then took place.Its resonant frequency is strictly corresponding one by one with this place's temperature value, and linear with the dut temperature value.Obviously, if can measure its resonant frequency, just can know the temperature value at this place.During resonance, the vibration that quartz tuning-fork temperature sensor 205 produces is a kind of mechanical vibration, or is called supersonic vibration.Utilize the ultrasound wave receiving transducer 203 can be at the external quartz tuning-fork temperature sensor 205 ultrasonic waves transmitted vibration signals 207 that receive.Then, utilize soft, the hardware technology of one-chip computer 204 again, can on character display 202, demonstrate the time of its resonant frequency, dut temperature value, swallowable capsule ball 101 etc.; Cooperate voltage controlled oscillator 201 can adjust the frequency of the closed loop that constitutes by voltage controlled oscillator 201 and miniature antenna 209, also can control starting or stoping of quartz tuning-fork temperature sensor 205; In addition, utilize cooperating of microminiature neodymium iron boron magnetic iron 12 in electric magnet contact 211 and the capsule ball 101, can also control capsule ball 101 in any one time of staying etc. of digestive tract.
Because the effect of gastric juice, gelatin film 14 can dissolved and digestion.At this moment, the gastric juice as body fluid can pass through drainage screen 9, the miniature corrugated tube 4 of entering electronic capsule 101 inside.At this moment, because as the inflow of the gastric juice of body fluid, the granular superabsorbent volumetric expansion polymeric material 6 that therefore is filled in bodily fluid sampling memory element 17 will constantly absorb gastric juice, and produce volumetric expansion rapidly.At this moment, get into the miniature corrugated tube 4 of oral capsule ball 101 inside through drainage screen 9, body fluid suction port 3 as the gastric juice of body fluid.Therefore the granular superabsorbent volumetric expansion polymeric material 6 that is filled in the bodily fluid sampling memory element of corrugated tube will constantly absorb intestinal juice, and produce volumetric expansion rapidly.Obviously, the volume of volumetric expansion polymeric material granule 6 expands rapidly, and the medicament 5 that causes being positioned at medicament deposit unit 18 receives the extruding of corrugated tube, thereby emits from medical pharmacy floss hole 2.
Claims (7)
1. adopting the oral electronic capsule of wireless and passive type of quartz tuning-fork pick off is to be made up of oral capsule ball and external reception controller two large divisions; It is characterized in that: the outermost layer of its oral capsule ball is by the ferritic stainless steel capsule housing of gel parcel, and there are the temperature sensor of resonance type quartz crystal tuning fork, inductance coil, microtubule and microminiature neodymium iron boron magnetic iron, medical pharmacy floss hole, body fluid suction port, medicament deposit unit, medicament exhaust unit, microtubule, bodily fluid sampling memory element in its inside, miniature corrugated tube, superabsorbent volumetric expansion polymeric material granule, diaphragm seal, the drainage screen made from strike, the medicated powder that is positioned at medicament deposit unit.
2. the oral electronic capsule of wireless and passive type of employing quartz tuning-fork pick off according to claim 1; In its ferritic stainless steel capsule housing that is wrapped up by gel, have fore-end and rear end part; It is characterized in that: at fore-end the temperature sensor of resonance type quartz crystal tuning fork, inductance coil, microtubule, medical pharmacy floss hole and microminiature neodymium iron boron magnetic iron are installed, and at rear end part body fluid suction port, medicament deposit unit, medicament exhaust unit, bodily fluid sampling memory element are installed, miniature corrugated tube, superabsorbent volumetric expansion polymeric material granule, diaphragm seal, the drainage screen made from strike, the medicament that is positioned at medicament deposit unit.
3. according to the oral electronic capsule of wireless and passive type of claim 1 or the described employing quartz tuning-fork of claim 2 pick off; It is characterized in that: its fore-end is to be made up of upper part and end portion; And upper part and end portion be form axisymmetricly; Medical pharmacy floss hole and microtubule all place on its axis of symmetry; Temperature sensor of resonance type quartz crystal tuning fork and miniature inductance coil are connected into a loop, and end parts placed on it also is close to capsule housing, and microminiature neodymium iron boron magnetic iron places its end portion.
4. according to the oral electronic capsule of wireless and passive type of claim 1 or the described employing quartz tuning-fork of claim 2 pick off; It is characterized in that: the end at capsule ball fore-end is provided with the medical pharmacy floss hole; Its aperture is less than 0.01mm, and is provided with the body fluid suction port at an end of capsule ball rear end part, and its aperture is greater than the medicament floss hole; And the outermost layer in the body fluid suction port is equipped with diaphragm seal, in the set inside of sealing film drainage screen.
5. according to the oral electronic capsule of wireless and passive type of claim 1 or the described employing quartz tuning-fork of claim 2 pick off; It is characterized in that: at the internal equipment of the rear end part of oral capsule ball the miniature corrugated tube made from strike; Its opening is connected with the body fluid suction port, and has filled the volumetric expansion polymeric material granule with super absorption characteristic in the inside of corrugated tube.
6. the oral electronic capsule of wireless and passive type of employing quartz tuning-fork pick off according to claim 1 is characterized in that: the external reception controller of the oral electronic capsule of this wireless and passive type is to be made up of voltage controlled oscillator, character display, ultrasound wave receiving transducer, one-chip computer, derailing switch, miniature antenna, power supply and electric magnet contact.
7. according to the oral electronic capsule of wireless and passive type of claim 1 or the described employing quartz tuning-fork of claim 6 pick off; It is characterized in that: its ultrasound wave receiving transducer and one-chip computer link; One line conductor of one-chip computer and derailing switch connect; And derailing switch is connecting the electric magnet contact, and its power supply links with one-chip computer, voltage controlled oscillator respectively, and voltage controlled oscillator and miniature antenna link.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220206717 CN202568214U (en) | 2012-05-10 | 2012-05-10 | Wireless passive type oral electronic capsule adopting quartz tuning fork sensor |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220206717 CN202568214U (en) | 2012-05-10 | 2012-05-10 | Wireless passive type oral electronic capsule adopting quartz tuning fork sensor |
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| Publication Number | Publication Date |
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| CN202568214U true CN202568214U (en) | 2012-12-05 |
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| CN 201220206717 Expired - Fee Related CN202568214U (en) | 2012-05-10 | 2012-05-10 | Wireless passive type oral electronic capsule adopting quartz tuning fork sensor |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104688277A (en) * | 2013-12-10 | 2015-06-10 | 郑兆珉 | Clinical specimen sampling instrument and method thereof |
| CN105362055A (en) * | 2015-12-15 | 2016-03-02 | 上海交通大学 | Vibration capsule system based on wireless energy supplying |
| CN109222874A (en) * | 2018-11-09 | 2019-01-18 | 安翰光电技术（武汉）有限公司 | Alimentary canal sampling capsule |
| CN109330627A (en) * | 2018-10-09 | 2019-02-15 | 安翰光电技术（武汉）有限公司 | The capsule system for sampling and releasing the drug can either synchronously or asynchronously be completed |
| CN109497917A (en) * | 2019-01-11 | 2019-03-22 | 安翰科技(武汉)股份有限公司 | Alimentary canal sampling capsule |
| CN110974311A (en) * | 2019-12-24 | 2020-04-10 | 华中科技大学鄂州工业技术研究院 | Intestinal microorganism collection capsule |
| CN111544051A (en) * | 2020-05-21 | 2020-08-18 | 温州芳植生物科技有限公司 | Self-sampling device and method utilizing intestinal tract driving force |
| CN114052798A (en) * | 2021-11-11 | 2022-02-18 | 安翰科技(武汉)股份有限公司 | Sampling capsule |
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- 2012-05-10 CN CN 201220206717 patent/CN202568214U/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104688277A (en) * | 2013-12-10 | 2015-06-10 | 郑兆珉 | Clinical specimen sampling instrument and method thereof |
| CN105362055A (en) * | 2015-12-15 | 2016-03-02 | 上海交通大学 | Vibration capsule system based on wireless energy supplying |
| CN105362055B (en) * | 2015-12-15 | 2017-10-03 | 上海交通大学 | Vibration capsule system based on wireless energy supply |
| JP7153633B2 (en) | 2016-08-18 | 2022-10-14 | ビオラ・セラピューティクス・インコーポレイテッド | Sampling system and related materials and methods |
| CN109330627A (en) * | 2018-10-09 | 2019-02-15 | 安翰光电技术（武汉）有限公司 | The capsule system for sampling and releasing the drug can either synchronously or asynchronously be completed |
| CN109330627B (en) * | 2018-10-09 | 2021-02-09 | 安翰科技(武汉)股份有限公司 | Capsule system capable of synchronously or asynchronously completing sampling and medicine release |
| CN109222874A (en) * | 2018-11-09 | 2019-01-18 | 安翰光电技术（武汉）有限公司 | Alimentary canal sampling capsule |
| CN109222874B (en) * | 2018-11-09 | 2024-04-09 | 安翰科技(武汉)股份有限公司 | Digestive tract sampling capsule |
| CN109497917A (en) * | 2019-01-11 | 2019-03-22 | 安翰科技(武汉)股份有限公司 | Alimentary canal sampling capsule |
| CN110974311A (en) * | 2019-12-24 | 2020-04-10 | 华中科技大学鄂州工业技术研究院 | Intestinal microorganism collection capsule |
| CN110974311B (en) * | 2019-12-24 | 2022-08-30 | 华中科技大学鄂州工业技术研究院 | Intestinal microorganism collection capsule |
| CN111544051A (en) * | 2020-05-21 | 2020-08-18 | 温州芳植生物科技有限公司 | Self-sampling device and method utilizing intestinal tract driving force |
| CN114052798A (en) * | 2021-11-11 | 2022-02-18 | 安翰科技(武汉)股份有限公司 | Sampling capsule |
| CN114052798B (en) * | 2021-11-11 | 2024-02-13 | 安翰科技(武汉)股份有限公司 | sampling capsule |
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