CN201239143Y - Instrument for monitoring physiological signal of laboratory animal - Google Patents
Instrument for monitoring physiological signal of laboratory animal Download PDFInfo
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- CN201239143Y CN201239143Y CNU2008200415264U CN200820041526U CN201239143Y CN 201239143 Y CN201239143 Y CN 201239143Y CN U2008200415264 U CNU2008200415264 U CN U2008200415264U CN 200820041526 U CN200820041526 U CN 200820041526U CN 201239143 Y CN201239143 Y CN 201239143Y
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Abstract
The utility model discloses a physiological signal monitor for experimental animals, which comprises a plurality of physiological signal sensors, treatment circuits, a data collection card and a computer, wherein the treatment circuits corresponding to the receiving signals of each sensor are connected in parallel on the data collection card connected with the computer having a software processing program; and the computer having the software processing program comprises an instrument softpanel unit and a function program unit, the instrument softpanel unit controls the running of the program, and the function program unit receives the control signals of the instrument softpanel unit to perform each test function. The utility model utilizes the computer having the software processing program to carry out the virtualization of each kind of monitors so as to realize the purpose that various collected physical signs are displayed on the same computer to be processed and analyzed, and the monitor avoids the trouble of purchasing a plurality of instruments, saves experimental cost and is convenient to operate.
Description
Technical field
This utility model relates to a kind of animal testing instrument, is specifically related to a kind of monitor that is used for the various physiological signals of test experiments animal, comprises the test to physiological signals such as electrocardiosignal, blood pressure, body temperature.
Background technology
At present, biological, field of medicaments has become the emphasis of many countries research and development, becomes the core of International Technology competition.And laboratory animal is life sciences, study of pharmacy essential condition, and its quality is directly connected to the accuracy and the repeatability of result of study.The scientific research and the production application in many fields such as biology, medicine all be unable to do without zoopery.
External developed country is at the early 1990s animal specific instrument and equipment that just become basically universal.And in China, the research and development ability of zoopery equipment special and equipment very a little less than, the mechanism that specializes in Related product exploitation almost is blank, equipment that zoopery is required and equipment mainly depend on import, cost an arm and a leg.So, domestic basically still with clinical human instrument and equipment replacement of the same type, had a strong impact on zoopery result's accuracy and level, the medical science, pharmacy and the development of life science that have restricted the laboratory animal science and be correlated with.
The physiological signal of realizing animal comprises: electrocardiosignal, body temperature signal, blood pressure signal, electroneurographic signal, breath signal or the like, traditional bio signal collection is to be formed by function different electronic machine and hand dipping tool combinations with processing system, need use electrocardiograph as electrocardiosignal, blood pressure signal needs blood pressure instrument etc., the detecting instrument and the display device of a kind of correspondence of every like this test one class signal demand, experiment fees is higher, and tests loaded down with trivial details; Simultaneously, the data of each test can't be carried out the electronics preservation, preserve to be printed as paper spare mode usually at present, perhaps just do not preserve, and make troubles to contrasting repeatedly test data (especially multistage by stages test).
Therefore, develop the zoopery instrumentation and the equipment that are fit to China's national situation, improve the zoopery quality, the level that improves China's life science is had profound significance.
Summary of the invention
This utility model purpose provides a kind of laboratory animal physiologic signal monitoring instrument, uses this instrument, but all kinds of physiological signals of test animal reduce experiment fees, use easy to operate.
For achieving the above object, the technical solution adopted in the utility model is: a kind of laboratory animal physiologic signal monitoring instrument, comprise a plurality of physiological signal sensors, the treatment circuit of corresponding each pick off received signal, each described treatment circuit is connected on the data collecting card, and is connected and contains the computer of software processes program with this capture card; The described computer that contains the software processes program comprises as lower unit: the instrument softpanel unit of control sequence operation reaches the function program unit that receives described instrument softpanel unit controls signal and finish each test function.
In the technique scheme, described physiological signal sensor can comprise test experiments animal electrocardiosignal, the body temperature signal, blood pressure signal, signal corresponding sensor (as core signal sensor) such as breath signal, recording various types of signal inputs in the corresponding signal processing circuit, carry out respective handling (adopting existing medical science account form) to signal, repeated transmission is defeated by data collecting card and is carried out the A/D conversion, send in the computer that contains the software processes program, described instrument softpanel unit, form by control among the Lab Windows/CVI and menu, start by the control on the operation user interface, stop sampling, the size of control sampling rate, baseline of each passage waveform or the like; According to the physiological characteristics of laboratory animal, adopt data acquisition, real-time waveform demonstration, data storage, printing, data storage and the functional units such as playback, analysis of Lab Windows/CVI programming realization to laboratory animal blood pressure, body temperature, electrocardio etc.
In the technique scheme, described function program unit is made up of data acquisition unit, data display unit, data storage and playback unit and data processing unit, described data acquisition unit receives the control signal that described instrument softpanel unit sends, carry out the collection of test data, and show by data display unit output.To record Various types of data (or waveform) and the data (or waveform) after data processing unit is handled show by data display unit, and data storage and playback unit are preserved Various types of data get off with document form, check and comparison so that call at any time.
In the technique scheme, described physiological signal sensor is made up of EGC sensor, pressure transducer and temperature sensor, and its output connects with corresponding described signal processing circuit respectively.
In the technique scheme, comprise conversion of signals and counting circuit and two-stage amplifying circuit in the described signal processing circuit, the voltage of conversion and counting circuit output is through the output of two-stage amplifying circuit, with described data acquisition card connection.Since the signal that records of laboratory animal a little less than, utilize the two-stage amplifying circuit that signal is amplified at double, so that to its processing.
Because the technique scheme utilization, the advantage that this utility model compared with prior art has is:
1, this utility model constitutes all kinds of virtual instruments by the functional unit in the computer that contains the software processes program, according to kind to needs test experience animal physiological signal, dispose corresponding a plurality of pick off, electrocardio with laboratory animal, body temperature, physiological signals such as blood pressure convert the corresponding signal of telecommunication to, and pass through corresponding signal processing circuit, the input computer, by instrument softpanel unit controls, the function program cell processing, in real time be presented at computer screen on the form of waveform or data measured signal, electrocardiogram with laboratory animal, body temperature, multiple physical signs such as blood pressure concentrates on the computer and shows, saved the trouble of buying many instruments, save experiment fees, made things convenient for operation;
2, by data storage and playback unit are set, can preserve with the e-file form the data or the experimental result that record data and carried out analysis, processing so that call at any time check and data relatively, help carrying out of experimental work.
Description of drawings
Fig. 1 is the structural principle block diagram of this utility model embodiment one;
Fig. 2 be among this utility model embodiment one I, II lead, the signal processing circuit sketch map of unipolar chest lead;
Fig. 3 is that the combination of unipolar chest lead among this utility model embodiment one realizes circuit diagram;
Fig. 4 is blood pressure signal treatment circuit sketch map I among this utility model embodiment one;
Fig. 5 is blood pressure signal treatment circuit sketch map II among this utility model embodiment one;
Fig. 6 is a processes temperature signal circuit diagram among this utility model embodiment one.
The specific embodiment
Below in conjunction with drawings and Examples this utility model is further described:
Embodiment one: extremely shown in Figure 6 referring to Fig. 1, a kind of laboratory animal physiologic signal monitoring instrument, comprise EGC sensor, pressure transducer and 3 physiological signal sensors of temperature sensor, the corresponding treatment circuit that receives each sensor signal, each described treatment circuit is connected on the data collecting card, and is connected the computer that contains the software processes program with capture card; The described computer that contains the software processes program comprises as lower unit: the instrument softpanel unit of control sequence operation reaches the function program unit that receives described instrument softpanel unit controls signal and finish each test function.
Described function program unit is made up of data acquisition unit, data display unit, data storage and playback unit and data processing unit, described data acquisition unit receives the control signal that described instrument softpanel unit sends, carry out the collection of test data, and by data display unit output demonstration, to record Various types of data (or waveform) and the data (or waveform) after data processing unit is handled show by data display unit, and data storage and playback unit are preserved Various types of data get off with document form, check and comparison so that call at any time.
Comprise conversion of signals and counting circuit and two-stage amplifying circuit in the described signal processing circuit, the voltage of conversion and counting circuit output is through preposition amplification and the output of voltage amplification two-stage amplifying circuit, with described data acquisition card connection.Described instrument softpanel unit is made up of control among the Lab Windows/CVI and menu, starts, stops sampling by the control on the operation user interface, the size of control sampling rate, baseline of each passage waveform or the like; With Lab Windows/CVI language design function program, finish above-mentioned to laboratory animal blood pressure, body temperature, cardiac electrical data acquisition, real-time waveform demonstration, data storage, printing, data storage and functional units such as playback, analysis.
Each signal processing circuit in the present embodiment is as follows:
1. electrocardiosignal treatment circuit
The pick off that the measurement of electrocardiosignal is adopted is 10 EGC sensor of leading, and measuring principle is the Ai Shi triangulation method.The reflection of bipolar standard ecg leads be the electrocardio potential difference between two summits in the Ai Shi triangle, if leg-of-mutton three summits of Ai Shi are respectively the right hand, left hand and left foot, be transmitted to the electrocardio potential difference on the left hand and the right hand when I electrocardiosignal of leading is cardiomotility so, it is the potential difference that is transmitted between the right hand and the left foot that II leads, and it is the electrocardio potential difference that is transmitted between left hand and the left foot that III leads.If being transmitted to the electrocardio current potential of the right hand, left hand and left foot during cardiomotility is respectively U
R, U
LAnd U
F, then I, II, the III combinatorial principle of leading can be expressed by following formula:
The unipolarity precordial lead electrocardiogram generally has 6 to lead, and is called V1, V2, V3, V4, V5, V6 respectively.The combinatorial principle of unipolarity chest lead can be expressed with following formula:
V
n＝U
cn-(U
R+U
L+U
F)/3 (2)
In the formula (2), Vn is V1～V6, and Ucn is the electrocardio current potential of chest specific part C1～C6.
According to above operation principle, electrocardio measuring circuit totally 8 tunnel: 2 road bipolar standard lead I, II is led, 6 road chest leads, the operation principle of each bipolar standard lead and each unipolar chest lead identical (realizing that circuit is identical), difference is the access of input and output and selecting for use of operational amplifier, and physical circuit as shown in Figure 2.Wherein, in bipolar standard lead I, II led circuit diagram, operational amplifier adopts that IC106/A realizes was I leads I=U in the bipolar lead
L-U
RWith preposition amplification, IC106/B realizes the secondary amplification of voltage and moving up and down of baseline; And in the unipolar chest lead circuit diagram, operational amplifier adopts IC108/A and IC108/B, and the adder in the combination of 6 road chest leads (formula (2)) is realized by Fig. 3 circuit.
2. blood pressure signal treatment circuit
The pressure transducer that pressure transducer adopts the silicon varistor to constitute.It has adopted a kind of non-toxic transparent plastic to make shell, in case there is bubble to occur all can be observed like this in the solution, flushing valve is used for blood is washed out to prevent that catheter end from producing blood clotting from end of conduit, the Wheatstone bridge of forming by four silicon varistor diaphragms on the silicon chip, according to the isolated requirement of safety, silicon chip does not directly contact with solution, but contacts with solution by the elastic silica gel of good biocompatibility.Because the output of pick off is the output of electric bridge, so as long as provide certain electric bridge bridge to press, voltage signal output is just arranged when pick off is experienced pressure, its signal processing circuit is shown in Fig. 4,5.
The measurement of blood pressure signal has two-way: diastolic pressure and systolic pressure, the two-way measuring principle is identical, is last amplification difference.The output voltage BP1 of pick off is connected on 2C1, the 2C2, and BP2 is connected on 2C11, the 2C12.The bridge of electric bridge is pressed respectively and is provided by 1 foot of IC307/A and the 7 feet output of IC307/B, be connected on respectively 2C3 and 2C4 (), 2C9 and 2C10 () on.IC307 is used for providing the electric bridge bridge to press to pick off among the figure, and IC301 and IC302 are used for the output of pick off is amplified and the impedance conversion.
3. processes temperature signal circuit
What temperature sensor was adopted is the critesistor of negative temperature coefficient.The temperature measurement signal treatment circuit as shown in Figure 6, two of pick off output terminates on 3C1 and the 3C2, i.e. R402 among the figure.Because critesistor is non-linear bigger, so constitute simple linear circuit at the both sides of pick off resistance R S in parallel.The measuring circuit of temperature has adopted Wheatstone bridge, and bridge is pressed by the output of voltage stabilizing chip and obtained after the RW2 dividing potential drop, is 2.0～2.5V.Regulating RW1 makes temperature electric bridge in the time of 25 ℃ be output as zero.When temperature changed, the resistance of pick off changed, and the balance of electric bridge is destroyed, and two arms produce certain potential difference, after IC401/A and IC401/B amplification, sent into A/D and changed.
Claims (4)
1. laboratory animal physiologic signal monitoring instrument, it is characterized in that: comprise a plurality of physiological signal sensors, the treatment circuit of corresponding each pick off received signal, each described treatment circuit is connected on the data collecting card, and is connected and contains the computer of software processes program with this capture card; The described computer that contains the software processes program comprises as lower unit: the instrument softpanel unit of control sequence operation reaches the function program unit that receives described instrument softpanel unit controls signal and finish each test function.
2. laboratory animal physiologic signal monitoring instrument according to claim 1, it is characterized in that: described function program unit is made up of data acquisition unit, data display unit, data storage and playback unit and data processing unit, described data acquisition unit receives the control signal that described instrument softpanel unit sends, carry out the data acquisition of test signal, and carry out the demonstration of data and waveform by data display unit, by data storage and playback unit, storage and the playback of carrying out data show.
3. laboratory animal physiologic signal monitoring instrument according to claim 1, it is characterized in that: described physiological signal sensor is made up of EGC sensor, pressure transducer and temperature sensor, and its output connects with corresponding described signal processing circuit respectively.
4. laboratory animal physiologic signal monitoring instrument according to claim 1, it is characterized in that: comprise conversion of signals and counting circuit and two-stage amplifying circuit in the described signal processing circuit, the voltage of conversion and counting circuit output is through the output of two-stage amplifying circuit, with described data acquisition card connection.
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| Application Number | Priority Date | Filing Date | Title |
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| CNU2008200415264U CN201239143Y (en) | 2008-08-04 | 2008-08-04 | Instrument for monitoring physiological signal of laboratory animal |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008200415264U CN201239143Y (en) | 2008-08-04 | 2008-08-04 | Instrument for monitoring physiological signal of laboratory animal |
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| CN201239143Y true CN201239143Y (en) | 2009-05-20 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102156427A (en) * | 2011-03-01 | 2011-08-17 | 上海大学 | Animal test bed monitoring system |
| CN106725399A (en) * | 2016-12-29 | 2017-05-31 | 深圳先进技术研究院 | A kind of light regulates and controls animal blood pressure real-time monitoring system |
| CN111369853A (en) * | 2020-03-19 | 2020-07-03 | 上海梦之路数字科技有限公司 | Medical integrated experimental teaching system and implementation method thereof |
| CN113974588A (en) * | 2021-11-12 | 2022-01-28 | 成都泰盟软件有限公司 | Multi-dimensional automatic evaluation system for animal experiment operation |
-
2008
- 2008-08-04 CN CNU2008200415264U patent/CN201239143Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102156427A (en) * | 2011-03-01 | 2011-08-17 | 上海大学 | Animal test bed monitoring system |
| CN106725399A (en) * | 2016-12-29 | 2017-05-31 | 深圳先进技术研究院 | A kind of light regulates and controls animal blood pressure real-time monitoring system |
| CN111369853A (en) * | 2020-03-19 | 2020-07-03 | 上海梦之路数字科技有限公司 | Medical integrated experimental teaching system and implementation method thereof |
| CN113974588A (en) * | 2021-11-12 | 2022-01-28 | 成都泰盟软件有限公司 | Multi-dimensional automatic evaluation system for animal experiment operation |
| CN113974588B (en) * | 2021-11-12 | 2024-01-05 | 成都泰盟软件有限公司 | Multi-dimensional automatic evaluation system for animal experiment operation |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090520 Termination date: 20110804 |