CN202184970U - Base-modified urethral stent with chitosan coating - Google Patents
Base-modified urethral stent with chitosan coating Download PDFInfo
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- CN202184970U CN202184970U CN201120264070XU CN201120264070U CN202184970U CN 202184970 U CN202184970 U CN 202184970U CN 201120264070X U CN201120264070X U CN 201120264070XU CN 201120264070 U CN201120264070 U CN 201120264070U CN 202184970 U CN202184970 U CN 202184970U
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- chitosan
- urethra rack
- base
- modified
- chitosan coating
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Abstract
The utility model discloses a base-modified urethral stent with a chitosan coating, which is prepared in net-like cylindrical vessel shape by nickel-titanium alloy wires. A modified chitosan coating is coated in periphery of the nickel-titanium alloy wires.
Description
Technical field
This utility model relates to the urethra rack that uses in a kind of hypospadias repair operation.
Background technology
Chitosan is de-acetyl chitin and the product that obtains, and it is a kind of unbodied vitrina, nontoxic, harmless, easily biological-degradable; Free from environmental pollution, and the environmentally friendly functional high molecule material with characteristics such as good adsorption property, film property, hygroscopicity, prior its excellent biological function that is based on; Biodegradable; Catabolite generally to the human non-toxic side effect, is not put aside in vivo, non-immunogenicity; Have the regulating action to the body cell growth, the effect that suppresses growth of microorganism, regulating action, promotion wound healing effect and adsorption, even can also start immunologic function coagulation function.Therefore, chitosan, becomes first choice of the present clinical practice with its multi-functional synergism at clinical medicine.Chitosan is used to operation suture thread, medical adhesive-bonded fabric, bone support and intravascular stent etc. at present, but Shang Weijian is used for the correlational study of urethra rack.
In hypospadias repair operation, the urethra rack that is widely used, existing urethra rack adopt titanium nickel metal material to process, and its main shortcoming is the discomfort of urinating, and is prone to lead to complications, and does not possess the effect of auxiliary treatment simultaneously, function singleness.
Summary of the invention
The purpose of this utility model is to overcome the shortcoming of urethra rack in the past, and a kind of chitosan coat urethra rack that quickens wound healing, reduces amount of bleeding is provided.
For reaching above purpose, this utility model takes following technical scheme to be achieved:
A kind of baseization chitosan modified coating urethra rack, this urethra rack is processed netted cylindrical conduit shape by nitinol alloy wire, it is characterized in that, and said nitinol alloy wire periphery is coated with the chitosan modified coating.
In the such scheme, described urethra rack internal diameter scribbles watertight composition.
This utility model urethra rack adopts baseization chitosan modified coating, and it has oxygen permeability and the characteristic that promotes wound healing preferably, can induce the huge cell of having a liking for effectively, suppresses the transfer of antibacterial etc.; The wound healing that helps postoperative patient, the time of raising rehabilitation.
Description of drawings
Fig. 1 is the structural representation of this utility model.
Fig. 2 is the longitudinal section view of Fig. 1.
Fig. 3 is the sectional drawing of nitinol alloy wire among Fig. 1.
Among Fig. 1 to Fig. 3: 1, nitinol alloy wire; 2, urethra rack; 3, watertight composition; 4, modification of chitosan coating.
The specific embodiment
Below in conjunction with accompanying drawing and embodiment to this utility model further explain.
Shown in Figure 2 like Fig. 1, urethra rack 2 is processed netted cylindrical conduit shape by nitinol alloy wire 1, and urethra rack 2 internal diameters scribble watertight composition 3, and watertight composition 3 adopts the chitin fiber layer that is insoluble in water, can prevent that urine flow is out-of-date chitosan coat is washed away.Nitinol alloy wire 1 periphery is coated with chitosan modified coating 4 (Fig. 3).
Though contain free amino in the chitosan, it can only be dissolved in diluted acids such as hydrochloric acid, acetic acid, lactic acid, benzoic acid, formic acid, and can not be water-soluble, aqueous slkali and organic solvent mostly.This just big limitations Application of Chitosan.This utility model adopts the chitosan coat urethra rack; Wherein the modification of chitosan coating 4 of nitinol alloy wire 1 periphery coating is a kind of baseization chitosan modified coating; Promptly be with amino group on the chitosan molecule and oh group; React with organic acid derivatives such as acyl chlorides, anhydride, it can be continued, discharge chitosan chronically, and good pH dependency is arranged.
Modification of chitosan coating 4 can adopt following 3 kinds of schemes: 1, alkylation modification chitosan: adopt alkylated reaction can on the amino of chitosan, carry out N one alkylation, generate corresponding N one alkylate.To chitin modified, can prepare ethyl chitosan with alkyl halide, butyl chitosan, octyl group chitosan and cetyl chitosan etc.Through the chitosan of alkylation modification, can improve the mechanical performance and the hydrophobic property of chitosan molecule.2, chitosan quaternary ammonium salinization: adopt glycidyl trimethylammonium chloride and chitosan reaction, can in chitosan molecule, introduce quaternary ammonium salt group, make chitosan quaternary ammonium salt.The season that steric hindrance is big, hydratability is strong owing in chitosan, induce one has weakened the hydrogen bond between chitosan molecule greatly by the salt group, has increased the water solublity of chitosan derivatives.3, lecithin modification chitosan: it is in 1% the acetic acid solution that the 1.0g chitosan is dissolved into the 100mL volume fraction, is heated to 90 ℃; 1.0g lecithin is dissolved in the ethanol of heat, join while hot in the chitosan solution, stir, insulation 30min.The gained solids is the lecithin modification chitosan after waving most solvent, and the solid porphyrize is subsequent use.
Claims (2)
1. baseization chitosan modified coating urethra rack, this urethra rack is processed netted cylindrical conduit shape by nitinol alloy wire, it is characterized in that, and said nitinol alloy wire periphery is coated with the chitosan modified coating.
2. baseization chitosan modified coating urethra rack as claimed in claim 1 is characterized in that described urethra rack internal diameter scribbles watertight composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120264070XU CN202184970U (en) | 2011-07-25 | 2011-07-25 | Base-modified urethral stent with chitosan coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120264070XU CN202184970U (en) | 2011-07-25 | 2011-07-25 | Base-modified urethral stent with chitosan coating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202184970U true CN202184970U (en) | 2012-04-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201120264070XU Expired - Fee Related CN202184970U (en) | 2011-07-25 | 2011-07-25 | Base-modified urethral stent with chitosan coating |
Country Status (1)
| Country | Link |
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| CN (1) | CN202184970U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106237376A (en) * | 2016-03-28 | 2016-12-21 | 上海交通大学医学院附属第九人民医院 | Titanio biomaterial for medical purpose that chitosan quaternary ammonium salt group compound film is modified and preparation method thereof |
| CN111867516A (en) * | 2018-01-31 | 2020-10-30 | 弹性钛合金植入物有限责任公司 | Self-expanding mesh endoprosthesis for endoscopic hernia repair |
-
2011
- 2011-07-25 CN CN201120264070XU patent/CN202184970U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106237376A (en) * | 2016-03-28 | 2016-12-21 | 上海交通大学医学院附属第九人民医院 | Titanio biomaterial for medical purpose that chitosan quaternary ammonium salt group compound film is modified and preparation method thereof |
| CN106237376B (en) * | 2016-03-28 | 2019-06-07 | 上海交通大学医学院附属第九人民医院 | The modified titanium-based biomaterial for medical purpose and preparation method thereof of chitosan quaternary ammonium salt group compound film |
| CN111867516A (en) * | 2018-01-31 | 2020-10-30 | 弹性钛合金植入物有限责任公司 | Self-expanding mesh endoprosthesis for endoscopic hernia repair |
| CN111867516B (en) * | 2018-01-31 | 2023-12-29 | 钛合金纺织品公司 | Self-expanding mesh endoprosthesis for endoscopic hernia repair |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120411 Termination date: 20140725 |
|
| EXPY | Termination of patent right or utility model |