CN201404282Y - Antibacterial peptide carrying slow release bone screw - Google Patents
Antibacterial peptide carrying slow release bone screw Download PDFInfo
- Publication number
- CN201404282Y CN201404282Y CN2009201264463U CN200920126446U CN201404282Y CN 201404282 Y CN201404282 Y CN 201404282Y CN 2009201264463 U CN2009201264463 U CN 2009201264463U CN 200920126446 U CN200920126446 U CN 200920126446U CN 201404282 Y CN201404282 Y CN 201404282Y
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- screw
- bone screw
- antibacterial peptide
- slow release
- bone
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Abstract
The utility model discloses an antibacterial peptide carrying slow release bone screw. The antibacterial peptide carrying slow release bone screw comprises a bone screw; and the bone screw comprises ascrew head (1) and a screw rod (2). The antibacterial peptide carrying slow release bone screw is characterized in that antibacterial peptide slow release layers (3) are coated on the outer surfacesof the screw head (1) and the screw rod (2); and each antibacterial peptide slow release layer (3) adopts a hydroxyapatite coating combined with beta defensin one to three or lactoferrin one to eleven. The utility model has multifunctional efficiencies in powerful infection resistance, bacteria biological membrane formation suppression, I-stage bone fracture therapy, and the like; the bone screw can give off beta defensin one to three or lactoferrin one to eleven from the inside out in certain time in early stage, so as to suppress and destroy the formation of a biological membrane, fundamentally change the action mode of a conventional antibiotic, solve the technical problem that antibacterial peptide is not high-temperature resistant, suppress the formation and the development of the biological membrane directly, and obtain the curative effect in preventing fixed articles from infecting each other.
Description
Technical field
This utility model belongs to the surgery medical material, specifically, is the bone screw that a kind of outer surface is coated with the antibacterial peptide slow release layer.
Background technology
Open fracture post-operative infection rate reaches 3～29% in daily; In the wartime firearm injury, because tissue injury and seriously polluted, 0.5cm has a large amount of antibacterials to exist with interior around trajectory, even the infection rate of bone and soft tissue is still up to 25%～40% after the debridement, as use internal fixation then infection rate increase more than 30%.Therefore, wound type osteomyelitis is not well solved always.General traditional Therapeutic Method: use surgical means such as thorough debridement or focal cleaning to remove most of antibacterial earlier; On this basis, use the temporary fixed fracture site of exterior fixation bracket; The heavy dose of antibiotic of whole body or topical application is eliminated residual antibacterial; Treat that wound closes.Go fixedly fracture site of internal fixation method such as intramedullary pin after determine not have infecting again.Intramedullary pin and locking then are regarded as taboo with internal fixation such as screws in open fracture and firearm injury, this is because antibacterial and implant material adhere to and form the main pathological basis that complete biomembrane is the fixture infections relating, and accounting for the deep, staphylococcus aureus and staphylococcus epidermidis detect 70～90% of antibacterial, wherein methicillin-resistant gold Portugal bacterium about 60%, recently even VRSA occurred, cause the clinical available severe situation of antibiotic-free that faces.And, when give bone screw to other synthetism material in locking, fixedly the time, residual pathogenic bacterium can adhere on fixture and a large amount of breeding, the formation biomembrane heightens its virulence, head and shoulders above the antibacterial ability of the traditional application process of antibiotic.Therefore, the use external fixation is arranged also, but external fixation have pin site infection rate height (5.9%～19%), in metaphysis fracture, be difficult for fixing, draw point is loosening and have a strong impact on patient's life, be not easy to shortcoming such as nursing.
The utility model content
Technical problem to be solved in the utility model is to provide a kind of powerful infection and suppresses the film formed sustained-release antimicrobial peptide bone screw of bacterium living beings.
The technical solution of the utility model is as follows: a kind of sustained-release antimicrobial peptide bone screw, comprise bone screw, this bone screw is made up of screw head and shank of screw, it is characterized in that: the outer surface of described screw head and shank of screw all is coated with the antibacterial peptide slow release layer, and described antibacterial peptide slow release layer is the hydroxyapatite coating layer that is combined with beta-alexin-1～3 or lactoferrin 1-11.
Local different according to what use, there are some bone screws to have through hole on axially, be hollow type.There are some shanks of screw to have screw thread by the top of screw head.There are some shank of screw bottoms to have screw thread.Have some screw head end faces to have mounting groove, this mounting groove connects the screw head both sides, and this mounting groove top is rectangle, and the bottom is circular.Have some screw head end faces to have screw, this screw hole wall top symmetry has breach.There are some screw head outer circumference surfaces to have screw thread.
Beneficial effect: the utlity model has powerful infection and suppress that bacterial biof iotalm forms and the I phase treats to fracture etc. and has multi-efficiency, bone screw is the early stage release beta-alexin-1～3 or the lactoferrin 1-11 of from-inner-to-outer within a certain period of time, the directly formation of inhibition and disrupting biofilm, fundamentally changed traditional antibiotic model of action, and solved the technical barrier that antibacterial peptide can not withstand high temperatures, directly suppress biomembranous formation and development, obtain the curative effect of prevention fixture infections relating.
Description of drawings
Fig. 1 is the structural representation of embodiment 1;
Fig. 2 is the structural representation of embodiment 1;
Fig. 3 is the structural representation of embodiment 2;
Fig. 4 is the structural representation of embodiment 3;
Fig. 5 is the structural representation of embodiment 4;
Fig. 6 is the structural representation of embodiment 5;
Fig. 7 is the structural representation of embodiment 6;
The specific embodiment
The utility model is described in further detail below in conjunction with drawings and Examples:
Embodiment 1
As shown in Figure 1 and Figure 2, a kind of sustained-release antimicrobial peptide bone screw of this utility model, this bone screw is made up of screw head 1 and shank of screw 2, the outer surface of described screw head 1 and shank of screw 2 all is coated with sustained-release antimicrobial peptide layer 3, and described antibacterial peptide slow release layer 3 is for being combined with the hydroxyapatite coating layer of beta-alexin-1.The locking that can be used as blade plate is used.
As shown in Figure 3, a kind of sustained-release antimicrobial peptide bone screw of this utility model, this bone screw is made up of screw head 1 and shank of screw 2, described screw head 1 end face has mounting groove 1a, this mounting groove 1a connects screw head 1 both sides, this mounting groove 1a top is rectangle, and the bottom is circular, is pedicle screw.The outer surface of described screw head 1 and shank of screw 2 all is coated with sustained-release antimicrobial peptide layer 3, and described antibacterial peptide slow release layer 3 is for being combined with the hydroxyapatite coating layer of beta-alexin-2.
As shown in Figure 4, a kind of sustained-release antimicrobial peptide bone screw of this utility model, this bone screw is made up of screw head 1 and shank of screw 2, and described screw head 1 end face has screw, and this screw hole wall top symmetry has breach 1b, is pedicle screw.The outer surface of described screw head 1 and shank of screw 2 all is coated with sustained-release antimicrobial peptide layer 3, and described antibacterial peptide slow release layer 3 is for being combined with the hydroxyapatite coating layer of beta-alexin-3.
Embodiment 4
As shown in Figure 5, a kind of sustained-release antimicrobial peptide bone screw of this utility model, this bone screw is made up of screw head 1 and shank of screw 2, and described screw head 1 outer circumference surface has screw thread.Described shank of screw 2 has screw thread by the top of screw head 1.The bottom does not have screw thread and the supporting use of intramedullary pin.The outer surface of described screw head 1 and shank of screw 2 all is coated with sustained-release antimicrobial peptide layer 3, and described antibacterial peptide slow release layer 3 is for being combined with the hydroxyapatite coating layer of lactoferrin 1-11.
Embodiment 5
As shown in Figure 6, a kind of sustained-release antimicrobial peptide bone screw of this utility model, this bone screw is made up of screw head 1 and shank of screw 2, and described shank of screw 2 bottoms have screw thread, and screw thread is not opened on top.The outer surface of described screw head 1 and shank of screw 2 all is coated with sustained-release antimicrobial peptide layer 3, and described antibacterial peptide slow release layer 3 is for being combined with the hydroxyapatite coating layer of beta-alexin-3.
Embodiment 6
As shown in Figure 7, a kind of sustained-release antimicrobial peptide bone screw of this utility model, this bone screw is made up of screw head 1 and shank of screw 2, has through hole 4 on described bone screw is axial, is hollow type.The outer surface of described screw head 1 and shank of screw 2 all is coated with sustained-release antimicrobial peptide layer 3, and described antibacterial peptide slow release layer 3 is for being combined with the hydroxyapatite coating layer of beta-alexin-1.
Claims (7)
1, a kind of sustained-release antimicrobial peptide bone screw, comprise bone screw, this bone screw is made up of screw head (1) and shank of screw (2), it is characterized in that: the outer surface of described screw head (1) and shank of screw (2) all is coated with antibacterial peptide slow release layer (3), and described antibacterial peptide slow release layer (3) is for being combined with the hydroxyapatite coating layer of beta-alexin-1～3 or lactoferrin 1-11.
2, according to the described sustained-release antimicrobial peptide bone screw of claim 1, it is characterized in that: have through hole (4) on described bone screw is axial.
3, according to claim 1 or 2 described sustained-release antimicrobial peptide bone screws, it is characterized in that: described shank of screw (2) has screw thread by the top of screw head (1).
4, according to claim 1 or 2 described sustained-release antimicrobial peptide bone screws, it is characterized in that: described shank of screw (2) bottom has screw thread.
5, according to the described sustained-release antimicrobial peptide bone screw of claim 1, it is characterized in that: described screw head (1) end face has mounting groove (1a), and this mounting groove (1a) connects screw head (1) both sides, and this mounting groove (1a) top is rectangle, and the bottom is circular.
6, according to the described sustained-release antimicrobial peptide bone screw of claim 1, it is characterized in that: described screw head (1) end face has screw, and this screw hole wall top symmetry has breach (1b).
7, according to the described sustained-release antimicrobial peptide bone screw of claim 1, it is characterized in that: described screw head (1) outer circumference surface has screw thread.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201264463U CN201404282Y (en) | 2009-02-25 | 2009-02-25 | Antibacterial peptide carrying slow release bone screw |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201264463U CN201404282Y (en) | 2009-02-25 | 2009-02-25 | Antibacterial peptide carrying slow release bone screw |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201404282Y true CN201404282Y (en) | 2010-02-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009201264463U Expired - Fee Related CN201404282Y (en) | 2009-02-25 | 2009-02-25 | Antibacterial peptide carrying slow release bone screw |
Country Status (1)
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| CN (1) | CN201404282Y (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889896A (en) * | 2010-07-05 | 2010-11-24 | 苏州市百得医疗器械有限公司 | Hydroxyapatite bone screw |
| CN103893836A (en) * | 2014-04-01 | 2014-07-02 | 浙江大学 | Screw capable of absorbing compound interface and manufacturing method of screw |
| CN104107085A (en) * | 2013-04-17 | 2014-10-22 | 上海市同济医院 | Member connecting rod with accurate and slow drug-dosage releasing function |
| CN108670381A (en) * | 2018-05-25 | 2018-10-19 | 大博医疗科技股份有限公司 | Drug loaded device and its medicine-carrying method for spicule implantation material |
| CN112274282A (en) * | 2020-12-07 | 2021-01-29 | 中日友好医院(中日友好临床医学研究所) | Medicine-carrying orthodontic anchorage nail |
| CN112451137A (en) * | 2020-12-07 | 2021-03-09 | 中日友好医院(中日友好临床医学研究所) | Just abnormal anchorage nail of medicine carrying convenient to remove |
-
2009
- 2009-02-25 CN CN2009201264463U patent/CN201404282Y/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889896A (en) * | 2010-07-05 | 2010-11-24 | 苏州市百得医疗器械有限公司 | Hydroxyapatite bone screw |
| CN104107085A (en) * | 2013-04-17 | 2014-10-22 | 上海市同济医院 | Member connecting rod with accurate and slow drug-dosage releasing function |
| CN104107085B (en) * | 2013-04-17 | 2016-03-23 | 上海市同济医院 | A kind of component connecting rod with the accurate slow-release function of drug dose |
| CN103893836A (en) * | 2014-04-01 | 2014-07-02 | 浙江大学 | Screw capable of absorbing compound interface and manufacturing method of screw |
| CN103893836B (en) * | 2014-04-01 | 2016-01-27 | 浙江大学 | A kind of screw of Absorbable rod compound interface and preparation method |
| CN108670381A (en) * | 2018-05-25 | 2018-10-19 | 大博医疗科技股份有限公司 | Drug loaded device and its medicine-carrying method for spicule implantation material |
| CN108670381B (en) * | 2018-05-25 | 2023-11-28 | 大博医疗科技股份有限公司 | Drug carrying device for bone needle implant and drug carrying method thereof |
| CN112274282A (en) * | 2020-12-07 | 2021-01-29 | 中日友好医院(中日友好临床医学研究所) | Medicine-carrying orthodontic anchorage nail |
| CN112451137A (en) * | 2020-12-07 | 2021-03-09 | 中日友好医院(中日友好临床医学研究所) | Just abnormal anchorage nail of medicine carrying convenient to remove |
| CN112274282B (en) * | 2020-12-07 | 2021-10-22 | 中日友好医院(中日友好临床医学研究所) | Medicine-carrying orthodontic anchorage nail |
| CN112451137B (en) * | 2020-12-07 | 2021-10-26 | 中日友好医院(中日友好临床医学研究所) | Just abnormal anchorage nail of medicine carrying convenient to remove |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100217 Termination date: 20140225 |