CN202522547U - Liquid chromatography preparation system - Google Patents
Liquid chromatography preparation system Download PDFInfo
- Publication number
- CN202522547U CN202522547U CN2012201226514U CN201220122651U CN202522547U CN 202522547 U CN202522547 U CN 202522547U CN 2012201226514 U CN2012201226514 U CN 2012201226514U CN 201220122651 U CN201220122651 U CN 201220122651U CN 202522547 U CN202522547 U CN 202522547U
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- high pressure
- pressure pump
- detector
- liquid chromatography
- preparation system
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Abstract
The utility model discloses a liquid chromatography preparation system, which comprises a high-pressure infusion pump, a uv detector, an admission valve, a preparation chromatographic column and a man-machine operation interface accommodating chromatographic working software, the high-pressure infusion pump and the uv detector are stacked in a building block manner; the high-pressure infusion pump is controlled by adopting a 32 bit RISC central compressor and a 32 bit DSP stepper drive processor; and an RS232 interface in communication connection with a chromatography working station is arranged on the uv detector. The liquid chromatography preparation system has the advantages of small size, beautiful appearance, high sensitivity of detector, wide linear range and high cost performance.
Description
Technical field
The utility model relates to the chromatographic resolution Instrument technology field, relates in particular to a kind of preparation system of liquid chromatography.
Background technology
Preparative liquid chromatography (HPLC:High Performance Liquid Chromatography) is one of effective ways of present widely used separation, analysis, purified organic compound (comprising the inorganics that can change organic compound through chemical reaction into).In known organic compound, have 80% can separate, analyze approximately, and, therefore be particularly suitable for the organic compound and the living matter of higher boiling, difficult gasification volatilization, poor heat stability because the method mild condition can not destroyed sample with preparative liquid chromatography.The HPLC system generally by high pressure pump, UV-detector, hand sampling valve, chromatographic column, and these several parts of chromatogram working software form.Wherein high pressure pump, UV-detector, and the preparative chromatography post be three the most key positions.The HPLC system that has also has gradient elution device, online degasser, automatic sampler, lives with post or protection, column temperature controller etc., and more existing HPLC appearance also have Control System of Microcomputer, can carry out self-reacting device control and data processing.
At present common liquid chromatography preparation system manufacturer be mostly external as: this Waters company of U.S.'s water, U.S. Agilent Agilent company, day island proper Tianjin SHIMADZU company, German Nore etc.; Domestic have Shanghai Wufeng Science Instrument Co. Ltd.; Shanghai standing grain industry science Instr Ltd., Dalian is according to Lyntech Corporation (US) 10177 South 77th East Avenue Tulsa, Oklahoma 74133 U.S. etc.Yet there are drawbacks such as bulky, that profile is attractive in appearance inadequately and cost an arm and a leg mostly in the liquid chromatography preparation system that these manufacturer production are produced.In addition, existing liquid chromatography preparation system detector sensitivity is not enough, and its range of linearity is narrower, and noise is bigger, also may damage sample after the detection.
The utility model content
The purpose of the utility model is, a kind of liquid chromatography preparation system is provided, its advantages of small volume, good looking appearance, and detector sensitivity is higher, range of linearity broad, cost performance are higher.
For realizing above-mentioned purpose; The utility model provides a kind of liquid chromatography preparation system; Comprise: high pressure pump, UV-detector, sampling valve, preparative chromatography post, and in be provided with the man machine operation interface of chromatogram working software; Adopt the overlapping setting of brick pattern between said high pressure pump and the UV-detector; This high pressure pump adopts the RISC central processing unit of 32 bit arithmetics and 32 bit DSP stepper drive processors to control, and this UV-detector is provided with the RS232 interface that is connected with the chromatographic work station communication.
In the utility model, high pressure pump comprises first high pressure pump, and second high pressure pump, UV-detector, first high pressure pump, and second high pressure pump adopt the overlapping successively setting of brick pattern.
Wherein, said UV-detector, first high pressure pump, and second high pressure pump on be equipped with several functions control buttons.
Concrete, said first high pressure pump, and second high pressure pump all adopt double plunger independently to control, this first high pressure pump, reach second high pressure pump and also be respectively equipped with replaceable pump head.
Said replaceable pump head can adopt the pump head of 250mL-5L.
In addition, said first high pressure pump, and second high pressure pump on also be equipped with RS232, RS482, and Ethernet interface.
The liquid chromatography preparation system of the utility model, it adopts brick pattern leading in the world to establish mode, good looking appearance, advantages of small volume; It adopts up-to-date 32 superelevation computing RISC central processing unit+32 bit DSP stepper drive processors control; Detector sensitivity is higher, and range of linearity broad and noise are lower, and it adopts digital output; Can not destroy sample after the detection; Moreover it carries out the control of a whole set of instrument through the RS232 interface by chromatographic data work of treatment station, can satisfy the needs that the user produces and studies simultaneously.
Description of drawings
Fig. 1 is the structural representation of a kind of specific embodiment of the utility model liquid chromatography preparation system.
Embodiment
As shown in Figure 1; The utility model provides a kind of liquid chromatography preparation system; It comprises: high pressure pump, UV-detector 10, sampling valve 20, preparative chromatography post 30, and in be provided with the man machine operation interface 40 of chromatogram working software; Adopt the overlapping setting of brick pattern between said high pressure pump and the UV-detector 10; This high pressure pump adopts Reduced Instruction Set Computer (the RISC:reduced instruction set computer) central processing unit of 32 bit arithmetics and 32-bit number signal Processing (DSP:Digital Signal Processing) stepper drive processor to control, and this UV-detector 10 is provided with the RS232 interface (not shown) that is connected with the chromatographic work station communication.
In the utility model; High pressure pump comprises first high pressure pump 52, and second high pressure pump 52; UV-detector 10, first high pressure pump 52, and second high pressure pump 54 adopt the overlapping successively setting of brick patterns; Because it adopts leading in the world at present brick pattern design, make it have profile comparatively attractive in appearance, and volume is comparatively small and exquisite.As a kind of specific embodiment of the utility model, said first high pressure pump 52, and second high pressure pump 54 all adopt double plunger independently to control.In addition; This first high pressure pump 52, and second high pressure pump 54 also be respectively equipped with replaceable pump head (not shown); This replaceable pump head can be according to user's needs, and as being equipped with the pump head of 250ml to 5L, its pump head can be configured to the pattern of equal altitudes, linear gradient.A kind of preferred embodiment as the utility model; Said first high pressure pump 52, and second high pressure pump 54 on also be equipped with RS232, RS482, and Ethernet interface (not shown); The setting of this multiple communication mode; Host computer can be controlled the high pressure pump of many same model simultaneously, and can verify gradient curve gradient mode through the monitoring of host computer, so that high pressure pump is controlled.
In the utility model, said UV-detector 10, first high pressure pump 52, and second high pressure pump 54 on be equipped with several functions control buttons 12, all functions all can be carried out through these several functions control buttons 12.UV-detector 10 in the utility model is in order to measuring the variation of separated sample component specific character, and is responsive to certain physics or the chemical property of component in the sample, and that this character is moving phase is not available, or under operating conditions, do not show at least.This UV-detector 10 adopts digital output design, and signal is accomplished number conversion and zeroing processing by single-chip microcomputer behind 24 A/D, handles the back result to the RS232 interface; Sensitivity is higher, the range of linearity is wide, noise is low; Be applicable to gradient elution, can reach 1ng, do not destroy sample after the detection strong absorbing material detectability; Can be used for preparation and the use of connecting with any detecting device.
Include LCD 42 in the man-machine interface 40 of the utility model, in the utility model specific embodiment, this LCD 42 can adopt the LCD of 192x64mm, makes user written program more directly perceived, and is more convenient.
When the liquid chromatography preparation system of the utility model was worked, the moving phase in the reservoir was squeezed into this system by high pressure pump, and sample solution gets into moving phases through sampling valve 20; Be written in the look preparation spectrum post (stationary phase) 30 by moving phase, because each component in the sample solution has different partition factors two in mutually, when two do relative motion in mutually; The assigning process of the absorption-desorb of process repeated multiple times; Each component produces bigger difference on translational speed, be separated into single component and in post, flow out successively, during through UV-detector 10; Sample concentration is converted into electric signal and is sent to registering instrument, and data print with the collection of illustrative plates form.Under suitable condition; Different component in the separable solution of preparative liquid chromatography, sample feed liquor phase chromatogram preparation system, through anti-phase 18 after liquid chromatography separates; Retention time with chromatographic peak is qualitative, utilizes chromatographic peak area to carry out quantitatively with concentration is linear within the specific limits.
In sum, the liquid chromatography preparation system of the utility model, it adopts brick pattern leading in the world to establish mode; Good looking appearance, advantages of small volume, it adopts up-to-date 32 superelevation computing RISC central processing unit+32 bit DSP stepper drive processors control, and detector sensitivity is higher; Range of linearity broad and noise are lower; And it adopts digital output, can not destroy sample after the detection, moreover; It carries out the control of a whole set of instrument through the RS232 interface by chromatographic data work of treatment station, can satisfy the needs that the user produces and studies simultaneously.
The above; For the person of ordinary skill of the art; Can make other various corresponding changes and distortion according to the technical scheme and the technical conceive of the utility model, and all these changes and distortion all should belong to the protection domain of the utility model accompanying Claim.
Claims (6)
1. liquid chromatography preparation system; Comprise high pressure pump, UV-detector, sampling valve, preparative chromatography post, and in be provided with the man machine operation interface of chromatogram working software; It is characterized in that; Adopt the overlapping setting of brick pattern between said high pressure pump and the UV-detector, this high pressure pump adopts the RISC central processing unit of 32 bit arithmetics and 32 bit DSP stepper drive processors to control, and this UV-detector is provided with the RS232 interface that is connected with the chromatographic work station communication.
2. liquid chromatography preparation system as claimed in claim 1; It is characterized in that; Said high pressure pump comprises first high pressure pump, and second high pressure pump, UV-detector, first high pressure pump, and second high pressure pump adopt the overlapping successively setting of brick pattern.
3. liquid chromatography preparation system as claimed in claim 2 is characterized in that, said UV-detector, first high pressure pump, and second high pressure pump on be equipped with several functions control buttons.
4. liquid chromatography preparation system as claimed in claim 2; It is characterized in that; Said first high pressure pump, and second high pressure pump all adopt double plunger independently to control, this first high pressure pump, reach second high pressure pump and also be respectively equipped with replaceable pump head.
5. liquid chromatography preparation system as claimed in claim 4 is characterized in that, said replaceable pump head adopts the pump head of 250mL-5L.
6. liquid chromatography preparation system as claimed in claim 4 is characterized in that, said first high pressure pump, and second high pressure pump on be equipped with RS232, RS482, and Ethernet interface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012201226514U CN202522547U (en) | 2012-03-28 | 2012-03-28 | Liquid chromatography preparation system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012201226514U CN202522547U (en) | 2012-03-28 | 2012-03-28 | Liquid chromatography preparation system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202522547U true CN202522547U (en) | 2012-11-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012201226514U Expired - Lifetime CN202522547U (en) | 2012-03-28 | 2012-03-28 | Liquid chromatography preparation system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202522547U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106662556A (en) * | 2014-08-08 | 2017-05-10 | 株式会社岛津制作所 | Preparative liquid chromatograph and separation condition searching method |
-
2012
- 2012-03-28 CN CN2012201226514U patent/CN202522547U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106662556A (en) * | 2014-08-08 | 2017-05-10 | 株式会社岛津制作所 | Preparative liquid chromatograph and separation condition searching method |
| CN106662556B (en) * | 2014-08-08 | 2018-06-19 | 株式会社岛津制作所 | Preparative liquid chromatography device and preparation condition heuristic approach |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20121107 |