CN105950461A - Single cell nano accurate drug delivery system - Google Patents
Single cell nano accurate drug delivery system Download PDFInfo
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- CN105950461A CN105950461A CN201610576671.1A CN201610576671A CN105950461A CN 105950461 A CN105950461 A CN 105950461A CN 201610576671 A CN201610576671 A CN 201610576671A CN 105950461 A CN105950461 A CN 105950461A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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Abstract
The invention discloses a single cell nano accurate drug delivery system which comprises a working table control system, detection plates, a drug delivery device and a drug deliver arm control system, wherein the working table control system and the drug deliver arm control system form a horizontal bat shape and are made of metal, the working table control system is a disc, the detection plates are placed on the working table control system, and the drug deliver arm control system is of a small horizontal bat shape. The drug delivery device is arranged in the drug deliver arm control system. The drug deliver arm control system controls the drug delivery device to absorb an A drug downward through lifting movement, then the drug is delivered to single cells in the detection plates, after drug delivery needles of the drug deliver device are changed, the working table control system shifts the detection plates to the drug deliver device through rotation, and injection of a B drug is performed. The single cell nano accurate drug delivery system can detect curative effect difference of breast cancer cells to various clinical anticancer drugs in a nanoscale living body, the drug is delivered to the insides and outsides of the single cells accurately, damage to the cells is small, and follow-up cultivation and detection of the cells are favorable.
Description
Technical field
The present invention relates to a kind of accurate drug-supplying system of unicellular nanometer, belong to biological medicine instrument and equipment.
Background technology
The research being currently based on individual cell level increasingly comes into one's own and becomes a kind of trend studied from now on.It is widely used to the fields such as single celled DNA cloning, gene order-checking and individual cell level subcellular fraction drug-supplying system research.Currently for mammary cancer chemotherapy, doctor is mainly according to checking result: as imaging examination (such as B ultrasonic, CT, nuclear magnetic resonance, NMR) and pathological examination results determine to the classification and dosage with chemotherapeutics.But these results are not to be objectively directly administered foundation, often by doctors experience, the impact of the subjective factorss such as level, even doctor-patient relationship, thus have impact on the therapeutic effect of patient.
It is directed to the instrument that precisely makes up a prescription of breast carcinoma chemotherapy drugs, there is no matured product at present and occur.But the drug resistance analysis for chemotherapeutics mainly has gene test and two kinds of methods of animal model test clinically, as follows:
Gene test can detect the Drug resistance status of medicine from DNA level, and the DNA drug resistance of certain already known sudden change is had point-device judgement.But the DNA quantity in human body is the hugest, even in a small amount of sample, DNA quantity is the most surprising, thus the result of detection has great limitation, the detection time is relatively for a long time (5-7 days) simultaneously, and the DNA of unknown mutation is often produced wrong judgement.Operationally, needing the very strict and flow process of complexity, environmental factors that otherwise can be external can have influence on the reliability of testing result easily.Additionally testing cost is the most somewhat expensive.
Animal model test is the most common a kind of detection method.At present the analysis majority to breast carcinoma resistance be by cancerous cell from human implantation to animal with (such as white mice) develop into malignant tumor.Then to its medicine feed, observe its effect and carry out medicine adjustment again.Although this method avoids the limitation of gene test, but the detection detection time is relatively long, and generally at 3-5 month, the treatment to patient is the most unfavorable.Simultaneously as be acquisition test data with animal after all, there is deviation with human body, its accuracy and reliability there is also difference.
Any of the above method, some methods are inefficient or inconvenient operation or expensive, easy damaging cells, therefore, explore an accurate drug-supplying system of unicellular nanometer simple to operate, quick, efficient, reliable the most meaningful.
Summary of the invention
In order to solve the problems referred to above, simplify technology mode further, convenient operation, improves accuracy and efficiency, alleviates workload, not damaging cells, the single cancerous cell Different therapeutical effect to clinic cancer therapy drug is analyzed in convenient detection, and the present invention provides a kind of oscillation mode single cell separator, it is possible to quickly analyze the Different therapeutical effect of cancer therapy drug, thus before chemotherapy, provide scheme of making up a prescription the most accurately, therapeutic effect can also be followed the tracks of after chemotherapy simultaneously thus adjust pharmaceutical formulation.The accurate drug-supplying system of the unicellular nanometer of the present invention can be at the nanoscale In vivo detection cancerous cell Different therapeutical effect to various clinic cancer therapy drugs, sterile working can be ensured, use after each parts sterilizing, realize nanoscale operation, precisely it is administered outside unicellular intracellular, born of the same parents, little to cell injury, also help follow-up cultivation and the detection of cell.
The technical scheme is that
A kind of accurate drug-supplying system of unicellular nanometer, it is characterized in that: include workstation control system, detection plate, doser and administration arm control system, doser includes that administration pump, pump intake, administration distribution pipe, needle exchange joint and administration needle, workstation control system and administration arm control system form horizontal racket type.Workstation control system and administration arm control system material are metal.Workstation control system is disk.Being administered arm control system is little horizontal racket type.
Detection sheet material matter is organic polymer material.
Being administered distribution tubing matter is vinyon material.
The square array distribution of administration needle is being administered in arm control system.
Administration needle material is quartz material.
Administration needle tip size is Nano grade.
The invention has the beneficial effects as follows: the present invention is in order to can be at the nanoscale In vivo detection cancerous cell Different therapeutical effect to various clinic cancer therapy drugs.Described administration arm control system controls to draw under described doser A medicine by elevating movement, then it is administered in the individual cells in described detection plate, after changing the described administration needle of described doser, described detection plate is transferred under described doser by rotating by described workstation control system, carry out the injection of medicine B, etc..
Accompanying drawing explanation
Fig. 1 is the front view of the accurate drug-supplying system of unicellular nanometer；
Fig. 2 is the top view of the accurate drug-supplying system of unicellular nanometer；
Fig. 3 is unicellular nanometer accurate drug-supplying system administration needle administration figure.
In figure: 10. workstation control system, 101. worktable rotaries drive, 102. workbench, 20. detection plates, 201. detection micropores, 30. dosers, 301. administration pumps, 302. pump intakes, 303. medicament distribution pipes, 304. needle exchange joints, 305. administration needles, 40. are administered arm control system, 401. are administered arm lifting drives, 402. screw drive, 403. are administered arm, 50. cells.
Detailed description of the invention
In order to make the object, technical solutions and advantages of the present invention clearer, describe the present invention with specific embodiment below in conjunction with the accompanying drawings.
As shown in Figure 1 to Figure 3, the one accurate drug-supplying system of unicellular nanometer of the present invention, including workstation control system 10, detection plate 20, doser 30 and administration arm control system 40, doser 30 includes administration pump 301, pump intake 302, is administered distribution pipe 303, needle exchange joint 304 and administration needle 305, and workstation control system 10 and administration arm control system 40 form horizontal racket type.Workstation control system 10 is disk.Being administered arm control system 40 is little horizontal racket type.Workstation control system 10 and administration arm control system 40 material are metal.In the present embodiment, workstation control system 10 and administration arm control system 40 material are rustless steel.
Workstation control system 10 rotates under worktable rotary drives the driving of 101, and detection plate 20 is placed on workstation control system 10, and by the rotary motion of workstation control system 10, detection plate 20 is replaced.
Being administered arm control system 40 to be lifted by screw thread 402 under being administered the driving that arm lifting drives 401, doser 30 is arranged on administration arm 403, and the square array of administration needle 305 arranges, administration needle 305 and detection plate 20 one_to_one corresponding.In the present embodiment, administration needle 305 arranges with 5 × 5 arrays, corresponding with detection plate.
Administration needle 305 is fixed by needle exchange joint 304 and is changed.
Administration needle 305 material is glass material, and in the present embodiment, administration needle 305 material is hollow quartz tube.
Administration needle 305 a size of Nano grade, in the present embodiment, administration needle 305 size reaches 600nm.
Medicine A, under the driving being administered arm control system 40, is pumped in administration needle 305 by administration pump 301 by doser 30 accurately, is then expelled to medicine A detect in the cell 50 in plate micropore 201.Administration terminates, doser 30 is raised under the lifting being administered arm control system 40 drives, then administration needle 305 is changed, medicine B is pumped under the driving of administration pump 301 by administration needle 305, workstation control system 10 is after medicine A injects, changing detection plate 20 by rotating to drive, doser 30 carries out the injection of medicine B under the driving being administered arm control system 40.By the accurate pump medicine of administration pump 301 and administration, the administration needle of Nano grade, thus reach accurate dosed administration in unicellular 50 in detection plate, little to cell injury.In present embodiment, the administration needle of Nano grade can be administered into extracellular, intracellular, can be used for the Different therapeutical effect of various clinic cancer therapy drug.
In sum, the accurate drug-supplying system of unicellular nanometer of the present invention controls doser 30 pump medicine and administration by being administered arm control system 40, workstation control system 10 controls the one_to_one corresponding of detection plate 20 and changes after being administered, and can easily realize the accurate administration of various clinical medicine.The accurate drug-supplying system of the unicellular nanometer of the present invention can be at the nanoscale In vivo detection cancerous cell Different therapeutical effect to various clinic cancer therapy drugs, sterile working can be ensured, use after each parts sterilizing, realize nanoscale operation, precisely it is administered outside unicellular intracellular, born of the same parents, little to cell injury, also help follow-up cultivation and the detection of cell.
Claims (6)
1. the accurate drug-supplying system of unicellular nanometer, it is characterized in that: include workstation control system, detection plate, doser and administration arm control system, described doser includes administration pump, is administered distribution pipe, needle exchange joint and administration needle, described workstation control system and described administration arm control system form horizontal racket type, described workstation control system and described administration arm control system material are metal, described workstation control system is disk, and described administration arm control system is little horizontal racket type.
The accurate drug-supplying system of unicellular nanometer the most according to claim 1, it is characterised in that: described detection sheet material matter is organic polymer material.
The accurate drug-supplying system of unicellular nanometer the most according to claim 1, it is characterised in that: the described distribution tubing matter that is administered is vinyon material.
The accurate drug-supplying system of unicellular nanometer the most according to claim 1, it is characterised in that: the square array distribution of described administration needle is in described administration arm control system.
The accurate drug-supplying system of unicellular nanometer the most according to claim 1, it is characterised in that: described administration needle material is quartz material.
The accurate drug-supplying system of unicellular nanometer the most according to claim 1, it is characterised in that: described administration needle tip size is Nano grade.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610576671.1A CN105950461B (en) | 2016-07-20 | 2016-07-20 | The unicellular accurate delivery system of nanometer |
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| CN201610576671.1A CN105950461B (en) | 2016-07-20 | 2016-07-20 | The unicellular accurate delivery system of nanometer |
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| CN105950461A true CN105950461A (en) | 2016-09-21 |
| CN105950461B CN105950461B (en) | 2017-10-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108931660A (en) * | 2018-07-25 | 2018-12-04 | 江苏瑞明生物科技有限公司 | High-throughput full-automatic Susceptibility Test Analysis instrument |
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| CN1685233A (en) * | 2002-09-24 | 2005-10-19 | 英特尔公司 | Detecting molecular binding by monitoring feedback controlled cantilever deflections |
| CN101223268A (en) * | 2005-05-18 | 2008-07-16 | 康奈尔研究基金会（有限公司） | Pharmacokinetic-based culture system with biological barriers |
| CN104152345A (en) * | 2014-08-14 | 2014-11-19 | 江苏瑞明生物科技有限公司 | Microfluidic type single-cell separator |
| CN205774546U (en) * | 2016-07-20 | 2016-12-07 | 江苏瑞明生物科技有限公司 | The accurate drug-supplying system of unicellular nanometer |
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2016
- 2016-07-20 CN CN201610576671.1A patent/CN105950461B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1685233A (en) * | 2002-09-24 | 2005-10-19 | 英特尔公司 | Detecting molecular binding by monitoring feedback controlled cantilever deflections |
| CN101223268A (en) * | 2005-05-18 | 2008-07-16 | 康奈尔研究基金会（有限公司） | Pharmacokinetic-based culture system with biological barriers |
| CN104152345A (en) * | 2014-08-14 | 2014-11-19 | 江苏瑞明生物科技有限公司 | Microfluidic type single-cell separator |
| CN205774546U (en) * | 2016-07-20 | 2016-12-07 | 江苏瑞明生物科技有限公司 | The accurate drug-supplying system of unicellular nanometer |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108931660A (en) * | 2018-07-25 | 2018-12-04 | 江苏瑞明生物科技有限公司 | High-throughput full-automatic Susceptibility Test Analysis instrument |
| CN108931660B (en) * | 2018-07-25 | 2024-01-26 | 江苏瑞明生物科技有限公司 | High-flux full-automatic drug sensitivity test analyzer |
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