CN201653882U - Dim light detection system for full-automatic liquid-phase chemical luminescence exemption analyzer - Google Patents
Dim light detection system for full-automatic liquid-phase chemical luminescence exemption analyzer Download PDFInfo
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- CN201653882U CN201653882U CN2009202148760U CN200920214876U CN201653882U CN 201653882 U CN201653882 U CN 201653882U CN 2009202148760 U CN2009202148760 U CN 2009202148760U CN 200920214876 U CN200920214876 U CN 200920214876U CN 201653882 U CN201653882 U CN 201653882U
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Abstract
The utility model discloses a dim light detection system for a full-automatic liquid-phase chemical luminescence exemption analyzer, which comprises a dark room system, an optical fiber transmitter, an integrated type photon counting probe and a signal processing circuit, wherein chemical reagent, lighting reagent and human blood serum can generate different strength of lights after being mixed, reacted and incubated in the dark room system, dying light is transported to a light receiving window on the top end of the integrated type photon counting probe from the optical fiber transmitter, is processed in photoelectric conversion through the integrated type photon counting probe, outputs a voltage pulse signal with fixed pulse amplitude and width, is counted and processed by the signal processing circuit, and hands down a result to a computer at last. The dim light detection system for the full-automatic liquid-phase chemical luminescence exemption analyzer makes up the dynamic, flexible and suitable dark room system, can effectively and high-effectively transport luminous quantity of the chemical reagent to a photoelectric detection device, removes useless parasitic light interference, and accurately measures detected dying light signals.
Description
Technical field
The utility model relates to the exempt from service faint light detection system of analyser inside of a kind of full-automatic liquid chemiluminescence in the field of medical, is specially adapted to unit such as hospital and the batch patients serum is carried out human body exempts from service and do accurately to measure when analyzing.
Background technology
So far for this reason, the Chang Yong human body analytical approach of exempting from service has two kinds the most: a kind of is the radiation determination method of exempting from service, and another kind is the enzyme mark determination method of exempting from service.And traditional radiation exempt law has radioactivity, can cause certain harm to staff and environment, thereby limit its widespread use.The enzyme mark that belongs to the on-radiation assay method exempt from service determination method certainly will become after an exempt from service trend of detection method of human body.Because it is multi-disciplinary big comprehensive that the development of full-automatic chemical luminescence immunoassay instrument relates to light, electricity, machinery, computing machine, chemistry etc., the research and development of present domestic pertinent instruments also are in the starting stage.
Single photon counting is a kind of common method that faint light detects, traditional single photon counter is made up of many parts such as photomultiplier, high-tension circuit, bleeder circuit, preamplifier circuit, amplitude discriminator circuit, frequency divider sum counters, parts are more, requirement to each several part is also higher, particularly at aspects such as speed, propagation delay times.And require that each components is equipped with well each other, co-ordination, so difficultly accomplish good dynamic perfromance.
The utility model content
The technical problems to be solved in the utility model provides a kind of exempt from service low light level detection system of analyser of full-automatic liquid chemiluminescence that is used for, this system construction one dynamically, flexibly, the darkroom system that is suitable for, the luminous quantity of chemical reagent can be transferred to photoelectricity testing part effectively, efficiently, and remove useless veiling glare and disturb, and the faint optical signal that detects is measured accurately.
The technical scheme that its technical matters that solves the utility model adopts is: a kind of exempt from service low light level detection system of analyser of full-automatic liquid chemiluminescence that is used for comprises darkroom system, Optical Fiber Transmission device, integrated-type photon counting probe and signal processing circuit; Chemical reagent, luminous agent and human serum in the system of darkroom, mix, react and hatch after can produce the light of varying strength, this faint light is sent to the light receiving window of integrated-type photon counting probe tip by the Optical Fiber Transmission device, opto-electronic conversion through integrated-type photon counting probe is handled, export a voltage pulse signal with fixed pulse amplitude and width, count processing by signal processing circuit, end product is uploaded to computing machine.
Described darkroom system is made up of reaction cup, reaction cup support, fiber connector, stainless-steel tube and optical fiber, and the bonding probe that forms a whole of this fiber connector, stainless-steel tube and optical fiber places in the reaction cup, and this reaction cup is inserted reaction cup support.
Described Optical Fiber Transmission device is made up of fiber connector, stainless-steel tube, optical fiber, optical fiber head connector, optical fiber head Connection Block and optical filter; The integral body probe that this fiber connector, stainless-steel tube and optical fiber are formed enters reaction cup behind definite position, props up the darkroom system that is configured to reaction cup; This optical fiber head Connection Block closely is connected with described integrated-type photon counting probe, and wherein, the optical fiber head connector inserts optical fiber head Connection Block, the embedded tablet filter of optical fiber head Connection Block.
It is 1mm that described optical fiber adopts silica fibre, internal diameter.
The beneficial effect that the utility model produced is:
1, an end of reaction cup, reaction cup support and Optical Fiber Transmission device constitutes an independently darkroom jointly, and promptly a reaction cup is exactly an independently darkroom, does not disturb mutually, and is simple in structure, easy to detect, is applicable to the batch detection of full-automatic chemical light-emitting appearance.
2, adopt the Optical Fiber Transmission device to carry out the light conduction, conducting path is flexible, helps the installation of photoelectric detector.The embedded a slice 425nm of one end optical filtering place of Optical Fiber Transmission device, the interference of effectively removing parasitic light.
3, reaction cup adopts one-time formed glass cylinder, can reuse after cleaning, can not cause any pollution.
4, the utility model adopts integrated-type photon counting probe that photomultiplier, high-tension circuit, bleeder circuit, prime amplifier, amplitude discriminator and pulse shaper height are integrated, the volume miniaturization, the structure close mode, one encapsulation antijamming capability is strong, dynamic perfromance is good, can the pulsing broadening, overlapping phenomenon, and follow-up signal to measure building of treatment circuit simple and convenient.
Description of drawings
Below in conjunction with accompanying drawing and embodiment the utility model is described in further detail:
Fig. 1 is the theory diagram of the utility model low light level detection system;
Fig. 2 is the structural representation of darkroom system in the utility model;
Fig. 3 is the structural representation of Optical Fiber Transmission device in the utility model.
Wherein, A is that darkroom system, B are that Optical Fiber Transmission device, C are that integrated-type photon counting probe, D are signal processing circuits, the 1st, optical fiber, the 2nd, stainless-steel tube, the 3rd, fiber connector, the 4th, reaction cup support, the 5th, reaction cup, the 6th, confined space, the 8th, the optical fiber head connector, the 9th, optical fiber head Connection Block, the 10th, optical filter.
Embodiment
The principle of the utility model low light level detection system is as shown in Figure 1: this system partly is made up of the A of darkroom system, Optical Fiber Transmission device B, integrated-type photon counting probe C and signal processing circuit D etc.Chemical reagent, luminous agent and human serum etc. mix in the A of darkroom system, reaction and hatch after can produce the light of varying strength, this faint light is sent to the light receiving window on integrated-type photon counting probe C top by Optical Fiber Transmission device B, incide the photoelectric surface of inner photomultiplier, inspire electronics, behind electron multiplication repeatedly, collected and export a current impulse by anode, be converted to potential pulse and amplification by amplifier again, screen through high-speed comparator, be converted to a potential pulse output after the shaping with fixed pulse amplitude and width, D counts processing by signal processing circuit, and end product is uploaded to computing machine.
The darkroom A of system of the present utility model is made up of reaction cup 5, reaction cup support 4, fiber connector 3, stainless-steel tube 2 and optical fiber 1, as shown in Figure 2.Reaction cup 5 adopts one-time formed rectangular glass cylinder, the long 6mm of reaction cup 5 inwall bores, wide 4mm, high 40mm.Reaction cup support 4 comprises ten reaction cups by the light-proof material one-shot forming, can insert ten reaction cup 5 simultaneously.Fiber connector 3 is injection molded, adopts nonrigid plastic, can effectively prevent light leak.Fiber connector 3, stainless-steel tube 2 and optical fiber 1 is the suitable adhesive probe that forms a whole in addition, can free in and out reaction cup 5 under the cooperation of motion.When integral body probe enters reaction cup 5 after determine the position, it and reaction cup support 4 constitute the confined space 6 of a dark, just darkroom.The luminous quantity of reagent is transferred to the light receiving window of integrated-type photon counting probe C in the darkroom by Optical Fiber Transmission device B.
Optical Fiber Transmission device B of the present utility model is made up of an optical fiber and two connectors.Specifically, form by optical fiber head connector 8, optical fiber head Connection Block 9 and optical filter 10 among fiber connector among Fig. 23, stainless-steel tube 2, optical fiber 1 and Fig. 3.One and the reaction cup support 4 formation darkrooms of Optical Fiber Transmission device B, the other end closely is connected by optical fiber head Connection Block 9 and integrated-type photon counting probe C, wherein optical fiber head Connection Block 9 embedded tablet filters 10.Use Optical Fiber Transmission device B that the luminous transmission of reagent in the reaction cup 5 is arrived photoelectricity testing part (integrated-type photon counting probe C), transmission path is flexible, can freely carry out suitable bending, and the internal diameter of optical fiber 1 is 1mm.Optical filter 10 is a narrow band pass filter, the centre wavelength of optical filter 10 be 425 ± 2nm, bandwidth be 15nm, be of a size of 11.5 * 11.5 square.
The CH254 type photon counting probe that integrated-type photon counting probe C of the present utility model adopts Beijing Hamamatsu Technology Co., Ltd. to produce.This product can the direct voltage output pulse, and be convenient to the subsequent conditioning circuit direct census and use, and can be according to using needs regulate its operating voltage.This probe maximum count rate is more than or equal to the 5M per second.The integrated degree of this integrated-type photon counting probe C is high, and volume is little, the whole barrier enclosure that adopts, and antijamming capability is strong.
Signal processing circuit D of the present utility model is made up of 8 single-chip microcomputers of binary counter and little core company.Wherein binary counter adopts 4 scale-of-two synchronous counter 74F161AD, and its count frequency is up to 32MHz, and has the carry look ahead function.Single-chip microcomputer uses 8 CMOS flash memory single-chip microcomputer PIC16F917 that adopt the nanowatt technology, and the incoming frequency of oscillator/clock is DC-20MHz, and the instruction cycle is DC-200ns.The potential pulse of integrated-type photon counting probe C output is crossed counter at specific time back warp and is counted, and is read count results and is sent to computing machine by single-chip microcomputer.Signal processing circuit D's is simple in structure, is easy to realize.
This system be fully-automatic analyzer when carrying out batch detection, construct one dynamically, flexibly, the darkroom system that is suitable for; The luminous quantity of chemical reagent is transferred to photoelectricity testing part effectively, efficiently, and removes useless veiling glare and disturb; The faint optical signal that detects is measured accurately; Digital signal after the metering is carried out relevant treatment and is transferred to computer.
Claims (7)
1. one kind is used for the exempt from service low light level detection system of analyser of full-automatic liquid chemiluminescence, it is characterized in that this system comprises darkroom system, Optical Fiber Transmission device, integrated-type photon counting probe and signal processing circuit; Chemical reagent, luminous agent and human serum in the system of darkroom, mix, react and hatch after can produce the light of varying strength, this faint light is sent to the light receiving window of integrated-type photon counting probe tip by the Optical Fiber Transmission device, opto-electronic conversion through integrated-type photon counting probe is handled, export a voltage pulse signal with fixed pulse amplitude and width, count processing by signal processing circuit, end product is uploaded to computing machine.
2. the exempt from service low light level detection system of analyser of full-automatic liquid chemiluminescence that is used for according to claim 1, it is characterized in that, described darkroom system is made up of reaction cup, reaction cup support, fiber connector, stainless-steel tube and optical fiber, the bonding probe that forms a whole of this fiber connector, stainless-steel tube and optical fiber places in the reaction cup, and this reaction cup is inserted the reaction cup support.
3. the exempt from service low light level detection system of analyser of full-automatic liquid chemiluminescence that is used for according to claim 2, it is characterized in that, described reaction cup adopts one-time formed rectangle glass reaction cup, the long 6mm of inwall bore of this reaction cup, wide 4mm, high 40mm, described reaction cup support can be placed 10 reaction cup.
4. the exempt from service low light level detection system of analyser of full-automatic liquid chemiluminescence that is used for according to claim 1, it is characterized in that described Optical Fiber Transmission device is made up of fiber connector, stainless-steel tube, optical fiber, optical fiber head connector, optical fiber head Connection Block and optical filter; The integral body probe that this fiber connector, stainless-steel tube and optical fiber are formed enters reaction cup behind definite position, props up the darkroom system that is configured to reaction cup; This optical fiber head Connection Block closely is connected with described integrated-type photon counting probe, and wherein, the optical fiber head connector inserts optical fiber head Connection Block, the embedded tablet filter of optical fiber head Connection Block.
5. the exempt from service low light level detection system of analyser of full-automatic liquid chemiluminescence that is used for according to claim 4, it is characterized in that, described optical filter is a narrow band pass filter, the centre wavelength of described optical filter be 425 ± 2nm, bandwidth be 15nm, be of a size of 11.5 * 11.5 square.
6. according to each described exempt from service low light level detection system of analyser of full-automatic liquid chemiluminescence that is used for of claim 2-5, it is characterized in that it is 1mm that described optical fiber adopts silica fibre, internal diameter.
7. the exempt from service low light level detection system of analyser of full-automatic liquid chemiluminescence that is used for according to claim 1 is characterized in that, described signal processing circuit is made up of high speed binary counter and little core company low-power scm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202148760U CN201653882U (en) | 2009-12-31 | 2009-12-31 | Dim light detection system for full-automatic liquid-phase chemical luminescence exemption analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202148760U CN201653882U (en) | 2009-12-31 | 2009-12-31 | Dim light detection system for full-automatic liquid-phase chemical luminescence exemption analyzer |
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| Publication Number | Publication Date |
|---|---|
| CN201653882U true CN201653882U (en) | 2010-11-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009202148760U Expired - Fee Related CN201653882U (en) | 2009-12-31 | 2009-12-31 | Dim light detection system for full-automatic liquid-phase chemical luminescence exemption analyzer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102297857A (en) * | 2011-08-05 | 2011-12-28 | 山东优生医疗科技有限公司 | Intelligent red blood cell folate detector and detection method |
| CN102331493A (en) * | 2011-06-15 | 2012-01-25 | 上海丰汇生物研究有限公司 | Reusable reaction vessel for use on chemiluminesent immunoassay analyzer |
-
2009
- 2009-12-31 CN CN2009202148760U patent/CN201653882U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102331493A (en) * | 2011-06-15 | 2012-01-25 | 上海丰汇生物研究有限公司 | Reusable reaction vessel for use on chemiluminesent immunoassay analyzer |
| CN102331493B (en) * | 2011-06-15 | 2014-03-19 | 湖南康博生物科技有限公司 | Reusable reaction vessel for use on chemiluminesent immunoassay analyzer |
| CN102297857A (en) * | 2011-08-05 | 2011-12-28 | 山东优生医疗科技有限公司 | Intelligent red blood cell folate detector and detection method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101124 Termination date: 20151231 |
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| EXPY | Termination of patent right or utility model |