CN202199160U - Crystalizing tank for arteether - Google Patents
Crystalizing tank for arteether Download PDFInfo
- Publication number
- CN202199160U CN202199160U CN201120327553XU CN201120327553U CN202199160U CN 202199160 U CN202199160 U CN 202199160U CN 201120327553X U CN201120327553X U CN 201120327553XU CN 201120327553 U CN201120327553 U CN 201120327553U CN 202199160 U CN202199160 U CN 202199160U
- Authority
- CN
- China
- Prior art keywords
- tank
- arteether
- solvent
- tank body
- crystallizing tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NLYNIRQVMRLPIQ-XQLAAWPRSA-N artemotil Chemical compound C1C[C@H]2[C@H](C)CC[C@H]3[C@@H](C)[C@@H](OCC)O[C@H]4[C@]32OO[C@@]1(C)O4 NLYNIRQVMRLPIQ-XQLAAWPRSA-N 0.000 title claims abstract description 28
- 229960002970 artemotil Drugs 0.000 title claims abstract description 28
- 239000002904 solvent Substances 0.000 claims abstract description 28
- 238000011084 recovery Methods 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 3
- 239000002826 coolant Substances 0.000 claims description 4
- 238000010907 mechanical stirring Methods 0.000 claims description 3
- 238000002425 crystallisation Methods 0.000 abstract description 16
- 230000008025 crystallization Effects 0.000 abstract description 16
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000003430 antimalarial agent Substances 0.000 description 2
- 229960002521 artenimol Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 241000223960 Plasmodium falciparum Species 0.000 description 1
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 description 1
- 229930101531 artemisinin Natural products 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- BJDCWCLMFKKGEE-CMDXXVQNSA-N chembl252518 Chemical compound C([C@@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2O[C@H](O)[C@@H]4C BJDCWCLMFKKGEE-CMDXXVQNSA-N 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229930183339 qinghaosu Natural products 0.000 description 1
- 210000001563 schizont Anatomy 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
Images
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The utility model relates to a crystallizing tank for arteether, which comprises a tank holder, a tank arranged on the tank holder and a stirring device. The tank comprises a tank body and a tank cover hermetically connected with the tank body, a discharge outlet is arranged at the bottom of the tank body, a discharge valve is arranged at the discharge outlet, a feed inlet is arranged on the tank cover, and a jacket with a vapor inlet and a vapor outlet are arranged on the periphery of the tank body. The crystalizing tank for arteether is characterized by further comprising a solvent recovery unit connected with the tank. The solvent recovery unit comprises a connecting pipe, a condenser and a solvent collector, wherein one end of the connecting pipe is connected with the tank hermetically, the condenser is connected with the other end of the connecting pipe, and the solvent collector is connected with the condenser. Since the solvent recovery unit is added on the basis of the conventional crystallizing tank, quantity of solvent for crystallization is reduced, crystallization efficiency and crystallinity are both improved, while the recovered solvent can be reutilized, which is favorable for reducing cost.
Description
Technical field
< b TranNum=" 72 ">the utility model relates to a kind of crystallizing tank, and particularly a kind of arteether is used crystallizing tank.</b>
Background technology
< b TranNum=" 75 ">arteether is the ether derivative of dihydroartemisinine; Be to introduce the medicine of India by central authorities medicine first with fragrant plant institute (C IMAP) (L ucknow), it has carried out clinical widely preceding, animal and toxicologic study and in the India experimenter, has carried out clinical research for the drug regulation purpose.The World Health Organization has also been recommended the antimalarial agent of arteether as treatment life.Arteether is more effective than qinghaosu; It is a kind of desirable antimalarial agent; In particular for MDR and the concurrent bacterial strain of treatment plasmodium falciparum, arteether shows that clearance rate is killed the schizont effect faster, the heating checkout time of the weak point of being free from side effects and low recurrence rate.</b>
< b TranNum=" 77 ">arteether is that feedstock production obtains usually with the dihydroartemisinine, contains impurity in the arteether bullion that obtains, and need further purify through the purification means, and common purification mode is a recrystallization.Yet, be not the custom-designed crystallizing tank of arteether also at present, and take conventional crystallizing tank to carry out crystallization operation; There is following problem: when carrying out the recrystallization of arteether,, need to add a large amount of solvents usually in order to make the arteether bullion fully dissolve; Could guarantee that like this arteether can just not separate out in the process of carrying, yet, the arteether crude product solution is being joined in the crystallizing tank; When carrying out crystallization operation, a large amount of solvents obviously is unfavorable for separating out of arteether crystal again very much.And existing crystallizing tank does not have the device that reclaims solvent, and therefore, crystallization can only be carried out in the presence of high amounts of solvents, crystallization length consuming time, and percent crystallization in massecuite is low.</b>
Summary of the invention
< b TranNum=" 80 ">the utility model technical problem to be solved is the deficiency that overcomes prior art, provides a kind of arteether to use crystallizing tank, uses its crystallization of carrying out arteether, and percent crystallization in massecuite is high, and cost reduces.</b>
For solving the problems of the technologies described above, the utility model is taked following technical scheme:
< b TranNum=" 84 ">a kind of arteether is used crystallizing tank; It comprises a jar frame, is arranged on tank body and agitating device on jar frame, and said tank body comprises can body and the cover that is tightly connected with can body, and the bottom of said can body offers discharge port; And be provided with baiting valve in the discharge port position; Said cover is provided with charging aperture, also is provided with the chuck with steam inlet and coolant outlet in the can body periphery, particularly; Described crystallizing tank also comprises the solvent recovery unit that is connected with tank body, and this solvent recovery unit comprises an end and tank body tube connector that is tightly connected and the condenser that is connected with the other end of tube connector and the solvent receiver that is connected with condenser.</b>
Preferably, the cover of described tube connector and tank body is tightly connected < b TranNum=" 86 " >.</b>
< b TranNum=" 88 ">described agitating device adopts mechanical stirring device, and it comprises fire-proof motor, decelerator and anchor agitator.Crystallizing tank comprises that also the tetrafluoro of the stirring anchor periphery that is arranged on anchor agitator scrapes wall, and this tetrafluoro is scraped wall and is close on the can body inwall.Scrape the setting of wall, can prevent on the jar inwall, to form crystallization material film, on the one hand, prevent that the existence of expecting film from hindering heat transfer, on the other hand, reduce in the crystallization process product losses.In addition, crystallizing tank comprises that also being arranged on explosion-proof on the cover looks lamp and lead to the respirator in the tank body.</b>
Because the enforcement of above technical scheme, the utility model compared with prior art has following advantage:
< b TranNum=" 92 ">the utility model increases on traditional crystallizing tank basis has solvent recovery unit, and on the one hand, the quantity of solvent when having reduced crystallization helps improving crystalline rate and improves percent crystallization in massecuite; On the other hand, recovered solvent can utilize again, is beneficial to reduce cost.</b>
Description of drawings
< b TranNum=" 95 ">are done further detailed explanation below in conjunction with accompanying drawing and concrete embodiment to the utility model.</b>
Fig. 1 is for looking sketch map (partial cutaway) according to the arteether of the utility model with the master of crystallizing tank;
< b TranNum=" 99 ">wherein: 1, jar frame; 2, tank body; 20, can body; 200, discharge port; 21, cover; 210, charging aperture; 3, agitating device; 30, fire-proof motor; 31, decelerator; 32, anchor agitator; 4, baiting valve; 5, chuck; 50, steam inlet; 51, coolant outlet; 6, solvent recovery unit; 60, tube connector; 61, condenser; 62, solvent receiver; 8, the explosion-proof lamp of looking; 9, respirator; 12, tetrafluoro is scraped wall.</b>
The specific embodiment
< b TranNum=" 102 ">are as shown in Figure 1; Arteether according to present embodiment is used crystallizing tank; It comprises jar frame 1, is arranged on tank body 2, agitating device 3 and solvent recovery unit 6 on jar frame 1, and wherein: tank body 2 comprises can body 20 and the cover 21 that is tightly connected with can body 20, and the bottom of said can body 20 offers discharge port 200; And be provided with baiting valve 4 in discharge port 200 positions, cover 21 is provided with charging aperture 210, explosion-proof lamp 8 etc., respirator 9 etc. looked.Be provided with chuck 5 with steam inlet 50 and coolant outlet 51 in can body 20 peripheries.Solvent recovery unit 6 comprises condenser 61 that tube connector 60 that an end and cover 21 be tightly connected is connected with the other end with tube connector 60 and the solvent receiver 62 that is connected with condenser 61.</b>
< b TranNum=" 104 ">agitating device 3 adopts conventional mechanical stirring device, and it mainly comprises fire-proof motor 30, decelerator 31, anchor agitator 32.Anchor agitator 32 is provided with tetrafluoro and scrapes wall 12, and tetrafluoro is scraped wall 12 and is close to the inwall of can body 20, can prevent to form on can body 20 inwalls material film.These are known, do not give unnecessary details at this.</b>
When < b TranNum=" 106 ">adopt the crystallizing tank of the utility model to carry out the crystallization of arteether; Material heats in 5 pairs of tank bodies of chuck capable of using 2; Make a part of solvent evaporation after solvent recovery unit 6 reclaims; On the one hand, the quantity of solvent when having reduced crystallization helps improving crystalline rate and improves percent crystallization in massecuite; On the other hand, recovered solvent can utilize again, reduces cost.</b>
More than the utility model has been done detailed description; Its purpose is to let the personage that is familiar with this art can understand the content of the utility model and implements; Can not limit the protection domain of the utility model with this; All equivalences of doing according to the spirit of the utility model change or modify, and all should be encompassed in the protection domain of the utility model
Claims (5)
1. an arteether is used crystallizing tank; It comprises a jar frame (1), is arranged on tank body (2) and agitating device (3) on the said jar of frame (1); Said tank body (2) comprises can body (20) and the cover (21) that is tightly connected with can body (20); The bottom of said can body (20) offers discharge port (200); And be provided with baiting valve (4) in said discharge port (200) position; Said cover (21) is provided with charging aperture (210); Also be provided with the chuck (5) with steam inlet (50) and coolant outlet (51) in said can body (20) periphery, it is characterized in that: described crystallizing tank also comprises the solvent recovery unit (6) that is connected with said tank body (2), and said solvent recovery unit comprises condenser (61) that tube connector (60) that an end and described tank body (2) be tightly connected is connected with the other end with tube connector (60) and the solvent receiver (62) that is connected with condenser (61).
2. arteether according to claim 1 is used crystallizing tank, it is characterized in that: described tube connector (60) is tightly connected with the cover (21) of described tank body (2).
3. arteether according to claim 1 is used crystallizing tank, it is characterized in that: described agitating device (3) is a mechanical stirring device, and it comprises fire-proof motor (30), decelerator (31) and anchor agitator (32).
4. arteether according to claim 3 is used crystallizing tank; It is characterized in that: described crystallizing tank comprises that also the tetrafluoro of stirring anchor (320) periphery that is arranged on said anchor agitator (32) scrapes wall (12), and described tetrafluoro is scraped wall (12) and is close on said tank body (2) inwall.
5. arteether according to claim 1 is used crystallizing tank, it is characterized in that: described crystallizing tank comprises that also being arranged on explosion-proof on the said cover (21) looks lamp (8) and lead to the respirator (9) in the said tank body (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120327553XU CN202199160U (en) | 2011-09-02 | 2011-09-02 | Crystalizing tank for arteether |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120327553XU CN202199160U (en) | 2011-09-02 | 2011-09-02 | Crystalizing tank for arteether |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202199160U true CN202199160U (en) | 2012-04-25 |
Family
ID=45963298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201120327553XU Expired - Lifetime CN202199160U (en) | 2011-09-02 | 2011-09-02 | Crystalizing tank for arteether |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202199160U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107570025A (en) * | 2017-10-31 | 2018-01-12 | 新中天环保股份有限公司 | Solvent vapor recovery system |
-
2011
- 2011-09-02 CN CN201120327553XU patent/CN202199160U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107570025A (en) * | 2017-10-31 | 2018-01-12 | 新中天环保股份有限公司 | Solvent vapor recovery system |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104230803B (en) | Preparation method of hydroxychloroquine sulfate | |
| CN104892785B (en) | A kind of extracting method of algal polysaccharides | |
| CN109608361B (en) | Synthesis method of dichloroacetonitrile | |
| CN102350082B (en) | Crystallizing tank used for Arteether | |
| CN106866766A (en) | The preparation method and preparation system of a kind of medroxyprogesterone acetate | |
| CN202199160U (en) | Crystalizing tank for arteether | |
| CN204767571U (en) | Crystallizer is used in sugaring | |
| CN108558759A (en) | The method that one kettle way prepares celecoxib | |
| CN102391259B (en) | Nifuratel compound and preparation method thereof | |
| CN202052347U (en) | Continuous material dissolving and column chromatography recrystallization purification system | |
| CN102093263A (en) | Recycling method of levorotation camphorsulfonic acid serving as clopidogrel resolving agent | |
| CN101935293B (en) | Method for preparing arginine ketoprofenate | |
| CN107445869A (en) | A kind of synthetic method of Metformin hydrochloride | |
| CN102382072A (en) | Method for refining D-cycloserine | |
| CN105130876A (en) | Preparation process of novel indocyanine green | |
| CN103554136B (en) | Preparation method of cefmenoxine hydrochloride dry powder | |
| CN109096129A (en) | A kind of preparation method of L-carnitine-L-tartrate | |
| CN102633603B (en) | Method for preparing high-purity L-borneol | |
| CN101845070A (en) | Synthesis method of antineoplastic medicine capecitabine | |
| CN102030715B (en) | Method for synthetizing cytosine | |
| CN103435628A (en) | Purification method of benzenetetracarboxylic anhydride | |
| CN103772255A (en) | Method for extracting beta-carotene from algae by low-molecule organic matters/inorganic salt aqueous two-phase extraction | |
| CN103214485A (en) | Method suitable for industrial production of high-purity 9-hydroxy-risperidone | |
| CN103483232B (en) | Refining method of valnemulin hydrochloride | |
| CN102961899A (en) | Ethanol precipitation device with drying device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20161012 Address after: Qingdao Road South Chemical Industrial Park Industry in Wuyang County of Luohe City, Henan province 462400 area Patentee after: Wuyang lelexin Biological Medicine Co Ltd Address before: 3, building 7, building D, No. 215634, Guangdong Road, Zhangjiagang Free Trade Zone, Suzhou, Jiangsu Patentee before: Jiangsu Swithin Biological Medicine Engineering Research Center Co., Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Crystallizing tank used for Arteether Effective date of registration: 20171110 Granted publication date: 20120425 Pledgee: Bank of China Limited by Share Ltd Luohe branch Pledgor: Wuyang lelexin Biological Medicine Co Ltd Registration number: 2017990000990 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20181113 Granted publication date: 20120425 Pledgee: Bank of China Limited by Share Ltd Luohe branch Pledgor: Wuyang lelexin Biological Medicine Co Ltd Registration number: 2017990000990 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Crystallizing tank used for Arteether Effective date of registration: 20181120 Granted publication date: 20120425 Pledgee: Bank of China Limited by Share Ltd Luohe branch Pledgor: Wuyang lelexin Biological Medicine Co Ltd Registration number: 2018990001068 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20191105 Granted publication date: 20120425 Pledgee: Bank of China Limited by Share Ltd Luohe branch Pledgor: Wuyang lelexin Biological Medicine Co Ltd Registration number: 2018990001068 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| CX01 | Expiry of patent term |
Granted publication date: 20120425 |
|
| CX01 | Expiry of patent term |