CN202028233U - Column separation device used in technical process of cephalosporin antibiotics production - Google Patents
Column separation device used in technical process of cephalosporin antibiotics production Download PDFInfo
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- CN202028233U CN202028233U CN2011201212930U CN201120121293U CN202028233U CN 202028233 U CN202028233 U CN 202028233U CN 2011201212930 U CN2011201212930 U CN 2011201212930U CN 201120121293 U CN201120121293 U CN 201120121293U CN 202028233 U CN202028233 U CN 202028233U
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- silica gel
- gel column
- silicagel column
- sodium
- intermediate product
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Abstract
The utility model relates to a column separation device used in the technical process of cephalosporin antibiotics production, which comprises a primary silica gel column 1, a secondary silica gel column 2 and a tertiary silica gel column 3, wherein the bottom of the primary silica gel column 1 is connected with the top of the secondary silica gel column 2 through a pipeline, the bottom of the secondary silica gel column 2 is connected with the top of the tertiary silica gel column 3 through a pipeline, the mesh number of the silica gel filled in the primary silica gel column 1 is 80 to 100 meshes, the mesh number of silica gel filled in the secondary silica gel column 2 is 120 to 150 meshes, and the mesh number of the silica gel filled in the tertiary silica gel column 3 is 200 to 300 meshes, and the three silica gel columns are all silica gel G. Through the technical scheme of combining and utilizing three kinds of silica gel columns with different mesh numbers, the purity and the quality of products are greatly improved.
Description
Technical field
The utility model relates to the post separator, the post separator of using in especially a kind of cephalosporin analog antibiotic production process.
Background technology
Cephalosporin analog antibiotic is the antibiotic of a class wide spectrum, has antimicrobial spectrum wider, the penicillin resistant enzyme, and advantage such as curative effect height, toxicity are low, and allergic reaction is few is occupied crucial status in anti-infective therapy.
Often purity is not high for the product that the post separator of using in the existing cephalosporin analog antibiotic production process obtains, the utility model adopts the post separator of the silicagel column coupling of three different meshes, remove more impurity, improved the purity of separated product greatly.
Summary of the invention
The purpose of this utility model is to provide the post separator of using in a kind of cephalosporin analog antibiotic production process.
The purpose of this utility model is achieved in that
The post separator of using in the cephalosporin analog antibiotic production process, comprise the one-level silicagel column, secondary silicagel column, three grades of silicagel columns, wherein: one-level silicagel column bottom links to each other with secondary silicagel column top by pipeline, and secondary silicagel column bottom links to each other with three grades of silicagel column tops by pipeline; The order number of the silica gel of loading in the one-level silicagel column is that the order number of the silica gel loaded in 80-100 order, the secondary silicagel column is that the order number of the silica gel loaded in 120-150 order, the three grades of silicagel columns is the 200-300 order.
The post separator of using in a kind of cephalosporin analog antibiotic production process, the post separating technology of using in the cephalosporin analog antibiotic production process is: the cephalosporin analog antibiotic intermediate product by one-level silicagel column, secondary silicagel column and three grades of silicagel columns, obtains purer intermediate product and enters next production link successively.
Description of drawings
Fig. 1 is a structural representation of the present utility model.
Reference numeral: one-level silicagel column 1,2, three grades of silicagel columns 3 of secondary silicagel column.
The specific embodiment
Below in conjunction with embodiment and contrast accompanying drawing and be described in further detail to this reality is novel.
Embodiment 1:
The post separator of using in the cephalosporin analog antibiotic production process, comprise one-level silicagel column 1,2, three grades of silicagel columns 3 of secondary silicagel column, wherein: one-level silicagel column 1 bottom links to each other with secondary silicagel column 2 tops by pipeline, and secondary silicagel column 2 bottoms link to each other with three grades of silicagel column 3 tops by pipeline; The order number of the silica gel of loading in the one-level silicagel column 1 is that the order number of the silica gel loaded in 80-100 order, the secondary silicagel column 2 is that the order number of the silica gel loaded in 120-150 order, the three grades of silicagel columns 3 is the 200-300 order.
Embodiment 2:
With embodiment 1, the post separating technology of using in the cephalosporin analog antibiotic production process is: the cephalosporin analog antibiotic intermediate product by one-level silicagel column, secondary silicagel column and three grades of silicagel columns, obtains purer intermediate product and enters next production link successively.The silica gel of loading in three silicagel columns is silica G.All the other are with embodiment 1.
The cephalosporin analog antibiotic intermediate product can be the Cefuroxime Sodium intermediate product, the cefonicid sodium intermediate product, the Cefotaxime Sodium intermediate product, the Cefazolin sodium intermediate product, cefoperazone sodium intermediate product, Cefradine intermediate product, the Ceftriaxone Sodium intermediate product, the Cefodizime Sodium intermediate product, cefminox sodium intermediate product, cefoperazone sodium intermediate product, cefpiramide intermediate product.
Above-mentioned Cefuroxime Sodium intermediate product, the cefonicid sodium intermediate product, the Cefotaxime Sodium intermediate product, Cefazolin sodium intermediate product, cefoperazone sodium intermediate product, the Cefradine intermediate product, the Ceftriaxone Sodium intermediate product, Cefodizime Sodium intermediate product, cefminox sodium intermediate product, cefoperazone sodium intermediate product, cefpiramide are that the cephalosporin analog antibiotic intermediate product of representative can be again by washing, and oven dry obtains the cephalosporin analog antibiotic intermediate product of pressed powder.
Cephalosporin analog antibiotic can be a Cefuroxime Sodium, cefonicid sodium, Cefotaxime Sodium, Cefazolin sodium, cefoperazone sodium, Cefradine, Ceftriaxone Sodium, Cefodizime Sodium, cefminox sodium, cefoperazone sodium, cefpiramide.
Above-mentioned Cefuroxime Sodium, cefonicid sodium, Cefotaxime Sodium, Cefazolin sodium, cefoperazone sodium, Cefradine, Ceftriaxone Sodium, Cefodizime Sodium, cefminox sodium, cefoperazone sodium, cefpiramide are that the cephalosporin analog antibiotic of representative can be again by washing, and oven dry obtains the cephalosporin analog antibiotic of pressed powder.
The cephalosporin analog antibiotic of pressed powder can obtain the cephalosporin analog antibiotic of inner wrapping again by the packing link.Cephalosporin analog antibiotic generally adds the injection that water and diluent can obtain cephalosporin analog antibiotic and is used for injection.
Claims (1)
1. the post separator of using in the cephalosporin analog antibiotic production process, comprise one-level silicagel column (1), secondary silicagel column (2), three grades of silicagel columns (3), it is characterized by: one-level silicagel column (1) bottom links to each other with secondary silicagel column (2) top by pipeline, and secondary silicagel column (2) bottom links to each other with three grades of silicagel columns (3) top by pipeline; The order number of the silica gel of loading in the one-level silicagel column (1) is that the order number of the silica gel loaded in 80-100 order, the secondary silicagel column (2) is that the order number of the silica gel loaded in 120-150 order, the three grades of silicagel columns (3) is the 200-300 order.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201212930U CN202028233U (en) | 2011-04-22 | 2011-04-22 | Column separation device used in technical process of cephalosporin antibiotics production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201212930U CN202028233U (en) | 2011-04-22 | 2011-04-22 | Column separation device used in technical process of cephalosporin antibiotics production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202028233U true CN202028233U (en) | 2011-11-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011201212930U Expired - Fee Related CN202028233U (en) | 2011-04-22 | 2011-04-22 | Column separation device used in technical process of cephalosporin antibiotics production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202028233U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103421025A (en) * | 2012-05-21 | 2013-12-04 | 上海医药工业研究院 | Method for preparing 7alpha-methoxyl cephalosporin C |
-
2011
- 2011-04-22 CN CN2011201212930U patent/CN202028233U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103421025A (en) * | 2012-05-21 | 2013-12-04 | 上海医药工业研究院 | Method for preparing 7alpha-methoxyl cephalosporin C |
| CN103421025B (en) * | 2012-05-21 | 2016-05-11 | 上海医药工业研究院 | Prepare the method for 7 α-methoxy cephalosporin C |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111109 Termination date: 20160422 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |