CN201404203Y - implanted biosensor - Google Patents
implanted biosensor Download PDFInfo
- Publication number
- CN201404203Y CN201404203Y CN2009200645735U CN200920064573U CN201404203Y CN 201404203 Y CN201404203 Y CN 201404203Y CN 2009200645735 U CN2009200645735 U CN 2009200645735U CN 200920064573 U CN200920064573 U CN 200920064573U CN 201404203 Y CN201404203 Y CN 201404203Y
- Authority
- CN
- China
- Prior art keywords
- electrode assemblie
- electrode
- biological sensors
- layer
- implantating biological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Abstract
The utility model discloses an implanted biosensor, which comprises a sensor probe consisting of a first electrode component and a second electrode component. The first electrode component is connected with the second electrode component via a conducting wire, the first electrode component is sleeved inside the tubular second electrode component, and the pipe wall of the second electrode componentis equipped with at least one micro-pore. The implanted biosensor is simple and compact in structure, small in volume, fine in stability, high in measuring precision and long in service life.
Description
Technical field
This utility model is mainly concerned with field of biosensors in the armarium, refers in particular to a kind of implantating biological sensors.
Background technology
The portable diagnostic armarium that biosensor technique and microelectronics combine has improved countless people's quality of life.Most of patient of past will stand painful and inconvenience goes to hospital or clinic to confirm the state of an illness, can utilize portable checkout equipment to sit comfortably in now and monitor the state of an illness in the family.
However, field of biosensors still is faced with great challenge, and for example: single clearance-type pick off need puncture finger tip when blood sampling, and this can bring certain misery to the patient; Again for example: patient physiological or pathological parameter variation are subjected to all multifactor influences, its, concentration was unpredictalbe under the influence of various factorss such as ambient temperature, dietetic variety, emotion changes, physical exertion and individual physiological accretion rate moment, so the test of the single in a certain moment can accurately not reflect truth.
The twentieth century end, a kind of implantating biological sensors begins to be employed, and its advantage is some time dependent important physiology or pathological parameter in the METHOD FOR CONTINUOUS DETERMINATION body, the concentration of glucose, lactic acid etc. for example, thus obtain more accurate, more direct basis for estimation.It is the real-time concentration that directly detects in the tissue fluid, can reflect the variation of patient physiological environment really.Yet the development in implantable sensor field is slower, and accurately accurate on the market so far, satisfactory reliable product seldom.
The needs that implantable sensor can not satisfy Clinical detection are influenced by two aspect factors: the one, and the accuracy of biosensor itself, precision have problems, and can not reach the demand of long-term detection; Biocompatibility that the more important thing is pick off can not reach the needs of surveying in health check-up.Biocompatibility is biochemical factor on the one hand, and normal body stops foreign body to be invaded under immunoreactive effect, or the antigenicity foreign body is excreted; About factors such as the size of implant, geometry, surface flatness are all understood on the other hand test result, active substance contacts for a long time on in-vivo tissue cell and the pick off, will the test result of pick off be made a big impact.The patent publication No. of Zhejiang Sheng Meidinuo medical science and technology company limited application is: CN2782015Y, and the utility model name is called in the patent document of " Endermic implantating biological sensors " and has disclosed a kind of electrochemica biological sensor; On sensor construction, this patent optimal way adopts positive and negative two pin type electrodes, and pin type electrode comprises metal needle core and required tested enzyme layer.Implantable sensor need be by problems such as trocar implant into body in the conventional art though this patent has solved, but this patent comes with some shortcomings: for example two die openings are from far away, problems such as the positive and negative electrode relative area is less can have influence on the sensor test precision, the more important thing is that anodal surfactant directly contacts with tissue fluid, high molecular weight protein is easy at anodal surface aggregation, influences pick off service life.
The utility model content
The technical problems to be solved in the utility model just is: at the technical problem that prior art exists, this utility model provide a kind of simple and compact for structure, volume is little, the implantating biological sensors of good stability, certainty of measurement height, long service life.
For solving the problems of the technologies described above, this utility model by the following technical solutions.
A kind of implantating biological sensors, it comprises the sensor probe of being made up of first electrode assemblie and second electrode assemblie, first electrode assemblie links to each other by lead with second electrode assemblie, it is characterized in that: described first electrode assemblie is sheathed in tubulose second electrode assemblie, offers more than one micropore on the tube wall of second electrode assemblie.
As further improvement of the utility model:
The outer wall of described first electrode assemblie is provided with the bio-sensing layer.
The inner tubal wall of described second electrode assemblie is provided with the bio-sensing layer.
The outer tube wall of described second electrode assemblie is provided with biocompatible layer.
Described bio-sensing layer is for to be arranged in order the composite bed that forms by diffusion-restricted layer, bioactive layer.
Be equiped with reference electrode in described tubulose second electrode assemblie.
Described first electrode assemblie and second electrode assemblie are fixed on the one handle, are provided with the socket that links to each other with external wire in the described handle.
Compared with prior art, advantage of the present utility model just is: implantating biological sensors of the present utility model, first electrode assemblie is fixed in tubulose second electrode assemblie, first electrode assemblie and second electrode assemblie have been formed a bipolar electrode test macro, so the very simple compactness of its structure, volume are little, with low cost; Offer many micropores on tubulose second electrode assemblie in this utility model, small-molecule substance can combine with bio-sensing layer upper surface active substance by micropore in the test process, produce current signal, because the spacing distance of first electrode assemblie and second electrode assemblie is shorter, so can produce the current signal bigger than general pick off in the test process; Simultaneously, most of high molecular weight protein is electronegative in people's body fluid, tubulose second electrode assemblie negative charge that the surface produces when work can effectively repel high molecular weight protein and enter sensor internal, with active substance generation non-specific adsorption on the bio-sensing layer, can effectively prolong pick off like this in the intravital use mission of people.
Description of drawings
Fig. 1 is the structural representation of this utility model embodiment 1;
Fig. 2 is the interior outlet structure sketch map of handle among this utility model embodiment 1;
Fig. 3 is the structural representation of sensor probe among this utility model embodiment 1;
Fig. 4 is the structural representation of first electrode assemblie among this utility model embodiment 1;
Fig. 5 is the structural representation of second electrode assemblie among this utility model embodiment 1;
Fig. 6 is the structural representation of sensor probe among this utility model embodiment 2;
Fig. 7 is the structural representation of first electrode assemblie among this utility model embodiment 3;
Fig. 8 is the structural representation of second electrode assemblie among this utility model embodiment 3;
Fig. 9 is this utility model application example sketch map to the glucose responding current signal in phosphate buffer;
Figure 10 is that this utility model first electrode assemblie does not place the sketch map of the inherent phosphate buffer of second electrode assemblie to the glucose responding current signal.
Marginal data:
1, sensor probe 2, handle
3, external wire 4, second electrode assemblie
41, micropore 42, silver or silver chloride layer
43, metal needle tubing 44, biocompatible layer
5, first electrode assemblie 51, metal nook closing member
52, bio-sensing layer 6, fixed bolster
7, socket 8, reference electrode
The specific embodiment
Below with reference to specific embodiment and Figure of description this utility model is described in further details.
Embodiment 1: as Fig. 1, Fig. 2, Fig. 3, Fig. 4 and shown in Figure 5, implantating biological sensors of the present utility model, it comprises the sensor probe of being made up of first electrode assemblie 5 and second electrode assemblie 41, first electrode assemblie 5 links to each other by lead with second electrode assemblie 4, first electrode assemblie 5 and second electrode assemblie 4 are fixed on the one handle 2, be provided with the socket 7 that links to each other with external wire 3 in the handle 2, convenient first electrode assemblie 5 and second electrode assemblie 4 carry out the signal transmission with external instrument, and by it signal are transferred to respective detection equipment.Be provided with a carcass below the handle 2, material should adopt medical hypoallergenic adhesive plaster.First electrode assemblie 5 is an aciculiform, and second electrode assemblie 4 is a tubulose, and first electrode assemblie 5 is sheathed in second electrode assemblie 4 and by fixed bolster 6 and fixes, and offers more than one micropore 41 on the tube wall of second electrode assemblie 4; By this micropore 41, small-molecule substance can be easily contacts with active substance on first electrode assemblies 5 in second electrode assemblie 4 in the tissue fluid.
In the present embodiment, tubulose second electrode assemblie 4 comprises a metal needle tubing 43, and the inwall that the outer wall of metal needle tubing 43 is provided with biocompatible layer 44, the second electrode assemblies 4 is provided with silver or silver chloride layer 42, and metal needle tubing 43 can be made up of rustless steel, titanium alloy etc.Biocompatible layer 44 can be the rete of the thickness that forms on the outer wall surface of metal needle tubing 43 such as Merlon, polyurethane at the 5-20 micron, and compound silver or silver chloride layer 42 and metal needle tubing 43 are jointly as the pick off negative pole on tubulose second electrode assemblie 4 inwalls.
Aciculiform first electrode assemblie 5 comprises a metal nook closing member 51, and the outer surface of metal nook closing member 51 is provided with bio-sensing layer 52, and bio-sensing layer 52 is for to be arranged in order the composite bed that forms by diffusion-restricted layer, bioactive layer.The material of metal nook closing member 51 can be purity at the gold more than 99.9%, platinum, also can be at surface sputtering or be electroplate with the rustless steel or the titanium alloy of one deck platinum black.Can contain glucoseoxidase, Lactate Oxidase, cholesterol oxygen enzyme etc. in the bioactive layer outside the metal nook closing member 51 is the enzyme of natural electron conduction body with oxygen, bioactive layer can be fixed in the surface of metal nook closing member 51 by covalent cross-linking, as enzyme being dissolved in the mixed solution of chitosan, glutaraldehyde, form bioactive layer on the surface of metal nook closing member 51 by the sol-gel investment.The diffusion-restricted layer can be the semipermeable membrane that polrvinyl chloride, cellulose acetate, Polyethylene Glycol etc. form at the enzyme laminar surface, it limits detected material transit dose, as surveying glucose in health check-up, because detection time is long, oxygen deficiency in the body usually needs to limit the amount that glucose sees through at sensor surface.The diameter of first electrode assemblie 5 can be 0.1～0.2 millimeter, and the internal diameter of second electrode assemblie 4 can be 0.3～0.4 millimeter, and external diameter can be 0.5～0.6 millimeter, and the diameter of micropore 41 is 0.1～0.2 millimeter.Wherein, bioactive layer is positioned at inboard near metal nook closing member 51 in the composite bed of bio-sensing layer 52.
During work, first electrode assemblie 5 is fixed in second electrode assemblie 4, first electrode assemblie 5 and second electrode assemblie 4 have been formed a bipolar electrode test macro, offer many micropores 41 on tubulose second electrode assemblie 4, in the test process, small-molecule substance as: glucose, lactic acid, cholesterol etc. can combine with active substance in the bioactive layer by micropore 41, produce current signal.The spacing distance of first electrode assemblie 5 and second electrode assemblie 4 is shorter, can produce the current signal bigger than general pick off in the test process; Most of high molecular weight protein is electronegative in people's body fluid, tubulose second electrode assemblie 4 negative charge that the surface produces when work can effectively repel high molecular weight protein and enter sensor internal, with first electrode assemblie 5 non-specific adsorption taking place, can effectively prolong pick off like this in the intravital use mission of people.
Fig. 9 illustrates this pick off current signal characteristic curve to glucose responding in phosphate buffer, and vertical coordinate is represented the response current signal that pick off records among the figure, among the figure from left to right each ladder concentration of glucose raise 40 milligrams/deciliter successively.As shown in Figure 9, this pick off is not more than 2 minutes stabilization time, and the response of concentration of glucose transient change is less than 10 seconds, and the range of linearity that concentration of glucose is detected is not less than 600 milligrams/deciliter, transducer sensitivity height, good stability.As a comparison, first electrode assemblie 5 is taken out from second electrode assemblie 4, divide and open in the same phosphate buffer, the test down of same temperature and pH value, pick off to the current signal characteristic curve of glucose responding as shown in figure 10, be not difficult to find out that than sensitivity and all decline to some extent of stability of Fig. 9 pick off, the range of linearity has also narrowed down.
Embodiment 2: the structure of present embodiment and embodiment 1 and operation principle basically identical, its difference just is: as shown in Figure 6, can also be equiped with reference electrode 8 in tubulose second electrode assemblie 4, reference electrode 8 can be purity at platinum filament more than 99.9% or surface sputtering, be electroplate with the stainless steel silk of one deck platinum black, reference electrode 8 plays the effect of burning voltage in test process, help long-time test and obtain more accurate data of cutting.
Embodiment 3: the structure of present embodiment and embodiment 1 and operation principle basically identical, and its difference just is: as shown in Figure 8, bio-sensing layer 52 is arranged on the inner tubal wall of second electrode assemblie 4; As shown in Figure 7, silver or silver chloride layer 42 are arranged on the metal nook closing member 51 of the first electric level assembly 5.
The above only is a preferred implementation of the present utility model, and protection domain of the present utility model also not only is confined to the foregoing description, and all technical schemes that belongs under this utility model thinking all belong to protection domain of the present utility model.Should be pointed out that for those skilled in the art in the some improvements and modifications that do not break away under this utility model principle prerequisite, these improvements and modifications also should be considered as protection domain of the present utility model.
Claims (10)
1, a kind of implantating biological sensors, it comprises the sensor probe of being made up of first electrode assemblie (5) and second electrode assemblie (4) (1), first electrode assemblie (5) links to each other by lead with second electrode assemblie (4), it is characterized in that: described second electrode assemblie (4) is a tubulose, described first electrode assemblie (5) is sheathed in tubulose second electrode assemblie (4), offers more than one micropore (41) on the tube wall of second electrode assemblie (4).
2, implantating biological sensors according to claim 1 is characterized in that: the outer wall of described first electrode assemblie (5) is provided with bio-sensing layer (52).
3, implantating biological sensors according to claim 1 is characterized in that: the inner tubal wall of described second electrode assemblie (4) is provided with bio-sensing layer (52).
4, according to claim 1 or 2 or 3 described implantating biological sensors, it is characterized in that: the outer tube wall of described second electrode assemblie (4) is provided with biocompatible layer (44).
5, according to claim 1 or 2 or 3 described implantating biological sensors, it is characterized in that: bioactive layer and the diffusion-restricted layer formed composite bed of described bio-sensing layer (52) for being arranged in order from the inside to the outside.
6, implantating biological sensors according to claim 4 is characterized in that: bioactive layer and the diffusion-restricted layer formed composite bed of described bio-sensing layer (52) for being arranged in order from the inside to the outside.
7, according to claim 1 or 2 or 3 described implantating biological sensors, it is characterized in that: be equiped with reference electrode (8) in described tubulose second electrode assemblie (4).
8, implantating biological sensors according to claim 4 is characterized in that: be equiped with reference electrode (8) in described tubulose second electrode assemblie (4).
9, according to claim 1 or 2 or 3 described implantating biological sensors, it is characterized in that: described first electrode assemblie (5) and second electrode assemblie (4) are fixed on the one handle (2), are provided with the socket (7) that links to each other with external wire (3) in the described handle (2).
10, implantating biological sensors according to claim 8 is characterized in that: described first electrode assemblie (5) and second electrode assemblie (4) are fixed on the one handle (2), are provided with the socket (7) that links to each other with external wire (3) in the described handle (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200645735U CN201404203Y (en) | 2009-05-25 | 2009-05-25 | implanted biosensor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200645735U CN201404203Y (en) | 2009-05-25 | 2009-05-25 | implanted biosensor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201404203Y true CN201404203Y (en) | 2010-02-17 |
Family
ID=41675120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009200645735U Expired - Lifetime CN201404203Y (en) | 2009-05-25 | 2009-05-25 | implanted biosensor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201404203Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178513A (en) * | 2011-05-05 | 2011-09-14 | 长沙三诺生物传感技术股份有限公司 | Sandwich type biological sensor |
-
2009
- 2009-05-25 CN CN2009200645735U patent/CN201404203Y/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178513A (en) * | 2011-05-05 | 2011-09-14 | 长沙三诺生物传感技术股份有限公司 | Sandwich type biological sensor |
| CN102178513B (en) * | 2011-05-05 | 2013-02-27 | 长沙三诺生物传感技术股份有限公司 | Sandwich type biological sensor |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7979103B2 (en) | Catheter-free implantable needle biosensor | |
| CA1287380C (en) | Electrochemical cell sensor for continuous, short- term use in tissues and blood | |
| US8090426B2 (en) | Microelectronic biosensor plug | |
| US20140135605A1 (en) | Methods and systems for optimizing sensor function by the application of voltage | |
| Pfeiffer et al. | Amperometric lactate oxidase catheter for real-time lactate monitoring based on thin film technology | |
| Del Caño et al. | Ketone bodies detection: Wearable and mobile sensors for personalized medicine and nutrition | |
| Liu et al. | Transdermal amperometric biosensors for continuous glucose monitoring in diabetes | |
| CN201404203Y (en) | implanted biosensor | |
| CN101548878B (en) | Implanted biosensor | |
| CN207202871U (en) | A kind of physiologic parameter analysis system continuously or discontinuously | |
| CN201996544U (en) | Minimally invasive and continuous type monitoring sensor for glucose | |
| CN114847936A (en) | Flexible implantable platinum alloy array type sensor | |
| CN102038493A (en) | Biosensor of micropin type | |
| CN2782015Y (en) | Subcutaneous implantation type biosenser | |
| CN1296705C (en) | Control circuit for adjustable biological sensor and measuring method thereof | |
| Singh et al. | Applications of enzyme biosensors in diabetes | |
| CN219578881U (en) | Glucose monitoring probe and glucose monitor | |
| CN111426733B (en) | Electrode material for ascorbic acid sensor, biosensor, preparation method and application of biosensor | |
| CN213345656U (en) | Three-electrode subcutaneous implanted glucose sensor | |
| US11638545B2 (en) | Reducing sensor foreign body response via high surface area metal structures | |
| Kremer | Development of an electrochemical lactate sensor for foetal monitoring during birth | |
| Zheng | Applications of electrochemical biosensors for glucose detection | |
| Feng et al. | Recent Advances in Salivary Glucose Monitoring | |
| Yang et al. | Progress in the study of enzyme-free glucose electrochemical sensors | |
| He et al. | Helical Microfilament‐Electrode‐Based Semi‐Implantable Biosensors for In Vivo Electrochemical Detection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20100217 Effective date of abandoning: 20090525 |
|
| C56 | Change in the name or address of the patentee |
Owner name: CHANGSHA SINOCARE INC. Free format text: FORMER NAME: SANNUO BIOLOGICAL SENSING TECHNOLOGY CO., LTD., CHANGSHA |
|
| CP03 | Change of name, title or address |
Address after: 410013 Hunan province Changsha City torch high tech Zone Changsha Ji Xian Lu No. 28 Patentee after: Changsha Sinocare Inc. Address before: 410013 Hunan province Changsha City torch high tech Zone Changsha Ji Xian Lu Jingxin Tech Park Complex Building Patentee before: Sannuo Biological Sensing Technology Co., Ltd., Changsha |