CN202401065U - Alternating stress generating device - Google Patents
Alternating stress generating device Download PDFInfo
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- CN202401065U CN202401065U CN201220009881XU CN201220009881U CN202401065U CN 202401065 U CN202401065 U CN 202401065U CN 201220009881X U CN201220009881X U CN 201220009881XU CN 201220009881 U CN201220009881 U CN 201220009881U CN 202401065 U CN202401065 U CN 202401065U
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- heart pump
- solenoid operated
- flow
- operated directional
- thermostat
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Abstract
The utility model relates to an alternating stress generating device. According to the utility model, the impulse flowing out of a heart pump is divided into two flows after the blood pressure amplitude is adjusted by a compliance part: a branch 1 sequentially passes through a test module and a first peripheral resistance part, so that the power of human body blood flow can be realized; and a branch 2 passes through a second peripheral resistance part for exerting flow division effect, two culture solutions return to a liquid storing tank and a thermostat and then reflow to the heart pump through the liquid storing tank and the thermostat, so that one circulation is completed; a data acquiring module acquires the pressure of the resistance parts and the flow of the heart pump and transmits to a control module, and the control module outputs the pressure of the resistance parts and the flow of the heart pump to the test module, the liquid storing groove and the thermostat. According to the device, an alternating flowing blood flow dynamic experiment platform is built, so that not only can the requirement for creating a blood flow dynamic experiment environment which is approximate to the human body physiological condition be met, but also the multi-parameter and controllable experiment condition can be provided, thus, the more ideal experiment environment and means can be provided for deeply exploring the damage mechanism of the endangium.
Description
Technical field
The utility model relates to a kind of experiment porch device, particularly a kind of repeated stress generation device.
Background technology
The pathology mechanism of pulse atherosclerosis is complicated, but atherosclerosis demonstrates the focus selectivity of height, and promptly it always occurs in bending, bifurcated and the narrow positions of artery.The blood flow at these positions usually is accompanied by complex flow phenomenons such as mobile separation, backflow.Atherosclerotic height focus selectivity and regional flow's kinetic factor are closely related.Atherosclerosis mostly occurs in mobile low regime, the recirculating zone of vessel inner blood.The Hemodynamic characteristics that these zones are total is exactly the shearing stress (0-4dyne/cm2) or the low shearing stress of alternation of lower level.The high correlation of atherosclerosis and haemodynamics wall shear stress has caused the big rule of " wall shear stress influences endotheliocyte " has been touched research.Generally believe that at present the shearing stress of lower level is only the most dangerous haemodynamics factor of artery disease with long particle (like the blood fat matter) residence time.The shearing stress that atherosclerosis and blood flow produce is closely related.Shearing stress influences tunica intima from many aspects; Be to endothelial cell morphology and cytoskeleton effect on structure on the one hand; The size and Orientation that is shearing stress on the other hand changes in time, and promptly low shearing stress oscillatory flow also has bigger influence to the structure function of endotheliocyte.
The haemodynamics factor has dual mode to the research of endotheliocyte influence: a kind of is in the body experiment, and advantage is that the growing environment of endotheliocyte is real, and shortcoming is to be difficult to flow condition is done strict control; Another kind is that the endotheliocyte with isolated culture makes an experiment, and advantage is that flow condition can strict control, and shortcoming is an endothelial cell growth environment and at body situation incomplete similarity.
Research blood flow shearing stress is comparatively complicated to the influence of inner skin cell function in the body; Therefore experiment in vitro places flat board or other flow-through appts with cultured vascular endothelial usually, waits through control fluidic speed, viscosity and types of flow and studies the influence to vascular endothelial cell form, function and genetic expression of under different situations shearing stress, normal stress.
Summary of the invention
The utility model is the problem to the difficulty that now the blood flow stress studies is run into; A kind of repeated stress generation device has been proposed; This device is the haemodynamics experiment porch; Both satisfy to have created one more near the haemodynamics environment requirement of Human Physiology condition, multiparameter, controllable experiment condition can be provided, again for further investigation tunica intima micromechanism of damage provides better experimental situation and means.
The technical scheme of the utility model is: a kind of repeated stress generation device; Comprise heart pump, compliance members, the first Peripheral resistance parts, the second Peripheral resistance parts, reservoir and thermostat, tentative module, data acquisition module, control module; The effusive pulsating flow of heart pump divides two-way to flow after compliance members blood pressure regulation amplitude: branch 1 passes through the tentative module and the first Peripheral resistance parts successively, realizes the power of human bloodstream; Shunting action plays through the second Peripheral resistance parts in branch 2; The two-way nutrient solution is all got back to container for storing liquid and thermostat; Be back to heart pump by container for storing liquid and thermostat again; Accomplish a circulation, the flow of data collecting module collected resistance parts pressure and heart pump send control module, and control module outputs to tentative module and reservoir and thermostat.
Said tentative module comprises magnetic flow meter, first solenoid operated directional valve, cell culture chamber, second solenoid operated directional valve; First and second solenoid operated directional valves are the two-position three way solenoid operated directional valve; The magnetic flowmeter of the effusive pulsating flow of heart pump elder generation's process tentative module after compliance members; Magnetic flowmeter output gets into a passage of first solenoid operated directional valve; First solenoid operated directional valve in addition two passages connects two passages of second solenoid operated directional valve respectively, and cell culture chamber is connected in parallel on these two passages, and the 3rd passage output of second solenoid operated directional valve connects the first Peripheral resistance parts.
The beneficial effect of the utility model is: the utility model repeated stress generation device; Made up a novel haemodynamics experiment porch; Both satisfy to have created one more near the haemodynamics environment requirement of Human Physiology condition; Multiparameter, controllable experiment condition can be provided, for further investigation tunica intima micromechanism of damage provides better experimental situation and means again.
Description of drawings
Fig. 1 is the utility model alternation shearing stress generation device structured flowchart;
Fig. 2 is the utility model alternation shearing stress generation device alternation shearing stress recurrent state one figure;
Fig. 3 is the utility model alternation shearing stress generation device alternation shearing stress recurrent state two figure.
Embodiment
The utility model alternation shearing stress generation device simulated blood vessel inner blood makes cell be in the hematodinamics environment growth down of alternation shearing stress in the characteristic of low regime, recirculating zone that flows.
Alternation shearing stress generation device structural frames as shown in Figure 1, device is made up of heart pump I, compliance members II, the first Peripheral resistance parts IV, the second Peripheral resistance parts V, reservoir and thermostat VI, tentative module III, data acquisition module VII, control module VIII.After compliance members II blood pressure regulation amplitude, divide two-way to flow by the effusive pulsating flow of heart pump I: branch 1 passes through the tentative module III and the first Peripheral resistance parts IV successively, realizes the influence research of the kinetic parameter (pressure, flow, shearing stress) of human bloodstream to tunica intima; Shunting action plays through the second Peripheral resistance parts V in branch 2, and purpose is to regulate flow, pressure through branch 1 through regulating the Peripheral resistance size.Nutrient solution is got back to container for storing liquid and thermostat VI by two-way branch, is back to heart pump I by container for storing liquid and thermostat VI again, accomplishes a circulation.
Like Fig. 2, the shearing stress of alternation shown in 3 cycle diagram; The tentative module III comprises magnetic flow meter III-1, the first two-position three way solenoid operated directional valve III-2, cell culture chamber III-3, the second two-position three way solenoid operated directional valve III-4, often occurs in bending, bifurcated and the narrow positions of artery to atherosclerosis.And the common Hemodynamic characteristics in these zones is exactly the low shearing stress (0-4dyne/cm2) of alternation of lower level.
At t constantly, alternation shearing stress recurrent state one figure as shown in Figure 2 is from one tunnel shunting after the compliance members II is regulated pulse pressure difference of the effusive nutritive medium of heart pump I; Another road is earlier through magnetic flow meter III-1, and the interface through the first two-position three way solenoid operated directional valve III-2 3,4 links to each other with pipeline again, and interface 3 leads to; Interface 4 closes; Nutritive medium gets into pipeline by interface 3, and the interface 5 of the second two-position three way solenoid operated directional valve III-4 is closed, and interface 6 is logical; 3 are communicated with 6 mouthfuls, and cell culture chamber III-3 flow field direction is for just; T1 constantly, alternation shearing stress recurrent state two figure as shown in Figure 3, the reversing valve transposition, interface 1,8 closes, interface 2,7 is opened, 2 are communicated with 7 mouthfuls, accomplishing flows commutates.Produce the low shearing stress of alternation through switching-over, with mobile low regime, the recirculating zone of simulation in bending, bifurcated and the narrow positions generation of artery.
Data acquisition module is made up of pressure transmitter, differential pressure pickup, flow sensor, data acquisition board and computer.Can gather, show, preserve the experimental data such as pressure, pressure reduction, flow of test section in real time.The control module VIII is used to control the commutating frequency of jerk pump ripple frequency, solenoid operated directional valve, the temperature of thermostat.
Claims (2)
1. repeated stress generation device; It is characterized in that; Comprise heart pump, compliance members, the first Peripheral resistance parts, the second Peripheral resistance parts, reservoir and thermostat, tentative module, data acquisition module, control module; The effusive pulsating flow of heart pump divides two-way to flow after compliance members blood pressure regulation amplitude: branch 1 passes through the tentative module and the first Peripheral resistance parts successively, realizes the power of human bloodstream; Shunting action plays through the second Peripheral resistance parts in branch 2; The two-way nutrient solution is all got back to container for storing liquid and thermostat; Be back to heart pump by container for storing liquid and thermostat again; Accomplish a circulation, the flow of data collecting module collected resistance parts pressure and heart pump send control module, and control module outputs to tentative module and reservoir and thermostat.
2. according to the said repeated stress generation device of claim 1; It is characterized in that; Said tentative module comprises magnetic flow meter, first solenoid operated directional valve, cell culture chamber, second solenoid operated directional valve, and first and second solenoid operated directional valves are the two-position three way solenoid operated directional valve, the magnetic flowmeter of the effusive pulsating flow of heart pump elder generation's process tentative module after compliance members; Magnetic flowmeter output gets into a passage of first solenoid operated directional valve; First solenoid operated directional valve in addition two passages connects two passages of second solenoid operated directional valve respectively, and cell culture chamber is connected in parallel on these two passages, and the 3rd passage output of second solenoid operated directional valve connects the first Peripheral resistance parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220009881XU CN202401065U (en) | 2012-01-11 | 2012-01-11 | Alternating stress generating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220009881XU CN202401065U (en) | 2012-01-11 | 2012-01-11 | Alternating stress generating device |
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| Publication Number | Publication Date |
|---|---|
| CN202401065U true CN202401065U (en) | 2012-08-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201220009881XU Expired - Fee Related CN202401065U (en) | 2012-01-11 | 2012-01-11 | Alternating stress generating device |
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| Country | Link |
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| CN (1) | CN202401065U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103160436A (en) * | 2013-04-15 | 2013-06-19 | 上海理工大学 | Vascular endothelial cell elastic substrate culture device |
-
2012
- 2012-01-11 CN CN201220009881XU patent/CN202401065U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103160436A (en) * | 2013-04-15 | 2013-06-19 | 上海理工大学 | Vascular endothelial cell elastic substrate culture device |
| CN103160436B (en) * | 2013-04-15 | 2014-07-23 | 上海理工大学 | Vascular endothelial cell elastic substrate culture device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120829 Termination date: 20130111 |