CN201517079U - Device for purifying and concentrating sodium hyaluronate fermentation liquor - Google Patents
Device for purifying and concentrating sodium hyaluronate fermentation liquor Download PDFInfo
- Publication number
- CN201517079U CN201517079U CN2009201469641U CN200920146964U CN201517079U CN 201517079 U CN201517079 U CN 201517079U CN 2009201469641 U CN2009201469641 U CN 2009201469641U CN 200920146964 U CN200920146964 U CN 200920146964U CN 201517079 U CN201517079 U CN 201517079U
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- purifying
- tank
- jar
- resin
- fermented liquid
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Abstract
The utility model discloses a device for purifying and concentrating sodium hyaluronate fermentation liquor which is characterized in that the device at least comprises a reaction tank, wherein a stainless steel filter screen is arranged on the lower portion in the tank, resin is filled on the filter screen, a material inlet, a compression air inlet, an air discharge port, a brine inlet, a viewing mirror and a pressure meter are arranged on the upper portion of the tank wall, a mixed air inlet, a water inlet and a water outlet are arranged on the lower portion of the tank, the lateral face of the tank is provided with a liquid level gauge, a material outlet, a circulating water inlet and a circulating water outlet, and the reaction tank is provided with a baffle layer. The device enables sodium hyaluronate fermentation liquor to finish purification dewatering and concentration to generate settlement in the tank, lowers the protein content in the settlement to be smaller than or equal to 0.05 the endotoxin is smaller than or equal to 0.01Eu, and the solution clarity is bigger than or equal to 99%, thereby greatly purifying the sodium hyaluronate, providing excellent foundation for next steps, saving the consumption of ethanol by 50% simultaneously, saving cost, and improving the product quality.
Description
Affiliated technical field
The utility model relates to a kind of purifying and concentrates hyaluronate sodium fermented liquid device, relates to a kind of device that utilizes the resin method purifying to concentrate the hyaluronate sodium fermented liquid.
Background technology:
Hyaluronic acid sodium content in the fermented liquid of China's fermentative production hyaluronate sodium is about 0.3% at present, usually extracting method is that fermented liquid is squeezed in 3 times 95% ethanol, make hyaluronic acid produce the flocculence precipitation, also many impurity and intracellular toxin are also got off with hyaluronic acid is precipitated simultaneously.According to mensuration protein content≤0.1 in the spissated hyaluronate sodium throw out of traditional method purifying, intracellular toxin≤0.5Eu, clarity of solution 〉=98% is for later filtration causes very big difficulty.The utility model provides a kind of device that utilizes the resin method purifying to concentrate the hyaluronate sodium fermented liquid, by protein content≤0.05 in the spissated hyaluronate sodium throw out of this device purifying, intracellular toxin≤0.01Eu, clarity of solution 〉=99%, greatly purifying hyaluronate sodium.Simultaneously can save ethanol 50% above consumption, save cost, improve the quality of product.
The utility model content
The utility model provides a kind of purifying and concentrates hyaluronate sodium fermented liquid device, relates to a kind of device that utilizes the resin method purifying to concentrate the hyaluronate sodium fermented liquid.It is characterized in that device comprise at least a retort, jar in below establish be filled with resin on stainless steel filtering net, the filter screen, opening for feed, compressed air inlet, venting port, salt water inlet, visor, tensimeter are arranged at tank skin top; The air intlet of stirring, water-in, water port are arranged at the bottom of jar; There are liquidometer, discharge port, circulating water intake, circulating water outlet in the side of jar; The outer wall of retort has interlayer.
This device can be finished the hyaluronate sodium fermented liq purifying dehydration and concentrate and produce precipitation in jar, make that protein content drops in the throw out≤and 0.05, intracellular toxin≤0.01Eu, clarity of solution 〉=99%.Thereby greatly purifying hyaluronate sodium, for next procedure provides good basis, simultaneously can save ethanol 50% consumption, saved cost, improved the quality of product.
The new solution of finishing above-mentioned purpose is as follows:
A kind of purifying concentrates hyaluronate sodium fermented liquid device.It is characterized in that comprising at least that a retort, jar are that stainless steel or enamel are made, stainless steel can be used SUS304 sheet material; Below in jar stainless steel filtering net is arranged, filter screen is 200 orders, places 1/5 place of tank body; But potting resin on the filter screen, resin are the macroreticular strongly basic anion exchange resins, and model is Amberlite IRA900; Dowex1*1, loading level are 1/4 of tank volume; Opening for feed, compressed air inlet, salt water inlet, venting port, visor, tensimeter are arranged at tank skin top; The air intlet of stirring, water-in, water port are arranged at the bottom of jar; There are liquidometer, discharge port, circulating water intake, circulating water outlet in the side of jar; The retort interlayer.
Description of drawings:
A kind of purifying of Fig. 1 concentrates hyaluronate sodium fermented liquid device synoptic diagram:
1, retort 2, stainless steel filtering net 3, resin 4, opening for feed 5, compressed air inlet 6, salt water inlet 7, venting port 8, visor 9, tensimeter 10, stirring air intlet 11, water-in 12, water port 13, recirculated water inlet 14, circulating water outlet, 15, liquidometer 16, discharge port 17, retort interlayer.
Embodiment:
Enforcement of the present utility model is like this: purchase enamel reactor or get stainless steel SUS304 sheet material, make the retort 1 of similar reactor, stainless steel filtering net 2 is arranged below in jar, filter screen is 200 orders, places 1/5 place of tank body; But potting resin 3 on the filter screen, and resin is the macroreticular strongly basic anion exchange resin, and model is Amberlite IRA900; Dowex1*1, loading level are 1/4 of tank volume; Opening for feed 4, compressed air inlet 5, salt water inlet 6, venting port 7, visor 8, tensimeter 9 are arranged at tank skin top; The air intlet 10 of stirring, water-in 11, water port 12 are arranged at the bottom of jar; There are recirculated water inlet 13, circulating water outlet 14, liquidometer 15, discharge port 16 in the side of jar; Retort interlayer 17.
Production process is: the resin 3 that will clean is filled into above the stainless steel filtering net 2 in jar 1, and loading level is 1/4 of a tank volume; Inject the hyaluronate sodium fermented liquid from opening for feed 4, temperature remains on about 45 ℃, and the filtered air of stirring air intlet 10 feedings from pot bottom carries out pneumatic blending, makes resin 3 absorption 5 hours; From water port 12 mother liquor of draining, mother liquor can collect as fertilizer; When the mother liquor discharging is slow, can quicken discharging by compressed air pipe 5 pressurizations on jar top; After racking up mother liquor, put into pure water by the water inlet pipe 11 of jar bottom, resin several in the purge tank, bubbling air 10 stirs simultaneously, quickens cleaning speed, washes a large amount of impurity off; Bleed off washing water by lower drain port 12 then; Add 5% salt solution by jar top salt water inlet 6, pneumatic blending 3 hours, it is standby to collect washings, and the continuous washing secondary is collected the merging washings.
Claims (4)
1. a purifying concentrates hyaluronate sodium fermented liquid device, be particularly related to a kind of device that utilizes the resin method purifying to concentrate the hyaluronate sodium fermented liquid, it is characterized in that comprising at least a retort (1), have and be filled with resin (3) on stainless steel filtering net (2), the filter screen below in jar; Opening for feed (4), compressed air inlet (5), salt water inlet (6), venting port (7), visor (8), tensimeter (9) are arranged at tank skin top; Stirring air intlet (10), water-in (11), water port (12) are arranged at the bottom of jar; There are recirculated water inlet (13), circulating water outlet (14), liquidometer (15), discharge port (16) in the side of jar; Retort has interlayer (17).
2. a kind of purifying as claimed in claim 1 concentrates hyaluronate sodium fermented liquid device, and its feature can be that stainless steel, enamel material are made in retort (1); Stainless material is SUS304.
3. a kind of purifying as claimed in claim 1 concentrates hyaluronate sodium fermented liquid device, it is characterized in that a jar interior following filter screen (2), is 200 purpose stainless steel filtering nets; 1/5 place of position at the tank body height is set.
4. a kind of purifying as claimed in claim 1 concentrates hyaluronate sodium fermented liquid device, it is characterized in that being filled with in the jar resin (3), and resin is the macroreticular strongly basic anion exchange resin, and model is Amberlite IRA900; Dowex1*1; Loading level is 1/4 of a tank volume.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201469641U CN201517079U (en) | 2009-03-28 | 2009-03-28 | Device for purifying and concentrating sodium hyaluronate fermentation liquor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201469641U CN201517079U (en) | 2009-03-28 | 2009-03-28 | Device for purifying and concentrating sodium hyaluronate fermentation liquor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201517079U true CN201517079U (en) | 2010-06-30 |
Family
ID=42497799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009201469641U Expired - Fee Related CN201517079U (en) | 2009-03-28 | 2009-03-28 | Device for purifying and concentrating sodium hyaluronate fermentation liquor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201517079U (en) |
-
2009
- 2009-03-28 CN CN2009201469641U patent/CN201517079U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100630 Termination date: 20160328 |