CN202330356U - In-vitro analog device on human body lesion under magnetic field action - Google Patents
In-vitro analog device on human body lesion under magnetic field action Download PDFInfo
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- CN202330356U CN202330356U CN2011204579392U CN201120457939U CN202330356U CN 202330356 U CN202330356 U CN 202330356U CN 2011204579392 U CN2011204579392 U CN 2011204579392U CN 201120457939 U CN201120457939 U CN 201120457939U CN 202330356 U CN202330356 U CN 202330356U
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Abstract
The utility model discloses an in-vitro analog device on a human body lesion under the magnetic field action. The left side of the base is provided with a direct-current regulated power supply; the right side of the base is provided with a minitype pump; a magnetic field coil and a bracket are arranged between the direct-current regulated power supply and the minitype pump on the base; the magnetic field coil is connected with the direct-current regulated power supply by a lead; the liquid outlet of the minitype pump is provided with a liquid feeding hose of which the end part is arranged in a solution bottle; the liquid inlet is provided with a liquid outlet hose of which the end part is arranged in the solution bottle; the liquid feeding hose is fixed on the bracket to extend into the magnetic field coil; the solution bottle is filled with solution; the liquid feeding hose is provided with a medicine injection valve; and a liquid discharging hose is provided with a sampling valve. According to the in-vitro analog device on a human body lesion under the magnetic field action, the in-vivo blood circulation can be simulated, the medicine is kept at the tumor of a tumor patient to implement a treatment purpose under the action of the magnetic field, human body medicine feeding and extraction can be simulated, and the action effect of the magnetic field is analyzed by the extracted sample.
Description
Technical field
The utility model belongs to electromagnetic measurement instrument and meter technical field, is specifically related to the in-vitro simulated device of magnetic field to medicine circulation guide effect in the human body.
Background technology
Magnetic liposome is a kind of new targeting preparation of studying energetically both at home and abroad in recent years, and this preparation makes medicine have biological function, magnetic target function and treatment function simultaneously.The magnetic target delivery system is that medicine and magnetic material and auxiliary material is formulated, in enough external magnetic field guiding down, moves with blood flow, optionally arrives and be positioned the tumour target area.Medicine discharges from carrier with controlled way, on the cell of tumor tissues or subcellsular level, brings into play drug action then.After it gets in body, utilize the effect of external magnetic field can guide drugs directed in vivo move with location set in target administration.
Magnetic liposome is a kind of novel medicament oriented carrier, after in its entering body, utilizes the effect of external magnetic field can guide its directed in vivo moving, and focuses on the human lesion place and discharges then, makes the target property of liposome and selectivity stronger like this.
The research of magnetic liposome at present mainly improves in the performance of liposome itself, and to research in the application of external magnetic field seldom, for example problems such as the action of a magnetic field time, magnetic induction density, magnetic field gradient and three-dimensional location also do not have suitable research equipment so far.The experimental apparatus of existing in-vitro simulated usefulness adopts peristaltic pump to carry solution to be measured; The liquid of a solution bottle 5 is extracted in another solution bottle 5; Can not realize that testing liquid circulates; Can not simulate and the effect of magnetic lipid liquid solution outside magnetic field is imported the human body interior orientation down circulate, focus on the human lesion place and discharge then and reach therapeutic purposes.
Summary of the invention
The utility model technical matters to be solved is to overcome the shortcoming of above-mentioned technology, provides a kind of reasonable in design, simple in structure, easy to operate, the action of a magnetic field that simulated experiment is true to nature, practical in the in-vitro simulated device at human lesion place.
Solving the problems of the technologies described above the technical scheme that is adopted is: be provided with D.C. regulated power supply in the left side of base, the right side is provided with micropump; Be provided with field coil and support on the base between D.C. regulated power supply and the micropump; Field coil links to each other with D.C. regulated power supply through lead; The liquid outlet of micropump is provided with the end and places feeding flexible pipe, inlet in the solution bottle to be provided with the end to place the fluid flexible pipe in the solution bottle, and the feeding flexible pipe is fixed on and extend on the support in the field coil, in the solution bottle solution is housed; The feeding flexible pipe is provided with the injection valve, and the fluid flexible pipe is provided with sample valve.
The soft internal diameter to pipe and fluid flexible pipe of the feeding of the utility model is 2～4mm.
The solution of dress is phosphate buffer solution or water in the solution bottle of the utility model.
The utility model adopts the magnetic lipid liquid solution with circulating in the micropump outside magnetic field; Simulation imports the human body interior orientation with the magnetic lipid liquid solution and circulates; Focusing on the human lesion place discharges then and reaches the in-vitro simulated device of therapeutic purposes; But analogue body inner blood circulation and in addition magnetic field be used for research, the simulation human body advances medicine, takes out medicine, draw samples is analyzed the action effect in magnetic field at any time.The utlity model has advantages such as reasonable in design, simple in structure, easy to operate, that simulated experiment is true to nature, can be used for the analogue body external magnetic field circulating the effect of blood.
Description of drawings
Fig. 1 is the structural representation of an embodiment of the utility model.
Embodiment
To the utility model further explain, but the utility model is not limited to these embodiment below in conjunction with accompanying drawing and embodiment.
Embodiment 1
In Fig. 1, the in-vitro simulated device at the action of a magnetic field human lesion place of present embodiment is to be connected by D.C. regulated power supply 1, field coil 2, injection valve 3, feeding flexible pipe 4, solution bottle 5, fluid flexible pipe 6, sample valve 7, micropump 8, support 9, base 10 to constitute.
Left side at base 10 is equipped with D.C. regulated power supply 1 with the fixed connection of screw threads for fastening connector; The right side of base 10 is fixedly connected with the screw threads for fastening connector micropump 8 is installed; Micropump 8 is used for liquid circulation, and being fixedly connected with the screw threads for fastening connector between D.C. regulated power supply 1 and the micropump on the base 10 is equipped with field coil 2 and support 9, and field coil 2 passes through lead and links to each other with D.C. regulated power supply 1; After field coil 2 is connected with D.C. regulated power supply 1; Field coil 2 will produce magnetic field, and the strength of current through control D.C. regulated power supply 1 can change the magnetic field intensity that field coil 2 is produced.Feeding flexible pipe 4 is installed on the liquid outlet of micropump 8, and the internal diameter of feeding flexible pipe 4 is 3mm, and the other end of feeding flexible pipe 4 is inserted in the solution bottle 5; Fluid flexible pipe 6 is installed on the inlet of micropump 8, and the internal diameter of fluid flexible pipe 6 is 3mm, and the other end of fluid flexible pipe 6 is inserted in the solution bottle 5; Feeding flexible pipe 4 is fixed on the end of support 9, and the end of support 9 extend in the field coil 2, and injection valve 3 is installed on the feeding flexible pipe 4; Magnetic liposome is a kind of magnetic material; Be carrier, in include antineoplastic, be injected in the solution bottle 5 from injection valve 3.In the solution bottle 5 solution is housed, the solution of present embodiment is phosphate buffer solution, also can adopt water, and magnetic liposome is mixed with into the magnetic lipid liquid suspension with phosphate buffer solution.Sample valve 7 is installed on the fluid flexible pipe 6, opens sample valve 7, extract magnetic lipid suspending liquid, can detect magnetic lipid liquid suspension in the solution bottle 5.Behind micropump 8 and the power connection, micropump 8 runnings, magnetic lipid suspending liquid circulates in feeding flexible pipe 4, fluid flexible pipe 6, and simulate blood circulates in blood vessel.During use with coil stationary on the skin of cancer patient tumor locus, under the effect in magnetic field, magnetic lipid suspending liquid rests on the cancer patient tumor locus, plays the treatment function.
In the present embodiment, the internal diameter of feeding flexible pipe 4 and fluid flexible pipe 6 is 2mm.Other parts and connecting mode thereof are identical with embodiment 1.
In the present embodiment, the soft internal diameter to pipe 4 and fluid flexible pipe 6 of water is 4mm.Other parts and connecting mode thereof are identical with embodiment 1.
The principle of work of the utility model is following:
The inlet of micropump 8 is loaded onto feeding flexible pipe 4, and the liquid outlet of micropump 8 is loaded onto fluid flexible pipe 6, and the end of feeding flexible pipe 4 and fluid flexible pipe 6 two tubes all inserts the solution bottle 5 that fills phosphate buffer solution; Connect the power supply of micropump 8, formed a small-sized blood circulation analogue means between micropump 8, feeding flexible pipe 4, fluid flexible pipe 6 and the solution bottle 5, feeding flexible pipe 4 places in the magnetic field; Connect the D.C. regulated power supply 1 of field coil 2; Magnetic lipid suspending liquid circulates in feeding flexible pipe 4, fluid flexible pipe 6, through regulating strength of current controlling magnetic field size, adopts gaussmeter to measure magnetic induction density; During use with coil stationary on the skin of cancer patient tumor locus; Under the effect in magnetic field, magnetic lipid suspending liquid rests on the cancer patient tumor locus, plays the treatment function.
Claims (3)
1. the in-vitro simulated device at a action of a magnetic field human lesion place; It is characterized in that: be provided with D.C. regulated power supply (1) in the left side of base (10), the right side is provided with micropump (8); Base (10) is gone up between D.C. regulated power supply (1) and the micropump and is provided with field coil (2) and support (9); Field coil (2) links to each other with D.C. regulated power supply (1) through lead; The liquid outlet of micropump (8) is provided with the end and places feeding flexible pipe (4), inlet in the solution bottle (5) to be provided with the end to place the fluid flexible pipe (6) in the solution bottle (5), and feeding flexible pipe (4) is fixed on and extend on the support (9) in the field coil (2), and the solution bottle is equipped with solution in (5); Feeding flexible pipe (4) is provided with injection valve (3), and fluid flexible pipe (6) is provided with sample valve (7).
2. the in-vitro simulated device at the action of a magnetic field human lesion according to claim 1 place is characterized in that: the soft internal diameter to pipe (4) and fluid flexible pipe (6) of described feeding is 2～4mm.
3. the in-vitro simulated device at the action of a magnetic field human lesion according to claim 1 place is characterized in that: the solution of dress is phosphate buffer solution or water in the described solution bottle (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204579392U CN202330356U (en) | 2011-11-17 | 2011-11-17 | In-vitro analog device on human body lesion under magnetic field action |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011204579392U CN202330356U (en) | 2011-11-17 | 2011-11-17 | In-vitro analog device on human body lesion under magnetic field action |
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| CN202330356U true CN202330356U (en) | 2012-07-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011204579392U Expired - Fee Related CN202330356U (en) | 2011-11-17 | 2011-11-17 | In-vitro analog device on human body lesion under magnetic field action |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120222469A1 (en) * | 2011-03-04 | 2012-09-06 | Jian-Ping Xie | Apparatus and Procedure For In Vitro Measurement of a Substance, Nicotine, Released From a Smokeless Tobacco Product |
| CN109326190A (en) * | 2018-11-14 | 2019-02-12 | 浙江理工大学 | A kind of magnetic targeted photo-thermal therapy device for simulating biological body circulation |
-
2011
- 2011-11-17 CN CN2011204579392U patent/CN202330356U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120222469A1 (en) * | 2011-03-04 | 2012-09-06 | Jian-Ping Xie | Apparatus and Procedure For In Vitro Measurement of a Substance, Nicotine, Released From a Smokeless Tobacco Product |
| US9464972B2 (en) * | 2011-03-04 | 2016-10-11 | Jian-Ping Xie | Apparatus and procedure for in vitro measurement of a substance, nicotine, released from a smokeless tobacco product |
| CN109326190A (en) * | 2018-11-14 | 2019-02-12 | 浙江理工大学 | A kind of magnetic targeted photo-thermal therapy device for simulating biological body circulation |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120711 Termination date: 20141117 |
|
| EXPY | Termination of patent right or utility model |