CN201402263Y - Six-in-one detection reagent card for drug abuse - Google Patents
Six-in-one detection reagent card for drug abuse Download PDFInfo
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- CN201402263Y CN201402263Y CN2009201482824U CN200920148282U CN201402263Y CN 201402263 Y CN201402263 Y CN 201402263Y CN 2009201482824 U CN2009201482824 U CN 2009201482824U CN 200920148282 U CN200920148282 U CN 200920148282U CN 201402263 Y CN201402263 Y CN 201402263Y
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- drug abuse
- colloidal gold
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Abstract
The utility model relates to a drug abuse six-in-one detection reagent card belongs to colloidal gold detection area. The utility model discloses mainly constitute by detection card shell and colloidal gold test paper two parts. Six grooves are formed in the detection card shell and used for placing six kinds of abuse drug colloidal gold detection test paper of morphine, ketamine, benzodiazepine, barbiturate, methadone and buprenorphine. The utility model discloses whether contain morphine, ketamine, benzodiazepine, barbital, methadone and buprenorphine in can realizing one-step qualitative detection human urine to confirm whether to have the medicine abuse condition, have with low costs, small and exquisite simple and convenient, easy operation need not characteristics such as professional operating personnel operation.
Description
Technical field
The utility model relates to the reagent card of six kinds of psychotropic agents of a kind of step detection, belongs to the collaurum detection range.
Background technology
Drug abuse generally is meant has run counter to the medical application of generally acknowledging and social regulation and has used any medicine.This use is self-administration often, and continuous the generation reuses tendency behind disconnected medicine.Drug abuse often causes the harm to medication individual spirit and health, and then leads to the serious harm to entire society.
Morphine is topmost alkaloid in the opium (the about 10-15% of content), medically, morphine is a narcotic analgeiscs, but for a long time with producing severe dependency, in case lose supply, will produce sweat, tremble, tangible withrawal symptom such as heating, elevation of blood pressure, myalgia and spasm.The long-term morphine that uses can cause insanely, and heavy dose is sucked morphine, can cause breath stopped and death.
Ketamine (Ketamine) is a kind of non-barbiturates Intravenous Anesthesia agent, because its anesthetic action is fast, analgesia is strong, clinically as surgery anesthesia agent or anesthesia induction agent.Ketamine only needs simple processing just can obtain the solid ketamine, and the powder because its physical form is white in color usually is so be commonly called as " K powder ".The K powder has certain psychic dependence, easily makes humanoid one-tenth addiction.
(benzodiazepine drugs BZD) is applied to the clinical history that has had more than 40 year as hypnotic sedative agent to benzodiazepine, is used for the treatment of panic disorder by drugs approved by FDA at present, becomes the main medicine of treatment anxiety associated disorders.Although it has curative effect and security preferably, yet existing tangible proof shows that the prolonged application benzodiazepine can cause relying on, even also be like this when low dosage and therapeutic dose.Mainly show as and cause tangible abstinence syndrome after the drug withdrawal: anxiety, perceptual disturbance, poor appetite, insomnia etc., epileptic attack, delirium and mental disease appear in severe patient.
Barbiturate suppresses the pon reticulate texture, reduces the moving sleep of being sharp-eyed, even short-term is taken, drug withdrawal also can cause the knock-on of the moving sleep of being sharp-eyed, and it is unbroken to show as nightmare, uncomfortable feeling.So in case after taking barbiturate, tend to continue clothes and go down, difficulty is stopped, thereby easily forms dependence.The dependent mostly takes the medicine of short time effect, as secobarbital sodium, Amytal, amobarbital etc.General habituation dosage is 4～50 times of therapeutic dose, and such medicine and alcohol have cross resistance, can quicken habituation with the clothes barbiturate when drinking.Sometimes once taking in a large number just can habituation.
Methadone is a kind of narcotics of synthetic, because the same with drugs such as morphine and heroin, acts on opiate receptor, and its toxicity relatively a little less than, often be taken as the drugs substitute and be used for drug addiction treatment.But discover that at present methadone can produce dependence and withrawal symptom equally, and last longer than morphine and heroin.
Buprenorphine is a kind of medicine of and antagonistic activity exciting with opiate receptor, and it is a kind of highly lipophilic medicine, inject or the sublingual administration onset all than comparatively fast, low dosage can show the agonist activity of opiate receptor, the opiate receptor antagonism then appears in high dose.Buprenorphine has injection and tablet at present, and the many places of many countries and China also all use buprenorphine to come the heroin addiction person is carried out drug addiction treatment.Buprenorphine is except its pharmacologic action, also has relatively serious adverse, spinoff is similar to other opioid drug, modal have: easily habituation, nervous system damage, decrease of memory, insomnia, drowsiness, perspiration, constipation, headache, feel sick, hypertension be may cause and hypertension, respiration inhibition or the like brought out.Buprenorphine has the abuse condition of two kinds of danger closes: the one, and inappropriate oral as intravenous injection or excess dosage of tablet; The 2nd, share with other calm class medicines (diazepam, alcohol), use easily causes respiration inhibition like this, stupor even dead.
At present the method that drug abuse is detected is a lot, radioimmunoassay technique (RIA) for example, and enzyme enlarges immunoassay (EMIT), fluorescence immunoassay technology (FIA), enzyme linked immunosorbent assay (ELISA), gaseous mass spectrum coupling technique (GCMS) etc.But these technology ubiquities cost an arm and a leg, complicated operation, detection time long and need the professional to operate, and the application of collaurum method has solved above problem.
Colloidal gold technique is a kind of novel immunolabelling technique that is applied to antigen-antibody with collaurum as the tracer label thing.Its advantage is easy and simple to handle, is not subjected to time, site limitation, and is highly sensitive, do not need any instrument and equipment.This utility model has important social meaning and bigger practical value.
The utility model content
The utility model provides a kind of drug abuse six directions one detectable card at the problems referred to above, can a step detect six kinds of common drug abuse.
For achieving the above object, the utility model is by the following technical solutions:
A kind of drug abuse six directions one detectable card, by detection get stuck and six kinds of drug abuse colloidal gold test two parts form.
Detection is got stuck and is made up of card body and card cap, and the connected mode of the two is for pegging graft.Card body inside has six grooves to be used to place colloid gold test paper.There is information recording paper in the front of card body, is used to indicate title, detection explanation and the testing result of test strips.
Six kinds of drug abuse colloidal gold tests are formed by backing, golden pad, sample pad, nitrocellulose filter, absorption pad five parts.Absorption pad and sample pad lay respectively at the two ends of backing, and nitrocellulose filter links together at backing middle part one end and absorption pad overlapping, and the other end overlaps on by golden pad and sample pad and connects.Be coated with detection line and control line on the nitrocellulose filter.
Six kinds of drug abuse colloidal gold tests are put into respectively in the middle of inner six grooves of card body, and the sample pad end is exposed to card body outside.Be plugged on a time-out when blocking body and blocking cap, the sample pad end is closed among the card cap.
The used colloidal gold test of the utility model is to be received collaurum competition and detects principle and make, the gold pad is the monoclonal antibody of mouse source property abuse resistant drugs and the compound of collaurum, detection line is coated with drug abuse antigen on the nitrocellulose filter, is coated with the sheep anti mouse polyclonal antibody on the control line.
When inserting the sample pad end in the urine to be measured, because the capillarity urine is to absorption pad end chromatography.If when containing a certain amount of above drug abuse in the urine to be measured, sample arrives golden pad position, with drug abuse monoclonal antibody generation immune response and fully saturated it, when chromatography is to the detection line of nitrocellulose filter again, because drug abuse monoclonal antibody colloidal gold composite has not had vacant site and the drug abuse antigen combination on the nitrocellulose filter, so do not develop the color, what obtain like this is positive findings.
When not containing drug abuse in the urine to be measured, sample and golden pad do not react, and when chromatography is to nitrocellulose filter again, are fixed on drug abuse meeting " seizure " the monoclonal antibody colloidal gold composite on the nitrocellulose filter, so colour developing obtains negative findings.
Feminine gender still is the colour developing that all can react with the sheep anti mouse polyclonal antibody of nitrocellulose filter upper control line of drug abuse monoclonal antibody on the positive golden pad, if control line does not develop the color explanation detect invalid.
Adopt the drug abuse six directions one detectable jig of such scheme that following beneficial effect is arranged, i.e. low, the compact volume and convenience, simple to operate of cost, need not the professional can detect, and can a step detect six kinds of drug abuse simultaneously.
Description of drawings
Fig. 1 is a front view of the present utility model
Fig. 2 is a cut-open view of the present utility model
The front view of Fig. 3 drug abuse colloidal gold test
The cut-open view of Fig. 4 drug abuse colloidal gold test
1. detect and get stuck, 2. card body, 3. card cap, 4. information recording paper 5. detects explanation, 6. test paper explanation, 7. display window, 8. drug abuse colloidal gold test, 9. backing as a result, 10. absorption pad, 11. nitrocellulose filters, 12. gold medal pads, 13. sample pad, 14. detection line, 15. control lines, 16. grooves.
Embodiment:
As depicted in figs. 1 and 2, the utility model by detection get stuck 1 and drug abuse colloidal gold test 8 two parts form.Detection is got stuck and is comprised card body 2 and card cap 3 two parts, and the two connected mode is for pegging graft.In card body inside six grooves 16 are arranged, being used to place six kinds of drug abuse colloidal gold tests 8. promptly block body 2 above groove 16 front has information recording paper 4.Explanation of detecting 5, test paper explanation 6, display window 7 are as a result arranged on the information recording paper 4.Detect explanation 5 and be used to illustrate interpretation method as a result, test paper explanation 6 is used to illustrate the kind that detects test paper, and 7 nitrocellulose filters 11 with groove 16 Chinese traditional medicines abuse colloidal gold test 8 of display window are corresponding as a result.
As shown in Figure 3 and Figure 4, colloid gold test paper is made up of backing 9, absorption pad 10, nitrocellulose filter 11, golden pad 12, sample pad 13, absorption pad 10 and sample pad 13 lay respectively at the two ends of backing 9, nitrocellulose filter 11 links together at backing 9 middle parts, one end and absorption pad 10 overlappings, and the other end overlaps on sample pad 13 by golden pad 12 and connects.Be coated with detection line 14 and control line 15 on the nitrocellulose filter 11.Six kinds of detection lines that detect test paper are respectively morphine antigen, ketamine antigen, Benzodiazepine antigen, barbital antigen, methadone antigen, buprenorphine antigen, and control line is the sheep anti mouse polyclonal antibody.
Claims (3)
1. the drug abuse six directions one a detectable card is characterized in that comprising detecting and gets stuck (1) and drug abuse colloidal gold test (8) two parts; Detection get stuck (1) comprise card body (2) and card cap (3) two parts, card body (2) and card cap (3) connected mode are grafting; Card body (2) inside has six grooves (16) to be used to place drug abuse colloidal gold test (8); There is information recording paper (4) in card body (2) front; Have on the information recording paper (4) and detect explanation (5), test paper explanation (6), display window (7) as a result; Nitrocellulose filter (11) on the drug abuse colloidal gold test (8) in display window and the groove (16) is corresponding as a result; Drug abuse colloidal gold test (8) is fixed in the inner groove (16) of card body (2), form by backing (9), absorption pad (10), nitrocellulose filter (11), golden pad (12), sample pad (13), absorption pad (10) and sample pad (13) lay respectively at the two ends of backing (9), nitrocellulose filter (11) is at backing (9) middle part, one end and absorption pad (10) overlap and link together, and the other end overlaps on by golden pad (12) and sample pad (13) and connects.Be coated with detection line (14) and control line (15) on the nitrocellulose filter (11).
2. the drug abuse six directions one detectable card as claimed in claim 1 is characterised in that the detection line (14) on six kinds of drug abuse colloidal gold tests (8) wraps respectively by morphine antigen, ketamine antigen, Benzodiazepine antigen, barbital antigen, methadone antigen, buprenorphine antigen.
3. the drug abuse six directions one detectable card as claimed in claim 2, the antibody that is characterised in that mark on the golden pad is mouse source property.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201482824U CN201402263Y (en) | 2009-03-31 | 2009-03-31 | Six-in-one detection reagent card for drug abuse |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201482824U CN201402263Y (en) | 2009-03-31 | 2009-03-31 | Six-in-one detection reagent card for drug abuse |
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| Publication Number | Publication Date |
|---|---|
| CN201402263Y true CN201402263Y (en) | 2010-02-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009201482824U Expired - Lifetime CN201402263Y (en) | 2009-03-31 | 2009-03-31 | Six-in-one detection reagent card for drug abuse |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102879568A (en) * | 2011-07-12 | 2013-01-16 | 李彬 | Poison four-in-one joint detection test card |
| CN102928593A (en) * | 2011-12-27 | 2013-02-13 | 北京宝瑞源科技孵化有限公司 | Buprenorphine detection kit and preparation method thereof |
| CN103439483A (en) * | 2013-08-23 | 2013-12-11 | 苏州凯恩医药科技有限公司 | Novel urine test paper |
| CN109959795A (en) * | 2017-12-26 | 2019-07-02 | 北京勤邦生物技术有限公司 | A kind of development and application of matrix type test strips |
| EP3408672A4 (en) * | 2016-01-27 | 2019-10-23 | Undercover Colors, Inc. | Methods and apparatus for detecting compounds in liquids |
| CN111443205A (en) * | 2020-02-25 | 2020-07-24 | 古镜科技(深圳)有限公司 | Quintuplet test paper for detecting abuse of mental drugs and preparation thereof |
-
2009
- 2009-03-31 CN CN2009201482824U patent/CN201402263Y/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102879568A (en) * | 2011-07-12 | 2013-01-16 | 李彬 | Poison four-in-one joint detection test card |
| CN102928593A (en) * | 2011-12-27 | 2013-02-13 | 北京宝瑞源科技孵化有限公司 | Buprenorphine detection kit and preparation method thereof |
| CN103439483A (en) * | 2013-08-23 | 2013-12-11 | 苏州凯恩医药科技有限公司 | Novel urine test paper |
| EP3408672A4 (en) * | 2016-01-27 | 2019-10-23 | Undercover Colors, Inc. | Methods and apparatus for detecting compounds in liquids |
| CN109959795A (en) * | 2017-12-26 | 2019-07-02 | 北京勤邦生物技术有限公司 | A kind of development and application of matrix type test strips |
| CN111443205A (en) * | 2020-02-25 | 2020-07-24 | 古镜科技(深圳)有限公司 | Quintuplet test paper for detecting abuse of mental drugs and preparation thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20100210 |