CN201389073Y - Bone plate carrying slow release antibiotics - Google Patents
Bone plate carrying slow release antibiotics Download PDFInfo
- Publication number
- CN201389073Y CN201389073Y CN200920127119U CN200920127119U CN201389073Y CN 201389073 Y CN201389073 Y CN 201389073Y CN 200920127119 U CN200920127119 U CN 200920127119U CN 200920127119 U CN200920127119 U CN 200920127119U CN 201389073 Y CN201389073 Y CN 201389073Y
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- blade plate
- antibiotics
- bone plate
- slow
- slow release
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Abstract
The utility model discloses a bone plate carrying slow release antibiotics which comprises a bone plate (1), wherein a mounting hole (1a) is arranged on the bone plate (1). The bone plate carrying slow release antibiotics is characterized in that an antibiotics slow release layer (2) is covered on the outer surface of the bone plate (1), and the slow release layer (2) is a hydroxyapatite coating layer which is combined with antibiotics. The bone plate carrying slow release antibiotics has the behaviors of strongly resisting infection, inhibiting formation of bacteria biological films and treating bone fractures during I period and the like, the bone plate releases antibiotics in the early stage from inside to outside in a certain time, directly kills bacteria, solves the technical difficult problem that antibiotics can not resist high temperature, and obtains the curative effects of preventing relative infection of fixed objects.
Description
Technical field
This utility model belongs to the surgery medical material, specifically, is the blade plate that a kind of outer surface is coated with slow-release antibiotic.
Background technology
Open fracture post-operative infection rate reaches 3～29% in daily; In the wartime firearm injury, because tissue injury and seriously polluted, 0.5cm has a large amount of antibacterials to exist with interior around trajectory, even the infection rate of bone and soft tissue is still up to 25%～40% after the debridement, as use internal fixation then infection rate increase more than 30%.Therefore, wound type osteomyelitis is not well solved always.General traditional Therapeutic Method: use surgical means such as thorough debridement or focal cleaning to remove most of antibacterial earlier; On this basis, use the temporary fixed fracture site of exterior fixation bracket; The heavy dose of antibiotic of whole body or topical application is eliminated residual antibacterial; Treat that wound closes.Go fixedly fracture site of internal fixation method such as steel plate after determine not have infecting again.Then be regarded as taboo at internal fixation such as open fracture and firearm injury light plate screws, this is because antibacterial and implant material adhere to and form the main pathological basis that complete biomembrane is the fixture infections relating, and staphylococcus aureus and staphylococcus epidermidis account for the deep and detect 70～90% of antibacterial, and wherein methicillin-resistant gold Portugal bacterium about 60%.And when giving internal fixation such as steel plate, residual pathogenic bacterium can adhere on fixture and a large amount of breeding, form biomembrane its virulence heightened, head and shoulders above the antibacterial ability of antibiotic tradition application process.Therefore, the use external fixation is arranged also, but external fixation have pin site infection rate height (5.9%～19%), in metaphysis fracture, be difficult for fixing, draw point is loosening and have a strong impact on patient's life, be not easy to shortcoming such as nursing.
The utility model content
Technical problem to be solved in the utility model is to provide a kind of powerful infection and suppresses the film formed carrying slow-release antibiotic blade plate of bacterium living beings.
The technical solution of the utility model is as follows: a kind of carrying slow-release antibiotic blade plate, comprise blade plate, have installing hole on this blade plate, its key is: described blade plate outer surface is coated with the antibiotics slow release layer, and described slow release layer is the hydroxyapatite coating layer that is combined with antibiotics.Carrying slow-release antibiotic blade plate series of products are (New Zealand white rabbit) and external pharmacokinetics detection confirmation in body, have fixedly fracture site and powerful infection and the film formed effect of inhibition bacterium living beings, can keep 28 days effective antibiotic concentration in the part, biomechanical property does not descend.
Above-mentioned antibiotics is penicillins or cephalosporins or beta-lactam or clindamycin class or Macrolide or aminoglycosides or quinolones or glycopeptide class.
Above-mentioned blade plate material is that rustless steel or titanium alloy or multiple materials such as polyphosphazene polymer lactic acid or cobalt molybdenum alloy can use.
The installing hole of above-mentioned blade plate has female thread, as locking bone fracture plate.
Be made as bar shaped according to the above-mentioned blade plate of different needs.Above-mentioned blade plate is made as L shaped.Above-mentioned blade plate is made as Y shape.Above-mentioned blade plate is made as the approximate Herba Trifolii Pratentis of profile.And the blade plate of other required forms.
Beneficial effect: the utlity model has powerful infection and suppress that bacterial biof iotalm forms and the I phase treats to fracture etc. and has multi-efficiency, blade plate is the early stage release antibiotics of from-inner-to-outer within a certain period of time, direct kill bacteria, and solved the technical barrier that antibiotics can not withstand high temperatures, direct kill bacteria, reduce biomembranous formation and development, obtain the curative effect of prevention fixture infections relating.
Description of drawings
Fig. 1 is the structural representation of embodiment 1;
Fig. 2 is the structural representation of embodiment 2;
Fig. 3 is the structural representation of embodiment 3;
Fig. 4 is the structural representation of embodiment 4;
Fig. 5 is the structural representation of embodiment 5;
Fig. 6 is the A-A cutaway view of Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5.
The specific embodiment
The utility model is described in further detail below in conjunction with drawings and Examples:
Embodiment 1
As Fig. 1, shown in Figure 6, a kind of carrying slow-release antibiotic blade plate of this utility model, blade plate 1 material is a rustless steel.Blade plate 1 is bar shaped, have installing hole 1a on this blade plate 1, described blade plate 1 outer surface is coated with slow-release antibiotic 2, and described slow-release antibiotic 2 is for being combined with the hydroxyapatite coating layer of penicillins or cephalosporins or beta-lactam or clindamycin class or Macrolide or aminoglycosides or quinolones or glycopeptide antibiotics.
Embodiment 2
As Fig. 2, shown in Figure 6, a kind of carrying slow-release antibiotic blade plate of this utility model, blade plate 1 material is a titanium alloy.Blade plate 1 is L shaped, has installing hole 1a on this blade plate 1, and this installing hole 1a has the female thread that cooperates with mounting screw.Described blade plate 1 outer surface is coated with carrying slow-release antibiotic layer 2, and described carrying slow-release antibiotic 2 is for being combined with the hydroxyapatite coating layer of penicillins or cephalosporins or beta-lactam or clindamycin class or Macrolide or aminoglycosides or quinolones or glycopeptide antibiotics.
Embodiment 3
As Fig. 3, shown in Figure 6, a kind of carrying slow-release antibiotic blade plate of this utility model, blade plate 1 material is a titanium alloy.Blade plate 1 is L shaped, have installing hole 1a on this blade plate 1, described blade plate 1 outer surface is coated with antibiotics synthetism flaggy 2, and described slow-release antibiotic layer 2 is for being combined with the hydroxyapatite coating layer of penicillins or cephalosporins or beta-lactam or clindamycin class or Macrolide or aminoglycosides or quinolones or glycopeptide antibiotics.
Embodiment 4
As Fig. 4, shown in Figure 6, a kind of carrying slow-release antibiotic blade plate of this utility model, blade plate 1 material is a polyphosphazene polymer lactic acid, and blade plate 1 is a Y shape, has installing hole 1a on this blade plate 1, and this installing hole 1a has the female thread that cooperates with mounting screw.Described blade plate 1 outer surface is coated with slow-release antibiotic layer 2, and described carrying slow-release antibiotic layer 2 is for being combined with the hydroxyapatite coating layer of penicillins or cephalosporins or beta-lactam or clindamycin class or Macrolide or aminoglycosides or quinolones or glycopeptide antibiotics.
Embodiment 5
As Fig. 5, shown in Figure 6, a kind of carrying slow-release antibiotic blade plate of this utility model, blade plate 1 material is a cobalt molybdenum alloy, blade plate 1 is the Herba Trifolii Pratentis shape, have installing hole 1a on this blade plate 1, described blade plate 1 outer surface is coated with slow-release antibiotic layer 2, and described slow-release antibiotic layer 2 is for being combined with the hydroxyapatite coating layer of penicillins or cephalosporins or beta-lactam or clindamycin class or Macrolide or aminoglycosides or quinolones or glycopeptide antibiotics.
Claims (8)
1, a kind of carrying slow-release antibiotic blade plate, comprise blade plate (1), have installing hole (1a) on this blade plate (1), it is characterized in that: described blade plate (1) outer surface is coated with antibiotics slow release layer (2), and described slow release layer (2) is for being combined with the hydroxyapatite coating layer of antibiotics.
2, according to the described carrying slow-release antibiotic blade plate of claim 1, it is characterized in that: described antibiotics is penicillins or cephalosporins or beta-lactam or clindamycin class or Macrolide or aminoglycosides or quinolones or glycopeptide class.
3, according to claim 1 or 2 described carrying slow-release antibiotic blade plates, it is characterized in that: described blade plate (1) material is rustless steel or titanium alloy or polyphosphazene polymer lactic acid or cobalt molybdenum alloy.
4, according to the described carrying slow-release antibiotic blade plate of claim 3, it is characterized in that: the installing hole (1a) of described blade plate (1) has female thread.
5, according to the described carrying slow-release antibiotic blade plate of claim 4, it is characterized in that: described blade plate (1) is bar shaped.
6, according to the described carrying slow-release antibiotic blade plate of claim 4, it is characterized in that: described blade plate (1) is for L shaped.
7, according to described year antibiotics blade plate of claim 4, it is characterized in that: described blade plate (1) is Y shape.
8, according to the described carrying slow-release antibiotic blade plate of claim 4, it is characterized in that: described blade plate (1) profile is approximately Herba Trifolii Pratentis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200920127119U CN201389073Y (en) | 2009-04-24 | 2009-04-24 | Bone plate carrying slow release antibiotics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200920127119U CN201389073Y (en) | 2009-04-24 | 2009-04-24 | Bone plate carrying slow release antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201389073Y true CN201389073Y (en) | 2010-01-27 |
Family
ID=41595888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200920127119U Expired - Fee Related CN201389073Y (en) | 2009-04-24 | 2009-04-24 | Bone plate carrying slow release antibiotics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201389073Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526800A (en) * | 2012-01-05 | 2012-07-04 | 哈尔滨工业大学 | Method for uploading cefazolin sodium medicine film on micro-arc oxidation titanium implant |
| CN104825219A (en) * | 2015-05-03 | 2015-08-12 | 刘乐 | Bone plate for minimally invasive surgery |
-
2009
- 2009-04-24 CN CN200920127119U patent/CN201389073Y/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526800A (en) * | 2012-01-05 | 2012-07-04 | 哈尔滨工业大学 | Method for uploading cefazolin sodium medicine film on micro-arc oxidation titanium implant |
| CN104825219A (en) * | 2015-05-03 | 2015-08-12 | 刘乐 | Bone plate for minimally invasive surgery |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100127 Termination date: 20140424 |