CN201431696Y

CN201431696Y - Percutaneous absorption and leading-in device for biomacromolecule composition

Info

Publication number: CN201431696Y
Application number: CN2009200933624U
Authority: CN
Inventors: 冯来坤
Original assignee: Individual
Current assignee: Feng Laikun
Priority date: 2009-04-08
Filing date: 2009-04-08
Publication date: 2010-03-31
Anticipated expiration: 2019-04-08

Abstract

The utility model provides a percutaneous absorption and leading-in device for biomacromolecule composition. A leading-in probe is arranged at the bottom part of a leading-in body support saddle whilea buckled cover is arranged at the top part thereof, the leading-in probe comprises an anodal, a cathode and an insulating layer therebetween and is connected with a power supply, and a plurality offlow guide holes are formed on the cathode and are communicated with a liquid guide bottle bayonet via a flow guide tube. The utility model can realize not only efficient percutaneous absorption of the composition (biomacromolecule containing high molecular weights) of various molecular weights but also easier efficient percutaneous absorption of common non-biomacromolecule composition. As provedby experiments, the device can realize efficient percutaneous absorption of immunoglobrin G of biomacromolecule, and achieve efficient percutaneous absorption of Human Insulin Humulin (biomacromolecule), thereby generating favorable hypoglycemic effect for diabetic patients; and the device can also achieve efficient percutaneous absorption of growth factors (biomacromolecule) of human epithelial cells, thereby achieving remarkable beautifying functions such as skin-tendering and wrinkle-removing, and which can be applied in the fields of medical treatment, beautification, health-care, scientific research, etc.

Description

A kind of biomacromolecule composition Transdermal absorption gatherer

Technical field

This utility model provides a kind of biomacromolecule composition Transdermal absorption gatherer, is used for the efficient Transdermal absorption of various compositions, belongs to the medical apparatus technical field.

Background technology

Application on human skin is made of for three layers epidermis, corium and subcutaneous connective tissue.Horny layer is the part of epidermis, is positioned at the outermost layer of skin.Medicine or nutritional labeling, especially the biggest obstacle of biomacromolecule isoreactivity composition Transdermal absorption is to be positioned at outermost horny layer.The Transdermal absorption of biomacromolecule is the difficult problem of countries in the world research always, and does not thoroughly solve.Studies have shown that in a large number when skin was smeared merely, the transdermal absorption factor of micromolecule composition was no more than 1%, and the transdermal absorption factor of biomacromolecule composition is almost nil.

If can solve the especially Transdermal absorption problem of biomacromolecule of effective ingredient, will bring huge benefits and change to the human lives.Such as, diabetics is wanted lifelong insulin injection, and will inject 2-3 time every day, very painful.If can make the insulin Transdermal absorption, then can exempt patient's misery of injection throughout one's life.For another example, proved now multiple bioactie agent (as epithelical cell growth factor, EGF) have the beautification function of significant skin care wrinkle removing, but because of its can not Transdermal absorption, so can only intradermal injection use, and the injection beauty treatment almost can't be accepted and be difficult to promote.If can make EGF Transdermal absorption under the situation of not injecting, then bioactie agent will be very extensive in the application of beauty treatment fields.

Summary of the invention

This utility model provides a kind of biomacromolecule composition Transdermal absorption gatherer, has solved the problem of the efficient Transdermal absorption of biomacromolecule, has realized the Transdermal absorption of medicine and other various effective ingredient.

Technical solution of the present utility model is as follows: be provided with at importing body rest base and import probe, the top is the button cover, importing probe is formed and is connected with power supply with negative pole and insulating barrier at interval thereof by anodal, offer some pod apertures on the negative pole, pod apertures is communicated with drain bottle bayonet socket by mozzle.

In use, with being housed, the cillin bottle that imports medicinal liquid is inserted on the drain bottle bayonet socket, install the movable ingress pipe and the barometric pipe of mozzle, liquid can arrive the pod apertures of the electrode tip that imports probe by catheter, and flow on the skin, simultaneously, air enters cillin bottle by barometric pipe, to keep the pressure of the inside of a bottle balance.After the energized, promptly between the both positive and negative polarity that imports probe, form constant voltage, after importing head and contact skin, form little electric current in the skin.Under electric field action, the path and the intercellular substance that see through skin surface formation enter Skin Cell surrounding space and subcutaneous tissue from the effusive medicinal liquid of tap hole, thereby realize Transdermal absorption.

When using this utility model device effect skin, the electrode that imports probe produces little electric current and electric microfield, thereby generation moment micro-channel can take place to reset in moment in Skin Cell, the effective ingredient that imports in the liquid has specific electric charge, under the effect of electric field force, the instant channel that will produce by skin and Transdermal absorption.The degree of depth of Transdermal absorption, strong and weak different because of the size of electric current and electric field can artificially be regulated.

This device can be reset corneocyte under the pulse voltage effect, permeability can significantly improve; Under little function of current, the body of gland that is arranged in skin can be opened gradually, thereby cutaneous permeability is further strengthened.Active component sees through skin along intercellular substance, body of gland and other passages and enters in the body under the electric field force effect, and then combines with cell surface receptor, active cell signaling system, performance dependent interaction.

Human normal immunoglobulin's molecular weight almost is a molecular weight maximum in the biomacromolecule up to 150,000.When immunoglobulin G while is smeared at simple skin, can not Transdermal absorption, import and carry out Transdermal absorption with this utility model device, its absorbance is up to 87.6%.The degree of depth of Transdermal absorption can artificially be controlled, and simple to operate, and is easy to use, and no pain to skin zero damage, finds no side effect.

Good effect of the present utility model is: the efficient Transdermal absorption of composition (biomacromolecule of pbz polymer amount) that is used to make various molecular weight, the more easily efficient transdermal of general abiotic macromolecular components is absorbed, show that as experiment this device can make the efficient Transdermal absorption of biomacromolecule immunoglobulin G; Can make the efficient Transdermal absorption of insulin human (biomacromolecule), and diabetic is had good blood sugar reducing function; Also can make the efficient Transdermal absorption of human epidermal growth factor (biomacromolecule), thereby have beautification functions such as significant skin care, wrinkle removing.Can be widely used in fields such as medical treatment, beauty treatment, health care, scientific research.

Description of drawings

Fig. 1 is this utility model structure principle chart;

Fig. 2 is the skin contact structure principle chart of this utility model probe.

The specific embodiment

According to shown in Figure 1, be provided with probe socket 7 and import probe 8 importing body bearing 4 bottoms, the top for button cover 1 by buckle 2 with import body bearing 4 and be connected, importing is popped one's head in

Be made up of positive pole 9 and negative pole 11, positive pole 9 and negative pole 11 are cut off by insulating barrier 10 therebetween, and are connected (referring to Fig. 2) with power supply 6, offer some pod apertures 12 on the negative pole 11, and pod apertures 12 is communicated with drain bottle bayonet socket 3 by mozzle 5.

Claims

1, a kind of biomacromolecule composition Transdermal absorption gatherer, it is characterized in that: be provided with probe socket and import probe at importing body rest base, the top is the button cover, import probe by anodal and negative pole and spacer insulator layer is formed and be connected with power supply, offer some pod apertures on the negative pole, pod apertures is communicated with drain bottle bayonet socket by mozzle.