CN202562776U - Cell collecting and transferring device - Google Patents
Cell collecting and transferring device Download PDFInfo
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- CN202562776U CN202562776U CN2012201677877U CN201220167787U CN202562776U CN 202562776 U CN202562776 U CN 202562776U CN 2012201677877 U CN2012201677877 U CN 2012201677877U CN 201220167787 U CN201220167787 U CN 201220167787U CN 202562776 U CN202562776 U CN 202562776U
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- film tube
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- cell collection
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Abstract
The utility model belongs to the technical field of medical pathology examination, in particular to a cell collecting and transferring device comprising a rack, wherein a collecting mechanism and a containing mechanism are arranged on the rack, and the containing mechanism is disposed under the collecting mechanism which is connected with a lifting mechanism and a vertical rotating mechanism. The containing mechanism is provided with at least two cup bodies, and the rack is further provided with a horizontal displacement mechanism which enables the cup bodies to move relative to the collecting mechanism. The cell collecting and transferring device enables target cells in sampling cups to be collected selectively from impurities and to be transferred to a transferring cup. Operation is convenient and can be automatic. Cell smears made from the sampling cells after being processed through natural sinking method or centrifugation slide-making are constant in cell number, even in distribution, extrusion-free, overlap-free, and suitable for clinically improving detectable rates of pathological diagnoses.
Description
Technical field
The utility model belongs to medical pathological examination technical field, particularly a kind of cell collection and transfer device.
Background technology
Clinically; The human body cast-off cells are carried out pathological examinations such as morphology the diagnosis of diseases such as human body cancer is had irreplaceable effect; Morphological examination as women's cervical exfoliated cell is learned can be used for cervical cancer screening; In addition, to taking off cytological inspection and also help linked groups whether the diagnosis of canceration or other pathological changes takes place in phlegm, the ascites pleural fluid equal samples, wherein use the widest with the inspection of cervical exfoliated cell.Cervical carcinoma is modal gynecologic malignant tumor, the palace fall the inspection of exfoliative cytology painless, do not have wound, reliable results, be the first-selection of cervical disease examination.Cervical exfoliated cell is present in the cervical secretions, and in the cervical secretions except that cast-off cells, still contain impurity such as a large amount of mucus, red blood cell, leucocyte, the non-viable non-apoptotic cell that comes off.
The general Pap smear method that adopts of tradition cervical exfoliated cell inspection, this method elder generation at the cervix collect specimen, directly smears dyed again microscopy with cotton pole or Uterine neck bush etc. then on slide.The Pap smear technology makes the M & M of cervical carcinoma in the period of 50, reduce by 70%.But the lot of documents investigation shows; There is surprising failing to pinpoint a disease in diagnosis and misdiagnosis rate in the Pap smear method; Its reason is smear cell overlap, the extruding that Pap smear is made; There are impurity such as a large amount of red blood cells, leucocyte, mucus and the non-viable non-apoptotic cell that comes off in background, and makes the epithelial cell of diagnostic significance smudgy, thereby has a large amount of failing to pinpoint a disease in diagnosis or mistaken diagnosis.
Based on this, released many cell film-making new technologies both at home and abroad, mainly remove non-diagnosis impurity through technical finesse; Process thin-layer cell sheet clearly; Make the person that reads the sheet more be prone to observe, improve from face and detect positive rate, wherein representational technology has technology such as TCT and LCT.
Problems such as company of U.S. CCID (CYTIC) adopts ThinPrep cytolohgy test (being called for short TCT) thin layer tabletting technology, and the TCT technology has overcome that the material that traditional tabletting technology exists is too thick, cell overlap, blurred background and dyeing are not good.But the TCT technology has high technological requirement to the film and the slide contact process of film tube; Phenomenons such as this process contacts not exclusively as if existence or is subjected to displacement in the contact process all can have a strong impact on slice-making quality; The extruding of film-making process in addition, is prone to cause cellular morphology and changes.
U.S. Tripath Imaging Inc. (Tripath Imaging Inc) adopts Liquid – based Cytologic Tese (being called for short LCT) technology to carry out film-making.LCT film-making cell distribution is even, has a small amount of overlappingly but do not have the tractive distortion, and cell does not have degradation degeneration, and Color is good.But its operating process is more loaded down with trivial details, needs a large amount of manual operationss, and can not remove impurity fully in its gradient centrifugation process.
Italy Hospitex company adopts CytoFast (match is coated with) liquid based thin-layer cell moviemaking system, is made up of concussion appearance, cell density appearance, centrifugal pelleter, and its core technology is: quantitative criterion cell collection technology and the centrifugal tabletting technology of proportion.Measure the cell density in every increment basis through the cell density appearance, by built-in microcomputer control, adjust sampling amount automatically according to cell density, automatic application of sample is carried out in computer control, guarantees that the cell concentration of every smear is constant, can guarantee the homogeneity of film-making cell.But its manually-operated is more, but is difficult to realize robotization.
Summary of the invention
The purpose of the utility model be to provide to the deficiency of prior art a kind of can be from impure sample the device of quantitative collection and the cell that diverts the aim, help to improve the recall rate of clinical pathology diagnosis, simple to operate, help realizing robotization.
The utility model is realized through following technical scheme:
A kind of cell collection and transfer device are provided; Comprise frame; Frame is provided with collecting mechanism and splendid attire mechanism, and splendid attire mechanism is positioned at the below of collecting mechanism, and said collecting mechanism is connected with elevating mechanism and vertical rotating mechanism; Said splendid attire mechanism includes at least two cups, and said frame is also put and is provided with the horizontal shift mechanism that cup and collecting mechanism are relatively moved.
Wherein, said horizontal shift mechanism is connected with said collecting mechanism.
Wherein, said horizontal shift mechanism is connected with said splendid attire mechanism.
Wherein, Said collecting mechanism comprises film tube, film jacket casing, the gentle press mechanism of film tube stent; The bottom of said film tube is provided with the cell filter membrane; The openend of said film tube and said detachable connection of film jacket casing, the pipeline of said air pressure mechanism is communicated with said film tube through said film jacket casing, and said film tube is connected with said frame through said film tube stent.
Wherein, the pipeline of said air pressure mechanism is connected with pressure transducer.
Wherein, said splendid attire mechanism also comprises base, and said at least two cups are arranged at said base through one glass of support respectively.
Wherein, each said cup support is connected with a cup rotation motor.
Wherein, said film tube is connected with horizontal rotary mechanism, and horizontal rotary mechanism is connected with said film tube frame.
Wherein, said base is provided with two cups, and two cups are symmetrical set.
Wherein, Said vertical rotating mechanism comprises the vertical rotation motor of clamping part and the vertical rotation of control clamping part; Said elevating mechanism comprises the lift motor that screw mandrel and control screw mandrel rotatablely move, and said screw mandrel is connected with panel, and said vertical rotating mechanism is arranged at said panel.
Wherein, said frame also is provided with control device, and said elevating mechanism, said vertical rotating mechanism, said horizontal shift mechanism and said air pressure mechanism are electrically connected with said control device respectively.
The beneficial effect of the utility model is: a kind of cell collection and transfer device; Comprise frame; Frame is provided with collecting mechanism and splendid attire mechanism, and splendid attire mechanism is positioned at the below of collecting mechanism, and collecting mechanism is connected with elevating mechanism and vertical rotating mechanism; Splendid attire mechanism includes at least two cups, and frame is also put and is provided with the horizontal shift mechanism that cup and collecting mechanism are relatively moved; The utility model can make the target cell in the sample from impurity, optionally gather and be transferred in the transfer cup of splendid attire mechanism; Cell after the processing is through natural sedimentation or centrifuge method film-making; In the cell smear of processing cell quantity constant, be evenly distributed, do not have extruding, zero lap, help the recall rate of clinical raising pathological diagnosis; Simple to operate, help realizing robotization.
Description of drawings
Fig. 1 is the Facad structure synoptic diagram of the utility model.
Fig. 2 is the side structure synoptic diagram of the utility model.
Fig. 3 is the perspective view of the utility model.
Fig. 4 is the collecting mechanism of the utility model and the structural representation of splendid attire mechanism.
In Fig. 1 to Fig. 4, include:
1---frame 2---collecting mechanism 21---film tube
22---film tube stent 23---air pressure mechanism 24---cell filter membranes
25---film jacket casing 26---pipeline 27---pressure transducers
3---splendid attire mechanism 31---sample cup 32---transfer cups
33---base 34---cup support 35---cup rotation motors
4---elevating mechanism 41---screw mandrel 42---lift motors
5---vertical rotating mechanism 51---vertical rotation motor 52---clamping parts
6---control device.
Embodiment
embodiment one.
To shown in Figure 4, a kind of cell collection and transfer device comprise frame 1 like Fig. 1; Frame 1 is provided with collecting mechanism 2 and splendid attire mechanism 3; Splendid attire mechanism 3 is positioned at the below of collecting mechanism 2, and collecting mechanism 2 is connected with elevating mechanism 4 and vertical rotating mechanism 5, and splendid attire mechanism 3 includes at least two cups; Frame 1 is also put and is provided with the horizontal shift mechanism that cup and collecting mechanism are relatively moved, and horizontal shift mechanism is connected with said splendid attire mechanism 3.
The collecting mechanism 2 of present embodiment comprises film tube 21, film jacket casing 25, film tube stent 22 gentle press mechanisms 23; The bottom of said film tube 21 is provided with cell filter membrane 24; The openend of said film tube 21 and said 25 detachable connections of film jacket casing; The pipeline 26 of said air pressure mechanism 23 is communicated with said film tube 21 through said film jacket casing 25, and said film tube 21 is connected with said frame 1 through said film tube stent 22.
Said film tube 21 is the cylindrical shell that an end opening other end covers cell filter membrane 24; The openend of film tube 21 is connected with film jacket casing 25 removable seals through rubber ring; Said film jacket casing 25 is the cylindrical shell of both ends open; One of which end and film tube 21 detachable being tightly connected, the other end closely is connected with pipeline 26.One end of said pipeline 26 closely links to each other with film jacket casing 25, and the other end of pipeline 26 closely links to each other with air pressure mechanism 23.Said film tube 21, film jacket casing 25, pipeline 26 fuses and link to each other with film tube stent 22, and said film tube stent 22 is connected with frame 1, and film tube stent 22 can drive film tube 21, film jacket casing 25 vertically rotatablely moves.
Particularly, the membrane aperture of cell filter membrane 24 is less than the diameter of the target cell of required collection; Said air pressure mechanism 23 is forcing pump or vacuum pump, and said pipeline 26 is a flexible pipe.
The splendid attire mechanism 3 of present embodiment also comprises base 33, and said at least two cups are arranged at said base 33 through one glass of support 34 respectively, and each said cup support 34 is connected with a cup rotation motor 35.
Preferred embodiment base 33 is provided with two cups as one, and two cups are symmetrical set.Two cups are respectively sample cup 31 and shift cup 32, and sample cup 31 is used for the splendid attire cell-preservation liquid, shifts cup 32 and is used for splendid attire cell treating fluid; Cup support 34 is used for fixing sample cup 31 and shifts cup 32; Base 33 is used for carrying a cup support 34, uses sample cup 31 and shift cup 32 through circumference or back and forth movement to place in turn under the film tube 21.
During use, prepackage has cell-preservation liquid and cell treating fluid respectively in sample cup 31 and transfer cup 32, is eluted in the sample cup 31 with manual work earlier after the sample collection.Before carrying out cell collection and jump operation, sample cup 31 and transfer cup 32 are gone to cover and be stuck in glass support 34, film tube 21 is pushed in the film jacket casing 25.Concrete operation steps is:
is under the drive of elevating mechanism 4; Film tube stent 22 carries out top-down motion; Film tube 21 is inserted in the cell-preservation liquid of sample cup 31; Drive 34 rotations of cup support through rotation motor 35, with the cell sample mixing in the sample cup 31; Air pressure mechanism that
pipeline 26 other ends are connect 23 extracts negative pressure and the cavity through pipeline 26, film jacket casing 25, film tube 21 is delivered to negative pressure on cell filter membrane 24 surfaces of immersing in the cell-preservation liquid; Under suction function; Cell-preservation liquid is mobile in film tube 21 with target cell wherein; Diameter is hindered in cell filter membrane 24 outsides greater than the target cell of the membrane aperture of cell filter membrane 24; Diameter then enters in the film tube 21 less than the impurity and the cell-preservation liquid of the membrane aperture of cell filter membrane 24; Along with increasing gradually of cell gone up on cell filter membrane 24 surfaces; Negative pressure in the film tube 21 increase gradually, and during to certain threshold value, air pressure mechanism 23 stops to extract negative pressure;
is under the drive of elevating mechanism 4; The motion that film tube stent 22 carries out from bottom to top is being with film tube 21 to leave sample cup 31;
is under the effect of vertical rotating mechanism 5; Film tube 21 on the film tube stent 22 is done 180 ° of rotations; Liquid in the film tube 21 and impurity are discharged along pipeline 26, still drive 21 repositions of film tube by vertical rotating mechanism 5 at last;
horizontal shift mechanism drives base 33 Rotate 180s ° or move left and right; Make transfer cup 32 place the film tube 21 times through relative displacement; Film tube stent 22 carries out top-down motion under the drive of elevating mechanism 4; Film tube 21 is inserted in the cell treating fluid that shifts cup 32, and the relative motion (cup support 34 is rotated motion or film tube 21 is rotated motion) through cup support 34 and film tube 21 will be adsorbed in target cell on the film tube 21 and be eluted to and shift in glasss 32; The motion that
film tube stent 22 carries out from bottom to top; Be with film tube 21 to leave sample cup 31, thereby realizing target cell collection and transfer.
The utility model can make the target cell in the sample cup 31 from impurity, optionally gather and be transferred to and shift in the cup 32, and whole process operation is simple, can realize robotization.Cell after the processing is through natural sedimentation or centrifuge method film-making, in the cell smear of processing cell quantity constant, be evenly distributed, do not have extruding, zero lap, help the recall rate of clinical raising pathological diagnosis.
The pipeline 26 of the air pressure mechanism 23 of present embodiment is connected with pressure transducer 27, helps detecting in real time the atmospheric pressure value of the inner chamber of film tube 21, and convenient control is simple to operate.
The vertical rotating mechanism 5 of present embodiment comprises the vertical rotation motor 51 of clamping part 52 and the 52 vertical rotations of control clamping part; Elevating mechanism 4 comprises the lift motor 42 that screw mandrel 41 and control screw mandrel 41 rotatablely move; Said screw mandrel is connected with panel, and said vertical rotating mechanism is arranged at said panel.
Start vertical rotation motor 51, clamping part 52 clamps film tubes 21 and with film tube 21 and film jacket casing 25 vertical Rotate 180s °, discharges smoothly thereby help that the liquid in the sample cup 31 and impurity are passed through pipeline 26, and is simple to operate; Start lift motor 42, screw mandrel 41 can rotate up and down under the drive of motor, and elevating mechanism 4 drives vertical rotating mechanism 5 through panel and moves up and down, and guarantees that collecting mechanism 2 can realize moving up and down and vertical rotation, and is simple in structure, easy to use.
The frame 1 of present embodiment also is provided with control device 6; Said elevating mechanism 4, said vertical rotating mechanism 5, said horizontal shift mechanism and said air pressure mechanism 23 are electrically connected with said control device 6 respectively; The base 33 of the oscilaltion operation of collecting mechanism 2, the vertical rotation of film tube 21, splendid attire mechanism 3 horizontally rotate and the adjusting of air pressure size all through a control device 6 centralized control; Operation is convenient, and is easy to use.
embodiment two.
The difference of present embodiment and embodiment one is; The horizontal shift mechanism of present embodiment is connected with said collecting mechanism 2, starts horizontal shift mechanism, makes film tube stent 22 be with film tube 21 to place and shifts on the cup 32; Need not move the sample cup 31 and transfer cup 32 of splendid attire mechanism 3 like this; Also can realize the transfer of target cell, simple in structure, practical.
The splendid attire mechanism 3 of present embodiment also comprises base 33, and said at least two cups are arranged at said base 33 through one glass of support 34 respectively, and said film tube is connected with horizontal rotary mechanism, and horizontal rotary mechanism is connected with said film tube stent 22.
Under the drive of elevating mechanism 4, film tube stent 22 carries out top-down motion, and film tube 21 is inserted in the cell-preservation liquid of sample cup 31, drives film tube 21 rotation or move left and right through horizontal rotary mechanism, and is convenient with the cell sample mixing in the sample cup 31.
The frame 1 of present embodiment also is provided with control device 6; Said elevating mechanism 4, said vertical rotating mechanism 5, said horizontal shift mechanism and said air pressure mechanism 23 are electrically connected with said control device 6 respectively; The film tube stent 22 of the oscilaltion operation of collecting mechanism 2, the vertical rotation of film tube 21, collecting mechanism 2 horizontally rotate and the adjusting of air pressure size all through a control device 6 centralized control; Operation is convenient, and is easy to use.
All the other contents of present embodiment are identical with embodiment one, repeat no more here.
Should be noted that at last; Above true example is only in order to explain the technical scheme of the utility model; But not to the restriction of this practicality protection domain, although with reference to preferred embodiment the utility model has been done detailed explanation, those of ordinary skill in the art is to be understood that; Can make amendment or be equal to replacement the technical scheme of the utility model, and not break away from the essence and the scope of the utility model technical scheme.
Claims (10)
1. cell collection and transfer device; Comprise frame; It is characterized in that: frame is provided with collecting mechanism and splendid attire mechanism, and splendid attire mechanism is positioned at the below of collecting mechanism, and said collecting mechanism is connected with elevating mechanism and vertical rotating mechanism; Said splendid attire mechanism includes at least two cups, and said frame is also put and is provided with the horizontal shift mechanism that cup and collecting mechanism are relatively moved.
2. a kind of cell collection according to claim 1 and transfer device is characterized in that: said horizontal shift mechanism is connected with said collecting mechanism.
3. a kind of cell collection according to claim 1 and transfer device is characterized in that: said horizontal shift mechanism is connected with said splendid attire mechanism.
4. according to claim 2 or 3 described a kind of cell collection and transfer devices; It is characterized in that: said collecting mechanism comprises film tube, film jacket casing, the gentle press mechanism of film tube stent; The bottom of said film tube is provided with the cell filter membrane; The openend of said film tube and said detachable connection of film jacket casing, the pipeline of said air pressure mechanism is communicated with said film tube through said film jacket casing, and said film tube is connected with said frame through said film tube stent.
5. a kind of cell collection according to claim 4 and transfer device is characterized in that: the pipeline of said air pressure mechanism is connected with pressure transducer.
6. according to claim 2 or 3 described a kind of cell collection and transfer devices, it is characterized in that: said splendid attire mechanism also comprises base, and said at least two cups are arranged at said base through one glass of support respectively.
7. a kind of cell collection according to claim 6 and transfer device is characterized in that: each said cup support is connected with a cup rotation motor.
8. a kind of cell collection according to claim 6 and transfer device is characterized in that: said film tube is connected with horizontal rotary mechanism, and horizontal rotary mechanism is connected with said film tube frame.
9. a kind of cell collection according to claim 4 and transfer device; It is characterized in that: said vertical rotating mechanism comprises the vertical rotation motor of clamping part and the vertical rotation of control clamping part; Said elevating mechanism comprises the lift motor that screw mandrel and control screw mandrel rotatablely move; Said screw mandrel is connected with panel, and said vertical rotating mechanism is arranged at said panel.
10. a kind of cell collection according to claim 4 and transfer device; It is characterized in that: said frame also is provided with control device, and said elevating mechanism, said vertical rotating mechanism, said horizontal shift mechanism and said air pressure mechanism are electrically connected with said control device respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012201677877U CN202562776U (en) | 2012-04-19 | 2012-04-19 | Cell collecting and transferring device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012201677877U CN202562776U (en) | 2012-04-19 | 2012-04-19 | Cell collecting and transferring device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202562776U true CN202562776U (en) | 2012-11-28 |
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ID=47212421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012201677877U Expired - Fee Related CN202562776U (en) | 2012-04-19 | 2012-04-19 | Cell collecting and transferring device |
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| Country | Link |
|---|---|
| CN (1) | CN202562776U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107290544A (en) * | 2017-05-22 | 2017-10-24 | 中山大学 | Nanometer needle device of albumen and preparation method thereof can be extracted from individual cells minimally-invasive |
-
2012
- 2012-04-19 CN CN2012201677877U patent/CN202562776U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107290544A (en) * | 2017-05-22 | 2017-10-24 | 中山大学 | Nanometer needle device of albumen and preparation method thereof can be extracted from individual cells minimally-invasive |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121128 Termination date: 20180419 |