CN201182672Y - Novel nano memory alloy intrauterine device - Google Patents
Novel nano memory alloy intrauterine device Download PDFInfo
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- CN201182672Y CN201182672Y CNU2006200903752U CN200620090375U CN201182672Y CN 201182672 Y CN201182672 Y CN 201182672Y CN U2006200903752 U CNU2006200903752 U CN U2006200903752U CN 200620090375 U CN200620090375 U CN 200620090375U CN 201182672 Y CN201182672 Y CN 201182672Y
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- memory alloy
- copper
- intrauterine device
- novel nano
- shaped rest
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Abstract
the utility model relates to a novel nano memory alloy inner uterus contraceptive device which is characterized in that the titanium and nickel memory alloy material is adopted to make a V-shaped support, a composite material body and connecting lines; the composite material body is fixed on the V-shaped support, or part of the composite material body is fixed on the V-shaped support with the other part tied to the V-shaped support; the V-shaped support is provided with 1-15 bending parts. The volume of the composite material body is 0.1-400 mm<3> and is indicated in 1-20 segments; the segments can have different shapes and specifications; the surface of each segment can be coated with medicine film or not be coated with medicine film. The novel nano memory alloy inner uterus contraceptive device adopts the memory alloy to make the support; the composite material is attached to the support to deliver copper to the highest part for being distributed on the middle part of the uterus and the uterus orifice; the contraception effect of the contraceptive device is improved while the original performance of the memory alloy is not influenced; the defects of traditional IUD support material and the naked copper are overcome; the medicine film coated on the surface releases the medicine in the implantation initial stage of the IUD; the side reaction caused by the mechanical stimulation is relieved.
Description
Technical field
This utility model relates to a kind of women assembly of intra-uterine contraceptive apparatus, particularly a kind of novel nano memory alloy intrauterine device.
Background technology
Intrauterine device (IUD) is the contraceptive device that is placed in women's cavity of uterus, is a kind of reversible, long lasting contraceptive device, is the widely used contraceptive devices of present China women of child-bearing age.Intrauterine device is made with rustless steel, macromolecular material, silica gel, and common clinically has tens kinds, as the T type, uterine cavity type, O type, Ji Ni of band copper, fixed etc.; Cupric and indometacin medicine first palace type, γ type etc. are arranged; The Man Yuele that has that contains progestogen, these contraceptive devices utilize active contraceptive substance to stop the germ cell implantation, thereby reach the purpose of contraception.
The kind of IUD roughly can be divided into inertia IUD and copper IUD two classes, and inertia IUD does not contain any antifertility active substance, is stopped using by State Family Planning Commission.Copper IUD refers to add the active substance of antifertility on IUD, as noted above cupric and the pastille of comprising improved the contraceptive effect of IUD and reduced its side effect.The useful life of cupric palace IUD is relevant with the content of the surface area of copper and copper wire, generally can use 5～15 years or the longer time.The IUD useful life who contains progestogen and medicine and its content of medicines and every day burst size relevant, be generally 3～5 years.At present most popular is copper intrauterine devices.
Copper intrauterine devices (Cu IUD) has contraceptive effect preferably, be copper discharges copper ion after the hands corrosion in uterine cavity result, utilize the bio-toxicity of copper ion to kill sperm or suppress sperm motility, change the operation that the mucous character of cervix uteri is come sperm, can also reduce the activity of some enzyme, increase the sensitivity of uterus muscle and the change of endometrial cell metabolism and biochemical aspect, make the metabolism reduction of sperm etc.Existing copper intrauterine devices (Cu IUD) adopts exposed fully oxygen-free copper, and in order to pursue contraceptive effect, the trend that copper bearing surface area has continuous effort to increase; Also there is defective in the material of support, fatiguability, and the design of most products is imperfect, exists:
1, the contraceptive effect of copper increases and increases along with the surface area of copper, but surface area increases, and the side effect of band device also increases accordingly, hemorrhage and pain can occur;
2, IUD inserts the uterus initial stage, has Cu
+ 2The burst release phenomenon has pain and side reaction such as hemorrhage;
3, the corrosion process of naked copper is very complicated, is subjected to the influence of uterine cavity environment very big, is difficult to draw corrosion curve accurately, so Cu
+ 2Rate of release be difficult to control;
4, the effective rate of utilization of copper is very low, enters the Cu of solution
+ 2Only account for about 1/3 of Cu corrosion total amount, and the copper surface there is CaCO
3Etc. deposition, increase the weight of birth control apparatus to endometrial stimulation;
5, IUD adopts polyethylene or stainless steel stent mostly, with the polyethylene support is example, be placed on and be difficult to recover fully original shape after inserting uterine cavity in the sleeve pipe again, so these IUD put sleeve pipe mostly into before placement temporarily, and the time in sleeve pipe should not be above 3 minutes, because deformability is poor, the device process of getting of part IUD is very difficult;
6, at the bottom of IUD seldom can satisfy angle, palace, palace in form design, the palace body all has the existence of copper so Cu
+ 2Skewness in cavity of uterus.
Summary of the invention
This utility model has overcome the defective of above-mentioned existence, and purpose provides a kind of novel nano memory alloy intrauterine device.
A kind of novel nano memory alloy intrauterine device of this utility model content Description:
A kind of novel nano memory alloy intrauterine device of this utility model is characterized in that: be to be made of: V-shaped rest, composite bodies and connecting line; V-shaped rest adopts the ti-ni shape memory alloy material to make open V-shaped rest, what discharge the contraception active substance is composite bodies, both combinations are: composite bodies is fixed on the V-shaped rest, or a part is fixed on the V-shaped rest another part and fastens on V-shaped rest with connecting line.
1～15 bending is arranged on the V-shaped rest of the opening that the ti-ni shape memory alloy material is made.
The volume of composite bodies is 0.1～400mm
3, being 1～20 section, each section can be different shape and specifications, each section surface can coat the medicine film or not coat the medicine film.
Composite bodies is made by contraception active substance and macromolecular material.
The contraception active substance has three classes: 1, contain copper particle, 2, indometacin, 3, progestogen.
The combination of the contraception active substance that contains in each section can be: contain copper particle; Contain copper particle and indometacin; Contain copper particle and progestogen; Contain copper particle, indometacin and progestogen.
Containing copper particle can be nanoparticle and/or micron particle; The composition of nanoparticle is copper oxide or copper oxide and copper or copper oxide and copper and other metal and/or other metal-oxide or copper oxide and other metal and/or other metal-oxide; The composition of micron particle be copper oxide and/copper or copper oxide and/or copper and other metal and/or other metal-oxide.
Macromolecular material can be polyethylene, silicone rubber.
The medicine film is to be made of indometacin and/or progestogen and medicine film base material.
A kind of novel nano memory alloy intrauterine device of this utility model has adopted the movable mechanics principle in human body uterus, makes the bow-shaped support of birth control apparatus more reasonable on form, has complied with the form and the mechanics in human body uterus.The employing memorial alloy is that support, nanometer or micron particle composite are attached on the memory alloy stent and copper are sent the high-order bit of putting the uterus, and branch is in middle part, uterus and orifice of uterus place, when can not influencing the original performance of memorial alloy, increased the contraceptive effect of birth control apparatus, overcome the defective of conventional I UD timbering material and naked copper, surface coated medicine film discharges medicine at the IUD initial stage of inserting, and alleviates Cu
+ 2And the caused side reaction of IUD mechanical irritation.
Description of drawings
Fig. 1 is an A type nano memory alloy intrauterine device structural representation
Fig. 2 is an A type nano memory alloy intrauterine device structural representation
Fig. 3 is a Type B nano memory alloy intrauterine device structural representation
Fig. 4 is a Type B nano memory alloy intrauterine device structural representation
Among the figure: 1 is that composite bodies, 2 is that V-shaped rest, 3 is connecting line.
The specific embodiment
This utility model is achieved in that the novel nano memory alloy intrauterine device, is to be made of: V-shaped rest, composite bodies and connecting line; V-shaped rest adopts the ti-ni shape memory alloy material to make open V-shaped rest, what discharge the contraception active substance is composite bodies, both combinations are: composite bodies is fixed on the V-shaped rest, or a part is fixed on the V-shaped rest another part and fastens on V-shaped rest with connecting line.Open its design of V-shaped rest meets the movable mechanics principle in uterus, composite bodies is fixed on the V-shaped rest (A type) or a part to be fixed on the V-type support another part and to fasten on V-shaped rest (Type B), on open V-shaped rest, 1～15 bending is arranged, can in the human body temperature scope, keep the shape of design, and have super-elasticity, not yielding.The form in nano memory alloy intrauterine device and uterus is compliance, and V-shaped rest is open shape, because the weak elastic force of support can relax birth control apparatus two arms with contracting of uterus and actuate, is keeping dynamic equilibrium, is difficult for incarceration and comes off to bottom offset.
The volume of composite bodies is 0.1～400mm
3, being 1～20 section, each section surface can coat the medicine film or not coat the medicine film, and composite bodies is by the contraception active substance and macromolecular material is compound makes, and the medicine film is to be made of indometacin and/or progestogen and medicine film base material.
The contraception active substance has three classes: 1, contain copper particle, 2, indometacin, 3, progestogen.The combination of the contraception active substance that contains in each section can be: contain copper particle; Contain copper particle and indometacin; Contain copper particle and progestogen; Contain copper particle, indometacin and progestogen.Containing copper particle can be nanoparticle and/or micron particle, and the composition of nanoparticle is copper oxide or copper oxide and copper or copper oxide and copper and other metal and/or other metal-oxide or copper oxide and other metal and/or other metal-oxide; The composition of micron particle be copper oxide and/copper or copper oxide and/or copper and other metal and/or other metal-oxide.Macromolecular material can be polyethylene, silicone rubber etc.After nano memory alloy intrauterine device is admitted to uterine cavity, composite is distributed in uterine cavity everywhere, and especially the composite of two arms is sent and puts palace Jiao Chu, is in high-order bit " place, pass ", therefore can more effectively disturb sperm to enter and embryo nidation, thereby improve contraceptive effect.
The compound mode of contraception active substance is shown in Table 1:
Table 1
Annotate: ● the combination in any mode of expression effective ingredient
Select nanoparticle or micron particle composite for use, (1), can make the metal ion sustained release, if the maximum release concentration Cs of metal ion is directly proportional with the volume fraction fm of nanoparticle or micron particle in the unit volume composite, be Cs=kfm, then its abrupt release speed C follows: dC/dt=K
DV (Cs-C), K
DMetal ion rate of release constant, factor such as the fundamental type of particle diameter, apparent condition and the polymer of it and nanoparticle or micron particle, degree of crystallinity is closely related; V is the volume of composite.This release profiles is steady, and the metal ion rate of release slowly reduces, and near constant release, thereby realizes controlled release.
(2), can improve the effective rate of utilization of copper significantly
Copper corrosive chemical equation in aqueous solution is as follows:
8Cu+O
2+H
2O→4Cu
2O+4H
++4e
-
Cu
2O+2H
+→Cu
2++H
2O+2e
-
Copper oxide chemical equation in aqueous solution is as follows:
CuO+2H
+→Cu
2++H
2O
This utility model adopts nanoparticle or micron particle, and the particle that is in this yardstick has bigger surface energy, makes that reaction is easier to be carried out to the right, thereby improves the effective rate of utilization of copper.
(3) reduction is to the dependency of oxygen
The corrosion of copper must aerobic participates in, because CuO is corrosive end-product, perfectly sound or part is used CuO thereby Cu in this material
2+Dispose procedure very little to the dependency of oxygen.
Dosing in intrauterine device adds indometacin and can alleviate side reaction; Add the collaborative contraception of progestogen and copper, and can treat menorrhagia.
Specify below in conjunction with accompanying drawing:
Among the figure: 1 is that composite bodies, 2 is that V-shaped rest, 3 is connecting line.
See that Fig. 1 is an A type nano memory alloy intrauterine device structural representation, each Duan Jun of composite bodies 1 is fixed on the memorial alloy V-shaped rest 2, no tailfiber.Composite bodies 1 each section can be different shape and specifications, and each section surface can coat the medicine film or not coat the medicine film.
See that Fig. 2 is an A type nano memory alloy intrauterine device structural representation, each Duan Jun in the composite bodies 1 is fixed on the memorial alloy V-shaped rest 2, fastens connecting line 3 for bottom one section.Composite bodies 1 each section can be different shape and specifications, and each section surface can coat the medicine film or not coat the medicine film.
See that Fig. 3 is a Type B nano memory alloy intrauterine device structural representation, composite bodies 1 has several sections to be fixed on the memorial alloy V-shaped rest 2, at the nethermost connecting line 3 of fastening subsidiary one section or several sections composite bodies 1 on curved of memorial alloy.Composite bodies 1 each section can be different shape and specifications, and each section surface can coat the medicine film or not coat the medicine film.
See that Fig. 4 is a Type B nano memory alloy intrauterine device structural representation, composite bodies 1 has several sections to be fixed on the memorial alloy V-shaped rest 2, fastens the connecting line 3 of subsidiary 1 section or several sections composite bodies 1 on the composite bodies 1 that is in the extreme higher position.Composite bodies 1 each section can be different shape and specifications, and each section surface can coat the medicine film or not coat the medicine film.
Claims (8)
1, a kind of novel nano memory alloy intrauterine device is characterized in that: be to be made of: V-shaped rest (2), composite bodies (1) and connecting line (3); V-shaped rest (2) adopts the ti-ni shape memory alloy material to make open V-shaped rest, what discharge the contraception active substance is composite bodies (1), both combinations are: composite bodies (1) is fixed on the V-shaped rest (2), or a part is fixed on V-shaped rest (2) and goes up another part and fasten on V-shaped rest with connecting line (3).
2, novel nano memory alloy intrauterine device according to claim 1 is characterized in that: 1～15 bending is arranged on the V-shaped rest of said opening (2).
3, novel nano memory alloy intrauterine device according to claim 1 is characterized in that: the volume of said composite bodies (1) is 0.1～400mm
3, being 1～20 section, each section can be different shape and specifications, each section surface can coat the medicine film or not coat the medicine film.
4, novel nano memory alloy intrauterine device according to claim 1 is characterized in that: said composite bodies (1) is made by contraception active substance and macromolecular material.
5, novel nano memory alloy intrauterine device according to claim 1 is characterized in that: said contraception active substance has three classes: contain copper particle, indometacin and progestogen.
6, novel nano memory alloy intrauterine device according to claim 1 is characterized in that: the combination of the contraception active substance that contains in each section of said composite bodies (1) is: contain copper particle; Contain copper particle and indometacin; Contain copper particle and progestogen; Contain copper particle, indometacin and progestogen.
7, novel nano memory alloy intrauterine device according to claim 4 is characterized in that: macromolecular material is polyethylene, silicone rubber.
8, novel nano memory alloy intrauterine device according to claim 3 is characterized in that: said medicine film is to be made of indometacin and/or progestogen and medicine film base material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2006200903752U CN201182672Y (en) | 2006-04-14 | 2006-04-14 | Novel nano memory alloy intrauterine device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2006200903752U CN201182672Y (en) | 2006-04-14 | 2006-04-14 | Novel nano memory alloy intrauterine device |
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| Publication Number | Publication Date |
|---|---|
| CN201182672Y true CN201182672Y (en) | 2009-01-21 |
Family
ID=40270407
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2006200903752U Expired - Lifetime CN201182672Y (en) | 2006-04-14 | 2006-04-14 | Novel nano memory alloy intrauterine device |
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|---|---|
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485601B (en) * | 2009-02-17 | 2010-06-02 | 山东省计划生育科学技术研究所 | H type intrauterine device |
| CN103251985A (en) * | 2012-02-13 | 2013-08-21 | 吴江永元生物科技有限公司 | Copper-containing intrauterine device |
| CN103385782A (en) * | 2012-05-08 | 2013-11-13 | 吴江永元生物科技有限公司 | Copper-containing intrauterine device |
| CN103784244A (en) * | 2012-10-30 | 2014-05-14 | 饶永 | Intrauterine implant |
-
2006
- 2006-04-14 CN CNU2006200903752U patent/CN201182672Y/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485601B (en) * | 2009-02-17 | 2010-06-02 | 山东省计划生育科学技术研究所 | H type intrauterine device |
| CN103251985A (en) * | 2012-02-13 | 2013-08-21 | 吴江永元生物科技有限公司 | Copper-containing intrauterine device |
| CN103385782A (en) * | 2012-05-08 | 2013-11-13 | 吴江永元生物科技有限公司 | Copper-containing intrauterine device |
| CN103385782B (en) * | 2012-05-08 | 2015-09-23 | 吴江永元生物科技有限公司 | A kind of copper intrauterine devices |
| CN103784244A (en) * | 2012-10-30 | 2014-05-14 | 饶永 | Intrauterine implant |
| CN103784244B (en) * | 2012-10-30 | 2016-03-23 | 吴江永元生物科技有限公司 | A kind of intrauterine implant |
| WO2014106315A1 (en) * | 2013-01-06 | 2014-07-10 | Rao Yong | Intrauterine implant |
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| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20090121 |
|
| EXPY | Termination of patent right or utility model |